{"id":"https://openalex.org/W4393859611","doi":"https://doi.org/10.1021/acsomega.3c09736","title":"Investigating the Protein-Based Therapeutic Relationship between Honey Protein SHP-60 and Bevacizumab on Angiogenesis: Exploring the Synergistic Effect through In Vitro and In Silico Analysis","display_name":"Investigating the Protein-Based Therapeutic Relationship between Honey Protein SHP-60 and Bevacizumab on Angiogenesis: Exploring the Synergistic Effect through In Vitro and In Silico Analysis","publication_year":2024,"publication_date":"2024-04-02","ids":{"openalex":"https://openalex.org/W4393859611","doi":"https://doi.org/10.1021/acsomega.3c09736","pmid":"https://pubmed.ncbi.nlm.nih.gov/38645361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11024967"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.3c09736","doi":"https://doi.org/10.1021/acsomega.3c09736","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1021/acsomega.3c09736","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09736?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09736?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051951796","display_name":"Mohsin Wahid","orcid":"https://orcid.org/0000-0002-1939-6565","observed_orcids":["https://orcid.org/0000-0002-1939-6565"]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Mohsin Wahid","raw_affiliation_strings":["Department of Pathology, Dow International Medical College, Dow University of Health Sciences, Karachi 74200, Pakistan","Dow Research Institute of Biotechnology and Biomedical Sciences, Dow University of Health Sciences, Karachi 74200, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-1939-6565","affiliations":[{"raw_affiliation_string":"Department of Pathology, Dow International Medical College, Dow University of Health Sciences, Karachi 74200, Pakistan","institution_ids":["https://openalex.org/I39727005"]},{"raw_affiliation_string":"Dow Research Institute of Biotechnology and Biomedical Sciences, Dow University of Health Sciences, Karachi 74200, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002422133","display_name":"Meshal Nazeer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Meshal Nazeer","raw_affiliation_strings":["Dow Research Institute of Biotechnology and Biomedical Sciences, Dow University of Health Sciences, Karachi 74200, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Research Institute of Biotechnology and Biomedical Sciences, Dow University of Health Sciences, Karachi 74200, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100682668","display_name":"Abdul S. Qadir","orcid":"https://orcid.org/0000-0002-9133-2558","observed_orcids":["https://orcid.org/0000-0002-9133-2558"]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]},{"id":"https://openalex.org/I4405260590","display_name":"United Medical and Dental College","ror":"https://ror.org/04084bq42","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405260590"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abdul Qadir","raw_affiliation_strings":["Department of Pharmacology, United Medical and Dental College, Karachi 75190, Pakistan","Dow Research Institute of Biotechnology and Biomedical Sciences, Dow University of Health Sciences, Karachi 74200, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-9133-2558","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, United Medical and Dental College, Karachi 75190, Pakistan","institution_ids":["https://openalex.org/I4405260590"]},{"raw_affiliation_string":"Dow Research Institute of Biotechnology and Biomedical Sciences, Dow University of Health Sciences, Karachi 74200, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068029545","display_name":"Muhammad Bilal Azmi","orcid":"https://orcid.org/0000-0001-8320-4479","observed_orcids":["https://orcid.org/0000-0001-8320-4479"]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Bilal Azmi","raw_affiliation_strings":["Department of Biochemistry, Dow Medical College, Dow University of Health Sciences, Karachi 74200, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-8320-4479","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Dow Medical College, Dow University of Health Sciences, Karachi 74200, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051951796"],"corresponding_institution_ids":["https://openalex.org/I39727005"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":1.1313,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71353216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"15","first_page":"17143","last_page":"17153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.13429999351501465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sidr-honey","display_name":"Sidr honey","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9259999990463257},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.9739999771118164},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7509999871253967},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8870000243186951},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tube-formation-assay","display_name":"tube formation assay","score":0.8069999814033508},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.5820000171661377},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.527999997138977},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8592997789382935},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8106153011322021},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7095105648040771},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6846407651901245},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4152825176715851},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4031723141670227},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37759625911712646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3628188371658325},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36120983958244324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21157747507095337},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09150594472885132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0914967954158783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08774450421333313}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.3c09736","doi":"https://doi.org/10.1021/acsomega.3c09736","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1021/acsomega.3c09736","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09736?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11024967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11024967","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11024967/pdf/ao3c09736.