{"id":"https://openalex.org/W4393387656","doi":"https://doi.org/10.21203/rs.3.rs-4193617/v1","title":"Adrenomedullin level in children with congenital adrenal hyperplasia: Relationship to vascular and left ventricular functions","display_name":"Adrenomedullin level in children with congenital adrenal hyperplasia: Relationship to vascular and left ventricular functions","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4393387656","doi":"https://doi.org/10.21203/rs.3.rs-4193617/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-4193617/v1","doi":"https://doi.org/10.21203/rs.3.rs-4193617/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4193617/v1","pdf_url":"https://www.researchsquare.com/article/rs-4193617/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-4193617/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033902425","display_name":"Hekma Saad Farghaly","orcid":"https://orcid.org/0000-0002-1904-7170","observed_orcids":["https://orcid.org/0000-0002-1904-7170"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hekma Farghaly","raw_affiliation_strings":["Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010274399","display_name":"Azza A. Eltayeb","orcid":"https://orcid.org/0000-0003-2517-021X","observed_orcids":["https://orcid.org/0000-0003-2517-021X"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Azza Eltayeb","raw_affiliation_strings":["Assiut University"],"raw_orcid":"https://orcid.org/0000-0003-2517-021X","affiliations":[{"raw_affiliation_string":"Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019839542","display_name":"Kotb Abbass Metwalley Kalil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Kotb Abbas Metwallley","raw_affiliation_strings":["Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113157425","display_name":"Shimaa kamal Mohammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shimaa kamal Mohammad","raw_affiliation_strings":["Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094299473","display_name":"Randa A. Kandiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Randa A. Kandiel","raw_affiliation_strings":["Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111680243","display_name":"Ghada Mohamed Saied","orcid":"https://orcid.org/0000-0001-6298-7363","observed_orcids":["https://orcid.org/0000-0001-6298-7363"]},"institutions":[{"id":"https://openalex.org/I4387155039","display_name":"New Valley University","ror":"https://ror.org/04349ry21","country_code":"EG","type":"education","lineage":["https://openalex.org/I4387155039"]},{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"GhadaMohamed Saied","raw_affiliation_strings":["New Valley University","New Valley University Azhar arabi Mohammed1 Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Valley University","institution_ids":["https://openalex.org/I4387155039"]},{"raw_affiliation_string":"New Valley University Azhar arabi Mohammed1 Assiut University","institution_ids":["https://openalex.org/I4387155039","https://openalex.org/I91041137"]}]},{"author_position":"last","author":{"id":null,"display_name":"Azhar arabi Mohammed1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azhar arabi Mohammed1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010274399"],"corresponding_institution_ids":["https://openalex.org/I91041137"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenomedullin","display_name":"adrenomedullin","score":0.949999988079071},{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.6629999876022339},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.7630000114440918},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mitral-deceleration-time","display_name":"mitral deceleration time","score":0.8889999985694885},{"id":"https://openalex.org/keywords/left-ventricular-mass-index","display_name":"left ventricular mass index","score":0.8450000286102295},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6899999976158142},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5350000262260437},{"id":"https://openalex.org/keywords/17-hydroxyprogesterone","display_name":"17-hydroxyprogesterone","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7009999752044678},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2777152744","wikidata":"https://www.wikidata.org/wiki/Q366935","display_name":"Adrenomedullin","level":3,"score":0.9654833674430847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6441934108734131},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5964067578315735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.592620313167572},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-4193617/v1","doi":"https://doi.org/10.21203/rs.3.rs-4193617/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4193617/v1","pdf_url":"https://www.researchsquare.com/article/rs-4193617/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-4193617/v1","doi":"https://doi.org/10.21203/rs.3.rs-4193617/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4193617/v1","pdf_url":"https://www.researchsquare.com/article/rs-4193617/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393387656.pdf","grobid_xml":"https://content.openalex.org/works/W4393387656.