{"id":"https://openalex.org/W4393317331","doi":"https://doi.org/10.3390/cancers16071344","title":"The Therapeutic Efficacy and Mechanism of Action of Gnetin C, a Natural Compound from the Melinjo Plant, in a Preclinical Mouse Model of Advanced Prostate Cancer","display_name":"The Therapeutic Efficacy and Mechanism of Action of Gnetin C, a Natural Compound from the Melinjo Plant, in a Preclinical Mouse Model of Advanced Prostate Cancer","publication_year":2024,"publication_date":"2024-03-29","ids":{"openalex":"https://openalex.org/W4393317331","doi":"https://doi.org/10.3390/cancers16071344","pmid":"https://pubmed.ncbi.nlm.nih.gov/38611022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11010822"},"language":"en","primary_location":{"id":"doi:10.3390/cancers16071344","doi":"https://doi.org/10.3390/cancers16071344","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16071344","pdf_url":"https://www.mdpi.com/2072-6694/16/7/1344/pdf?version=1711704802","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/16/7/1344/pdf?version=1711704802","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030374396","display_name":"Gisella Campanelli","orcid":"https://orcid.org/0000-0003-3946-0066","observed_orcids":["https://orcid.org/0000-0003-3946-0066"]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gisella Campanelli","raw_affiliation_strings":["Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104535140","display_name":"Ekniel Francois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekniel Francois","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021591040","display_name":"Prashanth Reddy Parupathi","orcid":"https://orcid.org/0000-0002-5749-1790","observed_orcids":["https://orcid.org/0000-0002-5749-1790"]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashanth Parupathi","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA"],"raw_orcid":"https://orcid.org/0000-0002-5749-1790","affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042652761","display_name":"Lakshmi Sirisha Devarakonda","orcid":"https://orcid.org/0009-0008-5880-4534","observed_orcids":["https://orcid.org/0009-0008-5880-4534"]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakshmi Sirisha Devarakonda","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044753294","display_name":"Ching Wen Yang","orcid":"https://orcid.org/0000-0002-5497-8616","observed_orcids":["https://orcid.org/0000-0002-5497-8616"]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching Yang","raw_affiliation_strings":["Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA"],"raw_orcid":"https://orcid.org/0000-0002-5497-8616","affiliations":[{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404273","display_name":"Avinash Kumar","orcid":"https://orcid.org/0000-0001-8132-5939","observed_orcids":["https://orcid.org/0000-0001-8132-5939"]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Avinash Kumar","raw_affiliation_strings":["Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA"],"raw_orcid":"https://orcid.org/0000-0001-8132-5939","affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016571184","display_name":"Anait S. Levenson","orcid":"https://orcid.org/0000-0003-0646-2575","observed_orcids":["https://orcid.org/0000-0003-0646-2575"]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anait S. Levenson","raw_affiliation_strings":["Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA","institution_ids":["https://openalex.org/I138873065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016571184","https://openalex.org/A5100404273"],"corresponding_institution_ids":["https://openalex.org/I138873065"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":2.6128,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.9018759,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"7","first_page":"1344","last_page":"1344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.30000001192092896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melinjo","display_name":"melinjo","score":0.781000018119812},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/stilbenes","display_name":"stilbenes","score":0.8519999980926514},{"id":"https://openalex.org/keywords/plant-derived-anticancer-agents","display_name":"plant-derived anticancer agents","score":0.7260000109672546},{"id":"https://openalex.org/keywords/pc-3m-cells","display_name":"PC-3M cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ribosomal-protein-s6-kinase","display_name":"S6K","score":0.7940000295639038},{"id":"https://openalex.org/keywords/4e-bp1","display_name":"4E-BP1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7920864820480347},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7469275593757629},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.7109687924385071},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7105273008346558},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6251505017280579},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.6018573045730591},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4382495880126953},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4374120831489563},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3974063992500305},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37267154455184937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36450690031051636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36004242300987244},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21251854300498962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18884479999542236}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers16071344","doi":"https://doi.org/10.3390/cancers16071344","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16071344","pdf_url":"https://www.mdpi.com/2072-6694/16/7/1344/pdf?version=1711704802","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11010822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11010822","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11010822/pdf/cancers-16-01344.