{"id":"https://openalex.org/W4393324769","doi":"https://doi.org/10.4103/ijn.ijn_277_22","title":"Nephrotic Syndrome and Posterior Reversible Encephalopathy Syndrome as Clinical Presentations of Gemcitabine-Induced Thrombotic Micro-Angiopathy","display_name":"Nephrotic Syndrome and Posterior Reversible Encephalopathy Syndrome as Clinical Presentations of Gemcitabine-Induced Thrombotic Micro-Angiopathy","publication_year":2023,"publication_date":"2023-03-07","ids":{"openalex":"https://openalex.org/W4393324769","doi":"https://doi.org/10.4103/ijn.ijn_277_22","pmid":"https://pubmed.ncbi.nlm.nih.gov/38645915","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11003583"},"language":"en","primary_location":{"id":"doi:10.4103/ijn.ijn_277_22","doi":"https://doi.org/10.4103/ijn.ijn_277_22","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijn.ijn_277_22","pdf_url":null,"source":{"id":"https://openalex.org/S65200941","display_name":"Indian Journal of Nephrology","issn_l":"0971-4065","issn":["0971-4065","1998-3662"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/ijn.ijn_277_22","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009897763","display_name":"Vijoy Kumar Jha","orcid":"https://orcid.org/0000-0003-0653-1366","observed_orcids":["https://orcid.org/0000-0003-0653-1366"]},"institutions":[{"id":"https://openalex.org/I4210153078","display_name":"Command Hospital Air Force","ror":"https://ror.org/05cx69s52","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801959050","https://openalex.org/I4210153078"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vijoy Kumar Jha","raw_affiliation_strings":["Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210153078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114171131","display_name":"Ramanjit Singh Akal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153078","display_name":"Command Hospital Air Force","ror":"https://ror.org/05cx69s52","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801959050","https://openalex.org/I4210153078"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramanjit Singh Akal","raw_affiliation_strings":["Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210153078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040338530","display_name":"Debasish Kar Mahapatra","orcid":"https://orcid.org/0000-0001-7281-5610","observed_orcids":["https://orcid.org/0000-0001-7281-5610"]},"institutions":[{"id":"https://openalex.org/I4210153078","display_name":"Command Hospital Air Force","ror":"https://ror.org/05cx69s52","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801959050","https://openalex.org/I4210153078"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debasish Mahapatra","raw_affiliation_strings":["Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India","institution_ids":["https://openalex.org/I4210153078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621625","display_name":"Alok Kumar Sharma","orcid":"https://orcid.org/0000-0002-6645-3227","observed_orcids":["https://orcid.org/0000-0002-6645-3227","https://orcid.org/0000-0002-3349-3580"]},"institutions":[{"id":"https://openalex.org/I4405259595","display_name":"Dr. Lal PathLabs Pvt Ltd (India)","ror":"https://ror.org/02ewfsf84","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4405259595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Alok Sharma","raw_affiliation_strings":["Department of Renal Pathology and Electron Microscopy, Lal PathLabs Limited, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Renal Pathology and Electron Microscopy, Lal PathLabs Limited, New Delhi, India","institution_ids":["https://openalex.org/I4405259595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114140957","display_name":"Bhanu Pratap Singh","orcid":"https://orcid.org/0000-0001-5346-4309","observed_orcids":["https://orcid.org/0000-0001-5346-4309"]},"institutions":[{"id":"https://openalex.org/I4210153078","display_name":"Command Hospital Air Force","ror":"https://ror.org/05cx69s52","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801959050","https://openalex.org/I4210153078"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhanu Pratap Singh","raw_affiliation_strings":["Department of Radiology, Command Hospital Air Force, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Command Hospital Air Force, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I4210153078"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114178223","display_name":"Rahil Arora","orcid":"https://orcid.org/0009-0003-0972-7695","observed_orcids":["https://orcid.org/0009-0003-0972-7695"]},"institutions":[{"id":"https://openalex.org/I4210153078","display_name":"Command Hospital Air Force","ror":"https://ror.org/05cx69s52","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801959050","https://openalex.org/I4210153078"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rahil Arora","raw_affiliation_strings":["Department of Medicine, Command Hospital Air Force, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Command Hospital Air Force, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I4210153078"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009897763"],"corresponding_institution_ids":["https://openalex.org/I4210153078"],"apc_list":null,"apc_paid":null,"fwci":0.201,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.38843837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"34","issue":"1","first_page":"74","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.9120000004768372},{"id":"https://openalex.org/keywords/posterior-reversible-encephalopathy-syndrome","display_name":"posterior