{"id":"https://openalex.org/W4393944367","doi":"https://doi.org/10.3389/fneur.2024.1303402","title":"Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial","display_name":"Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial","publication_year":2024,"publication_date":"2024-04-04","ids":{"openalex":"https://openalex.org/W4393944367","doi":"https://doi.org/10.3389/fneur.2024.1303402","pmid":"https://pubmed.ncbi.nlm.nih.gov/38638315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11024445"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2024.1303402","doi":"https://doi.org/10.3389/fneur.2024.1303402","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2024.1303402","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1303402/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1303402/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054824174","display_name":"Francisco Hern\u00e1ndez\u2010Bernal","orcid":"https://orcid.org/0000-0002-1857-4219","observed_orcids":["https://orcid.org/0000-0002-1857-4219"]},"institutions":[{"id":"https://openalex.org/I353511720","display_name":"Latin American School of Medicine","ror":"https://ror.org/02m74w963","country_code":"CU","type":"education","lineage":["https://openalex.org/I353511720","https://openalex.org/I4210122314"]},{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Francisco Hern\u00e1ndez-Bernal","raw_affiliation_strings":["Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Department of Comprehensive General Medicine, Latin American School of Medicine (ELAM), Havana, Cuba","Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Department of Comprehensive General Medicine, Latin American School of Medicine (ELAM), Havana, Cuba","institution_ids":["https://openalex.org/I353511720"]},{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094584589","display_name":"Donner Estenoz-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donner Estenoz-Garc\u00eda","raw_affiliation_strings":["Neurology Department, \"Antonio Luaces\" Hospital, Ciego de \u00c1vila, Cuba","Neurology Department, \"Antonio Luaces\" Hospital, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, \"Antonio Luaces\" Hospital, Ciego de \u00c1vila, Cuba","institution_ids":[]},{"raw_affiliation_string":"Neurology Department, \"Antonio Luaces\" Hospital, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094584590","display_name":"Juan H. Guti\u00e9rrez-Ronquillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan H. Guti\u00e9rrez-Ronquillo","raw_affiliation_strings":["Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Villa Clara, Cuba","Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Villa Clara, Cuba","institution_ids":[]},{"raw_affiliation_string":"Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035544491","display_name":"Yenima Mart\u00edn\u2010Bauta","orcid":"https://orcid.org/0000-0002-8673-9425","observed_orcids":["https://orcid.org/0000-0002-8673-9425"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Yenima Mart\u00edn-Bauta","raw_affiliation_strings":["Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082306450","display_name":"Karem M Catas\u00fas-\u00c1lvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Karen Catas\u00fas-\u00c1lvarez","raw_affiliation_strings":["Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104270807","display_name":"Mario Guti\u00e9rrez-Castillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Guti\u00e9rrez-Castillo","raw_affiliation_strings":["Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Villa Clara, Cuba","Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Villa Clara, Cuba","institution_ids":[]},{"raw_affiliation_string":"Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005282543","display_name":"Marbelys Guevara-Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-8860-3479","observed_orcids":["https://orcid.org/0000-0001-8860-3479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marbelys Guevara-Rodr\u00edguez","raw_affiliation_strings":["Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Villa Clara, Cuba","Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Villa Clara, Cuba","institution_ids":[]},{"raw_affiliation_string":"Neurology Department, \"Arnaldo Mili\u00e1n\" Hospital, Santa Clara, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094584592","display_name":"Aliuska Castro-Jer\u00e9z","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aliuska Castro-Jer\u00e9z","raw_affiliation_strings":["Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Gramma, Cuba","Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Gramma, Cuba","institution_ids":[]},{"raw_affiliation_string":"Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094584593","display_name":"Yoandra Fuentes-Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoandra