{"id":"https://openalex.org/W4393334624","doi":"https://doi.org/10.1002/cmdc.202400130","title":"Autocleaving Bonds for Better Drugs","display_name":"Autocleaving Bonds for Better Drugs","publication_year":2024,"publication_date":"2024-03-30","ids":{"openalex":"https://openalex.org/W4393334624","doi":"https://doi.org/10.1002/cmdc.202400130","pmid":"https://pubmed.ncbi.nlm.nih.gov/38553420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11219257"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.202400130","doi":"https://doi.org/10.1002/cmdc.202400130","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cmdc.202400130","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/cmdc.202400130","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069032292","display_name":"Jiaqi Guo","orcid":"https://orcid.org/0000-0002-0254-0401","observed_orcids":["https://orcid.org/0000-0002-0254-0401","https://orcid.org/0009-0005-0968-3201"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaqi Guo","raw_affiliation_strings":["Department of Chemistry Brandeis University 415 South Street Waltham MA 02454 USA"],"raw_orcid":"https://orcid.org/0000-0002-0254-0401","affiliations":[{"raw_affiliation_string":"Department of Chemistry Brandeis University 415 South Street Waltham MA 02454 USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104266898","display_name":"Annabelle Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annabelle Chang","raw_affiliation_strings":["Department of Chemistry Brandeis University 415 South Street Waltham MA 02454 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Brandeis University 415 South Street Waltham MA 02454 USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100602838","display_name":"Bing Xu","orcid":"https://orcid.org/0000-0002-4639-387X","observed_orcids":["https://orcid.org/0000-0002-4639-387X","https://orcid.org/0000-0001-7138-8936","https://orcid.org/0000-0002-7385-9954","https://orcid.org/0000-0002-7242-6495"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bing Xu","raw_affiliation_strings":["Department of Chemistry Brandeis University  415 South Street Waltham MA 02454 USA","Brandeis University, Department of Chemistry, 415 South St, 02454, 2454 Waltham, UNITED STATES"],"raw_orcid":"https://orcid.org/0000-0002-4639-387X","affiliations":[{"raw_affiliation_string":"Department of Chemistry Brandeis University  415 South Street Waltham MA 02454 USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Brandeis University, Department of Chemistry, 415 South St, 02454, 2454 Waltham, UNITED STATES","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100602838"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":{"value":3950,"currency":"USD","value_usd":3950},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00290529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"13","first_page":"e202400130","last_page":"e202400130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.8619999885559082},{"id":"https://openalex.org/keywords/controlled-hydrolysis","display_name":"controlled hydrolysis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/peptide-conjugates","display_name":"peptide conjugates","score":0.47699999809265137},{"id":"https://openalex.org/keywords/bacterial-growth-inhibition","display_name":"bacterial growth inhibition","score":0.4699999988079071},{"id":"https://openalex.org/keywords/tumor-cell-inhibition","display_name":"cancer cell inhibition","score":0.9340000152587891},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.9359101057052612},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.6405951976776123},{"id":"https://openalex.org/C31684184","wikidata":"https://www.wikidata.org/wiki/Q33293","display_name":"Peptide bond","level":3,"score":0.612074613571167},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.5427953600883484},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.533539891242981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5308861136436462},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4994950294494629},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4778420627117157},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4390139579772949},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4198247194290161},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38387563824653625},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3451356589794159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.315771222114563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24429026246070862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18788602948188782},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1515553593635559},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14267727732658386},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cmdc.202400130","doi":"https://doi.org/10.1002/cmdc.202400130","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cmdc.202400130","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:38553420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38553420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11219257","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11219257","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11219257/pdf/nihms-1982118.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/cmdc.202400130","doi":"https://doi.org/10.1002/cmdc.202400130","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cmdc.202400130","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2440123334","display_name":"Bioinspired Soft Materials","funder_award_id":"2011846","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2730000833","display_name":null,"funder_award_id":"DMR-2011846","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G3217119012","display_name":null,"funder_award_id":"CA142746","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3311319433","display_name":null,"funder_award_id":"DMR-2011846","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5934811239","display_name":null,"funder_award_id":"NIH CA142746","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7833242660","display_name":null,"funder_award_id":"2011846","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G9000863427","display_name":"Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines","funder_award_id":"R01CA142746","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393334624.pdf","grobid_xml":"https://content.openalex.org/works/W4393334624.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1969268706","https://openalex.org/W1979921174","https://openalex.org/W1980124523","https://openalex.org/W2007593295","https://openalex.org/W2013298034","https://openalex.org/W2084039931","https://openalex.org/W2291461503","https://openalex.org/W2461509262","https://openalex.org/W2948765951","https://openalex.org/W2951591557","https://openalex.org/W2982568361","https://openalex.org/W2983701606","https://openalex.org/W3037359618","https://openalex.org/W3045713079","https://openalex.org/W3096550744","https://openalex.org/W3151708782","https://openalex.org/W3199943581","https://openalex.org/W4210911787","https://openalex.org/W4212801432","https://openalex.org/W4239858085","https://openalex.org/W4283360200","https://openalex.org/W4285726905","https://openalex.org/W4366981339","https://openalex.org/W4377225369","https://openalex.org/W4382361822","https://openalex.org/W4384819823","https://openalex.org/W4386369214","https://openalex.org/W4389298489"],"related_works":["https://openalex.org/W4402615908","https://openalex.org/W2461509262","https://openalex.org/W4322628236","https://openalex.org/W7134253994","https://openalex.org/W2060451360","https://openalex.org/W4320038840","https://openalex.org/W4241408935","https://openalex.org/W4391248371","https://openalex.org/W4414407560","https://openalex.org/W6887814210"],"abstract_inverted_index":{"While":[0],"bond":[1,14],"formation":[2],"has":[3,16],"historically":[4],"been":[5],"the":[6,11,21,28,64,96,114],"mainstay":[7],"of":[8,13,23,30,66,88,98,117],"medicinal":[9],"chemistry,":[10],"phenomenon":[12],"cleavage":[15,32,46],"received":[17],"less":[18],"focus.":[19],"However,":[20],"success":[22],"numerous":[24],"oral":[25],"medications":[26],"demonstrates":[27],"importance":[29],"controlled":[31],"in":[33,123],"prodrugs":[34,100],"to":[35,43,60,62,94],"achieve":[36],"desired":[37],"therapeutic":[38],"outcomes.":[39],"Nevertheless,":[40],"effective":[41],"strategies":[42],"control":[44,95],"this":[45,118],"remain":[47],"limited.":[48],"This":[49],"concept":[50],"article":[51,74],"introduces":[52],"a":[53,84,110],"novel":[54],"approach:":[55],"employing":[56],"peptides":[57,90],"as":[58],"conjugates":[59,68],"drugs":[61],"modulate":[63],"hydrolysis":[65],"these":[67],"and":[69,103],"enhance":[70],"drug":[71],"efficacy.":[72],"The":[73],"begins":[75],"by":[76,83],"briefly":[77],"outlining":[78],"common":[79],"prodrug":[80],"strategies,":[81],"followed":[82],"few":[85],"representative":[86],"examples":[87],"how":[89],"can":[91],"be":[92],"leveraged":[93],"autohydrolysis":[97],"peptide-conjugated":[99],"for":[101],"bacterial":[102],"cancer":[104],"cell":[105],"inhibition.":[106],"Finally,":[107],"it":[108],"provides":[109],"brief":[111],"outlook":[112],"on":[113],"future":[115],"potential":[116],"promising":[119],"new":[120],"research":[121],"direction":[122],"molecular":[124],"medicine.":[125]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-30T00:00:00"}