{"id":"https://openalex.org/W4393139864","doi":"https://doi.org/10.1038/s41467-024-46953-x","title":"SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration","display_name":"SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration","publication_year":2024,"publication_date":"2024-03-25","ids":{"openalex":"https://openalex.org/W4393139864","doi":"https://doi.org/10.1038/s41467-024-46953-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/37066393","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10103985"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-46953-x","doi":"https://doi.org/10.1038/s41467-024-46953-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46953-x","pdf_url":"https://www.nature.com/articles/s41467-024-46953-x.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-46953-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003863265","display_name":"Jakob Hartmann","orcid":"https://orcid.org/0000-0002-1960-8177","observed_orcids":["https://orcid.org/0000-0002-1960-8177"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jakob Hartmann","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA. jhartmann@mclean.harvard.edu","Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":"https://orcid.org/0000-0002-1960-8177","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA. jhartmann@mclean.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023182072","display_name":"Thomas Bajaj","orcid":"https://orcid.org/0000-0001-6153-6608","observed_orcids":["https://orcid.org/0000-0001-6153-6608"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Bajaj","raw_affiliation_strings":["Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091517554","display_name":"Joy Otten","orcid":"https://orcid.org/0000-0003-4913-8230","observed_orcids":["https://orcid.org/0000-0003-4913-8230"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Joy Otten","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, 37075, G\u00f6ttingen, Germany","Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, 37075, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055068291","display_name":"Claudia Klengel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Klengel","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043500879","display_name":"Tim Ebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Ebert","raw_affiliation_strings":["Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059321249","display_name":"Anne\u2010Kathrin Gellner","orcid":"https://orcid.org/0000-0001-6920-1933","observed_orcids":["https://orcid.org/0000-0001-6920-1933"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne-Kathrin Gellner","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054778163","display_name":"Ellen Junglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ellen Junglas","raw_affiliation_strings":["Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109602462","display_name":"Kathrin Hafner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Hafner","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077579758","display_name":"Elmira A. Anderzhanova","orcid":"https://orcid.org/0000-0002-6441-4363","observed_orcids":["https://orcid.org/0000-0002-6441-4363"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elmira A. Anderzhanova","raw_affiliation_strings":["Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055217006","display_name":"Fiona Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Fiona Tang","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059266368","display_name":"Galen Missig","orcid":"https://orcid.org/0000-0001-9026-9342","observed_orcids":["https://orcid.org/0000-0001-9026-9342"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galen Missig","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004136346","display_name":"Lindsay Rexrode","orcid":"https://orcid.org/0000-0002-2689-8854","observed_orcids":["https://orcid.org/0000-0002-2689-8854"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay Rexrode","raw_affiliation_strings":["Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094235838","display_name":"Daniel T. Trussell","orcid":"https://orcid.org/0009-0006-8547-3828","observed_orcids":["https://orcid.org/0009-0006-8547-3828"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel T. Trussell","raw_affiliation_strings":["Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA"],"raw_orcid":"https://orcid.org/0009-0006-8547-3828","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036635113","display_name":"Katelyn X. Li","orcid":"https://orcid.org/0000-0001-8799-0534","observed_orcids":["https://orcid.org/0000-0001-8799-0534"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn X. Li","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042815463","display_name":"Max L. P\u00f6hlmann","orcid":"https://orcid.org/0000-0003-2230-2846","observed_orcids":["https://orcid.org/0000-0003-2230-2846"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Max L. P\u00f6hlmann","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021558891","display_name":"Sarah Mackert","orcid":"https://orcid.org/0000-0001-5074-4874","observed_orcids":["https://orcid.org/0000-0001-5074-4874"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah Mackert","raw_affiliation_strings":["Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5074-4874","affiliations":[{"raw_affiliation_string":"Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010621339","display_name":"Thomas M. Geiger","orcid":"https://orcid.org/0000-0002-6278-3990","observed_orcids":["https://orcid.org/0000-0002-6278-3990"]},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas M. Geiger","raw_affiliation_strings":["Institute for Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073837547","display_name":"Daniel E. Heinz","orcid":"https://orcid.org/0000-0001-7103-9621","observed_orcids":["https://orcid.org/0000-0001-7103-9621"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel E. Heinz","raw_affiliation_strings":["Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7103-9621","affiliations":[{"raw_affiliation_string":"Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029262587","display_name":"Roy Lardenoije","orcid":"https://orcid.org/0000-0002-9026-7870","observed_orcids":["https://orcid.org/0000-0002-9026-7870"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Roy Lardenoije","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, 37075, G\u00f6ttingen, Germany","Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, 37075, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010290773","display_name":"Nina Dedic","orcid":"https://orcid.org/0009-0000-3769-725X","observed_orcids":["https://orcid.org/0009-0000-3769-725X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina Dedic","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078256339","display_name":"Kenneth M. McCullough","orcid":"https://orcid.org/0000-0003-4908-2302","observed_orcids":["https://orcid.org/0000-0003-4908-2302"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M. McCullough","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":"https://orcid.org/0000-0003-4908-2302","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047956219","display_name":"Tomasz Pr\u00f3chnicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tomasz Pr\u00f3chnicki","raw_affiliation_strings":["Institute of Innate Immunity, University Hospital