{"id":"https://openalex.org/W4394008763","doi":"https://doi.org/10.1016/j.modpat.2024.100488","title":"Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma","display_name":"Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma","publication_year":2024,"publication_date":"2024-04-06","ids":{"openalex":"https://openalex.org/W4394008763","doi":"https://doi.org/10.1016/j.modpat.2024.100488","pmid":"https://pubmed.ncbi.nlm.nih.gov/38588881"},"language":"en","primary_location":{"id":"doi:10.1016/j.modpat.2024.100488","doi":"https://doi.org/10.1016/j.modpat.2024.100488","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.modpat.2024.100488","pdf_url":"https://www.modernpathology.org/article/S0893-3952(24)00068-1/pdf","source":{"id":"https://openalex.org/S33606366","display_name":"Modern Pathology","issn_l":"0893-3952","issn":["0893-3952","1530-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.modernpathology.org/article/S0893-3952(24)00068-1/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113164648","display_name":"Sol Beccari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sol Beccari","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103175381","display_name":"Esraa Mohamed","orcid":"https://orcid.org/0000-0002-6677-5103","observed_orcids":["https://orcid.org/0000-0002-6677-5103"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esraa Mohamed","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093242605","display_name":"Viva Voong","orcid":"https://orcid.org/0009-0002-2376-6781","observed_orcids":["https://orcid.org/0009-0002-2376-6781"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viva Voong","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054110540","display_name":"Stephanie Hilz","orcid":"https://orcid.org/0000-0002-6995-6719","observed_orcids":["https://orcid.org/0000-0002-6995-6719"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Hilz","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084231220","display_name":"Marisa Lafontaine","orcid":"https://orcid.org/0000-0002-2352-3299","observed_orcids":["https://orcid.org/0000-0002-2352-3299"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisa Lafontaine","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076038018","display_name":"Anny Shai","orcid":"https://orcid.org/0000-0001-7231-9326","observed_orcids":["https://orcid.org/0000-0001-7231-9326"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anny Shai","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024511651","display_name":"Yunita Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunita Lim","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jerry Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Martinez","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095094974","display_name":"Benjamin Switzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Switzman","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101329221","display_name":"Ryon L Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryon L. Yu","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011690840","display_name":"Janine Lupo","orcid":"https://orcid.org/0000-0002-0051-6387","observed_orcids":["https://orcid.org/0000-0002-0051-6387"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janine M. Lupo","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091099837","display_name":"Edward F. Chang","orcid":"https://orcid.org/0000-0003-2480-4700","observed_orcids":["https://orcid.org/0000-0003-2480-4700"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward F. Chang","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038354675","display_name":"Shawn L. Hervey\u2010Jumper","orcid":"https://orcid.org/0000-0003-4699-260X","observed_orcids":["https://orcid.org/0000-0003-4699-260X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn L. Hervey-Jumper","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006262715","display_name":"Mitchel Stuart Berger","orcid":"https://orcid.org/0000-0003-1983-4892","observed_orcids":["https://orcid.org/0000-0003-1983-4892"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchel S. Berger","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088197113","display_name":"J Costello","orcid":"https://orcid.org/0000-0003-3189-584X","observed_orcids":["https://orcid.org/0000-0003-3189-584X","https://orcid.org/0000-0001-7608-0885"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph F. Costello","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019140507","display_name":"Joanna J. Phillips","orcid":"https://orcid.org/0000-0002-3789-8120","observed_orcids":["https://orcid.org/0000-0002-3789-8120"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joanna J. Phillips","raw_affiliation_strings":["Department of Neurological Surgery, University of California, San Francisco, California; Neuropathology Division, Department of Pathology, University of California, San Francisco, California. Electronic address: Joanna.phillips@ucsf.edu"],"raw_orcid":"https://orcid.org/0000-0002-3789-8120","affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of California, San Francisco, California; Neuropathology Division, Department of Pathology, University of California, San Francisco, California. Electronic address: