{"id":"https://openalex.org/W4393439059","doi":"https://doi.org/10.1158/2326-6066.25523132","title":"Supplementary Figure 5 from Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer","display_name":"Supplementary Figure 5 from Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer","publication_year":2024,"publication_date":"2024-04-02","ids":{"openalex":"https://openalex.org/W4393439059","doi":"https://doi.org/10.1158/2326-6066.25523132"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.25523132","doi":"https://doi.org/10.1158/2326-6066.25523132","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523132","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.25523132","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042191581","display_name":"Hewitt Chang","orcid":"https://orcid.org/0000-0001-9760-2304","observed_orcids":["https://orcid.org/0000-0001-9760-2304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hewitt Chang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9760-2304","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004140836","display_name":"Jaqueline Marquez","orcid":"https://orcid.org/0000-0003-1685-9672","observed_orcids":["https://orcid.org/0000-0003-1685-9672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaqueline Marquez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1685-9672","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011757919","display_name":"Brandon K. Chen","orcid":"https://orcid.org/0000-0003-1472-5152","observed_orcids":["https://orcid.org/0000-0003-1472-5152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brandon K. Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1472-5152","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043396263","display_name":"Daniel M. Kim","orcid":"https://orcid.org/0009-0009-4662-6010","observed_orcids":["https://orcid.org/0009-0009-4662-6010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel M. Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4662-6010","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112567768","display_name":"Michael L. Cheng","orcid":"https://orcid.org/0000-0002-7409-288X","observed_orcids":["https://orcid.org/0000-0002-7409-288X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael L. Cheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7409-288X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043329779","display_name":"Eric V. Liu","orcid":"https://orcid.org/0000-0003-2286-0856","observed_orcids":["https://orcid.org/0000-0003-2286-0856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric V. Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2286-0856","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055381283","display_name":"Hai Liang Yang","orcid":"https://orcid.org/0009-0005-5662-5864","observed_orcids":["https://orcid.org/0009-0005-5662-5864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5662-5864","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3617-2627","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041993384","display_name":"Meenal Sinha","orcid":"https://orcid.org/0000-0002-4008-4080","observed_orcids":["https://orcid.org/0000-0002-4008-4080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meenal Sinha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4008-4080","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030986983","display_name":"Alexander Cheung","orcid":"https://orcid.org/0000-0002-2115-6966","observed_orcids":["https://orcid.org/0000-0002-2115-6966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Cheung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2115-6966","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082108817","display_name":"Serena S. Kwek","orcid":"https://orcid.org/0000-0001-5097-2711","observed_orcids":["https://orcid.org/0000-0001-5097-2711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serena S. Kwek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5097-2711","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091824858","display_name":"Eric D. Chow","orcid":"https://orcid.org/0000-0001-8079-918X","observed_orcids":["https://orcid.org/0000-0001-8079-918X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric D. Chow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8079-918X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052332846","display_name":"Mark Bridge","orcid":"https://orcid.org/0000-0002-2997-981X","observed_orcids":["https://orcid.org/0000-0002-2997-981X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Bridge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2997-981X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081123075","display_name":"Rahul Raj Aggarwal","orcid":"https://orcid.org/0000-0001-7003-7982","observed_orcids":["https://orcid.org/0000-0001-7003-7982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rahul R. Aggarwal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7003-7982","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079570071","display_name":"Terence W. Friedlander","orcid":"https://orcid.org/0000-0002-3630-4941","observed_orcids":["https://orcid.org/0000-0002-3630-4941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terence W. Friedlander","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3630-4941","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007578304","display_name":"Eric Jay Small","orcid":"https://orcid.org/0000-0003-3191-6268","observed_orcids":["https://orcid.org/0000-0003-3191-6268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric J. Small","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3191-6268","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091086178","display_name":"Mark