{"id":"https://openalex.org/W4393195508","doi":"https://doi.org/10.1016/j.antiviral.2024.105869","title":"Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals","display_name":"Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals","publication_year":2024,"publication_date":"2024-03-26","ids":{"openalex":"https://openalex.org/W4393195508","doi":"https://doi.org/10.1016/j.antiviral.2024.105869","pmid":"https://pubmed.ncbi.nlm.nih.gov/38548023"},"language":"en","primary_location":{"id":"doi:10.1016/j.antiviral.2024.105869","doi":"https://doi.org/10.1016/j.antiviral.2024.105869","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.antiviral.2024.105869","pdf_url":null,"source":{"id":"https://openalex.org/S137372404","display_name":"Antiviral Research","issn_l":"0166-3542","issn":["0166-3542","1872-9096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.antiviral.2024.105869","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085039745","display_name":"Jimena P\u00e9rez\u2010Vargas","orcid":"https://orcid.org/0000-0002-4337-7903","observed_orcids":["https://orcid.org/0000-0002-4337-7903"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jimena P\u00e9rez-Vargas","raw_affiliation_strings":["Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4337-7903","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074210029","display_name":"Gabriel Lemieux","orcid":"https://orcid.org/0000-0002-2313-5528","observed_orcids":["https://orcid.org/0000-0002-2313-5528"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I4405263170","display_name":"Institut de pharmacologie de Sherbrooke","ror":"https://ror.org/03hh81985","country_code":"CA","type":"facility","lineage":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gabriel Lemieux","raw_affiliation_strings":["Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2313-5528","affiliations":[{"raw_affiliation_string":"Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039394543","display_name":"Connor A.H. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Connor A.H. Thompson","raw_affiliation_strings":["Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033656891","display_name":"Antoine D\u00e9silets","orcid":"https://orcid.org/0000-0001-5081-5564","observed_orcids":["https://orcid.org/0000-0001-5081-5564"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I4405263170","display_name":"Institut de pharmacologie de Sherbrooke","ror":"https://ror.org/03hh81985","country_code":"CA","type":"facility","lineage":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Antoine D\u00e9silets","raw_affiliation_strings":["Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5081-5564","affiliations":[{"raw_affiliation_string":"Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040246965","display_name":"Siobhan Ennis","orcid":"https://orcid.org/0000-0002-0105-8269","observed_orcids":["https://orcid.org/0000-0002-0105-8269"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Siobhan Ennis","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0105-8269","affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101487586","display_name":"Guang Gao","orcid":"https://orcid.org/0000-0001-7523-2234","observed_orcids":["https://orcid.org/0000-0001-7523-2234"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Guang Gao","raw_affiliation_strings":["Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020481499","display_name":"Danielle G. Gordon","orcid":"https://orcid.org/0009-0006-4423-6551","observed_orcids":["https://orcid.org/0009-0006-4423-6551"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danielle G. Gordon","raw_affiliation_strings":["Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":"https://orcid.org/0009-0006-4423-6551","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026869101","display_name":"Annika Lea Schulz","orcid":"https://orcid.org/0009-0001-3986-2017","observed_orcids":["https://orcid.org/0009-0001-3986-2017"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Annika Lea Schulz","raw_affiliation_strings":["Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":"https://orcid.org/0009-0001-3986-2017","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089335621","display_name":"Masahiro Niikura","orcid":"https://orcid.org/0000-0001-6611-8616","observed_orcids":["https://orcid.org/0000-0001-6611-8616"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Masahiro Niikura","raw_affiliation_strings":["Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6611-8616","affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070476569","display_name":"Ivan R. Nabi","orcid":"https://orcid.org/0000-0002-0670-0513","observed_orcids":["https://orcid.org/0000-0002-0670-0513"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ivan Robert Nabi","raw_affiliation_strings":["Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0670-0513","affiliations":[{"raw_affiliation_string":"Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079171066","display_name":"Mel Krajden","orcid":"https://orcid.org/0000-0002-3477-8748","observed_orcids":["https://orcid.org/0000-0002-3477-8748"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2802940977","display_name":"BC Centre for Disease Control","ror":"https://ror.org/05jyzx602","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1308729876","https://openalex.org/I156965999","https://openalex.org/I2802940977"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mel Krajden","raw_affiliation_strings":["British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC, V5Z 4R4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada","British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC, V5Z 4R4, Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada"],"raw_orcid":"https://orcid.org/0000-0002-3477-8748","affiliations":[{"raw_affiliation_string":"British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC, V5Z 4R4, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2802940977"]},{"raw_affiliation_string":"British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, BC, V5Z 