{"id":"https://openalex.org/W4393870845","doi":"https://doi.org/10.1158/2767-9764.25534457","title":"FIGURE 2 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate","display_name":"FIGURE 2 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate","publication_year":2024,"publication_date":"2024-04-03","ids":{"openalex":"https://openalex.org/W4393870845","doi":"https://doi.org/10.1158/2767-9764.25534457"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.25534457","doi":"https://doi.org/10.1158/2767-9764.25534457","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25534457","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.25534457","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025507328","display_name":"Priyanka Hirani","orcid":"https://orcid.org/0000-0002-1347-5668","observed_orcids":["https://orcid.org/0000-0002-1347-5668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priyanka Hirani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1347-5668","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078730275","display_name":"Jacqueline R. McDermott","orcid":"https://orcid.org/0000-0001-8052-7133","observed_orcids":["https://orcid.org/0000-0001-8052-7133"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline McDermott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8052-7133","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052560631","display_name":"Vinothini Rajeeve","orcid":"https://orcid.org/0000-0002-6361-4291","observed_orcids":["https://orcid.org/0000-0002-6361-4291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinothini Rajeeve","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6361-4291","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046510449","display_name":"Pedro R. Cutillas","orcid":"https://orcid.org/0000-0002-3426-2274","observed_orcids":["https://orcid.org/0000-0002-3426-2274","https://orcid.org/0000-0002-4207-9349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro R. Cutillas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3426-2274","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076743192","display_name":"J. Louise Jones","orcid":"https://orcid.org/0000-0003-3880-3274","observed_orcids":["https://orcid.org/0000-0003-3880-3274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Louise Jones","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3880-3274","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081521025","display_name":"Daniel J. Pennington","orcid":"https://orcid.org/0000-0001-7889-9923","observed_orcids":["https://orcid.org/0000-0001-7889-9923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. Pennington","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7889-9923","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035268339","display_name":"Thomas N. Wight","orcid":"https://orcid.org/0000-0002-2794-4197","observed_orcids":["https://orcid.org/0000-0002-2794-4197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas N. Wight","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2794-4197","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053001744","display_name":"Salvatore Santamaria","orcid":"https://orcid.org/0000-0001-8670-7776","observed_orcids":["https://orcid.org/0000-0001-8670-7776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvatore Santamaria","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8670-7776","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004026163","display_name":"Kimberly M. Alonge","orcid":"https://orcid.org/0000-0002-2171-1640","observed_orcids":["https://orcid.org/0000-0002-2171-1640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly M. Alonge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2171-1640","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018077287","display_name":"Oliver M.T. Pearce","orcid":"https://orcid.org/0000-0003-3953-1629","observed_orcids":["https://orcid.org/0000-0003-3953-1629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver M.T. Pearce","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3953-1629","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.9660000205039978},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-immune-phenotype","display_name":"tumor immune phenotype","score":0.8050000071525574},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.6639999747276306},{"id":"https://openalex.org/keywords/col11a1","display_name":"COL11A1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/comp","display_name":"COMP","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6169999837875366},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.8580988645553589},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.6168643832206726},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5757477879524231},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5266941785812378},{"id":"https://openalex.org/C2775895372","wikidata":"https://www.wikidata.org/wiki/Q5104536","display_name":"Chondroitin sulfate proteoglycan","level":4,"score":0.5096888542175293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36715197563171387},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30778270959854126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2835506200790405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2497425079345703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18340972065925598},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16335561871528625},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14118841290473938},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.12769627571105957},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.12436768412590027},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.08825826644897461}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2767-9764.25534457","doi":"https://doi.org/10.1158/2767-9764.25534457","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25534457","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2767-9764.25534457.v1","doi":"https://doi.org/10.1158/2767-9764.25534457.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25534457.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.25534457","doi":"https://doi.org/10.1158/2767-9764.25534457","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.25534457","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393854670","https://openalex.org/W4393870843","https://openalex.org/W4393898937","https://openalex.org/W4393870846","https://openalex.org/W4393854684","https://openalex.org/W4393854651","https://openalex.org/W4393854504","https://openalex.org/W4393071030","https://openalex.org/W4393899102","https://openalex.org/W6982598906"],"abstract_inverted_index":{"VCAN":[0,117],"is":[1],"associated":[2],"with":[3,119],"T-cell":[4],"localization.":[5],"A,":[6],"Matrix":[7],"index":[8],"from":[9,39,67,94],"Pearce":[10],"and":[11,56,69,84,116],"colleagues":[12,70],"(14).":[13],"Arrows":[14],"indicate":[15],"upregulation":[16],"or":[17,22],"downregulation":[18],"at":[19],"gene":[20,29],"(G)":[21],"protein":[23],"(P)":[24],"level.":[25],"B,":[26],"Level":[27],"of":[28,31,45,59,89,92,97,110],"expression":[30,44,91],"top":[32],"five":[33,47],"upregulated":[34],"molecules":[35],"in":[36],"100":[37],"samples":[38],"TCGA":[40],"dataset.":[41],"C,":[42],"scRNA-seq":[43],"the":[46,54,57,90],"genes":[48,55],"indicating":[49],"which":[50],"cell":[51],"types":[52],"express":[53],"percentage":[58],"those":[60],"cells":[61],"that":[62],"are":[63],"positive.":[64],"Data":[65],"obtained":[66],"Wu":[68],"(25).":[71],"D,":[72],"IHC":[73,95,120],"completed":[74],"on":[75],"consecutive":[76],"TMA":[77,99],"cores":[78],"for":[79,113,122],"COL11A1,":[80],"COMP,":[81],"CTSB,":[82],"FN1,":[83],"VCAN.":[85],"Spearman":[86],"rank":[87],"correlation":[88],"proteins":[93],"analysis":[96],"eight":[98],"cores.":[100],"**,":[101],"P":[102],"<":[103],"0.01":[104],"(N":[105],"=":[106],"8).":[107],"E,":[108],"Comparison":[109],"dual":[111],"RNAscope":[112],"CTSB":[114],"(green)":[115],"(red)":[118],"staining":[121],"CD8.":[123]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-04T00:00:00"}
