{"id":"https://openalex.org/W4394063733","doi":"https://doi.org/10.1007/s40263-024-01086-z","title":"Synergism of Anti-CGRP Monoclonal Antibodies and OnabotulinumtoxinA in the Treatment of Chronic Migraine: A Real-World Retrospective Chart Review","display_name":"Synergism of Anti-CGRP Monoclonal Antibodies and OnabotulinumtoxinA in the Treatment of Chronic Migraine: A Real-World Retrospective Chart Review","publication_year":2024,"publication_date":"2024-04-07","ids":{"openalex":"https://openalex.org/W4394063733","doi":"https://doi.org/10.1007/s40263-024-01086-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/38583127","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11098928"},"language":"en","primary_location":{"id":"doi:10.1007/s40263-024-01086-z","doi":"https://doi.org/10.1007/s40263-024-01086-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40263-024-01086-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40263-024-01086-z.pdf","source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s40263-024-01086-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034634908","display_name":"Amira Salim","orcid":"https://orcid.org/0000-0001-5300-3983","observed_orcids":["https://orcid.org/0000-0001-5300-3983"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amira Salim","raw_affiliation_strings":["Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA","Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0001-5300-3983","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013183957","display_name":"Elise Hennessy","orcid":"https://orcid.org/0000-0003-2128-632X","observed_orcids":["https://orcid.org/0000-0003-2128-632X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise Hennessy","raw_affiliation_strings":["Neuroscience Institute, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Institute, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044076228","display_name":"Claire Sonneborn","orcid":"https://orcid.org/0000-0003-3038-5418","observed_orcids":["https://orcid.org/0000-0003-3038-5418"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Sonneborn","raw_affiliation_strings":["Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014871300","display_name":"Olivia Hogue","orcid":"https://orcid.org/0000-0002-3985-3831","observed_orcids":["https://orcid.org/0000-0002-3985-3831"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Hogue","raw_affiliation_strings":["Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-3985-3831","affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101039587","display_name":"Sudipa Biswas","orcid":"https://orcid.org/0009-0001-2148-6551","observed_orcids":["https://orcid.org/0009-0001-2148-6551"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudipa Biswas","raw_affiliation_strings":["Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028695340","display_name":"MaryAnn Mays","orcid":"https://orcid.org/0000-0002-6957-4219","observed_orcids":["https://orcid.org/0000-0002-6957-4219"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MaryAnn Mays","raw_affiliation_strings":["Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076831305","display_name":"Aarushi Suneja","orcid":"https://orcid.org/0009-0001-7081-5737","observed_orcids":["https://orcid.org/0009-0001-7081-5737"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aarushi Suneja","raw_affiliation_strings":["Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029504040","display_name":"Zubair A Ahmed","orcid":"https://orcid.org/0000-0002-7580-7453","observed_orcids":["https://orcid.org/0000-0002-7580-7453"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zubair Ahmed","raw_affiliation_strings":["Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041851834","display_name":"Ignacio Fernandez Mata","orcid":"https://orcid.org/0000-0003-1198-0633","observed_orcids":["https://orcid.org/0000-0003-1198-0633"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ignacio F. Mata","raw_affiliation_strings":["Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. matai@ccf.org","Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-1198-0633","affiliations":[{"raw_affiliation_string":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. matai@ccf.org","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041851834"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":3.7862,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.94228811,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"38","issue":"6","first_page":"481","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-cgrp-monoclonal-antibodies","display_name":"CGRP