4R4, Canada","institution_ids":["https://openalex.org/I2802940977"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041729989","display_name":"Pierre\u2010Luc Boudreault","orcid":"https://orcid.org/0000-0002-2032-7970","observed_orcids":["https://orcid.org/0000-0002-2032-7970"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I4405263170","display_name":"Institut de pharmacologie de Sherbrooke","ror":"https://ror.org/03hh81985","country_code":"CA","type":"facility","lineage":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pierre-Luc Boudreault","raw_affiliation_strings":["Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2032-7970","affiliations":[{"raw_affiliation_string":"Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075307650","display_name":"Richard Leduc","orcid":"https://orcid.org/0000-0001-6854-8003","observed_orcids":["https://orcid.org/0000-0001-6854-8003"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I4405263170","display_name":"Institut de pharmacologie de Sherbrooke","ror":"https://ror.org/03hh81985","country_code":"CA","type":"facility","lineage":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Richard Leduc","raw_affiliation_strings":["Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada. Electronic address: richard.leduc@usherbrooke.ca","Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada. Electronic address: richard.leduc@usherbrooke.ca","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]},{"raw_affiliation_string":"Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I135117807","https://openalex.org/I4405263170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053489966","display_name":"Fran\u00e7ois Jean","orcid":"https://orcid.org/0000-0002-6148-7460","observed_orcids":["https://orcid.org/0000-0002-6148-7460"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois Jean","raw_affiliation_strings":["Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address: fjean@mail.ubc.ca","Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6148-7460","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address: fjean@mail.ubc.ca","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5053489966","https://openalex.org/A5075307650"],"corresponding_institution_ids":["https://openalex.org/I135117807","https://openalex.org/I141945490","https://openalex.org/I4405263170"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":{"value":4040,"currency":"USD","value_usd":4040},"fwci":4.3143,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.95314683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"225","issue":null,"first_page":"105869","last_page":"105869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2-omicron-subvariants","display_name":"SARS-CoV-2 Omicron subvariants","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tmprss2","display_name":"TMPRSS2","score":0.7900000214576721},{"id":"https://openalex.org/keywords/camostat","display_name":"camostat","score":0.8159999847412109},{"id":"https://openalex.org/keywords/host-targeted-antiviral-therapy","display_name":"host-directed antiviral therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/virus-entry-inhibition","display_name":"viral entry inhibition","score":0.7839999794960022},{"id":"https://openalex.org/keywords/spike-protein-cleavage","display_name":"spike protein cleavage","score":0.8849999904632568},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8679999709129333},{"id":"https://openalex.org/keywords/remdesivir","display_name":"remdesivir","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nirmatrelvir","display_name":"nirmatrelvir","score":1.0},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ba-2-86","display_name":"BA.2.86","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bq-1-1","display_name":"BQ.1.1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/xbb-1-5","display_name":"XBB.1.5","score":0.9700000286102295},{"id":"https://openalex.org/keywords/eg-5-1","display_name":"EG.5.1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/calu-3-cells","display_name":"Calu-3 cells","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5356582999229431},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4873984456062317},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4646757245063782},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.45416221022605896},{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.449226051568985},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.42647042870521545},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.41013413667678833},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4001849591732025},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.35679590702056885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33188754320144653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20963111519813538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1323419213294983},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1034688651561737},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.053518980741500854},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0493239164352417},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.antiviral.2024.105869","doi":"https://doi.org/10.1016/j.antiviral.2024.105869","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.antiviral.2024.105869","pdf_url":null,"source":{"id":"https://openalex.org/S137372404","display_name":"Antiviral Research","issn_l":"0166-3542","issn":["0166-3542","1872-9096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Research","raw_type":"journal-article"},{"id":"pmid:38548023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38548023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05785152v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05785152","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antiviral Research, 2024, 225, pp.105869. &#x27E8;10.1016/j.antiviral.2024.105869&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.antiviral.2024.105869","doi":"https://doi.org/10.1016/j.antiviral.2024.105869","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.antiviral.2024.105869","pdf_url":null,"source":{"id":"https://openalex.org/S137372404","display_name":"Antiviral