{"id":"https://openalex.org/W4393858355","doi":"https://doi.org/10.1016/s2666-7568(24)00033-3","title":"The time course of motor and cognitive decline in older adults and their associations with brain pathologies: a multicohort study","display_name":"The time course of motor and cognitive decline in older adults and their associations with brain pathologies: a multicohort study","publication_year":2024,"publication_date":"2024-04-03","ids":{"openalex":"https://openalex.org/W4393858355","doi":"https://doi.org/10.1016/s2666-7568(24)00033-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/38582095","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11129202"},"language":"en","primary_location":{"id":"doi:10.1016/s2666-7568(24)00033-3","doi":"https://doi.org/10.1016/s2666-7568(24)00033-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2666-7568(24)00033-3","pdf_url":"http://www.thelancet.com/article/S2666756824000333/pdf","source":{"id":"https://openalex.org/S4210210722","display_name":"The Lancet Healthy Longevity","issn_l":"2666-7568","issn":["2666-7568"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-3","medline","norway-2","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Healthy Longevity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.thelancet.com/article/S2666756824000333/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007574006","display_name":"Shahram Oveisgharan","orcid":"https://orcid.org/0000-0001-6841-4830","observed_orcids":["https://orcid.org/0000-0001-6841-4830"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shahram Oveisgharan","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. Electronic address: shahram_oveisgharan@rush.edu","Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. Electronic address: shahram_oveisgharan@rush.edu","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610980","display_name":"Tianhao Wang","orcid":"https://orcid.org/0000-0001-8334-2476","observed_orcids":["https://orcid.org/0000-0001-8334-2476"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianhao Wang","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026996448","display_name":"Lisa Laverne Barnes","orcid":"https://orcid.org/0000-0002-0072-9817","observed_orcids":["https://orcid.org/0000-0002-0072-9817"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa L Barnes","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA","Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA","Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752","observed_orcids":["https://orcid.org/0000-0002-9482-1752"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A Schneider","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA","Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Department of Pathology, Rush University Medical Center, Chicago, IL, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Pathology, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Bennett","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020237298","display_name":"Aron S. Buchman","orcid":"https://orcid.org/0000-0002-6426-2742","observed_orcids":["https://orcid.org/0000-0002-6426-2742"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aron S Buchman","raw_affiliation_strings":["Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007574006"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":5780,"currency":"USD","value_usd":5780},"apc_paid":{"value":5780,"currency":"USD","value_usd":5780},"fwci":17.579,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.99714835,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"e336","last_page":"e345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3206","display_name":"Neuropsychology and Physiological Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motor-function-decline","display_name":"motor function decline","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9919999837875366},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8389999866485596},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tau-tangles","display_name":"tau tangles","score":0.699999988079071},{"id":"https://openalex.org/keywords/gait-disturbance","display_name":"gait disturbance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.8370000123977661},{"id":"https://openalex.org/keywords/preclinical-dementia","display_name":"preclinical dementia","score":0.4790000021457672},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.6010000109672546},{"id":"https://openalex.org/keywords/religious-orders-study","display_name":"Religious Orders Study","score":0.7699999809265137},{"id":"https://openalex.org/keywords/rush-memory-and-aging-project","display_name":"Rush Memory and Aging Project","score":0.9980000257492065},{"id":"https://openalex.org/keywords/multimodal-neuroimaging","display_name":"multimodal neuroimaging","score":0.3569999933242798},{"id":"https://openalex.org/keywords/multimodal-biomarkers","display_name":"multimodal