{"id":"https://openalex.org/W4393374471","doi":"https://doi.org/10.4103/rps.rps_210_23","title":"The protective effect of Thai rice bran on N-acetyl-\u03c1-aminophen-induced hepatotoxicity in mice","display_name":"The protective effect of Thai rice bran on N-acetyl-\u03c1-aminophen-induced hepatotoxicity in mice","publication_year":2024,"publication_date":"2024-03-01","ids":{"openalex":"https://openalex.org/W4393374471","doi":"https://doi.org/10.4103/rps.rps_210_23","pmid":"https://pubmed.ncbi.nlm.nih.gov/39035586","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11257212"},"language":"en","primary_location":{"id":"doi:10.4103/rps.rps_210_23","doi":"https://doi.org/10.4103/rps.rps_210_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/rps.rps_210_23","pdf_url":null,"source":{"id":"https://openalex.org/S2739408508","display_name":"Research in Pharmaceutical Sciences","issn_l":"1735-5362","issn":["1735-5362","1735-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/rps.rps_210_23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070361431","display_name":"Pitchaporn Wanyo","orcid":"https://orcid.org/0000-0002-4002-6403","observed_orcids":["https://orcid.org/0000-0002-4002-6403"]},"institutions":[{"id":"https://openalex.org/I4210130206","display_name":"Kalasin University","ror":"https://ror.org/02g702008","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210130206"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pitchaporn Wanyo","raw_affiliation_strings":["Department of Food Technology, Faculty of Agricultural Technology, Kalasin University, Kalasin 46000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Technology, Faculty of Agricultural Technology, Kalasin University, Kalasin 46000, Thailand","institution_ids":["https://openalex.org/I4210130206"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016024504","display_name":"Charinya So-In","orcid":"https://orcid.org/0000-0001-9128-9687","observed_orcids":["https://orcid.org/0000-0001-9128-9687"]},"institutions":[{"id":"https://openalex.org/I4210130206","display_name":"Kalasin University","ror":"https://ror.org/02g702008","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210130206"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Charinya So-In","raw_affiliation_strings":["Department of Food Technology, Faculty of Agricultural Technology, Kalasin University, Kalasin 46000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Technology, Faculty of Agricultural Technology, Kalasin University, Kalasin 46000, Thailand","institution_ids":["https://openalex.org/I4210130206"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016024504"],"corresponding_institution_ids":["https://openalex.org/I4210130206"],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.6944,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60128453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"19","issue":"2","first_page":"188","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8090000152587891},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.9200000166893005},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":0.984000027179718},{"id":"https://openalex.org/keywords/rice-cultivars","display_name":"rice varieties","score":0.7250000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5979999899864197},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8700000047683716},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8059999942779541},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7689999938011169},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.7839999794960022},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.739429771900177},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6559163331985474},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6235418915748596},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6020887494087219},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5970686078071594},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5573350191116333},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5094667077064514},{"id":"https://openalex.org/C2776873940","wikidata":"https://www.wikidata.org/wiki/Q188672","display_name":"Bran","level":3,"score":0.5056676864624023},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4864025413990021},{"id":"https://openalex.org/C2778945092","wikidata":"https://www.wikidata.org/wiki/Q262547","display_name":"Anthocyanin","level":2,"score":0.4296759068965912},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.41875195503234863},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4153939187526703},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3655717074871063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.361230731010437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2202264666557312},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21810907125473022},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/rps.rps_210_23","doi":"https://doi.org/10.4103/rps.rps_210_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/rps.rps_210_23","pdf_url":null,"source":{"id":"https://openalex.org/S2739408508","display_name":"Research in Pharmaceutical Sciences","issn_l":"1735-5362","issn":["1735-5362","1735-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11257212","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11257212","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11257212/pdf/RPS-19-188.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Pharm Sci","raw_type":"Text"},{"id":"pmid:39035586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39035586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:544b80b3647e45ef96f8618425edb4d3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/544b80b3647e45ef96f8618425edb4d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research in Pharmaceutical Sciences, Vol 19, Iss 2, Pp 188-202 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/rps.rps_210_23","doi":"https://doi.org/10.4103/rps.rps_210_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/rps.rps_210_23","pdf_url":null,"source":{"id":"https://openalex.org/S2739408508","display_name":"Research in Pharmaceutical Sciences","issn_l":"1735-5362","issn":["1735-5362","1735-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393374471.pdf","grobid_xml":"https://content.openalex.org/works/W4393374471.