{"id":"https://openalex.org/W4393989757","doi":"https://doi.org/10.1158/1538-7445.am2024-lb081","title":"Abstract LB081: Novel targeted oligonucleotide-based telomere disruptor for immunotherapy of diffuse large B-cell lymphoma","display_name":"Abstract LB081: Novel targeted oligonucleotide-based telomere disruptor for immunotherapy of diffuse large B-cell lymphoma","publication_year":2024,"publication_date":"2024-04-05","ids":{"openalex":"https://openalex.org/W4393989757","doi":"https://doi.org/10.1158/1538-7445.am2024-lb081"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-lb081","doi":"https://doi.org/10.1158/1538-7445.am2024-lb081","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-lb081","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035817701","display_name":"Chunsong Yu","orcid":"https://orcid.org/0000-0003-4823-7835","observed_orcids":["https://orcid.org/0000-0003-4823-7835"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunsong Yu","raw_affiliation_strings":["1City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014059510","display_name":"Yong Liang","orcid":"https://orcid.org/0000-0003-3679-3084","observed_orcids":["https://orcid.org/0000-0003-3679-3084"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Liang","raw_affiliation_strings":["1City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113210145","display_name":"Piotr M. Swiderski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr Swiderski","raw_affiliation_strings":["1City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074743570","display_name":"Larry W. Kwak","orcid":"https://orcid.org/0000-0002-1884-5349","observed_orcids":["https://orcid.org/0000-0002-1884-5349"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Kwak","raw_affiliation_strings":["1City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008219651","display_name":"Marcin Kortylewski","orcid":"https://orcid.org/0000-0002-6003-1816","observed_orcids":["https://orcid.org/0000-0002-6003-1816"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcin Kortylewski","raw_affiliation_strings":["1City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1301076528"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"7_Supplement","first_page":"LB081","last_page":"LB081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/6-thio-2-deoxyguanosine","display_name":"6-thio-2'-deoxyguanosine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cpg-oligodeoxynucleotides","display_name":"CpG oligodeoxynucleotides","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.8669999837875366},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.687890887260437},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.6632854342460632},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.561481773853302},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5330592393875122},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.49965453147888184},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.4297100305557251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.409185528755188},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36609959602355957},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3188477158546448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31403884291648865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2786290943622589},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2363344430923462},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1250855028629303}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-lb081","doi":"https://doi.org/10.1158/1538-7445.am2024-lb081","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-lb081","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096760656","https://openalex.org/W2045637853","https://openalex.org/W2005903392","https://openalex.org/W2417511905","https://openalex.org/W4295073628","https://openalex.org/W2175325490","https://openalex.org/W2362612357","https://openalex.org/W4250397071","https://openalex.org/W1999832612","https://openalex.org/W2988609983"],"abstract_inverted_index":{"Abstract":[0],"Telomerase":[1],"(TERT)":[2],"is":[3],"an":[4,313],"enzyme":[5],"critical":[6],"for":[7,350,364],"carcinogenesis":[8],"expressed":[9],"in":[10,67,70,118,125,161,224,241,276],"about":[11],"90%":[12],"of":[13,92,121,150,164,176,200,205,237,244,251,254,258,264,285,352,360],"human":[14,122,136,201],"cancers,":[15],"including":[16],"aggressive":[17,319],"diffuse":[18,353