{"id":"https://openalex.org/W4394021583","doi":"https://doi.org/10.5281/zenodo.10012831","title":"Dataset #1 related to article \"NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy\"","display_name":"Dataset #1 related to article \"NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy\"","publication_year":2023,"publication_date":"2023-10-17","ids":{"openalex":"https://openalex.org/W4394021583","doi":"https://doi.org/10.5281/zenodo.10012831"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.10012831","doi":"https://doi.org/10.5281/zenodo.10012831","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10012831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.10012831","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087418457","display_name":"Caterina Scirgolea","orcid":"https://orcid.org/0000-0001-9213-5532","observed_orcids":["https://orcid.org/0000-0001-9213-5532"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Scirgolea, Caterina","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081203794","display_name":"Rosa Sottile","orcid":"https://orcid.org/0000-0003-2950-9508","observed_orcids":["https://orcid.org/0000-0003-2950-9508"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sottile, Rosa","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102928134","display_name":"Marco De Luca","orcid":"https://orcid.org/0000-0001-8310-5526","observed_orcids":["https://orcid.org/0000-0001-8310-5526"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"De Luca, Marco","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065559074","display_name":"Silvia Carnevale","orcid":"https://orcid.org/0000-0002-9176-5636","observed_orcids":["https://orcid.org/0000-0002-9176-5636"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carnevale, Silvia","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081525912","display_name":"Simone Puccio","orcid":"https://orcid.org/0000-0003-4007-4365","observed_orcids":["https://orcid.org/0000-0003-4007-4365"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Puccio, Simone","raw_affiliation_strings":["UoS Milan","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UoS Milan","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099012717","display_name":"Alberto Susana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Susanna, Alberto","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079200066","display_name":"Valentina Ferrari","orcid":"https://orcid.org/0000-0001-8506-7076","observed_orcids":["https://orcid.org/0000-0001-8506-7076"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ferrari, Valentina","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039287392","display_name":"Alice Scarpa","orcid":"https://orcid.org/0009-0001-8710-0738","observed_orcids":["https://orcid.org/0009-0001-8710-0738"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Scarpa, Alice","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032709519","display_name":"Eloise Scamardella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Scamardella, Eloise","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028592466","display_name":"Simona Feno","orcid":"https://orcid.org/0000-0003-2573-1910","observed_orcids":["https://orcid.org/0000-0003-2573-1910"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Feno, Simona","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028972598","display_name":"F\u00e9d\u00e9rica De Paoli","orcid":"https://orcid.org/0000-0003-0069-2791","observed_orcids":["https://orcid.org/0000-0003-0069-2791"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"De Paoli, Federica","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058595498","display_name":"Giorgia Alvisi","orcid":"https://orcid.org/0000-0002-7708-851X","observed_orcids":["https://orcid.org/0000-0002-7708-851X"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alvisi, Giorgia","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059818282","display_name":"Chiara Camisaschi","orcid":"https://orcid.org/0000-0002-5205-919X","observed_orcids":["https://orcid.org/0000-0002-5205-919X"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Camisaschi, Chiara","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077450097","display_name":"Gabriele De Simone","orcid":"https://orcid.org/0000-0001-6103-4376","observed_orcids":["https://orcid.org/0000-0001-6103-4376"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"De Simone, Gabriele","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071954767","display_name":"Gianluca Basso","orcid":"https://orcid.org/0000-0002-8430-4727","observed_orcids":["https://orcid.org/0000-0002-8430-4727"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Basso, Gianluca","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092344990","display_name":"Desir\u00e9e Giuliano","orcid":"https://orcid.org/0000-0003-0576-4125","observed_orcids":["https://orcid.org/0000-0003-0576-4125"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]},{"id":"https://openalex.org/I4387153341","display_name":"Leibniz Institute for Immunotherapy","ror":"https://ror.org/00xn1pr13","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4387153341"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","IT"],"is_corresponding":false,"raw_author_name":"Giuliano, Desiree","raw_affiliation_strings":["IRCCS Humanitas Research Hospital","CITO","Leibniz Institute for Immunotherapy","University of Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]},{"raw_affiliation_string":"CITO","institution_ids":[]},{"raw_affiliation_string":"Leibniz Institute for Immunotherapy","institution_ids":["https://openalex.org/I4387153341"]},{"raw_affiliation_string":"University of Regensburg","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073353725","display_name":"Emilia Maria Cristina