{"id":"https://openalex.org/W4393900285","doi":"https://doi.org/10.1186/s13063-024-08066-0","title":"Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial","display_name":"Prednisolone Versus Colchicine for Acute Gout in Primary Care: statistical analysis plan for the pragmatic, multicenter, randomized, and double-blinded COPAGO non-inferiority trial","publication_year":2024,"publication_date":"2024-04-03","ids":{"openalex":"https://openalex.org/W4393900285","doi":"https://doi.org/10.1186/s13063-024-08066-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/38570873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10988876"},"language":"en","primary_location":{"id":"doi:10.1186/s13063-024-08066-0","doi":"https://doi.org/10.1186/s13063-024-08066-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-024-08066-0","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-024-08066-0","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-024-08066-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026734298","display_name":"Adrian Richter","orcid":"https://orcid.org/0000-0002-3372-2021","observed_orcids":["https://orcid.org/0000-0002-3372-2021"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Adrian Richter","raw_affiliation_strings":["Department of Prevention Research and Social Medicine, Institute for Community Medicine, University Medical Center Greifswald, Walther-Rathenau-Str. 48, 17475, Greifswald, Germany. adrian.richter@med.uni-greifswald.de","Department of Prevention Research and Social Medicine, Institute for Community Medicine, University Medical Center Greifswald, Walther-Rathenau-Str. 48, 17475, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3372-2021","affiliations":[{"raw_affiliation_string":"Department of Prevention Research and Social Medicine, Institute for Community Medicine, University Medical Center Greifswald, Walther-Rathenau-Str. 48, 17475, Greifswald, Germany. adrian.richter@med.uni-greifswald.de","institution_ids":["https://openalex.org/I2799318839"]},{"raw_affiliation_string":"Department of Prevention Research and Social Medicine, Institute for Community Medicine, University Medical Center Greifswald, Walther-Rathenau-Str. 48, 17475, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015206550","display_name":"Julia Truthmann","orcid":"https://orcid.org/0000-0002-2849-7608","observed_orcids":["https://orcid.org/0000-0002-2849-7608"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Truthmann","raw_affiliation_strings":["Department of General Practice, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2849-7608","affiliations":[{"raw_affiliation_string":"Department of General Practice, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091797466","display_name":"Eva Hummers","orcid":"https://orcid.org/0000-0003-2707-6067","observed_orcids":["https://orcid.org/0000-0003-2707-6067"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva Hummers","raw_affiliation_strings":["Department of General Practice, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2707-6067","affiliations":[{"raw_affiliation_string":"Department of General Practice, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084303672","display_name":"Julia Freyer Martins Pereira","orcid":"https://orcid.org/0000-0001-6119-0651","observed_orcids":["https://orcid.org/0000-0001-6119-0651"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Freyer Martins Pereira","raw_affiliation_strings":["Department of General Practice, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6119-0651","affiliations":[{"raw_affiliation_string":"Department of General Practice, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059322051","display_name":"Ildik\u00f3 G\u00e1gyor","orcid":"https://orcid.org/0000-0002-7974-7603","observed_orcids":["https://orcid.org/0000-0002-7974-7603"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ildik\u00f3 G\u00e1gyor","raw_affiliation_strings":["Department of General Practice, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7974-7603","affiliations":[{"raw_affiliation_string":"Department of General Practice, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109389871","display_name":"Franziska Schuster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franziska Schuster","raw_affiliation_strings":["Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080671080","display_name":"Amelie Witte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amelie Witte","raw_affiliation_strings":["Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111579491","display_name":"Susanne B\u00f6hm","orcid":"https://orcid.org/0000-0002-5807-8092","observed_orcids":["https://orcid.org/0000-0002-5807-8092"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne B\u00f6hm","raw_affiliation_strings":["Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069002722","display_name":"Alexandra