{"id":"https://openalex.org/W4393254151","doi":null,"title":"Treatment of Colon Cancer by Degradable rrPPC Nano-Conjugates Delivered STAT3 siRNA","display_name":"Treatment of Colon Cancer by Degradable rrPPC Nano-Conjugates Delivered STAT3 siRNA","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W4393254151"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:9e3848211ad6468aad4d8c0fa4b36330","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9e3848211ad6468aad4d8c0fa4b36330","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 15, Pp 9875-9890 (2020)","raw_type":"article"},"volume":null,"type":"article","indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/9e3848211ad6468aad4d8c0fa4b36330","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006447721","display_name":"Hong Zhang","orcid":"https://orcid.org/0000-0002-3930-6731","observed_orcids":["https://orcid.org/0000-0002-3930-6731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang H","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025256980","display_name":"Men K","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Men K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100731539","display_name":"Pan Chi","orcid":"https://orcid.org/0000-0002-0004-1174","observed_orcids":["https://orcid.org/0000-0002-0004-1174","https://orcid.org/0000-0003-4998-7769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pan C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028884087","display_name":"Yongfeng Gao","orcid":"https://orcid.org/0000-0001-6169-3478","observed_orcids":["https://orcid.org/0000-0001-6169-3478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gao Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454134","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-7163-8242","observed_orcids":["https://orcid.org/0000-0002-7163-8242","https://orcid.org/0009-0004-5182-4277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lei S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713942","display_name":"Guanghui Zhu","orcid":"https://orcid.org/0009-0005-2351-6055","observed_orcids":["https://orcid.org/0009-0005-2351-6055","https://orcid.org/0000-0003-1418-2768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhu G","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104155031","display_name":"Li R","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li R","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Y","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019924793","display_name":"Xiangfeng Duan","orcid":"https://orcid.org/0000-0002-4321-6288","observed_orcids":["https://orcid.org/0000-0002-4321-6288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duan X","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21334916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9380000233650208},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.6800000071525574},{"id":"https://openalex.org/keywords/sirna-nanocarriers","display_name":"siRNA nanocarriers","score":0.593999981880188},{"id":"https://openalex.org/keywords/crgd-peptide","display_name":"cRGD peptide","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5},{"id":"https://openalex.org/keywords/poly-ethylene-oxide","display_name":"poly(ethylene oxide)","score":0.7549999952316284},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.47999998927116394},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.46399998664855957},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.42899999022483826},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.4880000054836273},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.42399999499320984},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5734754800796509},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5020585060119629},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.4660922586917877},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.451323926448822},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44263532757759094},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4200066030025482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3462992310523987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3014441728591919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23628968000411987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1787985861301422},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15200409293174744},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13739526271820068},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.12782716751098633},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06803146004676819},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:9e3848211ad6468aad4d8c0fa4b36330","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9e3848211ad6468aad4d8c0fa4b36330","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 15, Pp 9875-9890 (2020)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:9e3848211ad6468aad4d8c0fa4b36330","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9e3848211ad6468aad4d8c0fa4b36330","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 15, Pp 9875-9890 (2020)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171998346","https://openalex.org/W3190281915","https://openalex.org/W4302082843","https://openalex.org/W1971601502","https://openalex.org/W3173864845","https://openalex.org/W2942479005","https://openalex.org/W2473033301","https://openalex.org/W1999324856","https://openalex.org/W2572030136","https://openalex.org/W4242751611"],"abstract_inverted_index":{"Hongjia":[0],"Zhang,1,*":[1],"Ke":[2,91],"Men,1,*":[3],"Congbin":[4],"Pan,1":[5],"Yan":[6],"Gao,1":[7],"Jingmei":[8],"Li,1":[9,15],"Sibei":[10],"Lei,1":[11],"Guonian":[12],"Zhu,1":[13],"Rui":[14],"Yuquan":[16],"Wei,1":[17],"Xingmei":[18],"Duan2":[19],"1State":[20],"Key":[21,63,135],"Laboratory":[22,64,94,136],"of":[23,37,45,48,52,65,69,72,77,83,95,109,116,120,124,137,141,144,149,155,165,199,279,312,339],"Biotherapy":[24,96],"and":[25,75,97,147,188,214,251,264,282,298,310],"Cancer":[26,98],"Center,":[27,99],"National":[28,100],"Clinical":[29,101],"Research":[30,102],"Center":[31,103],"for":[32,104,196,220,365],"Geriatrics,":[33,105],"West":[34,106],"China":[35,107],"Hospital":[36,108],"Sichuan":[38,41,50,56,66,110,122,128,138],"University,":[39,111],"Chengdu,":[40],"Province,":[42,67,139],"People\u2019s":[43,58,81,114,130,153],"Republic":[44,82,115,154],"China;":[46],"2Department":[47],"Pharmacy,":[49,121],"Academy":[51,123],"Medical":[53,125],"Sciences":[54,126],"&":[55,127],"Provincial":[57,129],"Hospital,":[59,131],"Personalized":[60,132],"Drug":[61,133],"Therapy":[62,134],"School":[68,140],"Medicine,":[70,142],"University":[71,143],"Electronic":[73,145],"Science":[74,146],"Technology":[76,148],"China,":[78,150],"Chengdu":[79,112,151],"610072,":[80,152],"China*These":[84],"authors":[85],"contributed":[86],"equally":[87],"to":[88,206,256,259],"this":[89,224],"workCorrespondence:":[90],"Men":[92],"StateKey":[93],"610041,":[113],"ChinaEmail":[117,156],"mendingbob@hotmail.comXingmei":[118],"DuanDepartment":[119],"duanxingmei2003@163.comBackground:":[157],"Drugs":[158],"that":[159,357],"work":[160],"based":[161,236],"on":[162,208,237],"the":[163,197,307],"mechanism":[164],"RNA":[166,185,371],"interference":[167],"have":[168],"shown":[169],"strong":[170,323],"potential":[171,362],"in":[172,182,273,285,326,350],"cancer":[173,221,296,329,368,376],"gene":[174,369],"therapy.":[175],"Although":[176],"significant":[177],"progress":[178],"has":[179],"been":[180],"made":[181],"small":[183],"interfering":[184],"(siRNA)":[186],"design":[187],"manufacturing,":[189],"ideal":[190,349],"delivery":[191,211,230],"system":[192,231],"remains":[193],"a":[194,226,361],"limitation":[195],"development":[198],"siRNA-based":[200,366],"drugs.":[201],"Particularly,":[202],"it":[203],"is":[204],"necessary":[205],"focus":[207],"parameters":[209],"including":[210,245],"efficiency,":[212],"stability,":[213],"safety":[215],"when":[216],"developing":[217],"siRNA":[218,229,292,319],"formulations":[219],"therapy.Methods:":[222],"In":[223,334],"work,":[225],"novel":[227],"degradable":[228],"cRGD-R9-PEG-PEI-Cholesterol":[232],"(rrPPC)":[233],"was":[234,269],"synthesized":[235,267],"low":[238],"molecular":[239],"weight":[240],"polyethyleneimine":[241],"(PEI).":[242],"Functional":[243],"groups":[244],"cholesterol,":[246],"cell":[247],"penetrating":[248],"peptides":[249],"(CPPs),":[250],"poly(ethylene":[252],"oxide)":[253],"were":[254],"introduced":[255],"PEI":[257],"backbone":[258],"attain":[260],"enhanced":[261],"transfection":[262],"efficiency":[263],"biocompatibility.Results:":[265],"The":[266],"rrPPC":[268,287,358],"dispersed":[270],"as":[271],"nanoparticles":[272,288,359],"water":[274],"with":[275,348],"an":[276],"average":[277],"size":[278],"195":[280],"nm":[281],"41.9":[283],"mV":[284],"potential.":[286],"could":[289],"efficiently":[290,342],"deliver":[291],"into":[293],"C26":[294],"clone":[295],"cells":[297],"trigger":[299],"caveolae-mediated":[300],"pathway":[301],"during":[302],"transmembrane":[303],"transportation.":[304],"By":[305],"loading":[306],"signal":[308],"transducer":[309],"activator":[311],"transcription":[313],"3":[314],"(STAT3)":[315],"targeting":[316],"siRNA,":[317],"rrPPC/STAT3":[318],"(rrPPC/siSTAT3)":[320],"complex":[321,341],"demonstrated":[322],"anti-cancer":[324],"effects":[325],"multiple":[327],"colon":[328,367,375],"models":[330],"following":[331],"local":[332],"delivery.":[333],"addition,":[335],"intravenous":[336],"(IV)":[337],"injection":[338],"rrPPC/siSTAT3":[340],"suppressed":[343],"lung":[344],"metastasis":[345],"tumor":[346],"progression":[347],"vivo":[351],"safety.Conclusion:":[352],"Our":[353],"results":[354],"provide":[355],"evidence":[356],"constitute":[360],"candidate":[363],"vector":[364],"therapy.Keywords:":[370],"interfering,":[372],"nanoparticle,":[373],"STAT3,":[374]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-03-29T00:00:00"}