{"id":"https://openalex.org/W4393356154","doi":"https://doi.org/10.1007/s00432-024-05685-7","title":"Prospects of molecular hydrogen in cancer prevention and treatment","display_name":"Prospects of molecular hydrogen in cancer prevention and treatment","publication_year":2024,"publication_date":"2024-03-31","ids":{"openalex":"https://openalex.org/W4393356154","doi":"https://doi.org/10.1007/s00432-024-05685-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/38555538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10982102"},"language":"en","primary_location":{"id":"doi:10.1007/s00432-024-05685-7","doi":"https://doi.org/10.1007/s00432-024-05685-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-024-05685-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-024-05685-7.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s00432-024-05685-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075681541","display_name":"Wenchang Zhou","orcid":"https://orcid.org/0000-0002-5819-4296","observed_orcids":["https://orcid.org/0000-0002-5819-4296"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenchang Zhou","raw_affiliation_strings":["Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China","Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Anesthesiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China","Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Anesthesiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077345834","display_name":"Wankun Chen","orcid":"https://orcid.org/0000-0001-7394-9266","observed_orcids":["https://orcid.org/0000-0001-7394-9266","https://orcid.org/0009-0004-8661-5133"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wankun Chen","raw_affiliation_strings":["Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China. chenwank@163.com","Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. chenwank@163.com","Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China. chenwank@163.com","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. chenwank@163.com","institution_ids":[]},{"raw_affiliation_string":"Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Anesthesiology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100382098","display_name":"Changhong Miao","orcid":"https://orcid.org/0000-0003-3516-8308","observed_orcids":["https://orcid.org/0000-0003-3516-8308","https://orcid.org/0009-0004-5760-2683"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changhong Miao","raw_affiliation_strings":["Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China. miaochangh@163.com","Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. miaochangh@163.com","Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology; Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China. miaochangh@163.com","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. miaochangh@163.com","institution_ids":[]},{"raw_affiliation_string":"Cancer Center, Zhongshan Hospital, Fudan University, No. 180 Feng-Lin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Anesthesiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077345834","https://openalex.org/A5100382098"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.8342,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.85031447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"150","issue":"4","first_page":"170","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.878000020980835},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6330000162124634},{"id":"https://openalex.org/keywords/gasotransmitters","display_name":"gasotransmitters","score":0.6669999957084656},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.5490000247955322},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7188990116119385},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6184053421020508},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6099231243133545},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5880327224731445},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5365669131278992},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5236025452613831},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4821912348270416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46075353026390076},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43823009729385376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4142743647098541},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4134068489074707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41273748874664307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3455328345298767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2358567714691162},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21050500869750977}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00432-024-05685-7","doi":"https://doi.org/10.1007/s00432-024-05685-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-024-05685-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-024-05685-7.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10982102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10982102","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"},{"id":"pmid:38555538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38555538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and clinical oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00432-024-05685-7","doi":"https://doi.org/10.1007/s00432-024-05685-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-024-05685-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-024-05685-7.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3448571320","display_name":null,"funder_award_id":"2020YFC2008400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8151448121","display_name":null,"funder_award_id":"81873948","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393356154.pdf","grobid_xml":"https://content.openalex.org/works/W4393356154.