{"id":"https://openalex.org/W4393523809","doi":"https://doi.org/10.3390/ijms25073949","title":"Effect of TRPV4 Antagonist GSK2798745 on Chlorine Gas-Induced Acute Lung Injury in a Swine Model","display_name":"Effect of TRPV4 Antagonist GSK2798745 on Chlorine Gas-Induced Acute Lung Injury in a Swine Model","publication_year":2024,"publication_date":"2024-04-02","ids":{"openalex":"https://openalex.org/W4393523809","doi":"https://doi.org/10.3390/ijms25073949","pmid":"https://pubmed.ncbi.nlm.nih.gov/38612759","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11011849"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25073949","doi":"https://doi.org/10.3390/ijms25073949","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25073949","pdf_url":"https://www.mdpi.com/1422-0067/25/7/3949/pdf?version=1712036931","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/25/7/3949/pdf?version=1712036931","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064017490","display_name":"Meghan S. Vermillion","orcid":"https://orcid.org/0000-0002-1602-7027","observed_orcids":["https://orcid.org/0000-0002-1602-7027"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Meghan S. Vermillion","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102638873","display_name":"Nathan Saari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathan Saari","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111159147","display_name":"M. A. Bray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathieu Bray","raw_affiliation_strings":["GSK, Collegeville, PA 19426, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Collegeville, PA 19426, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034419772","display_name":"Andrew M. Nelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew M. Nelson","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112384272","display_name":"Robert L. Bullard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L. Bullard","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003556349","display_name":"Karin Rudolph","orcid":"https://orcid.org/0000-0003-3606-1983","observed_orcids":["https://orcid.org/0000-0003-3606-1983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karin Rudolph","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110209244","display_name":"Andrew P. Gigliotti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew P. Gigliotti","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094327969","display_name":"Jeffrey Brendler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey Brendler","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042491821","display_name":"Jacob Jantzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob Jantzi","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007070596","display_name":"Philip J. Kuehl","orcid":"https://orcid.org/0000-0002-7567-3002","observed_orcids":["https://orcid.org/0000-0002-7567-3002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip J. Kuehl","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":"https://orcid.org/0000-0002-7567-3002","affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078271521","display_name":"Jacob D. McDonald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob D. McDonald","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023518948","display_name":"Mark E. Burgert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Burgert","raw_affiliation_strings":["GSK, Collegeville, PA 19426, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Collegeville, PA 19426, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112102276","display_name":"Waylon Weber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waylon Weber","raw_affiliation_strings":["Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085136051","display_name":"Scott K. Sucoloski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Sucoloski","raw_affiliation_strings":["GSK, Collegeville, PA 19426, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Collegeville, PA 19426, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083223367","display_name":"David J. Behm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Behm","raw_affiliation_strings":["GSK, Collegeville, PA 19426, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Collegeville, PA 19426, USA","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064017490"],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":1.7317,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"25","issue":"7","first_page":"3949","last_page":"3949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.14429999887943268,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpv4-antagonist","display_name":"TRPV4 antagonist","score":0.8389999866485596},{"id":"https://openalex.org/keywords/chlorine-gas-inhalation","display_name":"chlorine gas inhalation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9700000286102295},{"id":"https://openalex.org/keywords/chemical-lung-injury","display_name":"chemical lung injury","score":0.5410000085830688},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.8349999785423279},{"id":"https://openalex.org/keywords/alveolar-capillary-barrier","display_name":"alveolar-capillary barrier","score":0.8619999885559082},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.7570000290870667},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/lung-compliance","display_name":"lung compliance","score":0.5950000286102295},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7122442722320557},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4941594898700714},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48718589544296265},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.4805029630661011},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.4544071555137634},{"id":"https://openalex.org/C136936797","wikidata":"https://www.wikidata.org/wiki/Q2990558","display_name":"Pulmonary compliance","level":3,"score":0.44686853885650635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41775739192962646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4029637575149536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2947459816932678}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002713","descriptor_name":"Chlorine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms25073949","doi":"https://doi.org/10.3390/ijms25073949","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25073949","pdf_url":"https://www.mdpi.com/1422-0067/25/7/3949/pdf?version=1712036931","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11011849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11011849","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11011849/pdf/ijms-25-03949.