biomarkers","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6805075407028198},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5826297402381897},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5598832368850708},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.5518230199813843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5437144637107849},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5395388603210449},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.520084798336029},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.5064281225204468},{"id":"https://openalex.org/C2777433710","wikidata":"https://www.wikidata.org/wiki/Q5609571","display_name":"Grip strength","level":2,"score":0.4748694598674774},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.4394409954547882},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.41690561175346375},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3982967436313629},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3640947937965393},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.35302427411079407},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19062969088554382},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16911515593528748}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018737","descriptor_name":"Hand Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s2666-7568(24)00033-3","doi":"https://doi.org/10.1016/s2666-7568(24)00033-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2666-7568(24)00033-3","pdf_url":"http://www.thelancet.com/article/S2666756824000333/pdf","source":{"id":"https://openalex.org/S4210210722","display_name":"The Lancet Healthy Longevity","issn_l":"2666-7568","issn":["2666-7568"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-3","medline","norway-2","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Healthy Longevity","raw_type":"journal-article"},{"id":"pmid:38582095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38582095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The lancet. Healthy longevity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11129202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11129202","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11129202/pdf/nihms-1990779.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Lancet Healthy Longev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/s2666-7568(24)00033-3","doi":"https://doi.org/10.1016/s2666-7568(24)00033-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2666-7568(24)00033-3","pdf_url":"http://www.thelancet.com/article/S2666756824000333/pdf","source":{"id":"https://openalex.org/S4210210722","display_name":"The Lancet Healthy Longevity","issn_l":"2666-7568","issn":["2666-7568"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-1","ki-jl-3","medline","norway-2","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Healthy Longevity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1129744104","display_name":"Epidemiologic Study of Neural Reserve and Neurobiology of Aging","funder_award_id":"R01AG017917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1676023026","display_name":"Impaired Gait in Older Adults: Pathologies of Alzheimer's disease and Related Disorders","funder_award_id":"R01AG056352","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000863354","display_name":"Identifying resilience proteins in key motor tissues that drive motor and cognitive decline and offset the negative effects of ADRD pathologies within and outside the brain","funder_award_id":"R01AG075728","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000893450","display_name":"Thinking about walking: Can digital phenotyping of mobility improve the prediction of Alzheimer's dementia and inform on the pathologies and proteins contributing to this association?","funder_award_id":"R01AG079133","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000899922","display_name":"Racial Differences in Late-Life Cognitive decline and risk of Alzheimer's Disease","funder_award_id":"R01AG022018","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000921028","display_name":"Rush Alzheimer's Disease Research Center","funder_award_id":"P30AG072975","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393858355.pdf","grobid_xml":"https://content.openalex.org/works/W4393858355.