Mazza","orcid":"https://orcid.org/0000-0003-2424-3640","observed_orcids":["https://orcid.org/0000-0003-2424-3640"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Mazza, Emilia Maria Cristina","raw_affiliation_strings":["IRCCS Humanitas Research Hospital","University of Cambridge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]},{"raw_affiliation_string":"University of Cambridge","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034721902","display_name":"Luca Gattinoni","orcid":"https://orcid.org/0000-0003-2239-3282","observed_orcids":["https://orcid.org/0000-0003-2239-3282"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]},{"id":"https://openalex.org/I4387153341","display_name":"Leibniz Institute for Immunotherapy","ror":"https://ror.org/00xn1pr13","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4387153341"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","IT"],"is_corresponding":false,"raw_author_name":"Gattinoni, Luca","raw_affiliation_strings":["CITO","University of Regensburg","Leibniz Institute for Immunotherapy","Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CITO","institution_ids":[]},{"raw_affiliation_string":"University of Regensburg","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Leibniz Institute for Immunotherapy","institution_ids":["https://openalex.org/I4387153341"]},{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023859994","display_name":"Rahul Roychoudhuri","orcid":"https://orcid.org/0000-0002-5392-1853","observed_orcids":["https://orcid.org/0000-0002-5392-1853"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Roychoudhuri, Rahul","raw_affiliation_strings":["University of Cambridge","Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040513292","display_name":"Emanuele Voulaz","orcid":"https://orcid.org/0000-0002-9091-6797","observed_orcids":["https://orcid.org/0000-0002-9091-6797"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Voulaz, Emanuele","raw_affiliation_strings":["Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042920439","display_name":"Diletta Di Mitri","orcid":"https://orcid.org/0000-0002-9626-4259","observed_orcids":["https://orcid.org/0000-0002-9626-4259"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Di Mitri, Diletta","raw_affiliation_strings":["Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088558595","display_name":"Matteo Simonelli","orcid":"https://orcid.org/0000-0002-3958-7668","observed_orcids":["https://orcid.org/0000-0002-3958-7668"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simonelli, Matteo","raw_affiliation_strings":["Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":"https://orcid.org/0000-0002-3958-7668","affiliations":[{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083865832","display_name":"Agnese Losurdo","orcid":"https://orcid.org/0000-0001-5674-9350","observed_orcids":["https://orcid.org/0000-0001-5674-9350"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["AU","IT"],"is_corresponding":false,"raw_author_name":"Losurdo, Agnese","raw_affiliation_strings":["IRCCS Humanitas Research Hospital","University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]},{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082704499","display_name":"Davide Pozzi","orcid":"https://orcid.org/0000-0001-6436-0556","observed_orcids":["https://orcid.org/0000-0001-6436-0556"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["AU","IT"],"is_corresponding":false,"raw_author_name":"Pozzi, Davide","raw_affiliation_strings":["Humanitas University","IRCCS Humanitas Research Hospital","University of Melbourne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]},{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060453159","display_name":"Carlson Tsui","orcid":"https://orcid.org/0000-0003-0642-814X","observed_orcids":["https://orcid.org/0000-0003-0642-814X"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU","IT"],"is_corresponding":false,"raw_author_name":"Tsui, Carlson","raw_affiliation_strings":["University of Melbourne","University of Piemonte"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"University of Piemonte","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015395050","display_name":"Axel Kallies","orcid":"https://orcid.org/0000-0002-6312-6968","observed_orcids":["https://orcid.org/0000-0002-6312-6968"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU","IT"],"is_corresponding":false,"raw_author_name":"Kallies, Axel","raw_affiliation_strings":["University of Melbourne","University of Piemonte"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Melbourne","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"University of Piemonte","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083806681","display_name":"Elettra Barberis","orcid":"https://orcid.org/0000-0002-2296-9766","observed_orcids":["https://orcid.org/0000-0002-2296-9766"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barberis, Elettra","raw_affiliation_strings":["University of Piemonte","Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Piemonte","institution_ids":["https://openalex.org/I123338534"]},{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086249173","display_name":"Marcello Manfredi","orcid":"https://orcid.org/0000-0003-0632-5618","observed_orcids":["https://orcid.org/0000-0003-0632-5618"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manfredi, Marcello","raw_affiliation_strings":["University of Piemonte","Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Piemonte","institution_ids":["https://openalex.org/I123338534"]},{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085944050","display_name":"Mar\u00eda Rescigno","orcid":"https://orcid.org/0000-0002-6464-509X","observed_orcids":["https://orcid.org/0000-0002-6464-509X"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rescigno, Maria","raw_affiliation_strings":["IRCCS