],"large":[19,354],"B-cell":[20,355],"lymphoma":[21,65,76,110,223,299,356],"(DLBCL).":[22],"Targeting":[23],"TERT":[24],"proven":[25],"difficult":[26],"due":[27],"to":[28,31,38,54,106,131,325],"on-target":[29],"toxicities":[30],"non-malignant":[32,132],"hematopoietic":[33,138,165],"stem":[34,139,166],"cells":[35,66,77,124,134,140,169,172,178,322],"and":[36,69,73,97,109,141,193,302,315,327,375],"potentially":[37],"activated":[39,142],"immune":[40,270],"effector":[41],"cells.":[42,144],"To":[43],"overcome":[44],"these":[45],"challenges,":[46],"we":[47,214],"developed":[48],"novel":[49],"TLR9+":[50],"cell-selective":[51,309],"CpG-oligodeoxynucleotides":[52],"(ODNs)":[53],"deliver":[55],"telomere-damaging":[56],"nucleoside":[57],"analogue,":[58],"6-thio-2\u2019-deoxy-guanosine":[59],"(6tdG),":[60],"into":[61,95,103],"target":[62],"B":[63,177],"cell":[64,98,111,300],"vitro":[68],"vivo.":[71],"Human":[72],"mouse":[74],"TLR9+/TERT+":[75],"rapidly":[78],"internalized":[79],"CpG(6tdG)-oligonucleotides":[80,115,151],"through":[81],"active":[82],"endocytosis.":[83],"6tdG":[84,101,189,233],"molecules":[85],"were":[86,179],"released":[87],"from":[88],"the":[89,93,146,162,174,230,252,262,292,361],"3\u2019":[90],"end":[91],"oligonucleotide":[94,293],"cytosol":[96],"nucleus.":[99],"TERT-mediated":[100],"incorporation":[102],"telomeres,":[104],"led":[105],"DNA":[107],"damage":[108],"death.":[112],"In":[113,272],"vitro,":[114],"showed":[116],"potency":[117],"targeting":[119],"variety":[120],"DLBCL":[123,321],"nanomolar":[126],"range":[127],"without":[128,158],"detectable":[129,159],"toxicity":[130],"TERT\u2014":[133],"or":[135,170,203,210,235],"TERT+":[137,221,320],"T":[143,171,267,329],"Importantly,":[145],"repeated":[147],"systemic":[148],"administration":[149],"was":[152,239],"well-tolerated":[153],"by":[154],"humanized":[155],"hCD34/NOG":[156],"mice,":[157,278],"decrease":[160],"percentage":[163],"cells,":[167],"myeloid":[168],"although":[173],"numbers":[175],"partly":[180],"reduced":[181],"as":[182,208],"expected.":[183],"Intravenously":[184],"injected":[185],"CpG(6tdG)-oligonucleotides,":[186],"but":[187,228,282],"not":[188,229],"nucleoside,":[190],"had":[191],"potent":[192],"dose-dependent":[194],"antitumor":[195,269,305,331],"effects":[196],"against":[197,218,318],"xenotransplanted":[198],"models":[199],"GC-":[202],"ABC-subtypes":[204],"DLBCL,":[206],"such":[207],"OCI-Ly18":[209],"OCI-Ly3,":[211],"respectively.":[212],"Furthermore,":[213],"assessed":[215],"CpG(6tdG)-oligonucleotide":[216,259,279],"activity":[217,296],"aggressive,":[219],"syngeneic":[220],"E\u03bc-myc/15A":[222],"immunocompetent":[225],"mice.":[226,255],"CpG(6tdG)-oligonucleotide,":[227],"CpG-oligonucleotide":[231],"alone,":[232],"alone":[234],"co-injection":[236],"thereof,":[238],"effective":[240,314],"triggering":[242,297],"regression":[243,284],"established":[245],"15A":[246,286],"tumors":[247],"with":[248,261,323],"long-term":[249],"survival":[250],"majority":[253],"The":[256],"effect":[257],"correlated":[260],"activation":[263],"tumor":[265],"antigen-specific":[266],"cell-mediated":[268],"responses.":[271],"contrast,":[273],"when":[274],"tested":[275],"immunodeficient":[277],"induced":[280],"significant":[281],"transient":[283],"lymphoma.":[287],"These":[288],"results":[289],"suggest":[290],"that":[291],"elicits":[294],"two-pronged":[295],"direct":[298],"cytotoxicity":[301],"also":[303],"immune-mediated":[304],"effects.":[306],"Overall,":[307],"this":[308],"strategy":[310,317],"could":[311],"provide":[312],"safer":[316],"potential":[324],"engage":[326],"support":[328],"cell-based":[330],"immunity.":[332],"Citation":[333],"Format:":[334],"Chunsong":[335],"Yu,":[336],"Yong":[337],"Liang,":[338],"Piotr":[339],"Swiderski,":[340],"Larry":[341],"Kwak,":[342],"Marcin":[343],"Kortylewski.":[344],"Novel":[345],"targeted":[346],"oligonucleotide-based":[347],"telomere":[348],"disruptor":[349],"immunotherapy":[351],"[abstract].":[357],"In:":[358],"Proceedings":[359],"American":[362],"Association":[363],"Cancer":[365,387],"Research":[366],"Annual":[367],"Meeting":[368],"2024;":[369],"Part":[370],"2":[371],"(Late-Breaking,":[372],"Clinical":[373],"Trial,":[374],"Invited":[376],"Abstracts);":[377],"2024":[378],"Apr":[379],"5-10;":[380],"San":[381],"Diego,":[382],"CA.":[383],"Philadelphia":[384],"(PA):":[385],"AACR;":[386],"Res":[388],"2024;84(7_Suppl):Abstract":[389],"nr":[390],"LB081.":[391]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}