{"id":"https://openalex.org/W4393372897","doi":"https://doi.org/10.1021/acsinfecdis.3c00707","title":"Next Generation Chemiluminescent Probes for Antimalarial Drug Discovery","display_name":"Next Generation Chemiluminescent Probes for Antimalarial Drug Discovery","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4393372897","doi":"https://doi.org/10.1021/acsinfecdis.3c00707","pmid":"https://pubmed.ncbi.nlm.nih.gov/38556981","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11019541"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.3c00707","doi":"https://doi.org/10.1021/acsinfecdis.3c00707","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.3c00707","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acsinfecdis.3c00707","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094294859","display_name":"Angela Hellingman","orcid":"https://orcid.org/0009-0001-3686-1203","observed_orcids":["https://orcid.org/0009-0001-3686-1203"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Angela Hellingman","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0009-0001-3686-1203","affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094294860","display_name":"Kleopatra Sifoniou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kleopatra Sifoniou","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088022051","display_name":"Tamara Buser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tamara Buser","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043835671","display_name":"Basil T. Thommen","orcid":"https://orcid.org/0000-0001-7655-2440","observed_orcids":["https://orcid.org/0000-0001-7655-2440"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Basil T. Thommen","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058084274","display_name":"Annabelle Walz","orcid":"https://orcid.org/0009-0009-4847-3484","observed_orcids":["https://orcid.org/0009-0009-4847-3484"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Annabelle Walz","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045242649","display_name":"Armin Passecker","orcid":"https://orcid.org/0000-0002-5970-3339","observed_orcids":["https://orcid.org/0000-0002-5970-3339"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Armin Passecker","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Collins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Collins","raw_affiliation_strings":["NEMIS Technologies AG, 8804 Au, ZH, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEMIS Technologies AG, 8804 Au, ZH, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000522754","display_name":"Mario Hupfeld","orcid":"https://orcid.org/0000-0002-4012-9760","observed_orcids":["https://orcid.org/0000-0002-4012-9760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Hupfeld","raw_affiliation_strings":["NEMIS Technologies AG, 8804 Au, ZH, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEMIS Technologies AG, 8804 Au, ZH, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015175584","display_name":"Sergio Wittlin","orcid":"https://orcid.org/0000-0002-0811-0912","observed_orcids":["https://orcid.org/0000-0002-0811-0912"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Sergio Wittlin","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0811-0912","affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058149277","display_name":"Kathrin Witmer","orcid":"https://orcid.org/0000-0002-3159-7386","observed_orcids":["https://orcid.org/0000-0002-3159-7386"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Kathrin Witmer","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","NEMIS Technologies AG, 8804 Au, ZH, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"NEMIS Technologies AG, 8804 Au, ZH, Switzerland","institution_ids":[]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080282918","display_name":"Nicolas M. B. Brancucci","orcid":"https://orcid.org/0000-0003-0655-3266","observed_orcids":["https://orcid.org/0000-0003-0655-3266"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Nicolas M. B. Brancucci","raw_affiliation_strings":["Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","University of Basel, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015175584","https://openalex.org/A5058149277","https://openalex.org/A5080282918"],"corresponding_institution_ids":["https://openalex.org/I158937107","https://openalex.org/I1850255"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":4.3611,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.94724619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"1286","last_page":"1297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7231000065803528,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7231000065803528,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimalarial-drug-discovery","display_name":"antimalarial drug discovery","score":0.9399999976158142},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lacz-reporter","display_name":"lacZ reporter","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antimicrobial-resistance-surveillance","display_name":"antimicrobial resistance surveillance","score":0.5450000166893005},{"id":"https://openalex.org/keywords/artemisinin-resistance","display_name":"artemisinin resistance","score":0.8109999895095825},{"id":"https://openalex.org/keywords/low-detection-limit","display_name":"low detection limit","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7402172684669495},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.6335065960884094},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.5877776741981506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49976587295532227},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49601849913597107},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.494412899017334},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4572332799434662},{"id":"https://openalex.org/C2779124865","wikidata":"https://www.wikidata.org/wiki/Q418179","display_name":"Atovaquone","level":4,"score":0.42794084548950195},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.23174089193344116},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1121637225151062}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005697","descriptor_name":"Galactosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsinfecdis.3c00707","doi":"https://doi.org/10.1021/acsinfecdis.3c00707","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.3c00707","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11019541","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11019541","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11019541/pdf/id3c00707.