{"id":"https://openalex.org/W4393650849","doi":"https://doi.org/10.5281/zenodo.4537717","title":"Dataset related to article \"Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration\"","display_name":"Dataset related to article \"Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration\"","publication_year":2021,"publication_date":"2021-02-12","ids":{"openalex":"https://openalex.org/W4393650849","doi":"https://doi.org/10.5281/zenodo.4537717"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:4537718","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/4537718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/4537718","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050543823","display_name":"Matteo Stravalaci","orcid":"https://orcid.org/0000-0002-5636-4204","observed_orcids":["https://orcid.org/0000-0002-5636-4204"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stravalaci, Matteo","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Humanitas Clinical and Research Center IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Humanitas Clinical and Research Center IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008058290","display_name":"Francesca Davi","orcid":"https://orcid.org/0000-0002-4593-7089","observed_orcids":["https://orcid.org/0000-0002-4593-7089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Davi, Francesca","raw_affiliation_strings":["Humanitas Clinical and Research Center IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center IRCCS, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083182126","display_name":"Raffaella Parente","orcid":"https://orcid.org/0000-0003-3607-1380","observed_orcids":["https://orcid.org/0000-0003-3607-1380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Parente, Raffaella","raw_affiliation_strings":["Humanitas Clinical and Research Center IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center IRCCS, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007066407","display_name":"Marco Gobbi","orcid":"https://orcid.org/0000-0003-1014-6225","observed_orcids":["https://orcid.org/0000-0003-1014-6225"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gobbi, Marco","raw_affiliation_strings":["Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072130324","display_name":"Barbara Bottazzi","orcid":"https://orcid.org/0000-0002-1930-9257","observed_orcids":["https://orcid.org/0000-0002-1930-9257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bottazzi, Barbara","raw_affiliation_strings":["Humanitas Clinical and Research Center IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Humanitas Clinical and Research Center IRCCS, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048654641","display_name":"Alberto Mantovani","orcid":"https://orcid.org/0000-0001-5578-236X","observed_orcids":["https://orcid.org/0000-0001-5578-236X"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mantovani, Alberto","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Humanitas Clinical and Research Center IRCCS, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Humanitas Clinical and Research Center IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006588214","display_name":"Anthony J. Day","orcid":"https://orcid.org/0000-0002-1415-3134","observed_orcids":["https://orcid.org/0000-0002-1415-3134"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I2800776015","display_name":"Wellcome Centre for Cell-Matrix Research","ror":"https://ror.org/0094tm228","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800776015","https://openalex.org/I28407311","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Day, Anthony J","raw_affiliation_strings":["Wellcome Trust Centre for Cell-Matrix Research and Lydia Becker Institute of Immunology and Inflammation, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Cell-Matrix Research and Lydia Becker Institute of Immunology and Inflammation, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I2800776015","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008472386","display_name":"Simon J. Clark","orcid":"https://orcid.org/0000-0001-8394-8355","observed_orcids":["https://orcid.org/0000-0001-8394-8355"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Clark, Simon J","raw_affiliation_strings":["Universit\u00e4ts-Augenklinik T\u00fcbingen, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany AND The Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4ts-Augenklinik T\u00fcbingen, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany AND The Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899648","display_name":"Mario Rosario Romano","orcid":"https://orcid.org/0000-0003-0348-0532","observed_orcids":["https://orcid.org/0000-0003-0348-0532"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210119963","display_name":"Humanitas Castelli","ror":"https://ror.org/02ma9m113","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119963","https://openalex.org/I4210123782"]},{"id":"https://openalex.org/I4210123782","display_name":"Humanitas Gavazzeni","ror":"https://ror.org/035jrer59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123782"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Romano, Mario R","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Eye Center, Humanitas Gavazzeni-Castelli, Bergamo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Eye Center, Humanitas Gavazzeni-Castelli, Bergamo, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210119963","https://openalex.org/I4210123782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084284106","display_name":"Antonio Inforzato","orcid":"https://orcid.org/0000-0001-8110-0027","observed_orcids":["https://orcid.org/0000-0001-8110-0027"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Inforzato, Antonio","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Humanitas Clinical and Research Center IRCCS, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8110-0027","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Milan, Italy