{"id":"https://openalex.org/W4394002103","doi":"https://doi.org/10.1007/978-3-031-53858-2_1","title":"Clinical Implications of Germline Pathogenic Variants in the VHL Gene","display_name":"Clinical Implications of Germline Pathogenic Variants in the VHL Gene","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4394002103","doi":"https://doi.org/10.1007/978-3-031-53858-2_1"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-031-53858-2_1","doi":"https://doi.org/10.1007/978-3-031-53858-2_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-031-53858-2_1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Von Hippel-Lindau Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4393977314","display_name":"Von Hippel-Lindau Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031247002","display_name":"Eitan Friedman","orcid":"https://orcid.org/0000-0002-6745-1733","observed_orcids":["https://orcid.org/0000-0002-6745-1733"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800586481","display_name":"Assuta Medical Center","ror":"https://ror.org/04qkymg17","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800586481"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Eitan Friedman","raw_affiliation_strings":["Personalized Preventive Precision Medicine Initiative, Assuta Medical Center, Tel Aviv and the Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Personalized Preventive Precision Medicine Initiative, Assuta Medical Center, Tel Aviv and the Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800586481"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031247002"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800586481"],"apc_list":null,"apc_paid":null,"fwci":2.0423,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83440662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-hippel-lindau-disease","display_name":"von Hippel-Lindau disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vhl-gene","display_name":"VHL gene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/germline-pathogenic-variants","display_name":"germline pathogenic variants","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.8299999833106995},{"id":"https://openalex.org/keywords/phenotypic-variation","display_name":"phenotypic variability","score":0.7739999890327454},{"id":"https://openalex.org/keywords/penetrance","display_name":"penetrance","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cancer-surveillance","display_name":"cancer surveillance","score":0.6740000247955322},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7419999837875366},{"id":"https://openalex.org/keywords/risk-reducing-interventions","display_name":"risk-reducing interventions","score":0.7409999966621399},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.4390000104904175},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.6740000247955322},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.8526878356933594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6008996367454529},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5493301749229431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4806150794029236}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-031-53858-2_1","doi":"https://doi.org/10.1007/978-3-031-53858-2_1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-031-53858-2_1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Von Hippel-Lindau Disease","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W1534902561","https://openalex.org/W1749022239","https://openalex.org/W1910627688","https://openalex.org/W1928445625","https://openalex.org/W1964779968","https://openalex.org/W1964875278","https://openalex.org/W1971274724","https://openalex.org/W1972009030","https://openalex.org/W1973120052","https://openalex.org/W1979891446","https://openalex.org/W1980693574","https://openalex.org/W1992047314","https://openalex.org/W2000542531","https://openalex.org/W2020382129","https://openalex.org/W2037137142","https://openalex.org/W2037939021","https://openalex.org/W2040031153","https://openalex.org/W2043312477","https://openalex.org/W2057771750","https://openalex.org/W2061329487","https://openalex.org/W2068555261","https://openalex.org/W2068919366","https://openalex.org/W2075463096","https://openalex.org/W2076145832","https://openalex.org/W2093776019","https://openalex.org/W2093887297","https://openalex.org/W2095208234","https://openalex.org/W2097772834","https://openalex.org/W2099549514","https://openalex.org/W2099697409","https://openalex.org/W2100632625","https://openalex.org/W2108366666","https://openalex.org/W2115857023","https://openalex.org/W2123724520","https://openalex.org/W2135034560","https://openalex.org/W2135436036","https://openalex.org/W2144914570","https://openalex.org/W2147021356","https://openalex.org/W2149441684","https://openalex.org/W2167324724","https://openalex.org/W2169246212","https://openalex.org/W2172170481","https://openalex.org/W2220466394","https://openalex.org/W2317428842","https://openalex.org/W2335012284","https://openalex.org/W2414664756","https://openalex.org/W2497444444","https://openalex.org/W2514578518","https://openalex.org/W2551569844","https://openalex.org/W2566745542","https://openalex.org/W2573357293","https://openalex.org/W2614257677","https://openalex.org/W2622629840","https://openalex.org/W2622978308","https://openalex.org/W2625567931","https://openalex.org/W2630778880","https://openalex.org/W2743654837","https://openalex.org/W2753949998","https://openalex.org/W2786405572","https://openalex.org/W2808453128","https://openalex.org/W2825050015","https://openalex.org/W2888842456","https://openalex.org/W2912454862","https://openalex.org/W2913218828","https://openalex.org/W2941313378","https://openalex.org/W2946700687","https://openalex.org/W2969675173","https://openalex.org/W2979693172","https://openalex.org/W2989860363","https://openalex.org/W2995939030","https://openalex.org/W3017039194","https://openalex.org/W3033170663","https://openalex.org/W3084823027","https://openalex.org/W3089803871","https://openalex.org/W3110802119","https://openalex.org/W3115292038","https://openalex.org/W3118602265","https://openalex.org/W3138910257","https://openalex.org/W3156809320","https://openalex.org/W3198017715","https://openalex.org/W3202276715","https://openalex.org/W3209916949","https://openalex.org/W3211452731","https://openalex.org/W3215678173","https://openalex.org/W4200044103","https://openalex.org/W4200148700","https://openalex.org/W4205618597","https://openalex.org/W4212802671","https://openalex.org/W4212856940","https://openalex.org/W4214590721","https://openalex.org/W4224935359","https://openalex.org/W4381309404"],"related_works":["https://openalex.org/W2006622472","https://openalex.org/W7215084186","https://openalex.org/W7120415049","https://openalex.org/W2989860363","https://openalex.org/W7028555931","https://openalex.org/W2826798580","https://openalex.org/W2981072174","https://openalex.org/W3205180267","https://openalex.org/W2011499154","https://openalex.org/W2418785168"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2024-04-06T00:00:00"}