{"id":"https://openalex.org/W4393387527","doi":"https://doi.org/10.1021/acs.jpcb.3c06116","title":"DNA Packaging and Polycation Length Determine DNA Susceptibility to Free Radical Damage in Condensed DNA","display_name":"DNA Packaging and Polycation Length Determine DNA Susceptibility to Free Radical Damage in Condensed DNA","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4393387527","doi":"https://doi.org/10.1021/acs.jpcb.3c06116","pmid":"https://pubmed.ncbi.nlm.nih.gov/38557033"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jpcb.3c06116","doi":"https://doi.org/10.1021/acs.jpcb.3c06116","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpcb.3c06116","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64fb43c5b6ab98a41c162c1e/original/dna-packaging-and-polycation-length-determine-dna-susceptibility-to-free-radical-damage-in-condensed-dna.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085347493","display_name":"EI Oikeh","orcid":"https://orcid.org/0000-0002-4931-9085","observed_orcids":["https://orcid.org/0000-0002-4931-9085"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ehigbai Oikeh","raw_affiliation_strings":["Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States"],"raw_orcid":"https://orcid.org/0000-0002-4931-9085","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023911158","display_name":"Jesse Dylan Ziebarth","orcid":"https://orcid.org/0000-0002-2042-0972","observed_orcids":["https://orcid.org/0000-0002-2042-0972"]},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse Ziebarth","raw_affiliation_strings":["Department of Chemistry, University of Memphis, Memphis, Tennessee 38152, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Memphis, Memphis, Tennessee 38152, United States","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094299428","display_name":"Md Abu Monsur Dinar","orcid":"https://orcid.org/0000-0001-9801-6972","observed_orcids":["https://orcid.org/0000-0001-9801-6972"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Abu Monsur Dinar","raw_affiliation_strings":["Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Kirchhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kirchhoff","raw_affiliation_strings":["Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094299429","display_name":"Anastasiia Aronova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasiia Aronova","raw_affiliation_strings":["Chemical and Materials Engineering Department, University of Kentucky, Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Materials Engineering Department, University of Kentucky, Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051709163","display_name":"Thomas D. Dziubla","orcid":"https://orcid.org/0000-0003-2518-3926","observed_orcids":["https://orcid.org/0000-0003-2518-3926"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Dziubla","raw_affiliation_strings":["Chemical and Materials Engineering Department, University of Kentucky, Lexington, Kentucky 40506, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Materials Engineering Department, University of Kentucky, Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100724873","display_name":"Yongmei Wang","orcid":"https://orcid.org/0000-0002-7418-9489","observed_orcids":["https://orcid.org/0000-0002-7418-9489","https://orcid.org/0000-0002-1328-9574"]},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongmei Wang","raw_affiliation_strings":["Department of Chemistry, University of Memphis, Memphis, Tennessee 38152, United States"],"raw_orcid":"https://orcid.org/0000-0002-7418-9489","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Memphis, Memphis, Tennessee 38152, United States","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055253979","display_name":"Jason E. DeRouchey","orcid":"https://orcid.org/0000-0002-3624-4432","observed_orcids":["https://orcid.org/0000-0002-3624-4432"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason E. DeRouchey","raw_affiliation_strings":["Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States"],"raw_orcid":"https://orcid.org/0000-0002-3624-4432","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055253979"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.2366,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39681335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"128","issue":"14","first_page":"3329","last_page":"3339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.16590000689029694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12274","display_name":"Electrostatics and Colloid Interactions","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-condensation","display_name":"DNA condensation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.7540000081062317},{"id":"https://openalex.org/keywords/dna-oxidation","display_name":"DNA oxidation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/protamine","display_name":"protamine","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sperm-chromatin","display_name":"sperm chromatin","score":0.871999979019165},{"id":"https://openalex.org/keywords/polyarginine","display_name":"polyarginine","score":0.7379999756813049},{"id":"https://openalex.org/keywords/dna-protection","display_name":"DNA protection","score":0.6190000176429749},{"id":"https://openalex.org/keywords/histones","display_name":"histones","score":0.6869999766349792},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.3919999897480011},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2780835560","wikidata":"https://www.wikidata.org/wiki/Q5449573","display_name":"Protamine","level":3,"score":0.782590389251709},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7707529067993164},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7574973702430725},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7173109650611877},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6155582666397095},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5337532162666321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.462216317653656},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.42590299248695374},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3661695420742035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3517524003982544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.302961528301239},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.05614885687828064}],"mesh":[{"descriptor_ui":"D000071228","descriptor_name":"Polyelectrolytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011479","descriptor_name":"Protamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042003","descriptor_name":"DNA Packaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jpcb.3c06116","doi":"https://doi.org/10.1021/acs.jpcb.3c06116","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpcb.3c06116","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2023-s03tt","doi":"https://doi.org/10.26434/chemrxiv-2023-s03tt","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2023-s03tt","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64fb43c5b6ab98a41c162c1e/original/dna-packaging-and-polycation-length-determine-dna-susceptibility-to-free-radical-damage-in-condensed-dna.