Greser","orcid":"https://orcid.org/0000-0003-1191-0483","observed_orcids":["https://orcid.org/0000-0003-1191-0483"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Greser","raw_affiliation_strings":["Department of General Practice, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1191-0483","affiliations":[{"raw_affiliation_string":"Department of General Practice, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092866070","display_name":"Petra Kamin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Kamin","raw_affiliation_strings":["Department of General Practice, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Practice, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027865969","display_name":"Sylvia Stracke","orcid":"https://orcid.org/0000-0001-6200-4339","observed_orcids":["https://orcid.org/0000-0001-6200-4339"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylvia Stracke","raw_affiliation_strings":["Department of Internal Medicine A, Nephrology, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6200-4339","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine A, Nephrology, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046776695","display_name":"Marcus D\u00f6rr","orcid":"https://orcid.org/0000-0001-7471-475X","observed_orcids":["https://orcid.org/0000-0001-7471-475X"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus D\u00f6rr","raw_affiliation_strings":["Department of Internal Medicine B, Cardiology, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7471-475X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine B, Cardiology, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027711194","display_name":"Robin B\u00fclow","orcid":"https://orcid.org/0000-0003-1884-5784","observed_orcids":["https://orcid.org/0000-0003-1884-5784"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robin B\u00fclow","raw_affiliation_strings":["Institute for Radiology and Neuroradiology, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1884-5784","affiliations":[{"raw_affiliation_string":"Institute for Radiology and Neuroradiology, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090963996","display_name":"Stefan Engeli","orcid":"https://orcid.org/0000-0002-3087-971X","observed_orcids":["https://orcid.org/0000-0002-3087-971X"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Engeli","raw_affiliation_strings":["Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany","Institute of Pharmacology, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3087-971X","affiliations":[{"raw_affiliation_string":"Coordinating Center for Clinical Studies, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]},{"raw_affiliation_string":"Institute of Pharmacology, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085629703","display_name":"Jean\u2010Fran\u00e7ois Chenot","orcid":"https://orcid.org/0000-0001-8877-2950","observed_orcids":["https://orcid.org/0000-0001-8877-2950"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jean Fran\u00e7ois Chenot","raw_affiliation_strings":["Department of General Practice, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8877-2950","affiliations":[{"raw_affiliation_string":"Department of General Practice, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089998716","display_name":"Till Ittermann","orcid":"https://orcid.org/0000-0002-0154-7353","observed_orcids":["https://orcid.org/0000-0002-0154-7353"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Till Ittermann","raw_affiliation_strings":["Department SHIP-KEF, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0154-7353","affiliations":[{"raw_affiliation_string":"Department SHIP-KEF, Institute for Community Medicine, University Medical Center Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026734298"],"corresponding_institution_ids":["https://openalex.org/I2799318839"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.2632,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5396125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"25","issue":"1","first_page":"229","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gout-flares","display_name":"gout flares","score":0.9539999961853027},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8980000019073486},{"id":"https://openalex.org/keywords/pain-assessment","display_name":"pain assessment","score":0.41200000047683716},{"id":"https://openalex.org/keywords/numerical-rating-scale","display_name":"numerical rating scale","score":0.718999981880188},{"id":"https://openalex.org/keywords/joint-swelling-and-tenderness","display_name":"joint swelling and tenderness","score":0.6909999847412109},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.7480000257492065},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.6669999957084656},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.5009999871253967},{"id":"https://openalex.org/keywords/statistical-analysis-plan","display_name":"statistical analysis