{"id":"https://openalex.org/W4393999976","doi":"https://doi.org/10.1016/j.jposna.2024.100031","title":"Understanding the importance of peak bone mass","display_name":"Understanding the importance of peak bone mass","publication_year":2024,"publication_date":"2024-04-05","ids":{"openalex":"https://openalex.org/W4393999976","doi":"https://doi.org/10.1016/j.jposna.2024.100031","pmid":"https://pubmed.ncbi.nlm.nih.gov/40433296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12088333"},"language":"en","primary_location":{"id":"doi:10.1016/j.jposna.2024.100031","doi":"https://doi.org/10.1016/j.jposna.2024.100031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jposna.2024.100031","pdf_url":null,"source":{"id":"https://openalex.org/S4220651931","display_name":"Journal of the Pediatric Orthopaedic Society of North America","issn_l":"2768-2765","issn":["2768-2765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/I4405266784","host_organization_name":"Pediatric Orthopaedic Society of North America","host_organization_lineage":["https://openalex.org/I4405266784"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Pediatric Orthopaedic Society of North America","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jposna.2024.100031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058471813","display_name":"Timothy E. Hereford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Hereford","raw_affiliation_strings":["Nemours Children's Health, Wilmington, DE,\u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nemours Children's Health, Wilmington, DE,\u00a0USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032898172","display_name":"Alec S. Kellish","orcid":"https://orcid.org/0000-0002-7877-9486","observed_orcids":["https://orcid.org/0000-0002-7877-9486"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alec Kellish","raw_affiliation_strings":["Thomas Jefferson University, Philadelphia, PA,\u00a0USA","Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas Jefferson University, Philadelphia, PA,\u00a0USA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021166340","display_name":"Julie Balch Samora","orcid":"https://orcid.org/0000-0002-3700-7471","observed_orcids":["https://orcid.org/0000-0002-3700-7471","https://orcid.org/0000-0001-8311-8968"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Balch Samora","raw_affiliation_strings":["Nationwide Children's Hospital, Columbus, OH,\u00a0USA","Nationwide Children's Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nationwide Children's Hospital, Columbus, OH,\u00a0USA","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"Nationwide Children's Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013757696","display_name":"L. Reid Nichols","orcid":"https://orcid.org/0000-0002-6861-9673","observed_orcids":["https://orcid.org/0000-0002-6861-9673"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Louise Reid Nichols","raw_affiliation_strings":["Nemours Children's Health, Wilmington, DE,\u00a0USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nemours Children's Health, Wilmington, DE,\u00a0USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013757696"],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":19.8652,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.99826009,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"7","issue":null,"first_page":"100031","last_page":"100031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10992","display_name":"Forensic Anthropology and Bioarchaeology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1204","display_name":"Archeology (arts and humanities)"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peak-bone-mass","display_name":"peak bone mass","score":1.0},{"id":"https://openalex.org/keywords/bone-mineral-content","display_name":"bone mineral content","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.5440000295639038},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.6830000281333923},{"id":"https://openalex.org/keywords/peak-height-velocity","display_name":"peak height velocity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pediatric-fractures","display_name":"pediatric fractures","score":0.3919999897480011},{"id":"https://openalex.org/keywords/osteoporosis-risk","display_name":"osteoporosis risk","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.8299999833106995},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9620000123977661},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8759999871253967},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.996999979019165},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5590000152587891},{"id":"https://openalex.org/keywords/skeletal-health","display_name":"skeletal health","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2780712178","wikidata":"https://www.wikidata.org/wiki/Q25326559","display_name":"Peak bone mass","level":4,"score":0.8647475242614746},{"id":"https://openalex.org/C2993253760","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone mass","level":3,"score":0.8288730978965759},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6225689053535461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6069979071617126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5530512928962708},{"id":"https://openalex.org/C2992594941","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone mineral content","level":4,"score":0.4886189103126526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4237977862358093},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.38051480054855347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35157322883605957},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.2933323383331299},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.22614747285842896}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.jposna.2024.100031","doi":"https://doi.org/10.1016/j.jposna.2024.100031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jposna.2024.100031","pdf_url":null,"source":{"id":"https://openalex.org/S4220651931","display_name":"Journal