{"id":"https://openalex.org/W4393201033","doi":"https://doi.org/10.1158/2767-9764.c.7150591.v1","title":"Data from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment","display_name":"Data from Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment","publication_year":2024,"publication_date":"2024-03-26","ids":{"openalex":"https://openalex.org/W4393201033","doi":"https://doi.org/10.1158/2767-9764.c.7150591.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.c.7150591.v1","doi":"https://doi.org/10.1158/2767-9764.c.7150591.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7150591.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.c.7150591.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021340539","display_name":"Giorgia Maroni","orcid":"https://orcid.org/0000-0003-1866-5898","observed_orcids":["https://orcid.org/0000-0003-1866-5898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgia Maroni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1866-5898","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001656053","display_name":"Indira Krishnan","orcid":"https://orcid.org/0000-0003-4939-0866","observed_orcids":["https://orcid.org/0000-0003-4939-0866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Indira Krishnan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4939-0866","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067017743","display_name":"Roberta R. Alfieri","orcid":"https://orcid.org/0000-0001-6922-9696","observed_orcids":["https://orcid.org/0000-0001-6922-9696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta Alfieri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6922-9696","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053066961","display_name":"Valerie A. Maymi","orcid":"https://orcid.org/0009-0006-2395-6701","observed_orcids":["https://orcid.org/0009-0006-2395-6701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerie A. Maymi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-2395-6701","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053125313","display_name":"Nicole Pandell","orcid":"https://orcid.org/0000-0003-1182-4315","observed_orcids":["https://orcid.org/0000-0003-1182-4315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Pandell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1182-4315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085873910","display_name":"Eva Csizmadia","orcid":"https://orcid.org/0000-0003-1996-0370","observed_orcids":["https://orcid.org/0000-0003-1996-0370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Csizmadia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1996-0370","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017657729","display_name":"Junyan Zhang","orcid":"https://orcid.org/0009-0009-6738-2326","observed_orcids":["https://orcid.org/0009-0009-6738-2326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junyan Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-6738-2326","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063440637","display_name":"Marla L. Weetall","orcid":"https://orcid.org/0000-0002-2013-8096","observed_orcids":["https://orcid.org/0000-0002-2013-8096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marla Weetall","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2013-8096","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108911809","display_name":"Art Branstrom","orcid":"https://orcid.org/0000-0002-5917-6372","observed_orcids":["https://orcid.org/0000-0002-5917-6372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Art Branstrom","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5917-6372","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025362090","display_name":"Giulia Braccini","orcid":"https://orcid.org/0000-0003-2765-3979","observed_orcids":["https://orcid.org/0000-0003-2765-3979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulia Braccini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2765-3979","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094249685","display_name":"Eva Cabrera San Mill\u00e1n","orcid":"https://orcid.org/0000-0002-3251-1791","observed_orcids":["https://orcid.org/0000-0002-3251-1791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Cabrera San Mill\u00e1n","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3251-1791","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075276042","display_name":"Barbara Storti","orcid":"https://orcid.org/0000-0002-2758-0426","observed_orcids":["https://orcid.org/0000-0002-2758-0426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Storti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2758-0426","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074666736","display_name":"Ranieri Bizzarri","orcid":"https://orcid.org/0000-0002-8222-2672","observed_orcids":["https://orcid.org/0000-0002-8222-2672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranieri Bizzarri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8222-2672","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073105949","display_name":"Olivier N. Kocher","orcid":"https://orcid.org/0009-0001-0686-9095","observed_orcids":["https://orcid.org/0009-0001-0686-9095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Kocher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-0686-9095","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074322188","display_name":"Daniela S. Daniela Sanchez Bass\u00e8res","orcid":"https://orcid.org/0000-0001-7745-3567","observed_orcids":["https://orcid.org/0000-0001-7745-3567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela S. Daniela Sanchez Bass\u00e8res","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7745-3567","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024947185","display_name":"Robert S. Welner","orcid":"https://orcid.org/0000-0003-2498-9469","observed_orcids":["https://orcid.org/0000-0003-2498-9469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert S. Welner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2498-9469","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015967583","display_name":"Maria Cristina Magli","orcid":"https://orcid.org/0000-0003-3840-6148","observed_orcids":["https://orcid.org/0000-0003-3840-6148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Cristina