monoclonal antibodies","score":0.9679999947547913},{"id":"https://openalex.org/keywords/onabotulinumtoxina","display_name":"onabotulinumtoxinA","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dual-therapy","display_name":"dual therapy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5730000138282776},{"id":"https://openalex.org/keywords/migraine-days-per-month","display_name":"migraine days per month","score":0.6600000262260437},{"id":"https://openalex.org/keywords/headache-frequency-reduction","display_name":"headache frequency reduction","score":0.6079999804496765},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.39800000190734863},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.4869999885559082},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.4749999940395355},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.4560000002384186},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.3179999887943268},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.8960000276565552},{"id":"https://openalex.org/keywords/treatment-burden","display_name":"treatment burden","score":0.4359999895095825},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9038467407226562},{"id":"https://openalex.org/C2910587157","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Chronic Migraine","level":3,"score":0.7808464765548706},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.7788825035095215},{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.6992214918136597},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6728125810623169},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5722073912620544},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.513277530670166},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35186612606048584},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3347824811935425},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06108728051185608},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s40263-024-01086-z","doi":"https://doi.org/10.1007/s40263-024-01086-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40263-024-01086-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40263-024-01086-z.pdf","source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11098928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11098928","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11098928/pdf/40263_2024_Article_1086.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"Text"},{"id":"pmid:38583127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38583127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS drugs","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s40263-024-01086-z","doi":"https://doi.org/10.1007/s40263-024-01086-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40263-024-01086-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40263-024-01086-z.pdf","source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394063733.pdf","grobid_xml":"https://content.openalex.org/works/W4394063733.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W2002875177","https://openalex.org/W2006383126","https://openalex.org/W2007410119","https://openalex.org/W2007982098","https://openalex.org/W2028860345","https://openalex.org/W2029253166","https://openalex.org/W2055290905","https://openalex.org/W2068504032","https://openalex.org/W2088641212","https://openalex.org/W2138814983","https://openalex.org/W2156933229","https://openalex.org/W2162942726","https://openalex.org/W2309413820","https://openalex.org/W2556396441","https://openalex.org/W2591456584","https://openalex.org/W2608751463","https://openalex.org/W2760684802","https://openalex.org/W2768357559","https://openalex.org/W2792811290","https://openalex.org/W2805937849","https://openalex.org/W2893409070","https://openalex.org/W2901687990","https://openalex.org/W2910628827","https://openalex.org/W2961342778","https://openalex.org/W2970373125","https://openalex.org/W2970814103","https://openalex.org/W2974620985","https://openalex.org/W3003841605","https://openalex.org/W3007053288","https://openalex.org/W3013502865","https://openalex.org/W3040027196","https://openalex.org/W3046431585","https://openalex.org/W3135078565","https://openalex.org/W3154454412","https://openalex