of the Pediatric Orthopaedic Society of North America","issn_l":"2768-2765","issn":["2768-2765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/I4405266784","host_organization_name":"Pediatric Orthopaedic Society of North America","host_organization_lineage":["https://openalex.org/I4405266784"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Pediatric Orthopaedic Society of North America","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12088333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12088333","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12088333/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pediatr Soc North Am","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:10923469","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12088333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40433296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40433296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Pediatric Orthopaedic Society of North America","raw_type":"Journal Article"},{"id":"pmh:oai:jdc.jefferson.edu:medfp-1538","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/medfp/515","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Medicine Faculty Papers","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7bbec994ae624b6f89fbe4620fc23a80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7bbec994ae624b6f89fbe4620fc23a80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Pediatric Orthopaedic Society of North America, Vol 7, Iss , Pp 100031- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jposna.2024.100031","doi":"https://doi.org/10.1016/j.jposna.2024.100031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jposna.2024.100031","pdf_url":null,"source":{"id":"https://openalex.org/S4220651931","display_name":"Journal of the Pediatric Orthopaedic Society of North America","issn_l":"2768-2765","issn":["2768-2765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/I4405266784","host_organization_name":"Pediatric Orthopaedic Society of North America","host_organization_lineage":["https://openalex.org/I4405266784"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Pediatric Orthopaedic Society of North America","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393999976.pdf","grobid_xml":"https://content.openalex.org/works/W4393999976.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W175660244","https://openalex.org/W1571896605","https://openalex.org/W1606867770","https://openalex.org/W1964815707","https://openalex.org/W1987997128","https://openalex.org/W2002482355","https://openalex.org/W2005836587","https://openalex.org/W2012872055","https://openalex.org/W2013882372","https://openalex.org/W2032896309","https://openalex.org/W2037733089","https://openalex.org/W2058262707","https://openalex.org/W2069726034","https://openalex.org/W2071850968","https://openalex.org/W2093089036","https://openalex.org/W2107177713","https://openalex.org/W2119126572","https://openalex.org/W2119621057","https://openalex.org/W2123956924","https://openalex.org/W2132718347","https://openalex.org/W2134433004","https://openalex.org/W2141106453","https://openalex.org/W2153059487","https://openalex.org/W2165168351","https://openalex.org/W2166422685","https://openalex.org/W2170372671","https://openalex.org/W2171133944","https://openalex.org/W2257516528","https://openalex.org/W2463495180","https://openalex.org/W2480350260","https://openalex.org/W2922504410","https://openalex.org/W2924736117","https://openalex.org/W2966780068","https://openalex.org/W3014307370","https://openalex.org/W3049420207","https://openalex.org/W3112309355","https://openalex.org/W4225253214","https://openalex.org/W4320730155","https://openalex.org/W6639836851"],"related_works":["https://openalex.org/W2492934368","https://openalex.org/W4404581756","https://openalex.org/W7009799958","https://openalex.org/W9793237","https://openalex.org/W4211226882","https://openalex.org/W2440288500","https://openalex.org/W2624275603","https://openalex.org/W7096884873","https://openalex.org/W2170945485","https://openalex.org/W2547169855"],"abstract_inverted_index":{"Bone":[0,17],"mass":[1,32,49,57,86,104,119],"attained":[2,121],"early":[3],"in":[4,138,144,156],"life":[5],"is":[6,33,66,95,120],"one":[7],"of":[8,13,27,40,45,83,92,100,125,129,152,170],"the":[9,28,38,41,81,98,123,126,141],"most":[10],"important":[11],"determinants":[12],"lifelong":[14],"skeletal":[15],"health.":[16],"mineral":[18],"content":[19],"increases":[20,143],"exponentially":[21],"during":[22,35,134],"childhood.":[23],"In":[24],"fact,":[25],"40%-60%":[26],"total":[29],"adult":[30,153],"bone":[31,48,56,85,103,113,118,147,167],"accrued":[34],"puberty.":[36],"By":[37],"end":[39,124],"first":[42],"2":[43],"decades":[44],"life,":[46],"peak":[47,102,112,135,166],"has":[50,58],"been":[51],"reached.":[52],"Between":[53],"ages":[54],"20-50,":[55],"plateaued,":[59],"but":[60,146],"it":[61],"continues":[62],"to":[63,88,96],"remodel.":[64],"This":[65],"regulated":[67],"by":[68,122],"parathyroid":[69],"hormone":[70],"(PTH),":[71],"vitamin":[72],"D3,":[73],"and":[74,105,110,160],"insulin-like":[75],"growth":[76],"factor":[77],"1":[78],"(IGF-1).":[79],"After":[80],"age":[82],"50,":[84],"begins":[87],"decrease.":[89],"The":[90],"purpose":[91],"this":[93],"paper":[94],"review":[97],"importance":[99],"maximizing":[101],"factors":[106,163],"that":[107,164],"can":[108],"modify":[109],"maintain":[111],"mass.":[114,168],"Key":[115],"Concepts:":[116],"(1)Peak":[117],"second":[127],"decade":[128],"life.(2)There":[130],"are":[131,158],"more":[132],"fractures":[133],"height":[136],"velocity":[137],"adolescence":[139],"as":[140],"body":[142],"size":[145],"mineralization":[148],"lags":[149],"behind.(3)The":[150],"risk":[151,162],"osteoporosis":[154],"starts":[155],"childhood.(4)There":[157],"modifiable":[159],"nonmodifiable":[161],"affect":[165],"Level":[169],"Evidence:":[171],"IV.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":37},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-04-06T00:00:00"}