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:38611022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38611022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers16071344","doi":"https://doi.org/10.3390/cancers16071344","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers16071344","pdf_url":"https://www.mdpi.com/2072-6694/16/7/1344/pdf?version=1711704802","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6778524300","display_name":"MTA1- targeted strategies for prostate cancer management","funder_award_id":"R15CA216070","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393317331.pdf","grobid_xml":"https://content.openalex.org/works/W4393317331.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1980854517","https://openalex.org/W2008205044","https://openalex.org/W2008473350","https://openalex.org/W2055100889","https://openalex.org/W2087401773","https://openalex.org/W2090583090","https://openalex.org/W2093990255","https://openalex.org/W2109706412","https://openalex.org/W2114704791","https://openalex.org/W2118681564","https://openalex.org/W2120018526","https://openalex.org/W2121640179","https://openalex.org/W2123290749","https://openalex.org/W2127757047","https://openalex.org/W2129585918","https://openalex.org/W2130739077","https://openalex.org/W2152848438","https://openalex.org/W2157997047","https://openalex.org/W2158626602","https://openalex.org/W2161299239","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2290466312","https://openalex.org/W2294848008","https://openalex.org/W2319666950","https://openalex.org/W2341850709","https://openalex.org/W2608221087","https://openalex.org/W2939068656","https://openalex.org/W2946578289","https://openalex.org/W2951571214","https://openalex.org/W2954917865","https://openalex.org/W2971967007","https://openalex.org/W2995204555","https://openalex.org/W3007398141","https://openalex.org/W3023823430","https://openalex.org/W3037348089","https://openalex.org/W3084918145","https://openalex.org/W3107283506","https://openalex.org/W3186377737","https://openalex.org/W3205753537","https://openalex.org/W4205244908","https://openalex.org/W4236438320","https://openalex.org/W4255757691","https://openalex.org/W4281823708","https://openalex.org/W4294583800","https://openalex.org/W4311858752","https://openalex.org/W4315754639","https://openalex.org/W4365513375","https://openalex.org/W4387804137"],"related_works":["https://openalex.org/W2971967007","https://openalex.org/W4416980084","https://openalex.org/W3107283506","https://openalex.org/W7029004321","https://openalex.org/W4311858752","https://openalex.org/W2810247413","https://openalex.org/W4282940717","https://openalex.org/W4387804137","https://openalex.org/W3179733801","https://openalex.org/W2054397228"],"abstract_inverted_index":{"The":[0],"metastasis-associated":[1],"protein":[2,175,186],"1/protein":[3],"kinase":[4,177],"B":[5],"(MTA1/AKT)":[6],"signaling":[7,162],"pathway":[8,220],"has":[9],"been":[10],"shown":[11,28],"to":[12,149,216],"cooperate":[13],"in":[14,71,89,94,140,147,153,164,222],"promoting":[15],"prostate":[16,33,63,73,144,154,165,205],"tumor":[17],"growth.":[18],"Targeted":[19],"interception":[20],"strategies":[21],"by":[22,84],"plant-based":[23],"polyphenols,":[24],"specifically":[25],"stilbenes,":[26],"have":[27],"great":[29],"promise":[30],"against":[31,203],"MTA1-mediated":[32],"cancer":[34,64],"progression.":[35],"In":[36,105],"this":[37],"study,":[38],"we":[39],"employed":[40],"a":[41,109,196,213],"prostate-specific":[42],"transgenic":[43],"mouse":[44],"model":[45],"with":[46,128,142,200,207],"MTA1":[47,77,83,151],"overexpression":[48],"on":[49],"the":[50,76,95,168,223],"background":[51],"of":[52,82,98,101,113,125,170],"phosphatase":[53],"and":[54,61,135,137,179,211],"tensin":[55],"homolog":[56],"(Pten)":[57],"null":[58],"(R26MTA1;":[59],"Ptenf/f)":[60],"PC3M":[62,91],"cells":[65,92],"which":[66],"recapitulate":[67],"altered":[68],"molecular":[69],"pathways":[70],"advanced":[72,143],"cancer.":[74,145],"Mechanistically,":[75],"knockdown":[78],"or":[79],"pharmacological":[80],"inhibition":[81],"gnetin":[85,114,129,157,193],"C":[86,115,130,158,194],"(dimer":[87],"resveratrol)":[88],"cultured":[90],"resulted":[93],"marked":[96],"inactivation":[97],"mammalian":[99],"target":[100],"rapamycin":[102],"(mTOR)":[103],"signaling.":[104],"vivo,":[106],"mice":[107,141],"tolerated":[108],"daily":[110],"intraperitoneal":[111],"treatment":[112],"(7":[116],"mg/kg":[117],"bw)":[118],"for":[119],"12":[120],"weeks":[121],"without":[122],"any":[123],"sign":[124],"toxicity.":[126],"Treatment":[127],"markedly":[131],"reduced":[132,160],"cell":[133],"proliferation":[134],"angiogenesis":[136],"promoted":[138],"apoptosis":[139],"Further,":[146],"addition":[148],"decreasing":[150],"levels":[152],"epithelial":[155],"cells,":[156],"significantly":[159],"mTOR":[161,219],"activity":[163,169],"tissues,":[166],"including":[167],"mTOR-target":[171],"proteins:":[172],"p70":[173],"ribosomal":[174],"S6":[176],"(S6K)":[178],"eukaryotic":[180],"translational":[181],"initiation":[182],"factor":[183],"4E":[184],"(elF4E)-binding":[185],"1":[187],"(4EBP1).":[188],"Collectively,":[189],"these":[190],"findings":[191],"established":[192],"as":[195,209,212],"new":[197],"natural":[198],"compound":[199],"anticancer":[201],"properties":[202],"MTA1/AKT/mTOR-activated":[204],"cancer,":[206],"potential":[208],"monotherapy":[210],"possible":[214],"adjunct":[215],"clinically":[217],"approved":[218],"inhibitors":[221],"future.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-03-30T00:00:00"}