reversible encephalopathy syndrome","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7369999885559082},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/drug-induced-thrombotic-microangiopathy","display_name":"drug-induced thrombotic microangiopathy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9440000057220459},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.7279999852180481},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.7509999871253967},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.6959760785102844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6862047910690308},{"id":"https://openalex.org/C2777605182","wikidata":"https://www.wikidata.org/wiki/Q7234232","display_name":"Posterior reversible encephalopathy syndrome","level":3,"score":0.6747040748596191},{"id":"https://openalex.org/C2779703115","wikidata":"https://www.wikidata.org/wiki/Q539702","display_name":"Angiopathy","level":3,"score":0.6272637844085693},{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.5116977691650391},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4901745915412903},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.4406808018684387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4083002805709839},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.18902340531349182},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.13862183690071106},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12093114852905273},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07779386639595032},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07167431712150574},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06748640537261963},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4103/ijn.ijn_277_22","doi":"https://doi.org/10.4103/ijn.ijn_277_22","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijn.ijn_277_22","pdf_url":null,"source":{"id":"https://openalex.org/S65200941","display_name":"Indian Journal of Nephrology","issn_l":"0971-4065","issn":["0971-4065","1998-3662"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Nephrology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11003583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11003583","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11003583/pdf/IJN-34-074.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Nephrol","raw_type":"Text"},{"id":"pmid:38645915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38645915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of nephrology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.4103/ijn.ijn_277_22","doi":"https://doi.org/10.4103/ijn.ijn_277_22","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijn.ijn_277_22","pdf_url":null,"source":{"id":"https://openalex.org/S65200941","display_name":"Indian Journal of Nephrology","issn_l":"0971-4065","issn":["0971-4065","1998-3662"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Nephrology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393324769.pdf","grobid_xml":"https://content.openalex.org/works/W4393324769.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W145338079","https://openalex.org/W1967291435","https://openalex.org/W1987521792","https://openalex.org/W2013742546","https://openalex.org/W2027158730","https://openalex.org/W2040863616","https://openalex.org/W2136162480","https://openalex.org/W2156195447","https://openalex.org/W2169476427","https://openalex.org/W2782984432","https://openalex.org/W2804399406","https://openalex.org/W3105697630"],"related_works":["https://openalex.org/W2804399406","https://openalex.org/W1865838601","https://openalex.org/W4397048457","https://openalex.org/W4396996239","https://openalex.org/W4400117031","https://openalex.org/W2900248754","https://openalex.org/W2790217140","https://openalex.org/W4293168426","https://openalex.org/W4226136158","https://openalex.org/W4415440641"],"abstract_inverted_index":{"Gemcitabine-induced":[0],"thrombotic":[1,36],"micro-angiopathy":[2,37],"(GiTMA)":[3],"is":[4,89],"a":[5,13,22],"very":[6],"rare":[7],"pathology":[8],"of":[9,59,67,77,83],"micro-vascular":[10],"occlusion":[11],"with":[12,25,43,57,74],"poor":[14],"prognosis.":[15],"In":[16],"this":[17],"case":[18,53],"report,":[19],"we":[20],"present":[21],"young":[23],"male":[24],"pancreatic":[26],"carcinoma":[27],"who":[28],"received":[29],"gemcitabine":[30],"as":[31,40],"adjuvant":[32],"chemotherapy":[33],"and":[34,46,62,86],"developed":[35],"(TMA)":[38],"manifesting":[39],"nephrotic":[41],"syndrome":[42,50],"renal":[44],"dysfunction":[45,73],"posterior":[47],"reversible":[48],"encephalopathy":[49],"(PRES).":[51],"The":[52,65,81],"was":[54],"successfully":[55],"managed":[56],"discontinuation":[58],"the":[60,78],"drug":[61],"conservative":[63],"management.":[64],"pathogenesis":[66],"GiTMA":[68],"might":[69],"be":[70],"direct":[71],"endothelial":[72],"consequent":[75],"activation":[76],"clotting":[79],"system.":[80],"role":[82],"plasma":[84],"exchanges":[85],"monoclonal":[87],"antibodies":[88],"unclear":[90],"in":[91],"drug-induced":[92],"TMA.":[93]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-30T00:00:00"}