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W1048755173","https://openalex.org/W1843702144","https://openalex.org/W1873911178","https://openalex.org/W1904714471","https://openalex.org/W1972686849","https://openalex.org/W1977583079","https://openalex.org/W1995055171","https://openalex.org/W2006408441","https://openalex.org/W2007636933","https://openalex.org/W2008366967","https://openalex.org/W2017275974","https://openalex.org/W2042500166","https://openalex.org/W2044500327","https://openalex.org/W2048469790","https://openalex.org/W2059676446","https://openalex.org/W2073331259","https://openalex.org/W2077113765","https://openalex.org/W2091214272","https://openalex.org/W2093838944","https://openalex.org/W2102247752","https://openalex.org/W2107798887","https://openalex.org/W2109257509","https://openalex.org/W2145688263","https://openalex.org/W2151368213","https://openalex.org/W2154553542","https://openalex.org/W2159054927","https://openalex.org/W2163631544","https://openalex.org/W2166276338","https://openalex.org/W2169657429","https://openalex.org/W2170899588","https://openalex.org/W2277468569","https://openalex.org/W2465673666","https://openalex.org/W2471632092","https://openalex.org/W2503407514","https://openalex.org/W2512904058","https://openalex.org/W2551374520","https://openalex.org/W2552041992","https://openalex.org/W2557860987","https://openalex.org/W2605644047","https://openalex.org/W2626638947","https://openalex.org/W2733994766","https://openalex.org/W2765555750","https://openalex.org/W2765557965","https://openalex.org/W2784501904","https://openalex.org/W2787794728","https://openalex.org/W2792519068","https://openalex.org/W2797668595","https://openalex.org/W2803483268","https://openalex.org/W2807023521","https://openalex.org/W2809510969","https://openalex.org/W2861742259","https://openalex.org/W2885969317","https://openalex.org/W2893574061","https://openalex.org/W2894866383","https://openalex.org/W2898221037","https://openalex.org/W2898785855","https://openalex.org/W2900174742","https://openalex.org/W2905808540","https://openalex.org/W2909906511","https://openalex.org/W2910355986","https://openalex.org/W2913788177","https://openalex.org/W2920009718","https://openalex.org/W2925159351","https://openalex.org/W2943576188","https://openalex.org/W2946269862","https://openalex.org/W2958310296","https://openalex.org/W2962938520","https://openalex.org/W2971370669","https://openalex.org/W2972489154","https://openalex.org/W2977621363","https://openalex.org/W2978077164","https://openalex.org/W2980219860","https://openalex.org/W2982681607","https://openalex.org/W2985080704","https://openalex.org/W2987501675","https://openalex.org/W2988773550","https://openalex.org/W2999417355","https://openalex.org/W2999971336","https://openalex.org/W3001925819","https://openalex.org/W3005964018","https://openalex.org/W3010814208","https://openalex.org/W3021044908","https://openalex.org/W3024859680","https://openalex.org/W3028905308","https://openalex.org/W3040564571","https://openalex.org/W3080507616","https://openalex.org/W3081451680","https://openalex.org/W3083241614","https://openalex.org/W3087284075","https://openalex.org/W3087588976","https://openalex.org/W3087726072","https://openalex.org/W3090862270","https://openalex.org/W3096184588","https://openalex.org/W3107364628","https://openalex.org/W3107783166","https://openalex.org/W3113691179","https://openalex.org/W3115477054","https://openalex.org/W3115968256","https://openalex.org/W3119279345","https://openalex.org/W3125655055","https://openalex.org/W3128646645","https://openalex.org/W3131608869","https://openalex.org/W3131875598","https://openalex.org/W3140531652","https://openalex.org/W3154674003","https://openalex.org/W3169932635","https://openalex.org/W3180464509","https://openalex.org/W3193852797","https://openalex.org/W3196463433","https://openalex.org/W3199310080","https://openalex.org/W3202586121","https://openalex.org/W3206369863","https://openalex.org/W3213739506","https://openalex.org/W4206541998","https://openalex.org/W4210498051","https://openalex.org/W4213364680","https://openalex.org/W4220978943","https://openalex.org/W4225272939","https://openalex.org/W4294138012"],"related_works":["https://openalex.org/W2810504199","https://openalex.org/W2964503348","https://openalex.org/W3193852797","https://openalex.org/W2810333138","https://openalex.org/W4311674790","https://openalex.org/W4224923132","https://openalex.org/W2161431747","https://openalex.org/W4400723643","https://openalex.org/W4410009273","https://openalex.org/W3017258691"],"abstract_inverted_index":{"Abstract":[0],"Gas":[1],"signaling":[2,145],"molecules,":[3],"including":[4],"carbon":[5],"monoxide":[6],"(CO),":[7],"nitric":[8],"oxide":[9],"(NO),":[10],"and":[11,54,62,67,81,141,155,197,201],"hydrogen":[12,41],"sulfide":[13],"(H2S),":[14],"have":[15,19,38,129],"been":[16],"shown":[17,130],"to":[18,24,69,106,111,124],"cancer":[20,29,148,152,195,215],"therapeutic":[21,49],"potential,":[22],"pointing":[23],"a":[25,34,43,103],"new":[26,208],"direction":[27],"for":[28,210],"treatment.":[30],"In":[31,172],"recent":[32],"years,":[33],"series":[35],"of":[36,99,121,161,168,179,188,193,205,214],"studies":[37,128],"confirmed":[39],"that":[40,91,131],"(H2),":[42],"weakly":[44],"reductive":[45],"gas,":[46],"also":[47,163],"has":[48,74],"effects":[50],"on":[51,184],"various":[52,143],"cancers":[53],"can":[55,95],"mitigate":[56],"oxidative":[57],"stress":[58],"caused":[59],"by":[60,181],"radiation":[61],"chemotherapy,":[63],"reducing":[64],"tissue":[65],"damage":[66],"immunosuppression":[68],"improve":[70],"prognosis.":[71],"Meanwhile,":[72],"H2also":[73],"immunomodulatory":[75,170],"effects,":[76],"inhibiting":[77,151],"T":[78,83],"cell":[79,84,153],"exhaustion":[80],"enhancing":[82],"anti-tumor":[85,119],"function.":[86,171],"It":[87],"is":[88],"worth":[89],"noting":[90],"human":[92],"intestinal":[93,182],"flora":[94,183],"produce":[96],"large":[97],"amounts":[98],"H2daily,":[100],"which":[101],"becomes":[102],"natural":[104],"barrier":[105],"maintaining":[107],"the":[108,117,165,177,185,189,191,198,202,211],"body\u2019s":[109],"resistance":[110],"diseases":[112],"such":[113],"as":[114],"tumors.":[115],"Although":[116],"potential":[118],"mechanisms":[120],"H2are":[122],"still":[123],"be":[125,164],"investigated,":[126],"previous":[127],"H2can":[132],"selectively":[133],"scavenge":[134],"highly":[135],"toxic":[136],"reactive":[137],"oxygen":[138],"species":[139],"(ROS)":[140],"inhibit":[142],"ROS-dependent":[144],"pathways":[146],"in":[147],"cells,":[149],"thus":[150],"proliferation":[154],"metastasis.":[156],"The":[157],"ROS":[158],"scavenging":[159],"ability":[160],"H2may":[162],"underlying":[166,199],"mechanism":[167],"its":[169],"this":[173],"paper,":[174],"we":[175],"review":[176],"significance":[178],"H2produced":[180],"immune":[186],"homeostasis":[187],"body,":[190],"role":[192],"H2in":[194],"therapy":[196],"mechanisms,":[200],"specific":[203],"application":[204],"H2to":[206],"provide":[207],"ideas":[209],"comprehensive":[212],"treatment":[213],"patients.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-01T00:00:00"}
