{"id":"https://openalex.org/W4393496917","doi":"https://doi.org/10.1158/2326-6066.25523138","title":"Supplementary Figure 3 from Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer","display_name":"Supplementary Figure 3 from Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer","publication_year":2024,"publication_date":"2024-04-02","ids":{"openalex":"https://openalex.org/W4393496917","doi":"https://doi.org/10.1158/2326-6066.25523138"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.25523138","doi":"https://doi.org/10.1158/2326-6066.25523138","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.25523138","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042191581","display_name":"Hewitt Chang","orcid":"https://orcid.org/0000-0001-9760-2304","observed_orcids":["https://orcid.org/0000-0001-9760-2304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hewitt Chang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9760-2304","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004140836","display_name":"Jaqueline Marquez","orcid":"https://orcid.org/0000-0003-1685-9672","observed_orcids":["https://orcid.org/0000-0003-1685-9672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaqueline Marquez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1685-9672","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011757919","display_name":"Brandon K. Chen","orcid":"https://orcid.org/0000-0003-1472-5152","observed_orcids":["https://orcid.org/0000-0003-1472-5152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brandon K. Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1472-5152","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043396263","display_name":"Daniel M. Kim","orcid":"https://orcid.org/0009-0009-4662-6010","observed_orcids":["https://orcid.org/0009-0009-4662-6010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel M. Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4662-6010","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112567768","display_name":"Michael L. Cheng","orcid":"https://orcid.org/0000-0002-7409-288X","observed_orcids":["https://orcid.org/0000-0002-7409-288X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael L. Cheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7409-288X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043329779","display_name":"Eric V. Liu","orcid":"https://orcid.org/0000-0003-2286-0856","observed_orcids":["https://orcid.org/0000-0003-2286-0856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric V. Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2286-0856","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055381283","display_name":"Hai Liang Yang","orcid":"https://orcid.org/0009-0005-5662-5864","observed_orcids":["https://orcid.org/0009-0005-5662-5864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5662-5864","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3617-2627","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041993384","display_name":"Meenal Sinha","orcid":"https://orcid.org/0000-0002-4008-4080","observed_orcids":["https://orcid.org/0000-0002-4008-4080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meenal Sinha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4008-4080","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030986983","display_name":"Alexander Cheung","orcid":"https://orcid.org/0000-0002-2115-6966","observed_orcids":["https://orcid.org/0000-0002-2115-6966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Cheung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2115-6966","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082108817","display_name":"Serena S. Kwek","orcid":"https://orcid.org/0000-0001-5097-2711","observed_orcids":["https://orcid.org/0000-0001-5097-2711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serena S. Kwek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5097-2711","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091824858","display_name":"Eric D. Chow","orcid":"https://orcid.org/0000-0001-8079-918X","observed_orcids":["https://orcid.org/0000-0001-8079-918X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric D. Chow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8079-918X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052332846","display_name":"Mark Bridge","orcid":"https://orcid.org/0000-0002-2997-981X","observed_orcids":["https://orcid.org/0000-0002-2997-981X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Bridge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2997-981X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081123075","display_name":"Rahul Raj Aggarwal","orcid":"https://orcid.org/0000-0001-7003-7982","observed_orcids":["https://orcid.org/0000-0001-7003-7982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rahul R. Aggarwal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7003-7982","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079570071","display_name":"Terence W. Friedlander","orcid":"https://orcid.org/0000-0002-3630-4941","observed_orcids":["https://orcid.org/0000-0002-3630-4941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terence W. Friedlander","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3630-4941","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007578304","display_name":"Eric Jay Small","orcid":"https://orcid.org/0000-0003-3191-6268","observed_orcids":["https://orcid.org/0000-0003-3191-6268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric J. Small","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3191-6268","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091086178","display_name":"Mark Stuart Anderson","orcid":"https://orcid.org/0000-0002-3093-4758","observed_orcids":["https://orcid.org/0000-0002-3093-4758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Anderson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3093-4758","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073970384","display_name":"Lawrence H. Fong","orcid":"https://orcid.org/0000-0002-6428-428X","observed_orcids":["https://orcid.org/0000-0002-6428-428X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence Fong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6428-428X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.921999990940094},{"id":"https://openalex.org/keywords/rankl-blockade","display_name":"RANKL blockade","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.890999972820282},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":1.0},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/immune-cell-clusters","display_name":"immune cell clusters","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.936612606048584},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.840933084487915},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.7829010486602783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5280029773712158},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.5119884610176086},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4757544696331024},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46895331144332886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46326687932014465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.400859534740448},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32493162155151367},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15383434295654297},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15237632393836975},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.06968456506729126},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2326-6066.25523138","doi":"https://doi.org/10.1158/2326-6066.25523138","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2326-6066.25523138.v1","doi":"https://doi.org/10.1158/2326-6066.25523138.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523138.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/25523138","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Immune_Modulation_with_RANKL_Blockade_through_Denosumab_Treatment_in_Patients_with_Cancer/25523138","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.25523138","doi":"https://doi.org/10.1158/2326-6066.25523138","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393490873","https://openalex.org/W4391263693","https://openalex.org/W2889824279","https://openalex.org/W4392571383","https://openalex.org/W6958418310","https://openalex.org/W2792222033","https://openalex.org/W4404067407","https://openalex.org/W4362618929","https://openalex.org/W4400041200","https://openalex.org/W4362618935"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"3:":[2],"Expression":[3,53],"of":[4,18,37,54,68,85],"immune":[5,44,86],"checkpoints":[6],"at":[7,59],"baseline":[8,60],"(A)":[9],"A":[10],"uniform":[11],"manifold":[12],"approximation":[13],"and":[14,46,57,61],"projection":[15],"(UMAP)":[16],"plot":[17],"cells":[19,45],"from":[20,33,72],"all":[21],"peripheral":[22],"blood":[23],"mononuclear":[24],"cell":[25],"(PBMC)":[26],"samples":[27],"analyzed":[28],"with":[29,76],"Scaffold":[30],"using":[31],"data":[32],"cytometry":[34],"by":[35,49],"time":[36],"flight":[38],"(CyTOF).":[39],"Clusters":[40],"correspond":[41],"to":[42,81],"canonical":[43],"are":[47],"represented":[48],"distinct":[50],"colors.":[51],"(B)":[52],"PD-L1,":[55],"TIM3,":[56],"CTLA-4":[58],"post-treatment":[62],"timepoint":[63],"2":[64],"(TP2).":[65],"Raw":[66],"count":[67],"metal":[69],"ions":[70],"detected":[71],"CyTOF":[73],"were":[74],"asinh-transformed,":[75],"a":[77,82],"higher":[78,83],"value":[79],"corresponding":[80],"expression":[84],"checkpoint.":[87]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-03T00:00:00"}
