{"id":"https://openalex.org/W4393755429","doi":"https://doi.org/10.5281/zenodo.5494395","title":"Multi-Omic Approach Associates Blood Methylome with Bronchodilator Drug Response in Pediatric Asthma: Summary statistics","display_name":"Multi-Omic Approach Associates Blood Methylome with Bronchodilator Drug Response in Pediatric Asthma: Summary statistics","publication_year":2021,"publication_date":"2021-12-14","ids":{"openalex":"https://openalex.org/W4393755429","doi":"https://doi.org/10.5281/zenodo.5494395"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:5494396","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/5494396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Allergy and Clinical Immunology","raw_type":"dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/5494396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024377581","display_name":"Javier P\u00e9rez-Garc\u00eda","orcid":"https://orcid.org/0000-0001-7813-4381","observed_orcids":["https://orcid.org/0000-0001-7813-4381"]},"institutions":[{"id":"https://openalex.org/I158438070","display_name":"Universidad de La Laguna","ror":"https://ror.org/01r9z8p25","country_code":"ES","type":"education","lineage":["https://openalex.org/I158438070"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Perez-Garcia, Javier","raw_affiliation_strings":["Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7813-4381","affiliations":[{"raw_affiliation_string":"Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain","institution_ids":["https://openalex.org/I158438070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002837722","display_name":"Esther Herrera Luis","orcid":"https://orcid.org/0000-0003-4150-5454","observed_orcids":["https://orcid.org/0000-0003-4150-5454"]},"institutions":[{"id":"https://openalex.org/I158438070","display_name":"Universidad de La Laguna","ror":"https://ror.org/01r9z8p25","country_code":"ES","type":"education","lineage":["https://openalex.org/I158438070"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Herrera-Luis, Esther","raw_affiliation_strings":["Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4150-5454","affiliations":[{"raw_affiliation_string":"Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain","institution_ids":["https://openalex.org/I158438070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103177727","display_name":"Annie Li","orcid":"https://orcid.org/0009-0005-7020-5794","observed_orcids":["https://orcid.org/0009-0005-7020-5794"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li, Annie","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059079600","display_name":"Angel C. Y. Mak","orcid":"https://orcid.org/0000-0002-5372-4198","observed_orcids":["https://orcid.org/0000-0002-5372-4198"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mak, Angel CY","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084533856","display_name":"Scott Huntsman","orcid":"https://orcid.org/0000-0002-5440-6191","observed_orcids":["https://orcid.org/0000-0002-5440-6191"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huntsman, Scott","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060482624","display_name":"Sam S. Oh","orcid":"https://orcid.org/0000-0002-2815-6037","observed_orcids":["https://orcid.org/0000-0002-2815-6037"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oh, Sam S","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038265103","display_name":"Jennifer R. Elhawary","orcid":"https://orcid.org/0000-0003-3326-1680","observed_orcids":["https://orcid.org/0000-0003-3326-1680"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elhawary, Jennifer R","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088861717","display_name":"Celeste S. Eng","orcid":"https://orcid.org/0000-0001-7968-1862","observed_orcids":["https://orcid.org/0000-0001-7968-1862"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eng, Celeste","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059093059","display_name":"Kenneth B. Beckman","orcid":"https://orcid.org/0000-0001-8876-0706","observed_orcids":["https://orcid.org/0000-0001-8876-0706"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beckman, Kenneth B","raw_affiliation_strings":["University of Minnesota (UMN) Genomics Center, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota (UMN) Genomics Center, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004750663","display_name":"Donglei Hu","orcid":"https://orcid.org/0000-0002-0351-001X","observed_orcids":["https://orcid.org/0000-0002-0351-001X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donglei Hu","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113678209","display_name":"Michael A. LeNoir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lenoir, Michael A","raw_affiliation_strings":["Bay Area Pediatrics, Oakland, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bay Area Pediatrics, Oakland, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112465332","display_name":"Jos\u00e9 Rodr\u00edguez\u2010Santana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149710","display_name":"Centro de Neumologia Pediatrica","ror":"https://ror.org/05at36m36","country_code":"PR","type":"healthcare","lineage":["https://openalex.org/I4210149710"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Rodriguez-Santana, Jose","raw_affiliation_strings":["Centro de Neumolog\u00eda Pedi\u00e1trica, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Neumolog\u00eda Pedi\u00e1trica, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I4210149710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058484067","display_name":"Noah Zaitlen","orcid":"https://orcid.org/0000-0002-3553-3670","observed_orcids":["https://orcid.org/0000-0002-3553-3670"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaitlen, Noah","raw_affiliation_strings":["Department of Neurology, University of California, Los Angeles, California; Department of Computational Medicine, University of California, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, California; Department of Computational Medicine, University of California, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473165","display_name":"Jes\u00fas Villar","orcid":"https://orcid.org/0000-0001-5687-3562","observed_orcids":["https://orcid.org/0000-0001-5687-3562"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210098027","display_name":"Hospital Universitario de Gran Canaria Doctor Negr\u00edn","ror":"https://ror.org/00s4vhs88","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210098027"]},{"id":"https://openalex.org/I4210099160","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias","ror":"https://ror.org/0119pby33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Villar, Jes\u00fas","raw_affiliation_strings":["Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negr\u00edn, Las