{"id":"https://openalex.org/W4393851446","doi":"https://doi.org/10.1016/j.ekir.2024.02.364","title":"WCN24-1868 ASSIST: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CROSSOVER TRIAL OF ATRASENTAN IN PATIENTS WITH IGA NEPHROPATHY (IGAN) ON SGLT2I","display_name":"WCN24-1868 ASSIST: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CROSSOVER TRIAL OF ATRASENTAN IN PATIENTS WITH IGA NEPHROPATHY (IGAN) ON SGLT2I","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4393851446","doi":"https://doi.org/10.1016/j.ekir.2024.02.364"},"language":"en","primary_location":{"id":"doi:10.1016/j.ekir.2024.02.364","doi":"https://doi.org/10.1016/j.ekir.2024.02.364","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2024.02.364","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ekir.2024.02.364","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031510699","display_name":"Irene L. Noronha","orcid":"https://orcid.org/0000-0002-3208-4435","observed_orcids":["https://orcid.org/0000-0002-3208-4435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene L. Noronha","raw_affiliation_strings":["S\u00e3o Paulo, Nephrology, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00e3o Paulo, Nephrology, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055078486","display_name":"Jonathan Barratt","orcid":"https://orcid.org/0000-0002-9063-7229","observed_orcids":["https://orcid.org/0000-0002-9063-7229"]},"institutions":[{"id":"https://openalex.org/I2802445252","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Barratt","raw_affiliation_strings":["Department of Cardiovascular Sciences, Renal Medicine, University Hospitals of Leicester NHS Trust, Leicester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Renal Medicine, University Hospitals of Leicester NHS Trust, Leicester","institution_ids":["https://openalex.org/I2802445252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046692355","display_name":"Jos\u00e9 Luis G\u00f3rriz","orcid":"https://orcid.org/0000-0002-1134-9051","observed_orcids":["https://orcid.org/0000-0002-1134-9051"]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Luis G\u00f3rriz","raw_affiliation_strings":["Nephrology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085805044","display_name":"Sradha S. Kotwal","orcid":"https://orcid.org/0000-0002-3294-4087","observed_orcids":["https://orcid.org/0000-0002-3294-4087"]},"institutions":[{"id":"https://openalex.org/I183874623","display_name":"The George Institute for Global Health","ror":"https://ror.org/04h0zjx60","country_code":"GB","type":"facility","lineage":["https://openalex.org/I183874623","https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Sradha Kotwal","raw_affiliation_strings":["The George Institute for Global Health, Prince of Wales Hospital, Sydney"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The George Institute for Global Health, Prince of Wales Hospital, Sydney","institution_ids":["https://openalex.org/I183874623","https://openalex.org/I4210108821","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037021026","display_name":"Soo Kun Lim","orcid":"https://orcid.org/0000-0001-7589-5150","observed_orcids":["https://orcid.org/0000-0001-7589-5150"]},"institutions":[{"id":"https://openalex.org/I1296788130","display_name":"University Malaya Medical Centre","ror":"https://ror.org/00vkrxq08","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I1296788130"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Soo Kun Lim","raw_affiliation_strings":["Department of Medicine, University Malaya Medical Centre, Kuala Lumpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Malaya Medical Centre, Kuala Lumpur","institution_ids":["https://openalex.org/I1296788130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077188003","display_name":"Valeria V. Beckett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria Beckett","raw_affiliation_strings":["Biostatistics, Chinook Therapeutics, A Novartis Company, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Chinook Therapeutics, A Novartis Company, Seattle","institution_ids":["https://openalex.org/I4405270553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017435524","display_name":"Marianne Camargo","orcid":"https://orcid.org/0000-0003-2568-0105","observed_orcids":["https://orcid.org/0000-0003-2568-0105"]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianne Camargo","raw_affiliation_strings":["Clinical Development, Chinook Therapeutics, A Novartis Company, Seattle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development, Chinook Therapeutics, A Novartis Company, Seattle","institution_ids":["https://openalex.org/I4405270553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009128263","display_name":"Amy