{"id":"https://openalex.org/W4393389409","doi":"https://doi.org/10.1002/ctd2.286","title":"Unveiling a novel cellular stress response mechanism to photodamage","display_name":"Unveiling a novel cellular stress response mechanism to photodamage","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4393389409","doi":"https://doi.org/10.1002/ctd2.286"},"language":"en","primary_location":{"id":"doi:10.1002/ctd2.286","doi":"https://doi.org/10.1002/ctd2.286","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.286","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.286","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.286","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025951772","display_name":"Naibedya Dutta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naibedya Dutta","raw_affiliation_strings":["Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103097841","display_name":"Gilberto Garcia","orcid":"https://orcid.org/0000-0001-9959-650X","observed_orcids":["https://orcid.org/0000-0001-9959-650X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilberto Garcia","raw_affiliation_strings":["Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060527531","display_name":"Ryo Higuchi\u2010Sanabria","orcid":"https://orcid.org/0000-0001-8936-5812","observed_orcids":["https://orcid.org/0000-0001-8936-5812"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryo Higuchi\u2010Sanabria","raw_affiliation_strings":["Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060527531"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03255203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsf4","display_name":"HSF4","score":0.8080000281333923},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/photodamage","display_name":"photodamage","score":0.9330000281333923},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.7839999794960022},{"id":"https://openalex.org/keywords/coilin","display_name":"coilin","score":0.765999972820282},{"id":"https://openalex.org/keywords/rna-dna-hybrids","display_name":"RNA-DNA hybrids","score":0.7559999823570251},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.4819999933242798},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8289999961853027},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.5210000276565552},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.703294038772583},{"id":"https://openalex.org/C52981337","wikidata":"https://www.wikidata.org/wiki/Q24782817","display_name":"Heat shock factor","level":5,"score":0.6431217789649963},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5932705402374268},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.4704303443431854},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.46424826979637146},{"id":"https://openalex.org/C2776960578","wikidata":"https://www.wikidata.org/wiki/Q3705873","display_name":"Photoaging","level":2,"score":0.4399818480014801},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.4182884395122528},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.3888632357120514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3876511752605438},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3724650740623474},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3638184070587158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35400068759918213},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26860928535461426},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.19292941689491272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.158724844455719}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ctd2.286","doi":"https://doi.org/10.1002/ctd2.286","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.286","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.286","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2f548560be7248858ba1ee88555b08f7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2f548560be7248858ba1ee88555b08f7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Discovery, Vol 4, Iss 2, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ctd2.286","doi":"https://doi.org/10.1002/ctd2.286","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.286","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ctd2.286","source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6839470958","display_name":null,"funder_award_id":"2022-A-010-SUP","funder_id":"https://openalex.org/F4320306380","funder_display_name":"Larry L. Hillblom Foundation"},{"id":"https://openalex.org/G875742055","display_name":"More than just a load control: cytoskeletal form and function during aging","funder_award_id":"R00AG065200","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000904475","display_name":"USC-Buck Geroscience Training in the Biology of Aging","funder_award_id":"T32AG052374","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306380","display_name":"Larry L. Hillblom Foundation","ror":"https://ror.org/00br6vq85"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393389409.pdf","grobid_xml":"https://content.openalex.org/works/W4393389409.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1540044642","https://openalex.org/W2102824402","https://openalex.org/W2150269711","https://openalex.org/W2528851536","https://openalex.org/W2740483385","https://openalex.org/W3118263150","https://openalex.org/W3135036858","https://openalex.org/W3143937078","https://openalex.org/W4214925923","https://openalex.org/W4224293621"],"related_works":["https://openalex.org/W4384626889","https://openalex.org/W1999672291","https://openalex.org/W1970792061","https://openalex.org/W4412078866","https://openalex.org/W2314186878","https://openalex.org/W2134342835","https://openalex.org/W3009896256","https://openalex.org/W2410521632","https://openalex.org/W2761287732","https://openalex.org/W2017487552"],"abstract_inverted_index":{"Abstract":[0],"Ultraviolet":[1],"(UV)":[2],"radiation,":[3],"a":[4,59,75,159],"component":[5],"of":[6,19,55,115,129],"sunlight,":[7],"holds":[8],"both":[9],"advantageous":[10],"anddetrimental":[11],"effects":[12],"on":[13,111],"human":[14,146],"health.":[15],"While":[16,69],"shorter":[17],"wavelengths":[18,29],"UV":[20,123],"radiationaid":[21],"in":[22,104,117,145],"melanin":[23],"and":[24,34,106,120,131],"vitamin":[25],"D":[26],"synthesis,":[27],"longer":[28],"pose":[30],"risks":[31],"like":[32],"skincancer":[33],"premature":[35],"aging":[36],"due":[37],"to":[38,85,163],"DNA":[39,143],"damage.":[40,167],"To":[41],"combat":[42],"such":[43],"stress,":[44],"cellsemploy":[45],"various":[46],"mechanisms,":[47],"including":[48,91],"the":[49,112,132,153],"heat":[50,65],"shock":[51,66],"response":[52,57],"(HSR).":[53],"Activation":[54],"this":[56],"involves":[58],"highly":[60],"regulated":[61],"transcriptional":[62],"processorchestrated":[63],"by":[64,99],"factors":[67],"(HSFs).":[68],"HSF1":[70],"has":[71],"been":[72],"observed":[73,127],"as":[74,158],"keytranscription":[76],"factor":[77],"for":[78],"HSR,":[79],"other":[80],"HSFs":[81],"are":[82],"also":[83],"found":[84],"be":[86],"associated":[87],"withdiverse":[88],"cellular":[89],"functions,":[90],"stress":[92],"responses.":[93],"Here,":[94],"we":[95],"discuss":[96],"arecent":[97],"study":[98],"Feng":[100],"et":[101],"al.,":[102],"published":[103],"Clinical":[105],"Translational":[107],"Medicine,":[108],"shedding":[109],"light":[110],"novel":[113],"function":[114],"HSF4":[116,130],"regulating":[118],"inflammation":[119],"senescence":[121],"following":[122],"exposure.":[124],"The":[125],"researchers":[126],"acomplex":[128],"cofactor":[133],"COIL":[134],"(Coilin)":[135],"at":[136,156],"R\u2010loops\u2013aberrant":[137],"DNA\u2010RNAhybrid":[138],"structures":[139],"arising":[140],"from":[141],"UV\u2010induced":[142,165],"damage":[144],"skin":[147,166],"cells.":[148],"Inthe":[149],"study,":[150],"they":[151],"proposed":[152],"HSF4\u2010COIL":[154],"complex":[155],"R\u2010loops":[157],"potential":[160],"therapeutic":[161],"target":[162],"mitigate":[164]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-04-02T00:00:00"}