Palmas de Gran Canaria, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210098027","https://openalex.org/I4210099160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082055503","display_name":"Luisa N. Borrell","orcid":"https://orcid.org/0000-0002-0560-4853","observed_orcids":["https://orcid.org/0000-0002-0560-4853"]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Borrel, Luisa N","raw_affiliation_strings":["Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY, United States of America","institution_ids":["https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080971226","display_name":"Esteban G. Burchard","orcid":"https://orcid.org/0000-0001-7475-2035","observed_orcids":["https://orcid.org/0000-0001-7475-2035"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Burchard, Esteban G","raw_affiliation_strings":["Department of Medicine, University of California San Francisco, San Francisco, California, USA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Francisco, San Francisco, California, USA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053206767","display_name":"Maria del Mar Pino-Yanes","orcid":"https://orcid.org/0000-0003-0332-437X","observed_orcids":["https://orcid.org/0000-0003-0332-437X"]},"institutions":[{"id":"https://openalex.org/I158438070","display_name":"Universidad de La Laguna","ror":"https://ror.org/01r9z8p25","country_code":"ES","type":"education","lineage":["https://openalex.org/I158438070"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pino-Yanes, Maria","raw_affiliation_strings":["Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB), Universidad de La Laguna, La Laguna, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0332-437X","affiliations":[{"raw_affiliation_string":"Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB), Universidad de La Laguna, La Laguna, Spain","institution_ids":["https://openalex.org/I158438070","https://openalex.org/I2801357902","https://openalex.org/I4210115082"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.7879999876022339},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epigenome-wide-association-study","display_name":"epigenome-wide association study","score":0.8650000095367432},{"id":"https://openalex.org/keywords/african-american-children","display_name":"African American children","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cpg-sites","display_name":"CpG sites","score":0.6759999990463257},{"id":"https://openalex.org/keywords/differential-methylation","display_name":"differential methylation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/limma","display_name":"limma","score":0.36500000953674316},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"false discovery rate","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6742444634437561},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.6573846340179443},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4736660122871399},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4612821936607361},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4350982904434204},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4085177779197693},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33821266889572144},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3143104910850525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2745610475540161},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20095720887184143}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:zenodo.org:5494396","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/5494396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Allergy and Clinical Immunology","raw_type":"dataset"},{"id":"doi:10.5281/zenodo.5494395","doi":"https://doi.org/10.5281/zenodo.5494395","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5494395","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.5494396","doi":"https://doi.org/10.5281/zenodo.5494396","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.5494396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:5494396","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/5494396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Allergy and Clinical Immunology","raw_type":"dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4320718702","https://openalex.org/W3216935526","https://openalex.org/W4225319054","https://openalex.org/W4321596245","https://openalex.org/W4236598680","https://openalex.org/W4387296095","https://openalex.org/W2789082224","https://openalex.org/W3049586866","https://openalex.org/W4283397944","https://openalex.org/W4286470549"],"abstract_inverted_index":{"We":[0],"conducted":[1,37],"an":[2],"epigenome-wide":[3],"association":[4,30],"study":[5],"of":[6,101],"bronchodilator":[7],"drug":[8],"response":[9],"(BDR)":[10],"in":[11,72],"a":[12],"discovery":[13,18,135],"and":[14,34,47,59,122],"validation":[15],"design.":[16],"The":[17,29],"phase":[19],"was":[20,36],"focused":[21],"on":[22,63,85,91],"221":[23],"African":[24],"American":[25],"children":[26],"with":[27],"asthma.":[28],"between":[31],"DNA":[32],"methylation":[33],"BDR":[35],"using":[38],"the":[39,53,73,102,106,117,140],"limma":[40,57],"package":[41],"correcting":[42],"for":[43,116],"age,":[44],"sex,":[45],"ancestry,":[46],"tissue":[48],"heterogeneity.":[49],"Summary":[50],"statistics":[51],"include":[52],"output":[54],"from":[55],"toptable":[56],"function":[58],"CpG":[60],"annotation":[61,89],"(based":[62],"Illumina":[64,92],"EPIC":[65,93],"Manifest":[66,94],"file":[67,95],"v":[68,96],"1.0":[69,97],"B4)":[70],"organized":[71],"following":[74],"columns:":[75],"Probe:":[76],"Probe":[77],"ID":[78],"Chr:":[79],"chromosome":[80],"Pos:":[81],"genomic":[82],"position":[83],"based":[84,90],"GRCh37/hg19":[86],"Gene:":[87],"Gene":[88],"B4":[98],"logFC:":[99],"estimate":[100],"log2-fold-change":[103],"corresponding":[104],"to":[105],"effect":[107],"or":[108],"contrast":[109],"SE:":[110],"standard":[111],"error":[112],"AveExpr:":[113],"average":[114],"log2-expression":[115],"probe":[118],"over":[119],"all":[120],"arrays":[121],"channels":[123],"t:":[124],"moderated":[125],"t-statistic":[126],"P.value:":[127],"raw":[128],"p-value":[129,132],"FDR:":[130],"adjusted":[131],"by":[133],"false":[134],"rate":[136],"B:":[137],"log-odds":[138],"that":[139],"gene":[141],"is":[142],"differentially":[143],"expressed":[144],"Problem:":[145],"Flagged":[146],"potentially":[147],"problematic":[148],"probes":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-03T00:00:00"}