Humanitas Research Hospital","Humanitas University"],"raw_orcid":"https://orcid.org/0000-0002-6464-509X","affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]},{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052670403","display_name":"S\u00e9bastien Jaillon","orcid":"https://orcid.org/0000-0002-5600-855X","observed_orcids":["https://orcid.org/0000-0002-5600-855X"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jaillon, Sebastien","raw_affiliation_strings":["Humanitas University","IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas University","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045159459","display_name":"Enrico Lugli","orcid":"https://orcid.org/0000-0002-1964-7678","observed_orcids":["https://orcid.org/0000-0002-1964-7678"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lugli, Enrico","raw_affiliation_strings":["IRCCS Humanitas Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Humanitas Research Hospital","institution_ids":["https://openalex.org/I4210163047"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2084999978542328,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/t-cell-effector-function","display_name":"T cell effector function","score":0.9139999747276306},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.718999981880188},{"id":"https://openalex.org/keywords/interferon-gamma-production","display_name":"IFN-gamma production","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/t-cell-stemness","display_name":"T cell stemness","score":0.5600000023841858},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.8080000281333923},{"id":"https://openalex.org/keywords/checkpoint-blockade","display_name":"checkpoint blockade","score":0.5450000166893005},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8421944379806519},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7410138249397278},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6961451768875122},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6323854923248291},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5709054470062256},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5632038712501526},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45386481285095215},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4188104271888733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35347944498062134},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3382500410079956},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18636038899421692},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12016254663467407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10338717699050903},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5281/zenodo.10012831","doi":"https://doi.org/10.5281/zenodo.10012831","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10012831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.10012832","doi":"https://doi.org/10.5281/zenodo.10012832","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10012832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.10017245","doi":"https://doi.org/10.5281/zenodo.10017245","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10017245","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.5281/zenodo.10012831","doi":"https://doi.org/10.5281/zenodo.10012831","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10012831","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6967206997","https://openalex.org/W4401960367","https://openalex.org/W4401958901","https://openalex.org/W4402370991","https://openalex.org/W4404534614","https://openalex.org/W3139770082","https://openalex.org/W7124426419","https://openalex.org/W4405529818","https://openalex.org/W3024585412","https://openalex.org/W3137408549"],"abstract_inverted_index":{"CD8+":[0,17,39,85,100,119,148],"T":[1,18,63,86,101,120],"cells":[2,19,64,121],"control":[3],"tumors":[4,82,126],"but":[5],"inevitably":[6],"become":[7],"dysfunctional.":[8],"Ionic":[9],"metabolism":[10,142],"is":[11,143],"emerging":[12],"as":[13],"a":[14,71,84,144],"regulator":[15,146],"of":[16,61,80,99,147],"in":[20,66,70,83,125,155],"anti-tumor":[21,68],"immunity.":[22],"We":[23],"show":[24],"that":[25,108],"sodium":[26],"chloride":[27],"(NaCl)":[28],"counteracts":[29],"T-cell":[30,40,149],"dysfunction":[31],"to":[32,131],"promote":[33],"cancer":[34,156],"regression.":[35],"NaCl":[36,104,141],"supplementation":[37],"during":[38],"culture":[41],"induced":[42,137],"potent":[43],"effector":[44,97,150],"differentiation,":[45,92],"IFN-g":[46],"production":[47],"and":[48,93,114,127],"cytotoxicity":[49],"while":[50],"maintaining":[51],"gene":[52],"networks":[53],"responsible":[54],"for":[55,111],"stem-like":[56],"plasticity.":[57],"Accordingly,":[58],"adoptive":[59],"transfer":[60],"tumor-specific":[62],"resulted":[65],"superior":[67],"immunity":[69],"humanized":[72],"model.":[73],"In":[74,117],"mice,":[75],"high-salt":[76],"diet":[77],"reduced":[78],"growth":[79],"experimental":[81],"cell-dependent":[87],"manner,":[88],"by":[89,94,138],"inhibiting":[90],"terminal":[91],"enhancing":[95],"the":[96],"potency":[98],"cells.":[102],"Mechanistically,":[103],"enhanced":[105],"glutamine":[106],"consumption":[107],"was":[109],"critical":[110],"transcriptional,":[112],"epigenetic":[113],"functional":[115],"reprogramming.":[116],"humans,":[118],"undergoing":[122],"antigen":[123],"recognition":[124],"predicting":[128],"favorable":[129],"response":[130],"checkpoint":[132],"blockade":[133],"immunotherapy":[134],"resembled":[135],"those":[136],"NaCl.":[139],"Thus,":[140],"major":[145],"function,":[151],"with":[152],"potential":[153],"translation":[154],"immunotherapy.":[157]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-04-07T00:00:00"}