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1072662424","https://openalex.org/W1925097974","https://openalex.org/W2112800286","https://openalex.org/W2121892305","https://openalex.org/W2256859967","https://openalex.org/W2525477789","https://openalex.org/W2529405505","https://openalex.org/W2529712446","https://openalex.org/W2570377783","https://openalex.org/W2576561369","https://openalex.org/W2741180255","https://openalex.org/W2744804382","https://openalex.org/W2769588514","https://openalex.org/W2783038028","https://openalex.org/W2790143687","https://openalex.org/W2794938183","https://openalex.org/W2800659605","https://openalex.org/W2800988230","https://openalex.org/W2804818490","https://openalex.org/W2804922717","https://openalex.org/W2811448031","https://openalex.org/W2893807759","https://openalex.org/W2897169866","https://openalex.org/W2902550522","https://openalex.org/W2964577453","https://openalex.org/W2981716011","https://openalex.org/W2990996568","https://openalex.org/W3034926538","https://openalex.org/W3045794918","https://openalex.org/W3094642441","https://openalex.org/W3108095894","https://openalex.org/W3116567106","https://openalex.org/W3135502748","https://openalex.org/W3159423073","https://openalex.org/W3162250236","https://openalex.org/W3164237490","https://openalex.org/W3168473827","https://openalex.org/W3188836359","https://openalex.org/W3193853971","https://openalex.org/W3196633661","https://openalex.org/W3201009436","https://openalex.org/W4200120466","https://openalex.org/W4206950547","https://openalex.org/W4223444806","https://openalex.org/W4224945660","https://openalex.org/W4229458520","https://openalex.org/W4283749984","https://openalex.org/W4285594413","https://openalex.org/W4291512437","https://openalex.org/W4293769811","https://openalex.org/W4303622052","https://openalex.org/W4310185967","https://openalex.org/W4311902549","https://openalex.org/W4312056269","https://openalex.org/W4320496470","https://openalex.org/W4321793665","https://openalex.org/W4327748845","https://openalex.org/W4352994436","https://openalex.org/W4361011236","https://openalex.org/W4385210952","https://openalex.org/W4385648752","https://openalex.org/W4389882278","https://openalex.org/W4390115677","https://openalex.org/W6795132021"],"related_works":["https://openalex.org/W2181295787","https://openalex.org/W2979172931","https://openalex.org/W3159931518","https://openalex.org/W2082220042","https://openalex.org/W1997920135","https://openalex.org/W2089547659","https://openalex.org/W2620002973","https://openalex.org/W3115277273","https://openalex.org/W2726615519","https://openalex.org/W7159844008"],"abstract_inverted_index":{"Background":[0],"and":[1,12,34,51,54,72,92,113,136,144,166,176,179,188,207,219,232,237],"purpose:":[2],"N-acetyl-\u03c1-aminophen":[3],"(APAP)":[4],"is":[5],"a":[6,107,248],"widely":[7],"used":[8,246],"medication":[9],"with":[10,86,98],"analgesic":[11],"antipyretic":[13],"characteristics.":[14],"High":[15],"paracetamol":[16],"doses":[17],"can":[18],"damage":[19],"the":[20,42,70,192,198,235,242],"liver.":[21],"Thai-pigmented":[22],"rice":[23,48,96,122,196],"may":[24],"treat":[25],"numerous":[26],"liver":[27,114],"disorders":[28],"due":[29],"to":[30,40,69,226,244],"its":[31],"antioxidant,":[32,135],"anti-inflammatory,":[33],"glutathione-restoring":[35],"capabilities.":[36],"This":[37],"study":[38,76],"aimed":[39],"evaluate":[41],"phenolic":[43],"components":[44],"in":[45,57,150,159],"three":[46,193],"Thai":[47],"bran":[49,123],"extracts":[50],"their":[52],"antioxidant":[53,186,211,238],"hepatoprotective":[55,236],"activities":[56,140],"an":[58],"animal":[59],"model.":[60],"Experimental":[61],"approach:":[62],"Fifty":[63],"male":[64],"mice":[65,155],"were":[66,116],"randomly":[67],"assigned":[68],"control":[71],"APAP":[73,104,153],"studies.":[74],"Each":[75],"was":[77,147,197,223],"divided":[78],"into":[79],"5":[80],"groups":[81],"(n":[82],"=":[83],"5)":[84],"treated":[85],"distilled":[87],"water,":[88],"Hom":[89,93,142],"Mali,":[90],"Hang-Ngok,":[91],"Nil":[94],"(HN)":[95],"compared":[97],"N-acetylcysteine":[99,229],"with/without":[100],"60":[101],"mg/kg/day":[102],"of":[103,127,185,228],"orally":[105],"once":[106],"day":[108],"for":[109,118],"two":[110],"weeks.":[111],"Blood":[112],"sampling":[115],"collected":[117],"analysis.":[119],"Findings/Results:":[120],"HN":[121,195,240],"exhibited":[124,156],"higher":[125],"contents":[126],"total":[128,130,132],"phenolic,":[129],"flavonoid,":[131],"anthocyanin,":[133],"ferric-reducing":[134],"1,1-diphenyl-2-picrylhydrazyl":[137],"radical":[138],"scavenging":[139],"than":[141],"Mali":[143],"Hang-Ngok.":[145],"Anthocyanin":[146],"merely":[148],"detected":[149],"HN.":[151],"Following":[152],"administration,":[154],"significant":[157],"increases":[158],"hepatic":[160],"enzymes":[161,187],"including":[162],"alanine":[163],"aminotransferase":[164,168],"(ALT)":[165],"aspartate":[167],"(AST),":[169],"pro-inflammatory":[170],"cytokines":[171],"(tumor":[172],"necrosis":[173],"factor-alpha":[174],"(TNF-\u03b1)":[175],"interleukin-6":[177],"(IL-6)),":[178],"malondialdehyde":[180],"(MDA),":[181],"but":[182],"lower":[183],"levels":[184],"glutathione":[189,220],"profiles.":[190],"Amongst":[191],"cultivars,":[194],"only":[199],"compound":[200],"that":[201,222,227],"decreased":[202],"MDA,":[203],"ALT,":[204],"AST,":[205],"TNF-\u03b1,":[206],"IL-6":[208],"while":[209],"increasing":[210],"enzyme":[212],"activity":[213],"such":[214],"as":[215,247],"superoxide":[216],"dismutase,":[217],"catalase,":[218],"peroxidase":[221],"very":[224],"close":[225],"groups.":[230],"Conclusion":[231],"implications:":[233],"Given":[234],"properties,":[239],"has":[241],"potential":[243],"be":[245],"health":[249],"supplement.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-02T00:00:00"}