Research","issn_l":"0166-3542","issn":["0166-3542","1872-9096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3010065375","display_name":null,"funder_award_id":"GTX635679","funder_id":"https://openalex.org/F5947618042","funder_display_name":"GeneTex"},{"id":"https://openalex.org/G3838759754","display_name":null,"funder_award_id":"175622","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G7095799796","display_name":null,"funder_award_id":"HL344","funder_id":"https://openalex.org/F5947618042","funder_display_name":"GeneTex"},{"id":"https://openalex.org/G8942571263","display_name":"Pre-clinical development of broad-spectrum antiviral strategies against human respiratory viruses of pandemic concern","funder_award_id":"183813_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320323180","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F5947618042","display_name":"GeneTex","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W2002581355","https://openalex.org/W2020172485","https://openalex.org/W2150269543","https://openalex.org/W2971662549","https://openalex.org/W3009912996","https://openalex.org/W3013093478","https://openalex.org/W3017302293","https://openalex.org/W3020828664","https://openalex.org/W3022916237","https://openalex.org/W3024562929","https://openalex.org/W3027630905","https://openalex.org/W3035265089","https://openalex.org/W3044321933","https://openalex.org/W3048571801","https://openalex.org/W3110320917","https://openalex.org/W3111255098","https://openalex.org/W3137188303","https://openalex.org/W3154875420","https://openalex.org/W3173514762","https://openalex.org/W3175341024","https://openalex.org/W3180301457","https://openalex.org/W3187717873","https://openalex.org/W3189646261","https://openalex.org/W3201551509","https://openalex.org/W3201643297","https://openalex.org/W3202714244","https://openalex.org/W3205193484","https://openalex.org/W3215519285","https://openalex.org/W3216478751","https://openalex.org/W4200028684","https://openalex.org/W4200129278","https://openalex.org/W4200137031","https://openalex.org/W4200625712","https://openalex.org/W4206907302","https://openalex.org/W4210665241","https://openalex.org/W4220707716","https://openalex.org/W4221018380","https://openalex.org/W4226163566","https://openalex.org/W4280583684","https://openalex.org/W4284989724","https://openalex.org/W4285498541","https://openalex.org/W4289528710","https://openalex.org/W4292682196","https://openalex.org/W4293577332","https://openalex.org/W4306290643","https://openalex.org/W4308683905","https://openalex.org/W4311089805","https://openalex.org/W4313555740","https://openalex.org/W4315435781","https://openalex.org/W4317212025","https://openalex.org/W4320495180","https://openalex.org/W4320496953","https://openalex.org/W4321611793","https://openalex.org/W4321765768","https://openalex.org/W4376277283","https://openalex.org/W4385684131","https://openalex.org/W4385684825","https://openalex.org/W4387849815","https://openalex.org/W4394598449","https://openalex.org/W6807940930","https://openalex.org/W6848776366","https://openalex.org/W6861752873"],"related_works":["https://openalex.org/W4210665241","https://openalex.org/W4221018380","https://openalex.org/W7017182004","https://openalex.org/W3159970546","https://openalex.org/W6957990425","https://openalex.org/W4416673807","https://openalex.org/W4382753519","https://openalex.org/W4213344224","https://openalex.org/W4205193219","https://openalex.org/W4366496918"],"abstract_inverted_index":{"SARS-CoV-2":[0],"Omicron":[1,23,56,80,90,96,104,121,146,160,214],"subvariants":[2,24,57,91,97,161],"with":[3,12,203],"increased":[4],"transmissibility":[5],"and":[6,18,50,101,167,192,211,228],"immune":[7],"evasion":[8],"are":[9],"spreading":[10],"globally":[11],"alarming":[13],"persistence.":[14],"Whether":[15],"the":[16,26,47,60,79,114,142,184,217],"mutations":[17,53],"evolution":[19],"of":[20,29,46,52,54,62,74,119,138,145,221],"spike":[21,120],"(S)":[22],"alter":[25],"viral":[27,33,75],"hijacking":[28],"human":[30,68,85,163],"TMPRSS2":[31,69,118,131,186],"for":[32,77],"entry":[34,76,136],"remains":[35],"to":[36,43,112],"be":[37],"elucidated.":[38],"This":[39],"is":[40,70,133,178],"particularly":[41],"important":[42],"investigate":[44],"because":[45],"large":[48],"number":[49],"diversity":[51],"S":[55,143],"reported":[58],"since":[59],"emergence":[61],"BA.1.":[63],"Here":[64],"we":[65,107,124,149,174],"report":[66],"that":[67,126,151,176,197],"a":[71,109,128,134,222],"molecular":[72],"determinant":[73],"all":[78],"clinical":[81],"isolates":[82],"tested":[83],"in":[84,162],"lung":[86,165],"cells,":[87],"including":[88],"ancestral":[89],"(BA.1,":[92],"BA.2,":[93],"BA.5),":[94],"contemporary":[95],"(BQ.1.1,":[98],"XBB.1.5,":[99],"EG.5.1)":[100],"currently":[102],"circulating":[103],"BA.2.86.":[105,193],"First,":[106],"used":[108],"co-transfection":[110],"assay":[111],"demonstrate":[113],"endoproteolytic":[115],"cleavage":[116],"by":[117],"subvariants.":[122,147],"Second,":[123],"found":[125,175,196],"N-0385,":[127],"highly":[129],"potent":[130,182],"inhibitor,":[132,187],"robust":[135],"inhibitor":[137],"virus-like":[139],"particles":[140],"harbouring":[141],"protein":[144],"Third,":[148],"show":[150],"N-0385":[152,177,198,227],"exhibits":[153],"nanomolar":[154],"broad-spectrum":[155],"antiviral":[156],"activity":[157,202],"against":[158,189,213],"live":[159],"Calu-3":[164],"cells":[166],"primary":[168],"patient-derived":[169],"bronchial":[170],"epithelial":[171],"cells.":[172],"Interestingly,":[173],"10-20":[179],"times":[180],"more":[181],"than":[183],"repositioned":[185],"camostat,":[188],"BA.5,":[190],"EG.5.1,":[191],"We":[194],"further":[195],"shows":[199],"broad":[200],"synergistic":[201],"clinically":[204],"approved":[205],"direct-acting":[206],"antivirals":[207],"(DAAs),":[208],"i.e.,":[209],"remdesivir":[210],"nirmatrelvir,":[212],"subvariants,":[215],"demonstrating":[216],"potential":[218],"therapeutic":[219],"benefits":[220],"multi-targeted":[223],"treatment":[224],"based":[225],"on":[226],"DAAs.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-03-27T00:00:00"}