AND Humanitas Clinical and Research Center IRCCS, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pentraxin-3","display_name":"pentraxin 3","score":0.9509999752044678},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.984000027179718},{"id":"https://openalex.org/keywords/complement-factor-h","display_name":"complement factor H","score":0.9010000228881836},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.890999972820282},{"id":"https://openalex.org/keywords/c3b","display_name":"C3b","score":0.9679999947547913},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.972000002861023},{"id":"https://openalex.org/keywords/complement-inhibition","display_name":"complement inhibition","score":0.527999997138977},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.41499999165534973},{"id":"https://openalex.org/keywords/ternary-complex","display_name":"ternary complex","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C127901578","wikidata":"https://www.wikidata.org/wiki/Q21120502","display_name":"PTX3","level":3,"score":0.9557419419288635},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.819830060005188},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.6353298425674438},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.5455819964408875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3717540502548218},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3393442630767822},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3309546113014221},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20713374018669128},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2034028172492981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17432212829589844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13996031880378723},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07101860642433167},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.05444049835205078},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:zenodo.org:4537718","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/4537718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},{"id":"doi:10.5281/zenodo.4537717","doi":"https://doi.org/10.5281/zenodo.4537717","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.4537717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.4537718","doi":"https://doi.org/10.5281/zenodo.4537718","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.4537718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:4537718","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/4537718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"dataset"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3110505655","https://openalex.org/W1566181483","https://openalex.org/W2524411157","https://openalex.org/W4206301362","https://openalex.org/W1979510588","https://openalex.org/W2626516341","https://openalex.org/W4384626714","https://openalex.org/W1853339213","https://openalex.org/W1969658114","https://openalex.org/W1989747234"],"abstract_inverted_index":{"This":[0],"record":[1],"contains":[2],"data":[3],"related":[4],"to":[5,29,106,238,245],"article":[6],"\"Control":[7],"of":[8,23,37,44,76,81,112,139,159,249,262],"Complement":[9],"Activation":[10],"by":[11,252],"the":[12,24,34,40,45,56,63,73,77,88,117,137,142,147,172],"Long":[13,92],"Pentraxin":[14],"PTX3:":[15],"Implications":[16],"in":[17,39,52,62,116,127,141,156,167,184,193,236,241,258],"Age-Related":[18],"Macular":[19],"Degeneration\"":[20],"Abstract.":[21],"Dysregulation":[22],"complement":[25,53,64,82,154,226,239,250],"system":[26],"is":[27,72,96,129],"central":[28],"age-related":[30],"macular":[31],"degeneration":[32],"(AMD),":[33],"leading":[35],"cause":[36],"blindness":[38],"developed":[41],"world.":[42],"Most":[43],"genetic":[46],"variation":[47],"associated":[48,59],"with":[49,55,60,215,255],"AMD":[50,128,242],"resides":[51],"genes,":[54],"greatest":[57],"risk":[58],"polymorphisms":[61],"factor":[65,69],"H":[66,70],"(CFH)":[67],"gene;":[68],"(FH)":[71],"major":[74],"inhibitor":[75],"alternative":[78],"pathway":[79],"(AP)":[80],"that":[83,102,219],"specifically":[84],"targets":[85],"C3b":[86,218],"and":[87,121,145,150,175,217,243,260],"AP":[89,108,177],"C3":[90],"convertase.":[91],"pentraxin":[93,254],"3":[94],"(PTX3)":[95],"a":[97,125,157,185,211,222,231,246],"soluble":[98],"pattern":[99],"recognition":[100],"molecule":[101],"has":[103],"been":[104],"proposed":[105],"inhibit":[107],"activation":[109,155],"via":[110],"recruitment":[111],"FH.":[113],"Although":[114],"present":[115],"human":[118,143],"retina,":[119],"if":[120],"how":[122],"PTX3":[123,140,173,180,197,209,235],"plays":[124],"role":[126,233],"still":[130],"unclear.":[131],"In":[132],"this":[133,189,253],"work":[134],"we":[135],"demonstrated":[136],"presence":[138],"vitreous":[144],"studied":[146],"PTX3-FH-C3b":[148],"crosstalk":[149],"its":[151],"effects":[152],"on":[153,202,206],"model":[158],"retinal":[160],"pigment":[161],"epithelium":[162],"(RPE).":[163],"RPE":[164,182],"cells":[165,183],"cultured":[166],"inflammatory":[168,194],"AMD-like":[169],"conditions":[170],"overexpressed":[171],"protein,":[174],"up-regulated":[176],"activating":[178],"genes.":[179],"bound":[181],"physiological":[186],"setting,":[187],"however":[188],"interaction":[190],"was":[191],"reduced":[192],"conditions,":[195],"whereby":[196],"had":[198],"no":[199],"complement-inhibiting":[200],"activity":[201],"inflamed":[203],"RPE.":[204],"However,":[205],"non-cellular":[207],"surfaces,":[208],"formed":[210],"stable":[212],"ternary":[213],"complex":[214],"FH":[216],"acted":[220],"as":[221],"\"hot":[223],"spot\"":[224],"for":[225,234],"inhibition.":[227],"Our":[228],"findings":[229],"suggest":[230],"protective":[232],"response":[237],"dysregulation":[240],"point":[244],"novel":[247],"mechanism":[248],"regulation":[251],"potential":[256],"implications":[257],"pathology":[259],"pharmacology":[261],"AMD.":[263]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-03T00:00:00"}