{"id":"https://openalex.org/W4393869651","doi":"https://doi.org/10.1017/cts.2024.405","title":"478 Magnetic Resonance Biomarkers of Metabolic Dysfunction-Associated Steatotic Liver Disease","display_name":"478 Magnetic Resonance Biomarkers of Metabolic Dysfunction-Associated Steatotic Liver Disease","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4393869651","doi":"https://doi.org/10.1017/cts.2024.405"},"language":"en","primary_location":{"id":"doi:10.1017/cts.2024.405","doi":"https://doi.org/10.1017/cts.2024.405","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2024.405","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B5C38BA9F58B5D623EA9D12C3F19E2FF/S2059866124004059a.pdf/div-class-title-478-magnetic-resonance-biomarkers-of-metabolic-dysfunction-associated-steatotic-liver-disease-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B5C38BA9F58B5D623EA9D12C3F19E2FF/S2059866124004059a.pdf/div-class-title-478-magnetic-resonance-biomarkers-of-metabolic-dysfunction-associated-steatotic-liver-disease-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101379913","display_name":"Marissa Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Brown","raw_affiliation_strings":["University of Texas Health Science Center San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040841857","display_name":"Alexander Moody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Moody","raw_affiliation_strings":["University of Texas Health Science Center San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102262715","display_name":"Juan A. Vasquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Vasquez","raw_affiliation_strings":["University of Texas Health Science Center San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004538115","display_name":"John Blangero","orcid":"https://orcid.org/0000-0001-6250-5723","observed_orcids":["https://orcid.org/0000-0001-6250-5723"]},"institutions":[{"id":"https://openalex.org/I2802326326","display_name":"The University of Texas Rio Grande Valley","ror":"https://ror.org/02p5xjf12","country_code":"US","type":"education","lineage":["https://openalex.org/I2802326326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Blangero","raw_affiliation_strings":["University of Texas Rio Grande Valley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Rio Grande Valley","institution_ids":["https://openalex.org/I2802326326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041583991","display_name":"Luke Norton","orcid":"https://orcid.org/0000-0002-0231-5722","observed_orcids":["https://orcid.org/0000-0002-0231-5722"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke Norton","raw_affiliation_strings":["University of Texas Health Science Center San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036451016","display_name":"Geoffrey D. Clarke","orcid":"https://orcid.org/0000-0003-4559-6437","observed_orcids":["https://orcid.org/0000-0003-4559-6437"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey Clarke","raw_affiliation_strings":["University of Texas Health Science Center San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center San Antonio","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2925,"currency":"USD","value_usd":2925},"apc_paid":{"value":2925,"currency":"USD","value_usd":2925},"fwci":0.6067,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66167364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"8","issue":"s1","first_page":"141","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/liver-fibrosis-staging","display_name":"liver fibrosis staging","score":0.7459999918937683},{"id":"https://openalex.org/keywords/liver-stiffness","display_name":"liver stiffness","score":0.609000027179718},{"id":"https://openalex.org/keywords/intravoxel-incoherent-motion","display_name":"intravoxel incoherent motion","score":0.7739999890327454},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liver-fat-fraction","display_name":"liver fat fraction","score":0.9549999833106995},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5768213272094727},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5104386210441589},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5072400569915771},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4610769748687744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4136173129081726},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.33851927518844604},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19452229142189026},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13051056861877441}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1017/cts.2024.405","doi":"https://doi.org/10.1017/cts.2024.405","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2024.405","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B5C38BA9F58B5D623EA9D12C3F19E2FF/S2059866124004059a.pdf/div-class-title-478-magnetic-resonance-biomarkers-of-metabolic-dysfunction-associated-steatotic-liver-disease-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11035348","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11035348","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11035348/pdf/S2059866124004059a.