.org/W4205125475","https://openalex.org/W4220899296","https://openalex.org/W4230120862","https://openalex.org/W4282934967","https://openalex.org/W4387965026","https://openalex.org/W4390589446"],"related_works":["https://openalex.org/W4367305626","https://openalex.org/W4289526674","https://openalex.org/W4389368593","https://openalex.org/W4389447709","https://openalex.org/W3135078565","https://openalex.org/W4399357788","https://openalex.org/W4391474750","https://openalex.org/W4389683923","https://openalex.org/W3195859227","https://openalex.org/W7159797913"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"patients":[2,67,83,107,149,248,310],"with":[3,16,21,68,92,346],"chronic":[4,22,69],"migraine":[5,23,34,63],"do":[6],"not":[7],"achieve":[8],"clinically":[9],"meaningful":[10],"improvement":[11,342],"in":[12,66,115,254,316,343],"their":[13,371],"headache":[14],"frequency":[15],"monotherapy.":[17,295],"The":[18,37,76,171,181,200],"burden":[19],"associated":[20],"calls":[24],"for":[25,119,167,175],"a":[26,72,126,250,260,273,312,319,332],"multifaceted":[27],"treatment":[28,59,177,202,350],"approach":[29,183],"targeting":[30],"multiple":[31],"aspects":[32],"of":[33,39,47,80,111,131,144,157,173,203,223,245,275,308,334,348,357,374],"pathophysiology.":[35],"OBJECTIVE:":[36],"aim":[38],"this":[40,116],"study":[41],"was":[42,184,229],"to":[43,186,215,235,278,289,370],"evaluate":[44],"the":[45,204,208,226,246,265],"effect":[46],"concurrent":[48],"anti-calcitonin":[49],"gene-related":[50],"peptide":[51],"(CGRP)":[52],"monoclonal":[53],"antibody":[54],"(mAb)":[55],"and":[56,95,100,125,135,141,163,196,256,284,302,318,325,360],"onabotulinumtoxinA":[57],"(onabot)":[58],"on":[60],"median":[61,127,142,209,227,269],"monthly":[62],"days":[64],"(MMD)":[65],"migraine,":[70],"through":[71],"retrospective":[73],"study.":[74,117],"METHODS:":[75],"electronic":[77],"medical":[78],"records":[79],"Cleveland":[81],"Clinic":[82],"either":[84,158,349],"concurrently":[85,121],"(dual":[86],"therapy)":[87],"or":[88,161],"consecutively":[89,137],"(monotherapy)":[90],"treated":[91,122,138],"anti-CGRP":[93,159,293,306,329,358],"mAbs":[94,359],"onabot":[96,282,361],"between":[97],"June":[98],"2018":[99],"November":[101],"2021":[102],"were":[103,113,150,179],"extracted.":[104],"Only":[105],"adult":[106],"(\u2265":[108],"18":[109],"years":[110],"age)":[112],"included":[114],"MMDs":[118,174,211,228,270,317,344],"194":[120],"(86.6%":[123],"female":[124,140],"[interquartile":[128],"range]":[129],"age":[130,143],"51":[132],"[41-61]":[133],"years)":[134,148],"229":[136],"(88.2%":[139],"47":[145],"[IQR":[146],"39-57]":[147],"examined":[151],"at":[152,190],"baseline,":[153],"after":[154,292],"first":[155],"therapy":[156,166,339,356],"mAb":[160,294],"onabot,":[162,301,324],"following":[164],"dual":[165,224,338],"3":[168],"consecutive":[169,188,266],"months.":[170],"reduction":[172,253,315,333],"each":[176],"group":[178,206],"compared.":[180],"same":[182],"utilized":[185],"compare":[187],"monotherapy":[189,267,283,347],"separate":[191],"times":[192],"(n":[193],"=":[194],"229)":[195],"dual-therapy":[197,205,247],"groups.":[198],"RESULTS:":[199],"initial":[201],"reduced":[207],"(IQR)":[210],"from":[212,232,272,281,286,300,305,323,328],"30":[213,276],"(30-30)":[214],"15":[216,233,279],"(12-30)":[217,234],"[p":[218,238],"<":[219,239,352],"0.0001].":[220,240],"After":[221],"initiation":[222],"therapy,":[225],"further":[230],"decreased":[231,285],"8":[236],"(3-22)":[237],"A":[241],"majority":[242],"[132/194":[243],"(68.0%)]":[244],"reported":[249,259],"\u2265":[251,261,313,335],"50%":[252,314],"MMD":[255],"90/194":[257],"(46.4%)":[258],"75%":[262],"reduction.":[263],"For":[264],"group,":[268],"changed":[271],"baseline":[274],"(25-30)":[277],"(8-25)":[280],"25":[287],"(15-30)":[288],"12":[290],"(4-25)":[291],"Almost":[296],"half":[297],"(113/229":[298],"[49.3%]":[299],"104/229":[303],"[45.4%]":[304],"mAb)":[307,330],"these":[309],"achieved":[311,331],"minority":[320],"(38/229":[321],"[16.6%]":[322],"45/229":[326],"[19.7%]":[327],"75%.":[336],"Additionally,":[337],"showed":[340],"significant":[341],"compared":[345],"(p":[351],"0.0001).":[353],"CONCLUSION:":[354],"Dual":[355],"may":[362],"be":[363],"more":[364],"efficacious":[365],"than":[366],"monotherapy,":[367],"possibly":[368],"due":[369],"synergistic":[372],"mechanisms":[373],"action.":[375]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-08T00:00:00"}