Stuart Anderson","orcid":"https://orcid.org/0000-0002-3093-4758","observed_orcids":["https://orcid.org/0000-0002-3093-4758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Anderson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3093-4758","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073970384","display_name":"Lawrence H. Fong","orcid":"https://orcid.org/0000-0002-6428-428X","observed_orcids":["https://orcid.org/0000-0002-6428-428X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence Fong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6428-428X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rankl-blockade","display_name":"RANKL blockade","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.6119999885559082},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.4740000069141388},{"id":"https://openalex.org/keywords/t-cell-receptor-gene-expression","display_name":"T cell receptor gene expression","score":0.3709999918937683},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.5720000267028809},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pd-l2","display_name":"PD-L2","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.7419999837875366},{"id":"https://openalex.org/keywords/inducible-t-cell-costimulator","display_name":"ICOS","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tigit","display_name":"TIGIT","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ox40","display_name":"OX40","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.6970000267028809},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.5559999942779541},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.8029999732971191},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.930457592010498},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.844538688659668},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.8063396215438843},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.53912752866745},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5300832986831665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5254644155502319},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4960409104824066},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45770809054374695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4565443992614746},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3805979788303375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19034191966056824},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18396472930908203},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.0652107298374176},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2326-6066.25523132","doi":"https://doi.org/10.1158/2326-6066.25523132","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523132","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2326-6066.25523132.v1","doi":"https://doi.org/10.1158/2326-6066.25523132.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523132.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/25523132","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Immune_Modulation_with_RANKL_Blockade_through_Denosumab_Treatment_in_Patients_with_Cancer/25523132","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.25523132","doi":"https://doi.org/10.1158/2326-6066.25523132","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.25523132","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393490873","https://openalex.org/W4391263693","https://openalex.org/W4391930577","https://openalex.org/W4392571383","https://openalex.org/W4411290053","https://openalex.org/W2889824279","https://openalex.org/W7162512322","https://openalex.org/W3162207355","https://openalex.org/W4396587247","https://openalex.org/W2011904158"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"5:":[2],"Effects":[3],"of":[4,18,171],"concomitant":[5],"treatments":[6],"during":[7],"denosumab":[8],"treatment":[9],"Heatmaps":[10],"summarizing":[11],"log2":[12,155],"fold":[13,156],"changes":[14],"from":[15],"statistical":[16],"analysis":[17],"functional":[19],"markers":[20],"CD137,":[21],"CD27,":[22],"CD40,":[23],"CD40L,":[24],"CD71,":[25],"CD95,":[26],"CTLA-4,":[27],"HLA-DR,":[28],"ICOS,":[29],"Ki-67,":[30],"NKG2D,":[31],"OX40,":[32],"PD-1,":[33],"PD-L1,":[34],"PD-L2,":[35],"TIGIT":[36],"and":[37,49,65,69,72,87,91,110,137],"TIM3":[38],"when":[39],"comparing":[40],"(A)":[41],"patients":[42,52,75,80,94,100],"that":[43,53,81,95,101,121,147],"received":[44,76,82,96],"only":[45,77,83,97],"chemotherapy":[46,48,57,84,86,105],"or":[47,58,85,106],"steroids":[50,59,78,88,98,107],"with":[51,79,99,158],"did":[54,102],"not":[55,103],"receive":[56,104],"at":[60,89,108],"pretreatment":[61],"timepoint":[62],"1":[63],"(TP1)":[64],"post-treatment":[66],"timepoints":[67],"2":[68,170],"3":[70],"(TP2":[71],"TP3);":[73],"(B)":[74],"TP2":[90,109],"TP3;":[92],"(C)":[93],"TP3.":[111],"Each":[112],"box":[113],"in":[114,153,168],"the":[115,126,134,154,172],"heatmap":[116],"represents":[117,145],"a":[118,149],"lymphocyte":[119],"cluster":[120],"was":[122],"labeled":[123],"according":[124],"to":[125,132],"nearest":[127],"landmark":[128],"node":[129],"they":[130],"connect":[131],"on":[133],"scaffold":[135],"map":[136],"ordered":[138],"by":[139],"cell":[140],"count":[141],"abundance.":[142],"The":[143],"pseudocolor":[144],"clusters":[146],"showed":[148],"significant":[150],"difference":[151],"(q<0.05)":[152],"change,":[157],"red":[159],"being":[160,165],"significantly":[161,166],"higher,":[162],"while":[163],"blue":[164],"lower":[167],"group":[169],"two":[173],"comparison":[174],"groups.":[175]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-03T00:00:00"}