Joanna.phillips@ucsf.edu","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019140507"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":1.0612,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73349308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"37","issue":"6","first_page":"100488","last_page":"100488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-glioma","display_name":"diffuse glioma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/preanalytical-variables","display_name":"pre-analytical variables","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cold-ischemia-time","display_name":"cold ischemia time","score":0.9440000057220459},{"id":"https://openalex.org/keywords/formalin-fixation","display_name":"formalin fixation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ribosomal-protein-s6","display_name":"ribosomal protein S6","score":0.7129999995231628},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-sampling","display_name":"tumor sampling","score":0.7009999752044678},{"id":"https://openalex.org/keywords/idh-mutant-glioma","display_name":"IDH-mutant glioma","score":0.7739999890327454},{"id":"https://openalex.org/keywords/idh-wildtype-glioblastoma","display_name":"IDH-wildtype glioblastoma","score":0.8920000195503235},{"id":"https://openalex.org/keywords/biomarker-heterogeneity","display_name":"biomarker heterogeneity","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7938649654388428},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7846114039421082},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5953590869903564},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5706220269203186},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5067229866981506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.414492130279541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34051477909088135},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.28239190578460693},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26449766755104065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18518444895744324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11551091074943542}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.modpat.2024.100488","doi":"https://doi.org/10.1016/j.modpat.2024.100488","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.modpat.2024.100488","pdf_url":"https://www.modernpathology.org/article/S0893-3952(24)00068-1/pdf","source":{"id":"https://openalex.org/S33606366","display_name":"Modern Pathology","issn_l":"0893-3952","issn":["0893-3952","1530-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Pathology","raw_type":"journal-article"},{"id":"pmid:38588881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38588881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.modpat.2024.100488","doi":"https://doi.org/10.1016/j.modpat.2024.100488","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.modpat.2024.100488","pdf_url":"https://www.modernpathology.org/article/S0893-3952(24)00068-1/pdf","source":{"id":"https://openalex.org/S33606366","display_name":"Modern Pathology","issn_l":"0893-3952","issn":["0893-3952","1530-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G142050108","display_name":"Mitigation of preanalytic factors influencing brain tumor protein phosphorylation","funder_award_id":"U01CA229345","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2189199451","display_name":"Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer","funder_award_id":"U01CA168878","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2342450115","display_name":null,"funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G6793263369","display_name":null,"funder_award_id":"P50CA097257","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G839201715","display_name":null,"funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320337824","funder_display_name":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco"},{"id":"https://openalex.org/G9000121466","display_name":null,"funder_award_id":"CA097257","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000868711","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000884086","display_name":"Training Program in Translational Brain Tumor Research","funder_award_id":"T32CA151022","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000917356","display_name":"Brain Tumor SPORE Grant","funder_award_id":"P50CA097257","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337824","display_name":"Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco","ror":"https://ror.org/05yndxy10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394008763.pdf","grobid_xml":"https://content.openalex.org/works/W4394008763.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1792532087","https://openalex.org/W1928893444","https://openalex.org/W1968448861","https://openalex.org/W1969837875","https://openalex.org/W1986092833","https://openalex.org/W1998512193","https://openalex.org/W2007550555","https://openalex.org/W2020811395","https://openalex.org/W2026616100","https://openalex.org/W2028222053","https://openalex.org/W2032500497","https://openalex.org/W2046913227","https://openalex.org/W2052644075","https://openalex.org/W2071881327","https://openalex.org/W2074824216","https://openalex.org/W2078784420","https://openalex.org/W2097324774","https://openalex.org/W2108776415","https://openalex.org/W2109816625","https://openalex.org/W2115276344","https://openalex.org/W2125096000","https://openalex.org/W2130077384","https://openalex.org/W2134000127","https://openalex.org/W2137223606","https://openalex.org/W2139203226","https://openalex.org/W2148726987","https://openalex.org/W2150030728","https://openalex.org/W2150213160","https://openalex.org/W2157382176","https://openalex.org/W2162871269","https://openalex.org/W2309779470","https://openalex.org/W2313583523","https://openalex.org/W2320523858","https://openalex.org/W2336003242","https://openalex.org/W2572279197","https://openalex.org/W2597290376","https://openalex.org/W2616761213","https://openalex.org/W2741684011","https://openalex.org/W2768255508","https://openalex.org/W2789278189","https://openalex.org/W2790561936","https://openalex.org/W2890210405","https://openalex.org/W2896684230","https://openalex.org/W2913589503","https://openalex.org/W2931379341","https://openalex.org/W2952481429","https://openalex.org/W2963110900","https://openalex.org/W3036154696","https://openalex.org/W3038953452","https://openalex.org/W3039237638","https://openalex.org/W3091977395","https://openalex.org/W3126609356","https://openalex.org/W3149667941","https://openalex.org/W3158045410","https://openalex.org/W3207781928","https://openalex.org/W4200327950","https://openalex.org/W4210541723","https://openalex.org/W4221061350","https://openalex.org/W4372331154","https://openalex.org/W4385197506","https://openalex.org/W6657302865","https://openalex.org/W6679823295","https://openalex.org/W6852425837"],"related_works":["https://openalex.org/W4388590682","https://openalex.org/W3111338133","https://openalex.org/W4221061350","https://openalex.org/W2784050429","https://openalex.org/W2086800171","https://openalex.org/W658800366","https://openalex.org/W3032835748","https://openalex.org/W2393907265","https://openalex.org/W2391036106","https://openalex.org/W2899522885"],"abstract_inverted_index":{"Biomarker-driven":[0],"therapeutic":[1,25],"clinical":[2,30,153,192],"trials":[3,31,193],"require":[4],"the":[5,34,41,85,97,178,203,210,228,271],"implementation":[6],"of":[7,36,87,100,103,109,115,122,151,205,212,230,242,252,274,296],"standardized,":[8],"evidence-based":[9],"practices":[10],"for":[11,27,65,197],"sample":[12],"collection.":[13],"In":[14],"diffuse":[15,80,278],"glioma,":[16],"phosphatidylinositol":[17],"3":[18],"(PI3)-kinase/AKT/mTOR":[19],"(PI3/AKT/mTOR)":[20],"signaling":[21,276],"is":[22],"an":[23],"attractive":[24],"target":[26,121],"which":[28],"window-of-opportunity":[29],"could":[32],"facilitate":[33],"identification":[35],"promising":[37],"new":[38],"agents.":[39],"Yet,":[40],"relevant":[42],"preanalytic":[43,286],"variables":[44],"and":[45,71,78,134,136,216,232,284,294],"optimal":[46,248],"tumor":[47,73,175,249,261],"sampling":[48],"methods":[49],"necessary":[50],"to":[51,185,226],"measure":[52],"pathway":[53],"activity":[54,111],"are":[55,107],"unknown.":[56],"To":[57],"address":[58],"this,":[59],"we":[60,83,201],"used":[61],"a":[62],"murine":[63],"model":[64],"isocitrate":[66],"dehydrogenase":[67],"(IDH)-wildtype":[68],"glioblastoma":[69],"(GBM)":[70],"human":[72,260],"tissue,":[74],"including":[75,288],"IDH-wildtype":[76],"GBM":[77],"IDH-mutant":[79],"glioma.":[81],"First,":[82],"determined":[84],"impact":[86,204],"delayed":[88,186],"time-to-formalin":[89,289],"fixation,":[90,290],"or":[91,158],"cold":[92],"ischemia":[93],"time":[94],"(CIT),":[95],"on":[96,209],"quantitative":[98],"assessment":[99,273],"cellular":[101],"expression":[102,160,229,237,255],"6":[104],"phosphoproteins":[105],"that":[106],"readouts":[108],"PI3K/AK/mTOR":[110],"(phosphorylated-proline-rich":[112],"Akt":[113],"substrate":[114],"40":[116],"kDa":[117],"(p-PRAS40,":[118],"T246),":[119],"-mechanistic":[120],"rapamycin":[123],"(p-mTOR;":[124],"S2448);":[125],"-AKT":[126],"(p-AKT,":[127],"S473);":[128],"-ribosomal":[129],"protein":[130,141],"S6":[131],"(p-RPS6,":[132],"S240/244":[133],"S235/236),":[135],"-eukaryotic":[137],"initiation":[138],"factor":[139],"4E-binding":[140],"1":[142],"(p-4EBP1,":[143],"T37/46).":[144],"With":[145],"CITs":[146],"\u2265":[147],"2":[148],"hours,":[149],"typical":[150],"routine":[152],"handling,":[154],"all":[155],"had":[156],"reduced":[157],"altered":[159],"with":[161,181],"p-RPS6":[162,189,213,235,253],"(S240/244)":[163],"exhibiting":[164],"relatively":[165],"greater":[166],"stability.":[167],"A":[168],"similar":[169],"pattern":[170],"was":[171,224,238],"observed":[172],"using":[173],"patient":[174],"samples":[176,262],"from":[177,263],"operating":[179],"room":[180],"p-4EBP1":[182,231],"more":[183],"sensitive":[184],"fixation":[187],"than":[188],"(S240/244).":[190],"Many":[191],"utilize":[194],"unstained":[195],"slides":[196],"biomarker":[198],"evaluation.":[199],"Thus,":[200,270],"evaluated":[202],"slide":[206,291],"storage":[207,221,243,292],"conditions":[208],"detection":[211],"(S240/244),":[214],"p-4EBP1,":[215],"p-AKT.":[217],"After":[218],"5":[219],"months,":[220],"at":[222],"-80\u00b0C":[223],"required":[225],"preserve":[227],"p-AKT,":[233],"whereas":[234],"(240/244)":[236,254],"not":[239],"stable":[240],"regardless":[241],"temperature.":[244],"Biomarker":[245],"heterogeneity":[246,283],"impacts":[247],"sampling.":[250],"Quantification":[251],"in":[256,277],"multiple":[257,285],"regionally":[258],"distinct":[259],"8":[264],"patients":[265],"revealed":[266],"significant":[267],"intratumoral":[268,282],"heterogeneity.":[269],"accurate":[272],"PI3K/AKT/mTOR":[275],"glioma":[279],"must":[280],"overcome":[281],"factors,":[287],"conditions,":[293],"phosphoprotein":[295],"interest.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-07T00:00:00"}