K. Mottl","orcid":"https://orcid.org/0000-0002-4258-1726","observed_orcids":["https://orcid.org/0000-0002-4258-1726"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy K. Mottl","raw_affiliation_strings":["Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031624913","display_name":"Hiddo J.L. Heerspink","orcid":"https://orcid.org/0000-0002-3126-3730","observed_orcids":["https://orcid.org/0000-0002-3126-3730"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hiddo J.L. Heerspink","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen","institution_ids":["https://openalex.org/I1334415907"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":0.8194,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.73367298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"9","issue":"4","first_page":"S178","last_page":"S178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrasentan","display_name":"atrasentan","score":0.9779999852180481},{"id":"https://openalex.org/keywords/iga-nephropathy","display_name":"IgA nephropathy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/endothelin-a-receptor-antagonist","display_name":"endothelin A receptor antagonist","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7829999923706055},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.9940000176429749},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/glomerulonephritis","display_name":"glomerulonephritis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9541754722595215},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.7867311239242554},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.6518558263778687},{"id":"https://openalex.org/C122507166","wikidata":"https://www.wikidata.org/wiki/Q628906","display_name":"Crossover","level":2,"score":0.6313439607620239},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.598212718963623},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.5556097030639648},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4124760627746582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3721711337566376},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08758389949798584},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.08492153882980347},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06443116068840027},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.036181867122650146},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ekir.2024.02.364","doi":"https://doi.org/10.1016/j.ekir.2024.02.364","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2024.02.364","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ce64fca25b744f0fb3480eb242ee3c71","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ce64fca25b744f0fb3480eb242ee3c71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kidney International Reports, Vol 9, Iss 4, Pp S178- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ekir.2024.02.364","doi":"https://doi.org/10.1016/j.ekir.2024.02.364","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ekir.2024.02.364","pdf_url":null,"source":{"id":"https://openalex.org/S2764478277","display_name":"Kidney International Reports","issn_l":"2468-0249","issn":["2468-0249"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4380447981","https://openalex.org/W3172530387","https://openalex.org/W7142758309","https://openalex.org/W4212966769","https://openalex.org/W4386458059","https://openalex.org/W4229001749","https://openalex.org/W4403287054","https://openalex.org/W4396989830","https://openalex.org/W3152584659","https://openalex.org/W4406270316"],"abstract_inverted_index":{"IgA":[0],"nephropathy":[1],"(IgAN)":[2],"is":[3],"the":[4],"leading":[5],"cause":[6],"of":[7,31],"primary":[8],"glomerulonephritis":[9],"and":[10,26,45,52,70,80],"has":[11],"limited":[12],"treatment":[13,73],"options.":[14],"Endothelin":[15],"A":[16],"(ETA)":[17],"receptor":[18],"activation":[19],"drives":[20],"increase":[21],"in":[22,37,54,60,64,83,86],"proteinuria,":[23],"kidney":[24],"inflammation":[25],"fibrosis.":[27],"In":[28],"interim":[29],"results":[30],"a":[32,43,61],"phase":[33],"2,":[34],"open-label":[35],"study":[36],"patients":[38,65],"with":[39,66,74],"IgAN":[40],"(AFFINITY),":[41],"atrasentan,":[42],"potent":[44],"selective":[46],"ETA":[47],"antagonist,":[48],"was":[49],"well":[50],"tolerated":[51],"resulted":[53,82],"clinically":[55],"meaningful":[56],"proteinuria":[57],"reduction.":[58],"Meanwhile,":[59],"post-hoc":[62],"analysis":[63],"type":[67],"2":[68],"diabetes":[69],"CKD":[71],"(SONAR),":[72],"sodium":[75],"glucose":[76],"cotransporter-2":[77],"inhibitors":[78],"(SGLT2i)":[79],"atrasentan":[81,90],"greater":[84],"reductions":[85],"albuminuria":[87],"compared":[88],"to":[89],"alone":[91],"(n=14).":[92]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-04-04T00:00:00"}