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2037153463","https://openalex.org/W2090840528","https://openalex.org/W2111883921","https://openalex.org/W2115017507","https://openalex.org/W2125958962","https://openalex.org/W2129497119","https://openalex.org/W2148230634","https://openalex.org/W2162801491","https://openalex.org/W2162951717","https://openalex.org/W2256375944","https://openalex.org/W2527609605","https://openalex.org/W2549644052","https://openalex.org/W2755035583","https://openalex.org/W2795440516","https://openalex.org/W2809330972","https://openalex.org/W2897712355","https://openalex.org/W2923841692","https://openalex.org/W2979434443","https://openalex.org/W3010510502","https://openalex.org/W3019590260","https://openalex.org/W4211144975","https://openalex.org/W4229034412","https://openalex.org/W4282927200","https://openalex.org/W4307178533","https://openalex.org/W4321749341","https://openalex.org/W4380291824","https://openalex.org/W4386033687"],"related_works":["https://openalex.org/W4393858331","https://openalex.org/W2795440516","https://openalex.org/W4210664372","https://openalex.org/W2020680955","https://openalex.org/W2070990701","https://openalex.org/W4200587143","https://openalex.org/W4282927200","https://openalex.org/W7117307900","https://openalex.org/W2124330608","https://openalex.org/W7097578851"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"studies":[2,54,429],"have":[3],"reported":[4],"that":[5,398,419],"impaired":[6],"gait":[7,149,255,311,351,365,417,433],"precedes":[8,405,420],"cognitive":[9,22,199,277,309,325,381,406,421,442],"impairment":[10,434],"in":[11,26,69,206,391,402],"older":[12,27,403],"people.":[13],"We":[14],"aimed":[15],"to":[16,90,97,160,182,243,251,430],"characterise":[17],"the":[18,30,36,70,84,154,207,262,322,336,348,359,425],"time":[19,85,159,230],"course":[20],"of":[21,32,38,86,113,156,169,196,267,269,284,299,361,447],"and":[23,29,41,60,63,88,101,106,115,119,144,147,158,164,172,200,203,223,257,272,278,281,293,314,347,383],"motor":[24,116,201,279,400],"decline":[25,280,298,317,326,382,390,401],"individuals":[28],"association":[31,323,337,349,360],"these":[33],"declines":[34],"with":[35,276,297,308,324,338,350,363,374,415],"pathologies":[37,168,268],"Alzheimer's":[39,170,270],"disease":[40,171,271,291],"related":[42,173,273],"dementias.":[43],"METHODS:":[44],"This":[45,423],"multicohort":[46],"study":[47],"used":[48],"data":[49,121],"from":[50,241],"three":[51,77,107,301],"community-based":[52],"cohort":[53,188],"(Religious":[55],"Orders":[56],"Study,":[57,67],"Rush":[58],"Memory":[59],"Aging":[61,65],"Project,":[62],"Minority":[64],"Research":[66],"all":[68,76,300],"USA).":[71],"The":[72,265],"inclusion":[73],"criteria":[74],"for":[75,319,328,380,389,427,439],"cohorts":[78],"were":[79,122,175,185,204,221,226,295,305],"no":[80],"clinical":[81,92,437],"dementia":[82],"at":[83,177,211],"enrolment":[87],"consent":[89],"annual":[91,111],"assessments.":[93],"Eligible":[94],"participants":[95,189,220],"consented":[96],"post-mortem":[98,103,120],"brain":[99],"donation":[100],"had":[102,198],"pathological":[104],"assessments":[105],"or":[108,193],"more":[109,329],"repeated":[110],"measures":[112],"cognition":[114,129,238,249],"functions.":[117],"Clinical":[118],"analysed":[123],"using":[124],"functional":[125],"mixed-effects":[126],"models.":[127],"Global":[128],"was":[130,140,151,213,231,239],"based":[131,141,152],"on":[132,142,153],"19":[133],"neuropsychological":[134],"tests,":[135],"a":[136,148,436],"hand":[137,258,315,339,392],"strength":[138,259,340],"score":[139,150],"grip":[143],"pinch":[145],"strength,":[146],"number":[155],"steps":[157],"walk":[161],"8":[162],"feet":[163],"turn":[165],"360\u00b0.":[166],"Brain":[167],"dementias":[174,274],"assessed":[176],"autopsy.":[178],"FINDINGS:":[179],"From":[180],"1994":[181],"2022,":[183],"there":[184],"1570":[186],"eligible":[187],"aged":[190],"65":[191],"years":[192,215,233,245,332,344,354,369,376,385],"older,":[194],"1303":[195],"whom":[197],"measurements":[202],"included":[205],"analysis.":[208],"Mean":[209],"age":[210],"death":[212,346,371,378,387],"90\u00b73":[214],"(SD":[216],"6\u00b73),":[217],"905":[218],"(69%)":[219],"female,":[222],"398":[224],"(31%)":[225],"male.":[227],"Median":[228],"follow-up":[229],"9":[232],"(IQR":[234],"5-11).":[235],"On":[236],"average,":[237],"stable":[240],"25":[242],"15":[244],"before":[246,333,345,355,370,377,386],"death,":[247,334],"when":[248],"began":[250,342,352,367],"decline.":[252,407,422],"By":[253,357],"contrast,":[254,358],"function":[256,312,316,366,418],"declined":[260],"during":[261],"entire":[263],"study.":[264],"combinations":[266],"associated":[275,296,307,414],"their":[282],"onsets":[283],"associations":[285],"varied;":[286],"only":[287,341],"tau":[288,411],"tangles,":[289],"Parkinson's":[290],"pathology,":[292],"macroinfarcts":[294,362],"phenotypes.":[302],"Tau":[303],"tangles":[304,412],"significantly":[306],"decline,":[310,313],"(p<0\u00b70001":[318],"each);":[320],"however,":[321],"persisted":[327],"than":[330],"11":[331],"but":[335,409],"3\u00b757":[343],"3\u00b749":[353],"death.":[356],"declining":[364,416],"9\u00b725":[368],"(p<0\u00b70001)":[372],"compared":[373],"6\u00b765":[375],"(p=0\u00b70005)":[379],"2\u00b766":[384],"(p=0\u00b7024)":[388],"strength.":[393],"INTERPRETATION:":[394],"Our":[395],"findings":[396],"suggest":[397],"average":[399],"adults":[404],"Macroinfarcts":[408],"not":[410],"are":[413],"suggests":[424],"need":[426],"further":[428],"test":[431],"if":[432],"is":[435],"proxy":[438],"preclinical":[440],"vascular":[441],"impairment.":[443],"FUNDING:":[444],"National":[445],"Institutes":[446],"Health.":[448]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-04T00:00:00"}