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38612759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38612759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms25073949","doi":"https://doi.org/10.3390/ijms25073949","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25073949","pdf_url":"https://www.mdpi.com/1422-0067/25/7/3949/pdf?version=1712036931","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2960432347","display_name":null,"funder_award_id":"HHSO100201700009C/75A50122F61001","funder_id":"https://openalex.org/F4320333299","funder_display_name":"Biomedical Advanced Research and Development Authority"},{"id":"https://openalex.org/G3075476030","display_name":null,"funder_award_id":"HHSO100201700009C","funder_id":"https://openalex.org/F4320333299","funder_display_name":"Biomedical Advanced Research and Development Authority"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320333299","display_name":"Biomedical Advanced Research and Development Authority","ror":"https://ror.org/029y69023"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393523809.pdf","grobid_xml":"https://content.openalex.org/works/W4393523809.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1803784511","https://openalex.org/W1984001228","https://openalex.org/W2005026609","https://openalex.org/W2010909603","https://openalex.org/W2025578429","https://openalex.org/W2038663702","https://openalex.org/W2040584700","https://openalex.org/W2048567081","https://openalex.org/W2053144056","https://openalex.org/W2097466236","https://openalex.org/W2109256654","https://openalex.org/W2110127937","https://openalex.org/W2118051223","https://openalex.org/W2161328469","https://openalex.org/W2162262758","https://openalex.org/W2163161393","https://openalex.org/W2165344509","https://openalex.org/W2171848391","https://openalex.org/W2300461977","https://openalex.org/W2557368261","https://openalex.org/W2620241325","https://openalex.org/W2802226246","https://openalex.org/W2910252376","https://openalex.org/W2912822615","https://openalex.org/W2974815587","https://openalex.org/W3013962574","https://openalex.org/W3024695741","https://openalex.org/W3096628882","https://openalex.org/W3104358093","https://openalex.org/W3159917172","https://openalex.org/W3173486832"],"related_works":["https://openalex.org/W2010909603","https://openalex.org/W2971047382","https://openalex.org/W2038663702","https://openalex.org/W4388705133","https://openalex.org/W4285300721","https://openalex.org/W2318264080","https://openalex.org/W4413407871","https://openalex.org/W1969530790","https://openalex.org/W3168607359","https://openalex.org/W3175949791"],"abstract_inverted_index":{"As":[0],"a":[1,15,190],"regulator":[2],"of":[3,30,37,49,101,104,112,180,194],"alveolo-capillary":[4],"barrier":[5],"integrity,":[6],"Transient":[7],"Receptor":[8],"Potential":[9],"Vanilloid":[10],"4":[11],"(TRPV4)":[12],"antagonism":[13],"represents":[14],"promising":[16],"strategy":[17],"for":[18,86],"reducing":[19],"pulmonary":[20],"edema":[21],"secondary":[22],"to":[23,40,78,109,138],"chemical":[24],"inhalation.":[25],"In":[26,174],"an":[27],"experimental":[28],"model":[29,179],"acute":[31,91,183],"lung":[32,65,92,123,143,162,167,184],"injury":[33,93],"induced":[34],"by":[35,43,95],"exposure":[36,133],"anesthetized":[38],"swine":[39,178],"chlorine":[41,84,151,181],"gas":[42,85,152],"mechanical":[44],"ventilation,":[45],"the":[46,99,110],"dose-dependent":[47],"effects":[48],"TRPV4":[50],"inhibitor":[51],"GSK2798745":[52,154,186],"were":[53,59,72],"evaluated.":[54],"Pulmonary":[55],"function":[56],"and":[57,70,125,140],"oxygenation":[58,117],"measured":[60],"hourly;":[61],"airway":[62,68,136,164,170],"responsiveness,":[63,165],"wet-to-dry":[64,142,166],"weight":[66,144,168],"ratios,":[67,169],"inflammation,":[69,171],"histopathology":[71],"assessed":[73],"24":[74,130,147],"h":[75],"post-exposure.":[76],"Exposure":[77],"240":[79],"parts":[80],"per":[81],"million":[82],"(ppm)":[83],"\u226550":[87],"min":[88],"resulted":[89],"in":[90,98,106,176],"characterized":[94],"sustained":[96],"changes":[97],"ratio":[100],"partial":[102],"pressure":[103],"oxygen":[105,114],"arterial":[107],"blood":[108],"fraction":[111],"inspiratory":[113,120],"concentration":[115],"(PaO2/FiO2),":[116],"index,":[118],"peak":[119],"pressure,":[121],"dynamic":[122],"compliance,":[124],"respiratory":[126],"system":[127],"resistance":[128],"over":[129],"h.":[131,148],"Chlorine":[132],"also":[134],"heightened":[135],"response":[137],"methacholine":[139],"increased":[141],"ratios":[145],"at":[146],"Following":[149],"55-min":[150],"exposure,":[153],"marginally":[155],"improved":[156],"PaO2/FiO2,":[157],"but":[158],"did":[159,187],"not":[160,188],"impact":[161],"function,":[163],"or":[172],"histopathology.":[173],"summary,":[175],"this":[177],"gas-induced":[182],"injury,":[185],"demonstrate":[189],"clinically":[191],"relevant":[192],"improvement":[193],"key":[195],"disease":[196],"endpoints.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-04-03T00:00:00"}