Magli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3840-6148","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026770450","display_name":"Ivan Merelli","orcid":"https://orcid.org/0000-0003-3587-3680","observed_orcids":["https://orcid.org/0000-0003-3587-3680"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Merelli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3587-3680","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045917883","display_name":"John G. Clohessy","orcid":"https://orcid.org/0000-0001-5186-9775","observed_orcids":["https://orcid.org/0000-0001-5186-9775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John G. Clohessy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5186-9775","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041787149","display_name":"Azhar Ali","orcid":"https://orcid.org/0000-0002-5895-9076","observed_orcids":["https://orcid.org/0000-0002-5895-9076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azhar Ali","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5895-9076","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056687452","display_name":"Daniel Geoffrey Tenen","orcid":"https://orcid.org/0000-0002-6423-3888","observed_orcids":["https://orcid.org/0000-0002-6423-3888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel G. Tenen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6423-3888","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028495282","display_name":"Elena Levantini","orcid":"https://orcid.org/0000-0003-4612-3105","observed_orcids":["https://orcid.org/0000-0003-4612-3105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Levantini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4612-3105","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bmi1","display_name":"BMI1","score":0.875},{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tumor-endothelial-cell-interaction","display_name":"tumor-endothelial cell interaction","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tumor-fibroblast-interaction","display_name":"tumor-fibroblast interaction","score":0.9829999804496765},{"id":"https://openalex.org/keywords/genetically-engineered-mouse-models","display_name":"genetically engineered mouse models","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6078841090202332},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.42235249280929565},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34103256464004517},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3348035216331482},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31825315952301025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25727349519729614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23325613141059875},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.201244056224823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06080228090286255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.056729674339294434}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.c.7150591.v1","doi":"https://doi.org/10.1158/2767-9764.c.7150591.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7150591.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.c.7150591.v1","doi":"https://doi.org/10.1158/2767-9764.c.7150591.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7150591.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393191333","https://openalex.org/W4393181684","https://openalex.org/W4393190764","https://openalex.org/W4393190672","https://openalex.org/W4393190645","https://openalex.org/W4210910593","https://openalex.org/W4281641667","https://openalex.org/W4415519941","https://openalex.org/W7220663811","https://openalex.org/W7145179304"],"abstract_inverted_index":{"Abstract":[0],"Lung":[1],"cancer":[2,8,27,178],"is":[3,93,148],"the":[4,19,31,43,49,56,129,135,146,166],"leading":[5],"cause":[6],"of":[7,25,30,45,51,137,154],"deaths.":[9],"Lethal":[10],"pulmonary":[11],"adenocarcinomas":[12],"(ADC)":[13],"present":[14],"with":[15,55,76,99,183],"frequent":[16],"mutations":[17],"in":[18,48],"EGFR.":[20],"Genetically":[21],"engineered":[22],"murine":[23,110],"models":[24],"lung":[26],"expedited":[28],"comprehension":[29],"molecular":[32],"mechanisms":[33],"driving":[34],"tumorigenesis":[35],"and":[36,82,92,180],"drug":[37],"response.":[38],"Here,":[39],"we":[40,158],"systematically":[41],"analyzed":[42],"evolution":[44],"tumor":[46,58,90,126],"heterogeneity":[47],"context":[50],"dynamic":[52],"interactions":[53,182],"occurring":[54],"intermingled":[57],"microenvironment":[59],"(TME)":[60],"by":[61,97,176],"high-resolution":[62],"transcriptomics.":[63],"Our":[64],"effort":[65],"identified":[66],"vulnerable":[67],"tumor-specific":[68],"epithelial":[69],"cells,":[70,80],"as":[71,73],"well":[72],"their":[74,181],"cross-talk":[75],"niche":[77],"components":[78],"(endothelial":[79],"fibroblasts,":[81],"tumor-infiltrating":[83],"immune":[84],"cells),":[85],"whose":[86],"symbiotic":[87],"interface":[88],"shapes":[89],"aggressiveness":[91],"almost":[94],"completely":[95],"abolished":[96],"treatment":[98,153],"Unesbulin,":[100],"a":[101],"tubulin":[102],"binding":[103],"agent":[104],"that":[105],"reduces":[106],"B":[107],"cell\u2013specific":[108],"Moloney":[109],"leukemia":[111],"virus":[112],"integration":[113],"site":[114],"1":[115],"(BMI-1)":[116],"activity.":[117],"Simultaneous":[118],"magnetic":[119],"resonance":[120],"imaging":[121],"(MRI)":[122],"analysis":[123],"demonstrated":[124],"decreased":[125],"growth,":[127],"setting":[128],"stage":[130],"for":[131,141,152,190],"future":[132,191],"investigations":[133],"into":[134],"potential":[136],"novel":[138,174],"therapeutic":[139,192],"strategies":[140],"EGFR-mutant":[142,161],"ADCs.":[143],"Significance:":[144],"Targeting":[145],"TME":[147,185],"an":[149],"attractive":[150],"strategy":[151],"solid":[155],"tumors.":[156],"Here":[157],"revealed":[159],"how":[160],"landscapes":[162],"are":[163],"affected":[164],"at":[165],"single-cell":[167],"resolution":[168],"level":[169],"during":[170],"Unesbulin":[171],"treatment.":[172],"This":[173],"drug,":[175],"targeting":[177],"cells":[179],"crucial":[184],"components,":[186],"could":[187],"be":[188],"envisioned":[189],"advancements.":[193]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-03-27T00:00:00"}