{"id":"https://openalex.org/W4393988967","doi":"https://doi.org/10.1158/1538-7445.am2024-lb153","title":"Abstract LB153: Spatial transcriptomics of mouse parathyroid gland cells expressing an activating variant of gcm2","display_name":"Abstract LB153: Spatial transcriptomics of mouse parathyroid gland cells expressing an activating variant of gcm2","publication_year":2024,"publication_date":"2024-04-05","ids":{"openalex":"https://openalex.org/W4393988967","doi":"https://doi.org/10.1158/1538-7445.am2024-lb153"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-lb153","doi":"https://doi.org/10.1158/1538-7445.am2024-lb153","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-lb153","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049082534","display_name":"Priyanka Bolel","orcid":"https://orcid.org/0000-0001-7533-0782","observed_orcids":["https://orcid.org/0000-0001-7533-0782"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Bolel","raw_affiliation_strings":["1NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeremie O. Pina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremie O. Pina","raw_affiliation_strings":["2NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007179832","display_name":"Fabio Rueda Faucz","orcid":"https://orcid.org/0000-0001-7959-9842","observed_orcids":["https://orcid.org/0000-0001-7959-9842"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabio R. Faucz","raw_affiliation_strings":["2NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003919068","display_name":"Lee Scott Weinstein","orcid":"https://orcid.org/0000-0002-1899-5152","observed_orcids":["https://orcid.org/0000-0002-1899-5152"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee S. Weinstein","raw_affiliation_strings":["1NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031915018","display_name":"Sunita Kishore Agarwal","orcid":"https://orcid.org/0000-0002-7557-3191","observed_orcids":["https://orcid.org/0000-0002-7557-3191"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunita K. Agarwal","raw_affiliation_strings":["1NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"7_Supplement","first_page":"LB153","last_page":"LB153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gcm2","display_name":"GCM2","score":0.8339999914169312},{"id":"https://openalex.org/keywords/primary-hyperparathyroidism","display_name":"primary hyperparathyroidism","score":0.847000002861023},{"id":"https://openalex.org/keywords/familial-hyperparathyroidism","display_name":"familial hyperparathyroidism","score":0.8379999995231628},{"id":"https://openalex.org/keywords/parathyroid-neoplasms","display_name":"parathyroid tumors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7059999704360962},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.5960000157356262},{"id":"https://openalex.org/keywords/mouse-models-of-human-disease","display_name":"mouse models of human disease","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2778248654","wikidata":"https://www.wikidata.org/wiki/Q650401","display_name":"Parathyroid gland","level":4,"score":0.7405041456222534},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5177944898605347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44785481691360474},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4261774718761444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3202711045742035},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.2701728641986847},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24774813652038574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2425628900527954},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15889021754264832},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15519961714744568},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.15468084812164307}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-lb153","doi":"https://doi.org/10.1158/1538-7445.am2024-lb153","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-lb153","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414145746","https://openalex.org/W4387397040","https://openalex.org/W4205249974","https://openalex.org/W2741952607","https://openalex.org/W1997422001","https://openalex.org/W3037769666","https://openalex.org/W2127763051","https://openalex.org/W2142109476","https://openalex.org/W4415450247","https://openalex.org/W4307862766"],"abstract_inverted_index":{"Abstract":[0],"Tumors":[1],"of":[2,20,72,80,95,114,133,151,221,243,261,272,299,306,324,331,352,361,366],"one":[3],"or":[4],"multiple":[5],"parathyroid":[6,13,30,57,106,138,205,222,237,258,293,315,332,354],"glands":[7,223],"and":[8,12,39,227,263,274,278,309,313,328,381],"elevated":[9],"serum":[10],"calcium":[11],"hormone":[14],"(PTH)":[15],"are":[16],"the":[17,66,92,130,142,154,161,174,181,189,208,240,246,270,296,321,329,367],"common":[18],"characteristics":[19],"primary":[21],"hyperparathyroidism":[22],"(PHPT).":[23],"Genes":[24],"associated":[25],"with":[26,82,119,196,239,286],"familial":[27,83,120],"PHPT":[28,121],"(hereditary":[29],"tumors)":[31],"include":[32],"-":[33],"MEN1,":[34],"CDKN1B,":[35],"CDC73,":[36],"RET,":[37],"MAX":[38],"GCM2.":[40],"The":[41],"glial":[42],"cells":[43,238,260,294,316,356],"missing":[44],"2":[45,377],"(GCM2)":[46],"gene":[47,157],"functions":[48],"as":[49,102],"a":[50,78,103,147],"transcription":[51,182],"factor":[52],"that":[53,98,185],"is":[54],"essential":[55],"for":[56,188,370],"gland":[58,259,355],"development.":[59],"Heterozygous":[60],"germline":[61,110,149],"missense":[62,89,112,135],"variants":[63,90,327],"located":[64],"within":[65],"C-terminal":[67],"conserved":[68],"inhibitory":[69],"domain":[70],"(CCID)":[71],"GCM2":[73,99,191,325],"have":[74],"been":[75,123],"reported":[76,124],"in":[77,105,117,125,137,153,165,236,292,311],"subset":[79],"patients":[81,118],"PHPT.":[84],"In":[85,167],"functional":[86,322],"assays,":[87,173],"these":[88,307],"enhance":[91],"transcriptional":[93,215],"activity":[94],"GCM2,":[96,115],"suggesting":[97],"could":[100],"act":[101],"proto-oncogene":[104],"neoplasia.":[107],"A":[108],"recurrent":[109],"activating":[111,326,359],"variant":[113,136,163,177,198,211,242,298,360],"p.Y394S":[116,164,192],"has":[122],"various":[126],"publications.":[127],"To":[128],"study":[129],"direct":[131],"contribution":[132],"this":[134,197],"neoplasia,":[139],"we":[140,217],"used":[141],"CRISPR/Cas9":[143],"system":[144],"to":[145,160,231,283,302],"generate":[146],"heterozygous":[148],"knock-in":[150],"p.Y392S":[152,178,212,241,297],"mouse":[155,175,209,312,353],"Gcm2":[156,176,210,228,264,300],"(which":[158],"corresponds":[159],"human":[162,190,314],"GCM2).":[166],"GCM2-binding":[168],"site":[169],"mediated":[170],"luciferase":[171],"reporter":[172],"also":[179],"exhibited":[180,213],"enhancing":[183],"effect":[184],"was":[186,255,281],"observed":[187],"variant.":[193],"However,":[194],"mice":[195,230,266],"(Gcm2":[199],"+/Y392S)":[200],"did":[201],"not":[202],"show":[203],"obvious":[204],"tumors.":[206],"Because":[207],"enhanced":[214],"activity,":[216],"performed":[218,256,282],"spatial":[219],"transcriptomics":[220,277,351],"from":[224,295],"wildtype":[225],"(WT)":[226],"+/Y392S":[229,265],"examine":[232],"differentially":[233],"expressed":[234],"transcripts":[235,285],"Gcm2.":[244,275],"Using":[245],"10X":[247],"Genomics":[248],"Visium":[249],"platform,":[250],"spatially":[251],"resolved":[252],"RNA-seq":[253],"analysis":[254,280],"on":[257],"WT":[262],"specifically":[267],"marked":[268],"by":[269],"expression":[271,291],"Pth":[273],"Spatial":[276,350],"Pathway":[279],"evaluate":[284],"more":[287],"than":[288],"2-fold":[289],"increased":[290],"compared":[301],"WT.":[303],"Further":[304],"investigation":[305],"genes":[308],"pathways":[310],"can":[317],"provide":[318],"insights":[319],"into":[320],"consequences":[323],"pathophysiology":[330],"tumorigenesis.":[333],"Citation":[334],"Format:":[335],"Priyanka":[336],"Bolel,":[337],"Jeremie":[338],"O.":[339],"Pina,":[340],"Fabio":[341],"R.":[342],"Faucz,":[343],"Lee":[344],"S.":[345],"Weinstein,":[346],"Sunita":[347],"K.":[348],"Agarwal.":[349],"expressing":[357],"an":[358],"gcm2":[362],"[abstract].":[363],"In:":[364],"Proceedings":[365],"American":[368],"Association":[369],"Cancer":[371,393],"Research":[372],"Annual":[373],"Meeting":[374],"2024;":[375],"Part":[376],"(Late-Breaking,":[378],"Clinical":[379],"Trial,":[380],"Invited":[382],"Abstracts);":[383],"2024":[384],"Apr":[385],"5-10;":[386],"San":[387],"Diego,":[388],"CA.":[389],"Philadelphia":[390],"(PA):":[391],"AACR;":[392],"Res":[394],"2024;84(7_Suppl):Abstract":[395],"nr":[396],"LB153.":[397]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-04-06T00:00:00"}