plan","score":0.5559999942779541},{"id":"https://openalex.org/keywords/sample-size-calculation","display_name":"sample size determination","score":0.47200000286102295},{"id":"https://openalex.org/keywords/multiple-linear-regression","display_name":"multiple linear regression","score":0.5009999871253967},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.5680000185966492},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9385599493980408},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.8573846817016602},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.7301373481750488},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.6711199283599854},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6474118828773499},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.48773178458213806},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43495601415634155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42145252227783203},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4154511094093323},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3567103147506714}],"mesh":[{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006073","descriptor_name":"Gout","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006073","descriptor_name":"Gout","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011320","descriptor_name":"Primary Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13063-024-08066-0","doi":"https://doi.org/10.1186/s13063-024-08066-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-024-08066-0","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-024-08066-0","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3876128/v1","doi":"https://doi.org/10.21203/rs.3.rs-3876128/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3876128/v1","pdf_url":"https://www.researchsquare.com/article/rs-3876128/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10988876","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10988876","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Text"},{"id":"pmid:38570873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38570873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Equivalence Trial"},{"id":"pmh:oai:frl.publisso.de:frl:6499795","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10988876","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10988876/pdf/13063_2024_Article_8066.pdf","source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current controlled trials in cardiovascular medicine, 25(1):229","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:doaj.org/article:6db7793cdf5f420ea855b671b7d89128","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6db7793cdf5f420ea855b671b7d89128","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials, Vol 25, Iss 1, Pp 1-12 (2024)","raw_type":"article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/143145","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/143145","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s13063-024-08066-0","doi":"https://doi.org/10.1186/s13063-024-08066-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-024-08066-0","pdf_url":"https://trialsjournal.biomedcentral.com/counter/pdf/10.1186/s13063-024-08066-0","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[{"id":"https://openalex.org/G3913154239","display_name":"COPAGO - Randomisierte kontrollierte Studie zur Behandlung des akuten Gichtanfalls mit Prednisolon im Vergleich zu Colchicin in der haus\u00e4rztlichen Versorgung","funder_award_id":"01KG2022","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393900285.pdf","grobid_xml":"https://content.openalex.org/works/W4393900285.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1481796766","https://openalex.org/W1619185285","https://openalex.org/W1845661996","https://openalex.org/W1958971206","https://openalex.org/W1960517758","https://openalex.org/W1978251668","https://openalex.org/W2001307401","https://openalex.org/W2007326639","https://openalex.org/W2044504338","https://openalex.org/W2061623382","https://openalex.org/W2065974896","https://openalex.org/W2094780098","https://openalex.org/W2095674834","https://openalex.org/W2096998441","https://openalex.org/W2098931866","https://openalex.org/W2110093215","https://openalex.org/W2121044470","https://openalex.org/W2124239698","https://openalex.org/W2124881269","https://openalex.org/W2146730043","https://openalex.org/W2152740900","https://openalex.org/W2169239741","https://openalex.org/W2257116671","https://openalex.org/W2296106507","https://openalex.org/W2335302945","https://openalex.org/W2342181010","https://openalex.org/W2394416255","https://openalex.org/W2564839169","https://openalex.org/W2582743722","https://openalex.org/W2598707736","https://openalex.org/W2750736040","https://openalex.org/W2778174446","https://openalex.org/W2809123291","https://openalex.org/W2884313467","https://openalex.org/W2898107882","https://openalex.org/W2982516776","https://openalex.org