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},{"id":"pmid:38556981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38556981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsinfecdis.3c00707","doi":"https://doi.org/10.1021/acsinfecdis.3c00707","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.3c00707","pdf_url":null,"source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3443072535","display_name":"Deciphering Environmental Sensing in Malaria Parasites","funder_award_id":"200683","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393372897.pdf","grobid_xml":"https://content.openalex.org/works/W4393372897.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1801675115","https://openalex.org/W1965003536","https://openalex.org/W1969503178","https://openalex.org/W1972907204","https://openalex.org/W1974858723","https://openalex.org/W1990074634","https://openalex.org/W1990479619","https://openalex.org/W1990713801","https://openalex.org/W1998892616","https://openalex.org/W2000722808","https://openalex.org/W2003127960","https://openalex.org/W2009943836","https://openalex.org/W2015877731","https://openalex.org/W2016266809","https://openalex.org/W2021750210","https://openalex.org/W2021868082","https://openalex.org/W2026226265","https://openalex.org/W2028105781","https://openalex.org/W2055730063","https://openalex.org/W2057305457","https://openalex.org/W2064666859","https://openalex.org/W2069106055","https://openalex.org/W2090344797","https://openalex.org/W2091822521","https://openalex.org/W2094235433","https://openalex.org/W2096355268","https://openalex.org/W2098184601","https://openalex.org/W2103185393","https://openalex.org/W2104700616","https://openalex.org/W2104799919","https://openalex.org/W2105668259","https://openalex.org/W2114818342","https://openalex.org/W2114971505","https://openalex.org/W2115876799","https://openalex.org/W2127988487","https://openalex.org/W2143484788","https://openalex.org/W2143552714","https://openalex.org/W2145600860","https://openalex.org/W2187295707","https://openalex.org/W2345146459","https://openalex.org/W2591844450","https://openalex.org/W2767131556","https://openalex.org/W2798157446","https://openalex.org/W2948004964","https://openalex.org/W2955963459","https://openalex.org/W2966139534","https://openalex.org/W3048041047","https://openalex.org/W3048559773","https://openalex.org/W3070462113","https://openalex.org/W3084158514","https://openalex.org/W3089107717","https://openalex.org/W3095380498","https://openalex.org/W4211051628","https://openalex.org/W4211090760","https://openalex.org/W4296512773","https://openalex.org/W4317735743","https://openalex.org/W4381383523"],"related_works":["https://openalex.org/W7125472895","https://openalex.org/W2057305457","https://openalex.org/W2492708345","https://openalex.org/W2114818342","https://openalex.org/W2323561740","https://openalex.org/W2003335256","https://openalex.org/W2138741610","https://openalex.org/W2145600860","https://openalex.org/W4404643560","https://openalex.org/W3014507734"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Malaria":[7],"is":[8,87,94,123],"caused":[9],"by":[10,125,143],"parasites":[11,29,163,186],"of":[12,19,28,79,118,138,158,182,187],"the":[13,20,81,101,165,178,188],"Plasmodium":[14],"genus":[15],"and":[16,44,53,69,77,93,100,155],"remains":[17],"one":[18],"most":[21],"pressing":[22],"human":[23],"health":[24],"problems.":[25],"The":[26,116],"spread":[27],"resistant":[30,34],"to":[31,35,51,74,202],"or":[32,37,171],"partially":[33],"single":[36],"multiple":[38],"drugs,":[39],"including":[40,198],"frontline":[41],"antimalarial":[42,67,112],"artemisinin":[43],"its":[45,75],"derivatives,":[46],"poses":[47],"a":[48,90,109,127,139,144],"serious":[49],"threat":[50],"current":[52],"future":[54],"malaria":[55,196],"control":[56],"efforts.":[57],"In":[58],"vitro":[59],"drug":[60,71,113,203],"assays":[61],"are":[62,175],"important":[63],"for":[64,167],"identifying":[65],"new":[66],"compounds":[68,119],"monitoring":[70],"resistance.":[72],"Due":[73],"robustness":[76],"ease":[78],"use,":[80],"[":[82],"3":[83],"H]-hypoxanthine":[84],"incorporation":[85],"assay":[86],"still":[88],"considered":[89],"gold":[91],"standard":[92],"widely":[95],"applied,":[96],"despite":[97],"limited":[98,201],"sensitivity":[99],"dependence":[102],"on":[103,120],"radioactive":[104],"material.":[105],"Here,":[106],"we":[107],"present":[108],"first-of-its-kind":[110],"chemiluminescence-based":[111],"screening":[114],"assay.":[115],"effect":[117],"P.":[121,161],"falciparum":[122,162],"monitored":[124],"using":[126],"dioxetane-based":[128],"substrate":[129],"(AquaSpark":[130],"\u03b2-D-galactoside)":[131],"that":[132,177],"emits":[133],"high-intensity":[134],"luminescence":[135],"upon":[136],"removal":[137],"protective":[140],"group":[141],"(\u03b2-D-galactoside)":[142],"transgenic":[145],"\u03b2-galactosidase":[146],"reporter":[147],"enzyme.":[148],"This":[149],"biosensor":[150,190],"enables":[151],"highly":[152],"sensitive,":[153],"robust,":[154],"cost-effective":[156],"detection":[157,180],"asexual,":[159],"intraerythrocytic":[160],"without":[164],"need":[166],"parasite":[168],"enrichment,":[169],"washing,":[170],"purification":[172],"steps.":[173],"We":[174],"convinced":[176],"ultralow":[179],"limit":[181],"less":[183],"than":[184],"100":[185],"presented":[189],"system":[191],"will":[192],"become":[193],"instrumental":[194],"in":[195],"research,":[197],"but":[199],"not":[200],"screening.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-02T00:00:00"}