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W12321658","https://openalex.org/W196765476","https://openalex.org/W356975655","https://openalex.org/W1691926173","https://openalex.org/W1965561480","https://openalex.org/W1969830999","https://openalex.org/W1972087695","https://openalex.org/W1985839768","https://openalex.org/W1989760753","https://openalex.org/W1993852830","https://openalex.org/W2001471480","https://openalex.org/W2038563834","https://openalex.org/W2071650572","https://openalex.org/W2096073058","https://openalex.org/W2102482568","https://openalex.org/W2110903829","https://openalex.org/W2123992393","https://openalex.org/W2129488169","https://openalex.org/W2129797340","https://openalex.org/W2149226086","https://openalex.org/W2151298139","https://openalex.org/W2169211586","https://openalex.org/W2171193135","https://openalex.org/W2171268743","https://openalex.org/W2171651945","https://openalex.org/W2181682560","https://openalex.org/W2288605373","https://openalex.org/W2292841309","https://openalex.org/W2439202089","https://openalex.org/W2789924648","https://openalex.org/W2791367003","https://openalex.org/W2803213547","https://openalex.org/W2907525977","https://openalex.org/W2913693499","https://openalex.org/W3089213675","https://openalex.org/W3121223664","https://openalex.org/W3160982698","https://openalex.org/W4239814251","https://openalex.org/W4242444381","https://openalex.org/W4367186982"],"related_works":["https://openalex.org/W4242444381","https://openalex.org/W2803213547","https://openalex.org/W2561457353","https://openalex.org/W1899367565","https://openalex.org/W3121223664","https://openalex.org/W2046514856","https://openalex.org/W2362569568","https://openalex.org/W2158149399","https://openalex.org/W4252162403","https://openalex.org/W3007067420"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"To":[2],"evaluate":[3],"left":[4],"venticular,":[5],"vascular":[6,72],"endothelial":[7],"function":[8],"and":[9,43,51,64,89,103,114,151,220,229],"its":[10],"association":[11],"with":[12,18,24,56,131,145,208,224,232],"adrenomedullin":[13],"(AM)":[14],"levels":[15,45,102,141],"in":[16,121,129,206,212],"children":[17,23,130,207],"classic":[19,25,209],"CAH.":[20],"Methods:":[21],"42":[22,35],"CAH":[26,233],"(mean":[27],"age":[28],"of":[29,39,239],"13.5\u00b12.4":[30],"years)":[31],"were":[32,46,54,69,82,127,142],"compared":[33],"to":[34,75,123],"healthy":[36],"controls.":[37,124],"Measurement":[38],"17-hydroxy-progesterone,":[40],"total":[41],"testosterone,":[42],"AM":[44,101,140,202,248],"carried":[47],"out.":[48],"LV":[49],"functions":[50],"cardiac":[52],"dimensions":[53],"measured":[55,70],"traditional":[57],"echocardiography.":[58],"Brachial":[59],"artery":[60],"flow-mediated":[61],"dilation":[62],"(FMD%)":[63],"carotid":[65],"intima-media":[66],"thickness":[67],"(CA-IMT)":[68],"via":[71],"ultrasonography.":[73],"According":[74],"the":[76],"control":[77],"on":[78,134,217],"medical":[79,135,218],"treatment,":[80,219],"patients":[81],"classified":[83],"into":[84],"poor":[85],"(n":[86,91],"=":[87,92,156,166,171,180,188,198],"12)":[88],"good":[90],"30)":[93],"controlled":[94,133,216],"groups.":[95],"Results:":[96],"Patients":[97],"had":[98],"significant":[99],"higher":[100],"LVM":[104],"index":[105],"(LVMI),":[106],"while":[107],"lower":[108],"brachial":[109],"FMD%,":[110],"a":[111,115],"thicker":[112],"CA-IMT,":[113,228],"prolonged":[116],"mitral":[117,177,226],"deceleration":[118],"time":[119],"(DcT)":[120],"relation":[122],"These":[125],"changes":[126],"marked":[128],"poorly":[132],"treatment.":[136],"In":[137],"multivariate":[138],"analysis,":[139],"significantly":[143],"correlated":[144,223],"systolic":[146],"(OR":[147,155,170,179,187,195],"=;":[148],"95%":[149,158,164,173,182,190],")":[150],"diastolic":[152],"blood":[153],"pressures":[154],"2.9;":[157],"),":[159,168,185],"Testosterone":[160],"(":[161],"OR":[162],"=3.46;":[163],"CI":[165],"1.55-2.13,":[167],"LVMI":[169],"2.6;":[172],"CI:":[174,183,191],"1.1\u2013":[175],"1.13),":[176],"DcT":[178],"2.4;":[181],"1.15\u20132.05;":[184],"CA-IMT":[186],"1.6;":[189],"1.16\u20131.57)":[192],",and":[193],"FMD%":[194],"=2.6;":[196],"95%CI":[197],"1.33-2.89)":[199],".":[200],"Conclusions:":[201],"level":[203],"was":[204,222],"elevated":[205],"CAH,":[210],"especially":[211],"those":[213],"not":[214],"well":[215],"it":[221],"LVMI,":[225],"DcT,":[227],"FMD%.":[230],"Children":[231],"who":[234],"are":[235],"at":[236],"increased":[237],"risk":[238],"developing":[240],"subclinical":[241],"CV":[242],"problems":[243],"may":[244],"benefit":[245],"from":[246],"measuring":[247],"level.":[249]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-04-02T00:00:00"}