Fuentes-Gonz\u00e1lez","raw_affiliation_strings":["Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Gramma, Cuba","Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Gramma, Cuba","institution_ids":[]},{"raw_affiliation_string":"Neurology Department, \"Celia S\u00e1nchez\" Hospital, Manzanillo, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094584587","display_name":"Yulemis Pinto-Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulemis Pinto-Cruz","raw_affiliation_strings":["Neurology Department, \"Antonio Luaces\" Hospital, Ciego de \u00c1vila, Cuba","Neurology Department, \"Antonio Luaces\" Hospital, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, \"Antonio Luaces\" Hospital, Ciego de \u00c1vila, Cuba","institution_ids":[]},{"raw_affiliation_string":"Neurology Department, \"Antonio Luaces\" Hospital, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026195581","display_name":"Carmen Valenzuela\u2010Silva","orcid":"https://orcid.org/0000-0002-1082-2089","observed_orcids":["https://orcid.org/0000-0002-1082-2089"]},"institutions":[{"id":"https://openalex.org/I4210119680","display_name":"Instituto de Cibern\u00e9tica Matem\u00e1tica y F\u00edsica","ror":"https://ror.org/02n3qcb27","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210119680"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Carmen Valenzuela-Silva","raw_affiliation_strings":["Institute of Cybernetics, Mathematics, and Physics, Havana, Cuba","Institute of Cybernetics, Mathematics, and Physics, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cybernetics, Mathematics, and Physics, Havana, Cuba","institution_ids":["https://openalex.org/I4210119680"]},{"raw_affiliation_string":"Institute of Cybernetics, Mathematics, and Physics, Cuba","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049483448","display_name":"Verena L. Muzio\u2010Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-8595-9170","observed_orcids":["https://orcid.org/0000-0001-8595-9170"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Verena L. Muzio-Gonz\u00e1lez","raw_affiliation_strings":["Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Clinical Trial Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007300617","display_name":"H\u00e9ctor P\u00e9rez-Saad","orcid":"https://orcid.org/0000-0003-1133-4308","observed_orcids":["https://orcid.org/0000-0003-1133-4308"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"H\u00e9ctor P\u00e9rez-Saad","raw_affiliation_strings":["Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038700899","display_name":"Nelvys Subir\u00f3s","orcid":"https://orcid.org/0000-0002-4024-7759","observed_orcids":["https://orcid.org/0000-0002-4024-7759"]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Nelvys Subir\u00f3s-Mart\u00ednez","raw_affiliation_strings":["Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048156158","display_name":"Gerardo E Guill\u00e9n","orcid":"https://orcid.org/0000-0003-3098-0970","observed_orcids":["https://orcid.org/0000-0003-3098-0970"]},"institutions":[{"id":"https://openalex.org/I353511720","display_name":"Latin American School of Medicine","ror":"https://ror.org/02m74w963","country_code":"CU","type":"education","lineage":["https://openalex.org/I353511720","https://openalex.org/I4210122314"]},{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Gerardo E. Guill\u00e9n-Nieto","raw_affiliation_strings":["Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Department of Physiology, Latin American School of Medicine (ELAM), Havana, Cuba","Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Department of Physiology, Latin American School of Medicine (ELAM), Havana, Cuba","institution_ids":["https://openalex.org/I353511720"]},{"raw_affiliation_string":"Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045955201","display_name":"Diana Garc\u00eda-del-Barco-Herrera","orcid":"https://orcid.org/0000-0003-3654-490X","observed_orcids":["https://orcid.org/0000-0003-3654-490X"]},"institutions":[{"id":"https://openalex.org/I353511720","display_name":"Latin American School of Medicine","ror":"https://ror.org/02m74w963","country_code":"CU","type":"education","lineage":["https://openalex.org/I353511720","https://openalex.org/I4210122314"]},{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":true,"raw_author_name":"Diana Garcia-del-Barco-Herrera","raw_affiliation_strings":["Department of Physiology, Latin American School of Medicine (ELAM), Havana, Cuba","Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Latin American School of Medicine (ELAM), Havana, Cuba","institution_ids":["https://openalex.org/I353511720"]},{"raw_affiliation_string":"Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba","institution_ids":["https://openalex.org/I4210130720"]},{"raw_affiliation_string":"Neuroprotection Project, Biomedical Research Direction, Center for Genetic Engineering and