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:38645361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38645361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:942ce14b5b3741c1ace7fea3b698f203","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/942ce14b5b3741c1ace7fea3b698f203","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 9, Iss 15, Pp 17143-17153 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.3c09736","doi":"https://doi.org/10.1021/acsomega.3c09736","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1021/acsomega.3c09736","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09736?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393859611.pdf","grobid_xml":"https://content.openalex.org/works/W4393859611.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1539733143","https://openalex.org/W1891601085","https://openalex.org/W1926568554","https://openalex.org/W1967990316","https://openalex.org/W1992427191","https://openalex.org/W1997692849","https://openalex.org/W2016183704","https://openalex.org/W2018422420","https://openalex.org/W2029784094","https://openalex.org/W2045819991","https://openalex.org/W2055155126","https://openalex.org/W2057323620","https://openalex.org/W2057988592","https://openalex.org/W2070995184","https://openalex.org/W2071210867","https://openalex.org/W2072926442","https://openalex.org/W2085864769","https://openalex.org/W2088653807","https://openalex.org/W2098533150","https://openalex.org/W2121664033","https://openalex.org/W2127284798","https://openalex.org/W2128424069","https://openalex.org/W2129434797","https://openalex.org/W2144740308","https://openalex.org/W2155694671","https://openalex.org/W2171419407","https://openalex.org/W2204039024","https://openalex.org/W2317810164","https://openalex.org/W2342879933","https://openalex.org/W2345728841","https://openalex.org/W2526600278","https://openalex.org/W2565581893","https://openalex.org/W2571501394","https://openalex.org/W2584459311","https://openalex.org/W2742882502","https://openalex.org/W2767057860","https://openalex.org/W2891957518","https://openalex.org/W2906831992","https://openalex.org/W2953890168","https://openalex.org/W2973523639","https://openalex.org/W2988729564","https://openalex.org/W3001239246","https://openalex.org/W3002573892","https://openalex.org/W3083406432","https://openalex.org/W3085697992","https://openalex.org/W3108411718","https://openalex.org/W3127427563","https://openalex.org/W3128549283","https://openalex.org/W3136701056","https://openalex.org/W3176601331","https://openalex.org/W3187431608","https://openalex.org/W3211795435","https://openalex.org/W4234714728","https://openalex.org/W4282924046","https://openalex.org/W4285727388","https://openalex.org/W4310610818","https://openalex.org/W4367044891","https://openalex.org/W4375861939","https://openalex.org/W4377047223"],"related_works":["https://openalex.org/W1970634879","https://openalex.org/W4319985530","https://openalex.org/W4220947084","https://openalex.org/W3085697992","https://openalex.org/W2331564345","https://openalex.org/W2323859391","https://openalex.org/W2797600210","https://openalex.org/W2106417626","https://openalex.org/W2889377395","https://openalex.org/W6982170015"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Honey":[7,50],"is":[8,125,288],"a":[9,26,103,127,179],"natural":[10],"product":[11],"produced":[12],"by":[13,28,97,188],"honeybees,":[14],"which":[15],"has":[16],"been":[17],"used":[18,147,156],"not":[19],"only":[20],"as":[21,25,47],"food":[22],"but":[23],"also":[24],"medicine":[27],"humans":[29],"for":[30],"thousands":[31],"of":[32,59,105,115,129,174,207,213,228,251,268,276,278,282,294],"years.":[33],"In":[34],"this":[35],"study,":[36],"60":[37],"kDa":[38],"protein":[39,63,233],"was":[40,155,167,176,185],"purified":[41,62],"from":[42],"Pakistani":[43],"Sidr":[44],"honey":[45],"named":[46],"SHP-60":[48,196,237],"(Sidr":[49],"Protein-60),":[51],"and":[52,56,111,131,142,151,171,191,195,202,223,247,260,266,274,285,297],"its":[53],"antioxidant":[54,95],"potential":[55],"the":[57,80,134,152,172,218,243,258,292,295],"effect":[58],"Bevacizumab":[60,194,214],"with":[61,84,102,241,271],"on":[64,169],"in":[65,88,144,163,200,238,299],"vitro":[66,164],"angiogenesis":[67,199],"using":[68,178],"human":[69],"umbilical":[70],"vein":[71],"endothelial":[72],"cells":[73],"(HUVEC)":[74],"were":[75,146],"investigated.":[76],"We":[77,216,253],"further":[78],"validated":[79],"molecular":[81,220,224,239],"protein\u2013protein":[82,219],"(SHP-60":[83],"Bevacizumab)":[85],"interactions":[86,222,256],"through":[87],"silico":[89],"analysis.":[90],"It":[91],"showed":[92],"very":[93],"promising":[94],"activity":[96],"reducing":[98],"2,2-diphenyl-1-picrylhydrazyl":[99],"free":[100],"radicals":[101],"maximum":[104],"83%":[106],"inhibition":[107,208],"at":[108],"50":[109,114],"\u03bcM":[110,117],"an":[112],"IC":[113],"26.45":[116],"statistically":[118],"significant":[119,255],"(**":[120],"p":[121],"<":[122],"0.01).":[123],"Angiogenesis":[124],"considered":[126],"hallmark":[128],"cancer,":[130],"without":[132],"it,":[133],"tumor":[135],"cannot":[136],"grow":[137],"or":[138],"metastasize.":[139],"Bevacizumab,":[140,189],"SHP-60,":[141,190],"both":[143,192,197,242],"combination":[145,204],"to":[148,157,236,290],"treat":[149],"HUVEC,":[150],"MTT":[153],"assay":[154],"assess":[158],"cell":[159],"viability.":[160],"To":[161],"demonstrate":[162],"angiogenesis,":[165],"HUVEC":[166,183],"grown":[168],"Geltrex,":[170],"formation":[173,181],"endotubes":[175],"examined":[177],"tube":[180],"assay.":[182],"viability":[184],"dose-dependently":[186],"decreased":[187],"together.":[193],"inhibited":[198],"vitro,":[201],"their":[203],"displayed":[205],"levels":[206],"even":[209],"higher":[210],"than":[211],"those":[212],"alone.":[215],"investigated":[217],"docking":[221],"dynamics":[225],"simulation":[226],"analysis":[227],"MRJP3":[229,269],"(major":[230],"royal":[231],"jelly":[232],"3)":[234],"similar":[235],"weight":[240],"heavy":[244],"chain":[245,249],"(HC)":[246],"light":[248],"(LC)":[250],"Bevacizumab.":[252,279],"found":[254],"between":[257],"LC":[259,277],"MRJP3,":[261],"indicating":[262],"that":[263],"ASN468,":[264],"GLN470,":[265],"ASN473":[267],"interact":[270],"SER156,":[272],"SER159,":[273],"GLU161":[275],"The":[280],"integration":[281],"experimental":[283],"data":[284],"computational":[286],"techniques":[287],"believed":[289],"improve":[291],"reliability":[293],"findings":[296],"aid":[298],"future":[300],"drug":[301],"design.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-04T00:00:00"}