/W3090529871","https://openalex.org/W3154127147","https://openalex.org/W3175462489","https://openalex.org/W4205968280","https://openalex.org/W4230076583","https://openalex.org/W4387379600"],"related_works":["https://openalex.org/W4387379600","https://openalex.org/W6958353445","https://openalex.org/W2124881269","https://openalex.org/W2085340178","https://openalex.org/W7168561351","https://openalex.org/W2342181010","https://openalex.org/W2481543741","https://openalex.org/W2324843694","https://openalex.org/W4205968280","https://openalex.org/W4250807195"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"date,":[2],"colchicine":[3,62,134,230,362],"and":[4,110,193,220,247,282,301,334,341,363,378],"prednisolone":[5,60,122,227,305,364],"are":[6,200,259,348],"two":[7],"effective":[8],"therapies":[9],"for":[10,123,216,223,298],"the":[11,85,91,101,114,127,157,194,274,279,310,314,326,339],"treatment":[12,147,252,346],"of":[13,32,65,97,103,129,146,196,218,226,234,244,268,322,338,345,361,368,375],"acute":[14,34,70,79,163,372],"gout":[15,35,80,86,164,373],"but":[16],"have":[17,210],"never":[18],"been":[19],"compared":[20,228],"directly":[21],"in":[22,29,63,67,100,113,254,261,371],"a":[23,178,232,262,285,292,320,358],"randomized":[24,260],"clinical":[25],"trial.":[26],"In":[27],"addition,":[28],"previous":[30],"trials":[31],"treating":[33],"patients":[36,68,154,172,209,258,374],"with":[37,61,69,78,231,241],"concomitant":[38],"comorbidities":[39],"were":[40],"often":[41],"excluded":[42],"due":[43,160],"to":[44,46,74,156,161,169,176,211,214,221,229,249,330,379],"contraindications":[45],"naproxen.":[47],"STUDY":[48],"DESIGN:":[49],"This":[50],"pragmatic,":[51],"prospective,":[52],"double-blind,":[53],"double-dummy,":[54],"parallel-group,":[55],"randomized,":[56],"non-inferiority":[57,66,225],"trial":[58,353],"compares":[59],"terms":[64],"gout.":[71],"Patients":[72],"presenting":[73],"their":[75,366],"general":[76,158],"practitioner":[77,159],"can":[81],"be":[82,174,212],"included":[83],"if":[84,309],"attack":[87],"has":[88],"occurred":[89],"within":[90],"last":[92,275],"2":[93],"days.":[94],"A":[95],"total":[96],"60":[98],"practices":[99],"vicinity":[102],"three":[104],"university":[105],"medical":[106],"centers":[107],"(Greifswald,":[108],"G\u00f6ttingen,":[109],"W\u00fcrzburg)":[111],"participate":[112],"study.":[115],"The":[116,143,265,352],"intervention":[117],"group":[118,128],"receives":[119,132],"30":[120],"mg":[121],"5":[124],"days,":[125],"while":[126],"standard":[130],"care":[131,377],"low-dose":[133],"(day":[135],"1:":[136],"1.5":[137],"mg;":[138],"days":[139],"2-5:":[140],"1":[141,323],"mg).":[142],"first":[144,389],"dose":[145],"is":[148,278,306,317],"provided":[149],"at":[150,303],"day":[151,167,170,271],"0":[152,168],"when":[153],"present":[155],"an":[162],"attack.":[165],"From":[166],"6,":[171],"will":[173,354],"asked":[175],"complete":[177],"study":[179],"diary":[180],"on":[181,270,284,325,391],"daily":[182],"basis":[183],"regarding":[184,365],"pain":[185,269,302,369],"quantification.":[186],"For":[187],"safety":[188,382],"reasons,":[189],"potential":[190],"side":[191],"effects":[192],"course":[195],"systolic":[197],"blood":[198],"pressure":[199],"also":[201],"assessed.":[202],"STATISTICAL":[203],"ANALYSIS":[204],"PLAN:":[205],"N":[206],"=":[207],"314":[208],"recruited":[213],"compensate":[215],"10%":[217],"dropout":[219],"allow":[222],"showing":[224],"power":[233],"90%.":[235],"We":[236],"use":[237],"permuted":[238],"block":[239,242],"randomization":[240],"sizes":[243],"2,":[245],"4,":[246],"6":[248],"avoid":[250],"imbalanced":[251],"arms":[253],"this":[255],"multi-center":[256],"study;":[257],"1:1":[263],"ratio.":[264],"absolute":[266],"level":[267],"3":[272],"(in":[273],"24":[276],"h)":[277],"primary":[280,376],"outcome":[281],"measured":[283],"numerical":[286],"rating":[287],"scale":[288],"(NRS:":[289],"0-10).":[290],"Using":[291],"multiple":[293],"linear":[294],"regression":[295],"model":[296],"adjusted":[297],"age,":[299],"sex,":[300],"baseline,":[304],"considered":[307],"non-inferior":[308],"effect":[311],"estimate":[312],"including":[313],"confidence":[315],"intervals":[316],"lower":[318],"than":[319],"margin":[321],"unit":[324],"NRS.":[327],"Average":[328],"response":[329],"treatment,":[331],"joint":[332],"swelling":[333],"tenderness,":[335],"physical":[336],"function":[337],"joint,":[340],"patients'":[342],"global":[343],"assessment":[344],"success":[347],"secondary":[349],"outcomes.":[350],"DISCUSSION:":[351],"provide":[355],"evidence":[356],"from":[357],"direct":[359],"comparison":[360],"efficacy":[367],"reduction":[370],"indicate":[380],"possible":[381],"signals.":[383],"TRIAL":[384],"REGISTRATION:":[385],"ClinicalTrials.gov":[386],"Identifier:":[387],"NCT05698680":[388],"posted":[390],"January":[392],"26,":[393],"2023":[394],"(retrospectively":[395],"registered).":[396]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-04-04T00:00:00"}