Biotechnology, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045955201"],"corresponding_institution_ids":["https://openalex.org/I353511720","https://openalex.org/I4210130720"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.7538,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.83764928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":null,"first_page":"1303402","last_page":"1303402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9869999885559082},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6320000290870667},{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neurological-outcome","display_name":"neurological outcome","score":0.625},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nihss","display_name":"NIHSS","score":0.4650000035762787},{"id":"https://openalex.org/keywords/barthel-index","display_name":"Barthel Index","score":0.8769999742507935},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.953000009059906},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.5649999976158142},{"id":"https://openalex.org/keywords/acute-stroke-management","display_name":"acute stroke care","score":0.4410000145435333},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8781379461288452},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6674199104309082},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.6131243705749512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.607390284538269},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.602154552936554},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.58250492811203},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5779972076416016},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5180235505104065},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4695841670036316},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4190579056739807},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.2348361611366272},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fneur.2024.1303402","doi":"https://doi.org/10.3389/fneur.2024.1303402","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2024.1303402","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1303402/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11024445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11024445","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11024445/pdf/fneur-15-1303402.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:38638315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38638315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5456221c36d94b12b55e83f07318e7a4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5456221c36d94b12b55e83f07318e7a4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2024.1303402","doi":"https://doi.org/10.3389/fneur.2024.1303402","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2024.1303402","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1303402/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393944367.pdf","grobid_xml":"https://content.openalex.org/works/W4393944367.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W41769866","https://openalex.org/W1451867453","https://openalex.org/W1676366316","https://openalex.org/W1876503558","https://openalex.org/W1917111134","https://openalex.org/W1965676751","https://openalex.org/W1967015841","https://openalex.org/W1971974545","https://openalex.org/W1978747075","https://openalex.org/W1979486533","https://openalex.org/W1980339901","https://openalex.org/W1981066923","https://openalex.org/W1984874037","https://openalex.org/W1986360186","https://openalex.org/W1989914548","https://openalex.org/W1992442793","https://openalex.org/W1993484591","https://openalex.org/W2005714662","https://openalex.org/W2013257758","https://openalex.org/W2022380830","https://openalex.org/W2024938615","https://openalex.org/W2031023721","https://openalex.org/W2032541700","https://openalex.org/W2040386750","https://openalex.org/W2041080432","https://openalex.org/W2053680491","https://openalex.org/W2084869945","https://openalex.org/W2087304873","https://openalex.org/W2095861108","https://openalex.org/W2100248984","https://openalex.org/W2100449898","https://openalex.org/W2107026277","https://openalex.org/W2122965222","https://openalex.org/W2139597470","https://openalex.org/W2140698287","https://openalex.org/W2147802232","https://openalex.org/W2151286409","https://openalex.org/W2197429867","https://openalex.org/W2342090359","https://openalex.org/W2515111215","https://openalex.org/W2527592718","https://openalex.org/W2607427115","https://openalex.org/W2625474800","https://openalex.org/W2701376902","https://openalex.org/W2754229858","https://openalex.org/W2791824615","https://openalex.org/W2800305783","https://openalex.org/W2883861999","https://openalex.org/W2896185502","https://openalex.org/W2910807844","https://openalex.org/W2973951528","https://openalex.org/W3000460228","https://openalex.org/W3020278890","https://openalex.org/W3023339300","https://openalex.org/W3028006966","https://openalex.org/W3035510802","https://openalex.org/W3048654124","https://openalex.org/W3095119112","https://openalex.org