{"id":"https://openalex.org/W4393758121","doi":"https://doi.org/10.5281/zenodo.3708897","title":"Dataset related to article \"TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells.\"","display_name":"Dataset related to article \"TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells.\"","publication_year":2020,"publication_date":"2020-03-13","ids":{"openalex":"https://openalex.org/W4393758121","doi":"https://doi.org/10.5281/zenodo.3708897"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:3708898","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/3708898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/3708898","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049123139","display_name":"Barbara Romano","orcid":"https://orcid.org/0000-0003-2772-5231","observed_orcids":["https://orcid.org/0000-0003-2772-5231"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B, Romano","raw_affiliation_strings":["Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037992666","display_name":"Sudharshan Elangovan","orcid":"https://orcid.org/0000-0002-8783-626X","observed_orcids":["https://orcid.org/0000-0002-8783-626X"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elangovan S","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078160598","display_name":"Marco Erreni","orcid":"https://orcid.org/0000-0002-1922-0818","observed_orcids":["https://orcid.org/0000-0002-1922-0818"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erreni M","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sala E","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sala E","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012580266","display_name":"Luciana Petti","orcid":"https://orcid.org/0000-0001-8389-000X","observed_orcids":["https://orcid.org/0000-0001-8389-000X","https://orcid.org/0000-0002-9690-9328"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Petti L","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074144174","display_name":"Paolo Kunderfranco","orcid":"https://orcid.org/0000-0001-7477-8710","observed_orcids":["https://orcid.org/0000-0001-7477-8710","https://orcid.org/0000-0003-3636-3391"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Kunderfranco P","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077611338","display_name":"Luca Massimino","orcid":"https://orcid.org/0000-0003-3975-9148","observed_orcids":["https://orcid.org/0000-0003-3975-9148"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L, Massimino","raw_affiliation_strings":["Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040201671","display_name":"Silvia Restelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Restelli S","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072236804","display_name":"Shruti Sinha","orcid":"https://orcid.org/0009-0008-5273-2920","observed_orcids":["https://orcid.org/0009-0008-5273-2920"]},"institutions":[{"id":"https://openalex.org/I4210160365","display_name":"Istituto Nazionale Genetica Molecolare","ror":"https://ror.org/05rb1q636","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210160365"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sinha S","raw_affiliation_strings":["Genome Biology Unit, Istituto Nazionale di Genetica Molecolare \"Romeo ed Enrica Invernizzi\" (INGM), Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Biology Unit, Istituto Nazionale di Genetica Molecolare \"Romeo ed Enrica Invernizzi\" (INGM), Milan, Italy","institution_ids":["https://openalex.org/I4210160365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070921491","display_name":"Donatella Lucchetti","orcid":"https://orcid.org/0000-0001-8147-0079","observed_orcids":["https://orcid.org/0000-0001-8147-0079"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucchetti D","raw_affiliation_strings":["Institute of General Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Catholic University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Catholic University, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068607808","display_name":"Achille Anselmo","orcid":"https://orcid.org/0000-0001-6431-8518","observed_orcids":["https://orcid.org/0000-0001-6431-8518"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A, Anselmo","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015042839","display_name":"Colombo FS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"FS, Colombo","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050543823","display_name":"Matteo Stravalaci","orcid":"https://orcid.org/0000-0002-5636-4204","observed_orcids":["https://orcid.org/0000-0002-5636-4204"]},"institutions":[{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stravalaci M","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053082535","display_name":"Vincenzo Arena","orcid":"https://orcid.org/0000-0002-4363-6311","observed_orcids":["https://orcid.org/0000-0002-4363-6311"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arena V","raw_affiliation_strings":["Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078833018","display_name":"Silvia D\u2019Alessio","orcid":"https://orcid.org/0000-0001-7713-040X","observed_orcids":["https://orcid.org/0000-0001-7713-040X"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D'Alessio S","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011530256","display_name":"Federica Ungaro","orcid":"https://orcid.org/0000-0001-5395-7795","observed_orcids":["https://orcid.org/0000-0001-5395-7795"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ungaro F","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084284106","display_name":"Antonio Inforzato","orcid":"https://orcid.org/0000-0001-8110-0027","observed_orcids":["https://orcid.org/0000-0001-8110-0027"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A, Inforzato","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8110-0027","affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094346109","display_name":"Izzo AA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Izzo AA","raw_affiliation_strings":["Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003607573","display_name":"Alessandro Sgambato","orcid":"https://orcid.org/0000-0002-9487-4563","observed_orcids":["https://orcid.org/0000-0002-9487-4563"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sgambato A","raw_affiliation_strings":["Institute of General Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Catholic University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Catholic University, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006588214","display_name":"Anthony J. Day","orcid":"https://orcid.org/0000-0002-1415-3134","observed_orcids":["https://orcid.org/0000-0002-1415-3134"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I2800776015","display_name":"Wellcome Centre for Cell-Matrix Research","ror":"https://ror.org/0094tm228","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800776015","https://openalex.org/I28407311","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Day AJ","raw_affiliation_strings":["Wellcome Trust Centre for Cell-Matrix Research and Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine, & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Cell-Matrix Research and Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine, & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I2800776015","https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021553335","display_name":"Stefania Vetrano","orcid":"https://orcid.org/0000-0001-9825-2000","observed_orcids":["https://orcid.org/0000-0001-9825-2000"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S, Vetrano","raw_affiliation_strings":["Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9825-2000","affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center \u2013 IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele \u2013 Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tsg-6","display_name":"TSG-6","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":1.0},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.9110000133514404},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.4519999921321869},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.7820000052452087},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cytoskeleton-organization","display_name":"cytoskeletal organization","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.8517947196960449},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7895799875259399},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.6034827828407288},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4381408989429474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43205100297927856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42153042554855347},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4191407859325409},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39222589135169983},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34730100631713867},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18445110321044922},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10028150677680969}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:zenodo.org:3708898","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/3708898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},{"id":"doi:10.5281/zenodo.3708897","doi":"https://doi.org/10.5281/zenodo.3708897","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.3708897","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.3708898","doi":"https://doi.org/10.5281/zenodo.3708898","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.3708898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:3708898","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/3708898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2927888805","https://openalex.org/W4389022030","https://openalex.org/W2783235617","https://openalex.org/W2360853849","https://openalex.org/W4409981760","https://openalex.org/W2207961677","https://openalex.org/W4410870708","https://openalex.org/W3033378659","https://openalex.org/W4390404357","https://openalex.org/W2611829177"],"abstract_inverted_index":{"Mesenchymal":[0],"stem":[1],"cells":[2],"(MSCs)":[3],"are":[4,203],"well":[5],"established":[6],"to":[7,24,85,133,165,173,207],"have":[8],"promising":[9],"therapeutic":[10],"properties.":[11],"TNF-stimulated":[12],"gene-6":[13],"(TSG-6),":[14],"a":[15,28,57,213,220],"potent":[16],"tissue-protective":[17],"and":[18,74,93,117,154,170,191,219],"anti-inflammatory":[19],"factor,":[20],"has":[21],"been":[22],"demonstrated":[23,53],"be":[25,131],"responsible":[26],"for":[27,186],"significant":[29],"part":[30],"of":[31,45,65,71,81,88,110,119,144,189,195,200],"the":[32,42,79,86,124,137,174,187],"tissue-protecting":[33],"properties":[34,64,172,194],"mediated":[35],"by":[36],"MSCs.":[37,66,175,197],"Nevertheless,":[38],"current":[39],"knowledge":[40],"about":[41,216],"biological":[43,96,193],"function":[44],"TSG-6":[46,55,82,183],"in":[47,136,149,156,204],"MSCs":[48,160],"is":[49,56,184],"limited.":[50],"Here,":[51],"we":[52,211],"that":[54,60,78,182],"crucial":[58,185],"factor":[59],"influences":[61],"many":[62],"functional":[63],"The":[67,142],"transcriptomic":[68],"sequencing":[69],"analysis":[70],"wild-type":[72],"(WT)":[73],"TSG-6-/-":[75,98],"-MSCs":[76,99],"shows":[77],"loss":[80,118],"expression":[83],"leads":[84],"perturbation":[87],"several":[89],"transcription":[90],"factors,":[91],"cytokines,":[92],"other":[94,192],"key":[95],"pathways.":[97],"appeared":[100],"morphologically":[101],"different":[102],"with":[103,123,146],"dissimilar":[104],"cytoskeleton":[105],"organization,":[106],"significantly":[107],"reduced":[108],"size":[109],"extracellular":[111,138],"vesicles,":[112],"decreased":[113],"cell":[114,152],"proliferative":[115],"rate,":[116],"differentiation":[120],"abilities":[121],"compared":[122],"WT":[125],"cells.":[126],"These":[127],"cellular":[128],"effects":[129],"may":[130],"due":[132],"TSG-6-mediated":[134],"changes":[135,155],"matrix":[139],"(ECM)":[140],"environment.":[141],"supplementation":[143],"ECM":[145],"exogenous":[147],"TSG-6,":[148],"fact,":[150],"rescued":[151],"proliferation":[153],"morphology.":[157],"Importantly,":[158],"TSG-6-deficient":[159],"displayed":[161],"an":[162],"increased":[163],"capacity":[164],"release":[166],"interleukin-6":[167],"conferring":[168],"pro-inflammatory":[169],"pro-tumorigenic":[171],"Overall,":[176],"our":[177],"data":[178],"provide":[179],"strong":[180],"evidence":[181],"maintenance":[188],"stemness":[190],"murine":[196],"Some":[198],"dataset":[199],"this":[201,217],"research":[202],"prism":[205],"format,":[206],"ensure":[208],"open":[209],"access":[210],"attach":[212],"pdf":[214],"instruction":[215],"format":[218],"link":[221],"where":[222],"downoladed":[223],"it":[224]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-03T00:00:00"}