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:38557033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38557033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv-2023-s03tt","doi":"https://doi.org/10.26434/chemrxiv-2023-s03tt","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2023-s03tt","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64fb43c5b6ab98a41c162c1e/original/dna-packaging-and-polycation-length-determine-dna-susceptibility-to-free-radical-damage-in-condensed-dna.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2686849377","display_name":"CAREER: Linking Structure, Stability and Protection in Protamine Packaged DNA","funder_award_id":"1453168","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5394685512","display_name":null,"funder_award_id":"MCB-1453168","funder_id":"https://openalex.org/F4320337397","funder_display_name":"Division of Molecular and Cellular Biosciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393387527.pdf","grobid_xml":"https://content.openalex.org/works/W4393387527.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W160911776","https://openalex.org/W1031578623","https://openalex.org/W1604813558","https://openalex.org/W1736102530","https://openalex.org/W1945345558","https://openalex.org/W1963518591","https://openalex.org/W1979383336","https://openalex.org/W1982117833","https://openalex.org/W1983076555","https://openalex.org/W1984140215","https://openalex.org/W1985642222","https://openalex.org/W1987027200","https://openalex.org/W1988416664","https://openalex.org/W1992687375","https://openalex.org/W1994020848","https://openalex.org/W1998602216","https://openalex.org/W2005474893","https://openalex.org/W2008136951","https://openalex.org/W2012842529","https://openalex.org/W2019571705","https://openalex.org/W2020002410","https://openalex.org/W2029667189","https://openalex.org/W2041811684","https://openalex.org/W2044071441","https://openalex.org/W2046874889","https://openalex.org/W2052435597","https://openalex.org/W2070247422","https://openalex.org/W2070271523","https://openalex.org/W2071138149","https://openalex.org/W2071542355","https://openalex.org/W2072697652","https://openalex.org/W2081160511","https://openalex.org/W2081987320","https://openalex.org/W2091362477","https://openalex.org/W2092251734","https://openalex.org/W2093024907","https://openalex.org/W2103336074","https://openalex.org/W2115567167","https://openalex.org/W2136729627","https://openalex.org/W2139891258","https://openalex.org/W2140903035","https://openalex.org/W2150960435","https://openalex.org/W2154354875","https://openalex.org/W2154981196","https://openalex.org/W2160935121","https://openalex.org/W2161605421","https://openalex.org/W2161924850","https://openalex.org/W2171006004","https://openalex.org/W2244782642","https://openalex.org/W2560843938","https://openalex.org/W2564919749","https://openalex.org/W2725941071","https://openalex.org/W2761946576","https://openalex.org/W2763769301","https://openalex.org/W2799316872","https://openalex.org/W2913502276","https://openalex.org/W2942281532","https://openalex.org/W2962951846","https://openalex.org/W2982719129","https://openalex.org/W2995961938","https://openalex.org/W3003050051","https://openalex.org/W3012283905","https://openalex.org/W3042350830","https://openalex.org/W3047980318","https://openalex.org/W3118722948","https://openalex.org/W3120269428","https://openalex.org/W4205124607","https://openalex.org/W4205336731","https://openalex.org/W4255244349","https://openalex.org/W4298326625"],"related_works":["https://openalex.org/W2199300162","https://openalex.org/W2019571705","https://openalex.org/W2032328005","https://openalex.org/W4214501667","https://openalex.org/W2019408635","https://openalex.org/W2769468652","https://openalex.org/W7006166282","https://openalex.org/W2020953884","https://openalex.org/W1991516792","https://openalex.org/W2063480068"],"abstract_inverted_index":{"In":[0],"nature,":[1],"DNA":[2,13,36,54,85,94,99,119,124,138,172,190,194],"exists":[3],"primarily":[4],"in":[5,14,22,27,39,70,101],"a":[6,152,184],"highly":[7],"compacted":[8],"form.":[9],"The":[10,30,63,90],"compaction":[11],"of":[12,35,66,84,147],"vivo":[15],"is":[16,41,68,106],"mediated":[17],"by":[18,37,58,126,166],"cationic":[19],"proteins:":[20],"histones":[21],"somatic":[23],"nuclei":[24],"and":[25,60,122,174,193],"protamines":[26,38,67],"sperm":[28],"chromatin.":[29],"extreme,":[31],"nearly":[32],"crystalline":[33],"packaging":[34,95,120,139,191],"spermatozoa":[40],"thought":[42],"to":[43,76,80,92,98,116,142],"be":[44],"essential":[45],"for":[46],"both":[47],"efficient":[48],"genetic":[49],"delivery":[50],"as":[51,53,72],"well":[52],"protection":[55,100,165,195],"against":[56,196],"damage":[57,78,125,199],"mutagens":[59],"oxidative":[61],"species.":[62],"protective":[64],"role":[65],"required":[69],"sperm,":[71],"they":[73],"are":[74],"sensitive":[75],"ROS":[77],"due":[79],"the":[81,102,131,145,148,171],"progressive":[82],"loss":[83],"repair":[86],"mechanisms":[87],"during":[88],"maturation.":[89],"degree":[91],"which":[93],"directly":[96],"relates":[97],"condensed":[103,201],"state,":[104],"however,":[105],"poorly":[107],"understood.":[108],"Here,":[109],"we":[110,134],"utilized":[111],"different":[112],"polycation":[113,149,188],"condensing":[114],"agents":[115],"achieve":[117],"varying":[118],"densities":[121],"quantify":[123],"free":[127,197],"radical":[128,198],"oxidation":[129],"within":[130,200],"condensates.":[132],"Although":[133],"see":[135],"that":[136,159],"tighter":[137],"generally":[140],"leads":[141],"better":[143],"protection,":[144],"length":[146],"also":[150],"plays":[151],"significant":[153],"role.":[154],"Molecular":[155],"dynamics":[156],"simulations":[157],"suggest":[158,183],"longer":[160],"polyarginine":[161],"chains":[162],"offer":[163],"increased":[164],"occupying":[167],"more":[168,176],"space":[169],"on":[170],"surface":[173],"forming":[175],"stable":[177],"interactions.":[178],"Taken":[179],"together,":[180],"our":[181],"results":[182],"complex":[185],"interplay":[186],"among":[187],"properties,":[189],"density,":[192],"states.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-04-02T00:00:00"}