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6d0fd4d184cc4057910ef7e394184f8a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6d0fd4d184cc4057910ef7e394184f8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Translational Science, Vol 8, Pp 141-141 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1017/cts.2024.405","doi":"https://doi.org/10.1017/cts.2024.405","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2024.405","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B5C38BA9F58B5D623EA9D12C3F19E2FF/S2059866124004059a.pdf/div-class-title-478-magnetic-resonance-biomarkers-of-metabolic-dysfunction-associated-steatotic-liver-disease-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393869651.pdf","grobid_xml":"https://content.openalex.org/works/W4393869651.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416182916","https://openalex.org/W4402772962","https://openalex.org/W7167901731","https://openalex.org/W7162398730","https://openalex.org/W7142290289","https://openalex.org/W4416965000","https://openalex.org/W4407848321","https://openalex.org/W4401593357","https://openalex.org/W7214534904","https://openalex.org/W7204564173"],"abstract_inverted_index":{"OBJECTIVES/GOALS:":[0],"Metabolic":[1],"dysfunction-associated":[2,80],"steatotic":[3],"liver":[4,45,99,103,111,136,215,272],"disease":[5,35,216],"(MASLD)":[6],"is":[7,261],"a":[8,65],"major":[9],"public":[10],"health":[11],"concern":[12],"due":[13],"to":[14,97,154,157,176,187,253,262,293,300],"its":[15],"increasing":[16],"prevalence":[17],"and":[18,37,63,90,102,205,234,266,298,303,310,315],"association":[19],"with":[20,75,135,143,183,192],"type":[21],"2":[22],"diabetes":[23],"mellitus.":[24],"Non-invasive":[25],"magnetic":[26],"resonance-based":[27],"biomarkers":[28,109],"can":[29],"aid":[30],"in":[31,116,181,190,217,226,243,250,268,279,319],"the":[32,56,119,130,159,238,251,257,269,280,321],"monitoring":[33],"of":[34,39,70,110,133,147,214,240,271,313,324],"progression":[36],"identification":[38],"patients":[40,73,134,182],"at":[41],"risk":[42],"for":[43,125],"chronic":[44],"disease.":[46],"METHODS/STUDY":[47],"POPULATION:":[48],"Over":[49,275],"600":[50],"subjects":[51],"will":[52,94,113,139,151,173],"be":[53,95,114,152,174,188],"recruited":[54],"from":[55,64,256,290],"San":[57],"Antonio":[58],"Mexican":[59],"American":[60],"Family":[61],"Study":[62],"second":[66],"study,":[67],"which":[68],"consists":[69],"(i)":[71],"T2DM":[72],"diagnosed":[74],"either":[76],"MASLD":[77],"or":[78,83],"metabolic":[79,227],"steatohepatitis":[81],"(MASH)":[82],"(ii)":[84],"metabolically":[85],"healthy":[86],"controls.":[87],"Hydrogen-1":[88],"MRS":[89,316],"diffusion-weighted":[91],"MRI":[92,194,314],"(DW-MRI)":[93],"used":[96],"measure":[98],"fat":[100],"fraction":[101],"stiffness":[104,112],"biomarkers,":[105],"respectively.":[106],"Several":[107],"potential":[108],"evaluated":[115],"vivo":[117],"using":[118],"intravoxel":[120],"incoherent":[121],"motion":[122],"(IVIM)":[123],"model":[124],"DW-MRI.":[126],"To":[127],"further":[128],"improve":[129],"diagnostic":[131,161],"accuracy":[132,265],"fibrosis,":[137],"we":[138,169],"integrate":[140],"MRI/MRS":[141],"data":[142],"relevant":[144],"clinical":[145,212,311],"indicators":[146,213],"hepatic":[148,179,291,301],"metabolism.":[149],"Results":[150],"compared":[153],"biopsy":[155],"samples":[156],"evaluate":[158],"model\u2019s":[160],"accuracy.":[162],"RESULTS/ANTICIPATED":[163],"RESULTS:":[164],"Based":[165],"on":[166],"preliminary":[167],"data,":[168],"predict":[170],"that":[171],"IVIM":[172,203],"able":[175],"accurately":[177],"diagnose":[178],"fibrosis":[180,206,295],"MASLD,":[184],"allowing":[185],"it":[186,288],"implemented":[189],"clinics":[191],"high-field":[193],"units":[195],"easily.":[196],"Previous":[197],"studies":[198],"have":[199,221],"shown":[200,248],"correlations":[201],"between":[202],"estimates":[204],"stages,":[207],"however,":[208],"none":[209],"included":[210],"additional":[211],"their":[218],"models.":[219],"We":[220],"already":[222],"found":[223],"significant":[224],"differences":[225],"measurements":[228],"such":[229],"as":[230],"fasting":[231],"plasma":[232],"glucose":[233],"HbA1c":[235],"levels.":[236],"Additionally,":[237],"use":[239],"machine":[241],"learning":[242],"developing":[244],"these":[245],"models":[246],"has":[247],"improvements":[249],"ability":[252],"extract":[254],"features":[255],"data.":[258],"The":[259],"aim":[260],"achieve":[263],"high":[264],"robustness":[267],"staging":[270],"fibrosis.":[273],"DISCUSSION/SIGNIFICANCE:":[274],"100":[276],"million":[277],"people":[278],"US":[281],"are":[282,317],"affected":[283],"by":[284],"MASLD.":[285,325],"Without":[286],"treatment,":[287],"progresses":[289],"steatosis":[292],"MASH,":[294],"(liver":[296],"stiffening),":[297],"ultimately":[299],"cirrhosis":[302],"hepatocellular":[304],"carcinoma":[305],"(HCC).":[306],"Continued":[307],"research":[308],"efforts":[309],"implementation":[312],"vital":[318],"combating":[320],"growing":[322],"burden":[323]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-04-04T00:00:00"}