/W3096175908","https://openalex.org/W3097256238","https://openalex.org/W3120040334","https://openalex.org/W3123389740","https://openalex.org/W3128163600","https://openalex.org/W3135732112","https://openalex.org/W3137697476","https://openalex.org/W3185676635","https://openalex.org/W3195092573","https://openalex.org/W3213988304","https://openalex.org/W4239983921","https://openalex.org/W4280600625","https://openalex.org/W4281754945","https://openalex.org/W4292528167","https://openalex.org/W4292836117","https://openalex.org/W6941498469"],"related_works":["https://openalex.org/W7168959417","https://openalex.org/W2095861108","https://openalex.org/W2527592718","https://openalex.org/W1917111134","https://openalex.org/W7163909129","https://openalex.org/W2162914074","https://openalex.org/W2059339846","https://openalex.org/W1559316525","https://openalex.org/W2080155661","https://openalex.org/W2083849902"],"abstract_inverted_index":{"Objective:":[0],"This":[1],"study":[2,87,148,251,346],"tested":[3],"the":[4,78,86,201,245,250,282,312,357],"hypothesis":[5,252],"that":[6],"a":[7,67,151,163,174,267,304,326,348],"neuroprotective":[8],"combined":[9,313,330],"therapy":[10,116,336],"based":[11],"on":[12,187],"epidermal":[13],"growth":[14,18],"factor":[15],"(EGF)":[16],"and":[17,72,136,140,173,219,270,276,288,290,321],"hormone-releasing":[19],"hexapeptide":[20],"(GHRP6)":[21],"could":[22],"be":[23],"safe":[24],"for":[25,120,308],"acute":[26],"ischemic":[27,70],"stroke":[28,71],"patients,":[29],"admitting":[30],"up":[31],"to":[32,59,85,177,244,294],"30%":[33],"of":[34,80,154,168,179,196,205,221,285,328,342,356,361],"serious":[35],"adverse":[36],"events":[37,235],"(SAE)":[38],"with":[39,52,66,159,249,262,311],"proven":[40],"causality.":[41],"Methods:":[42],"A":[43],"multi-centric,":[44],"randomized,":[45],"open-label,":[46],"controlled,":[47],"phase":[48],"I-II":[49],"clinical":[50],"trial":[51],"parallel":[53],"groups":[54,88,320],"was":[55,117,126,253,337],"conducted":[56,186],"(July":[57],"2017":[58],"January":[60],"2018).":[61],"Patients":[62,260],"aged":[63],"18-80":[64],"years":[65],"computed":[68],"tomography-confirmed":[69],"less":[73],"than":[74,255],"12":[75],"h":[76],"from":[77],"onset":[79],"symptoms":[81],"were":[82,185,192,242],"randomly":[83],"assigned":[84],"I":[89,211,241],"(75":[90,100],"\u03bcg":[91,101],"rEGF":[92,102],"+":[93,103,264,334],"3.5":[94],"mg":[95,105],"GHRP6":[96,106,265,335],"i.v.,":[97,107],"n=10),":[98,108],"II":[99,227],"5":[104],"or":[109],"III":[110,350],"(standard":[111],"care":[112],"control,":[113],"n=16).":[114],"Combined":[115],"given":[118],"BID":[119],"7":[121],"days.":[122],"The":[123,147,339],"primary":[124],"endpoint":[125],"safety":[127],"over":[128],"6":[129,299],"months.":[130],"Secondary":[131],"endpoints":[132],"included":[133],"neurological":[134,269],"(NIHSS)":[135],"functional":[137,271,340],"[Barthel":[138],"index":[139],"modified":[141],"Rankin":[142],"scale":[143],"(mRS)]":[144],"outcomes.":[145],"Results:":[146],"population":[149],"had":[150,266],"mean":[152,175],"age":[153],"66":[155],"\u00b1":[156,181],"11":[157],"years,":[158],"21":[160],"men":[161],"(58.3%),":[162],"baseline":[164],"median":[165],"NIHSS":[166],"score":[167],"9":[169,195],"(95%":[170],"CI:":[171,217,231],"8-11),":[172],"time":[176],"treatment":[178,343],"7.3":[180],"2.8":[182],"h.":[183],"Analyses":[184],"an":[188],"intention-to-treat":[189],"basis.":[190],"SAEs":[191],"reported":[193],"in":[194,200,209,225,236,239,257,344],"16":[197],"(56.2%)":[198],"patients":[199,208,224,309],"control":[202],"group,":[203],"3":[204],"10":[206,222],"(30%)":[207],"Group":[210,226,240],"(odds":[212],"ratio":[213],"(OR):":[214],"0.33;":[215],"95%":[216,230],"0.06-1.78),":[218],"2":[220],"(20%)":[223],"(OR:":[228],"0.19;":[229],"0.03-1.22);":[232],"only":[233],"two":[234],"one":[237],"patient":[238],"attributed":[243],"intervention":[246],"treatment.":[247],"Compliance":[248],"greater":[254],"0.90":[256],"each":[258],"group.":[259],"treated":[261,310,319],"EGF":[263,333],"favorable":[268],"evolution":[272],"at":[273],"both":[274],"90":[275],"180":[277],"days,":[278],"as":[279],"evidenced":[280,303],"by":[281,291],"inferential":[283],"analysis":[284,302,316],"NIHSS,":[286],"Barthel,":[287],"mRS":[289,323],"their":[292],"moderate":[293],"strong":[295],"effect":[296],"size.":[297],"At":[298],"months,":[300],"proportion":[301],"higher":[305],"survival":[306],"rate":[307],"therapy.":[314,331],"Ancillary":[315],"including":[317],"merged":[318],"utility-weighted":[322],"also":[324],"showed":[325],"benefit":[327],"this":[329,345],"Conclusion:":[332],"safe.":[338],"benefits":[341],"supported":[347],"Phase":[349],"study.":[351],"Clinical":[352,362],"Trial":[353],"Registration:":[354],"RPCEC00000214":[355],"Cuban":[358],"Public":[359],"Registry":[360],"Trials,":[363],"Unique":[364],"identifier:":[365],"IG/CIGB-845I/IC/1601.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-04-05T00:00:00"}