Bonn, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Innate Immunity, University Hospital Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066544842","display_name":"Thomas Rhomberg","orcid":"https://orcid.org/0000-0002-4382-999X","observed_orcids":["https://orcid.org/0000-0002-4382-999X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Rhomberg","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":"https://orcid.org/0000-0002-4382-999X","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066419264","display_name":"Silvia Martinelli","orcid":"https://orcid.org/0000-0002-8784-2213","observed_orcids":["https://orcid.org/0000-0002-8784-2213"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia Martinelli","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8784-2213","affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030913508","display_name":"Antony Payton","orcid":"https://orcid.org/0000-0003-0335-152X","observed_orcids":["https://orcid.org/0000-0003-0335-152X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antony Payton","raw_affiliation_strings":["Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, M13 9PL, UK"],"raw_orcid":"https://orcid.org/0000-0003-0335-152X","affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, M13 9PL, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040415602","display_name":"Andrew Robinson","orcid":"https://orcid.org/0000-0003-2208-7728","observed_orcids":["https://orcid.org/0000-0003-2208-7728"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew C. Robinson","raw_affiliation_strings":["Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, M6 8HD, UK","Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre (MAHSC), Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0003-2208-7728","affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, M6 8HD, UK","institution_ids":["https://openalex.org/I28407311","https://openalex.org/I4210111611"]},{"raw_affiliation_string":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre (MAHSC), Manchester, UK","institution_ids":["https://openalex.org/I2799725268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086559537","display_name":"Valentin Stein","orcid":"https://orcid.org/0000-0003-1222-4928","observed_orcids":["https://orcid.org/0000-0003-1222-4928"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valentin Stein","raw_affiliation_strings":["Institute of Physiology II, University of Bonn, 53127, Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1222-4928","affiliations":[{"raw_affiliation_string":"Institute of Physiology II, University of Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009349672","display_name":"Eicke Latz","orcid":"https://orcid.org/0000-0003-1488-5666","observed_orcids":["https://orcid.org/0000-0003-1488-5666"]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eicke Latz","raw_affiliation_strings":["Deutsches Rheuma Forschungszentrum Berlin (DRFZ), 10117, Berlin, Germany","Institute of Innate Immunity, University Hospital Bonn, 53127, Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1488-5666","affiliations":[{"raw_affiliation_string":"Deutsches Rheuma Forschungszentrum Berlin (DRFZ), 10117, Berlin, Germany","institution_ids":["https://openalex.org/I4210095248"]},{"raw_affiliation_string":"Institute of Innate Immunity, University Hospital Bonn, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024383091","display_name":"William A. Carlezon","orcid":"https://orcid.org/0000-0002-4162-3947","observed_orcids":["https://orcid.org/0000-0002-4162-3947"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Carlezon","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060386448","display_name":"Felix Hausch","orcid":"https://orcid.org/0000-0002-3710-8838","observed_orcids":["https://orcid.org/0000-0002-3710-8838"]},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix Hausch","raw_affiliation_strings":["Institute for Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Organic Chemistry and Biochemistry, Technische Universit\u00e4t Darmstadt, 64287, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058281761","display_name":"Mathias V. Schmidt","orcid":"https://orcid.org/0000-0002-3788-2268","observed_orcids":["https://orcid.org/0000-0002-3788-2268"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias V. Schmidt","raw_affiliation_strings":["Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3788-2268","affiliations":[{"raw_affiliation_string":"Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030692004","display_name":"Chris Murgatroyd","orcid":"https://orcid.org/0000-0002-6885-7794","observed_orcids":["https://orcid.org/0000-0002-6885-7794"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Murgatroyd","raw_affiliation_strings":["Department of Life Sciences, Manchester Metropolitan University, Manchester, M15 6BH, UK"],"raw_orcid":"https://orcid.org/0000-0002-6885-7794","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Manchester Metropolitan University, Manchester, M15 6BH, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022556246","display_name":"Sabina Berretta","orcid":"https://orcid.org/0000-0002-4057-7766","observed_orcids":["https://orcid.org/0000-0002-4057-7766"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabina Berretta","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040412699","display_name":"Torsten Klengel","orcid":"https://orcid.org/0000-0001-7045-9229","observed_orcids":["https://orcid.org/0000-0001-7045-9229"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Torsten Klengel","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, 37075, G\u00f6ttingen, Germany","Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":"https://orcid.org/0000-0001-7045-9229","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, University Medical Center G\u00f6ttingen, 37075, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090063874","display_name":"Harry Pantazopoulos","orcid":"https://orcid.org/0000-0002-8905-8377","observed_orcids":["https://orcid.org/0000-0002-8905-8377"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry Pantazopoulos","raw_affiliation_strings":["Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073581575","display_name":"Kerry James Ressler","orcid":"https://orcid.org/0000-0002-5158-1103","observed_orcids":["https://orcid.org/0000-0002-5158-1103"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kerry J. Ressler","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA. kressler@mclean.harvard.edu","Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA"],"raw_orcid":"https://orcid.org/0000-0002-5158-1103","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA. kressler@mclean.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030860744","display_name":"Nils C. Gassen","orcid":"https://orcid.org/0000-0002-4265-3398","observed_orcids":["https://orcid.org/0000-0002-4265-3398"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Nils C. Gassen","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany. nils.gassen@ukbonn.de","Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany. nils.gassen@ukbonn.de","Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4265-3398","affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany. nils.gassen@ukbonn.de","institution_ids":["https://openalex.org/I4210145969"]},{"raw_affiliation_string":"Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, 53127, Bonn, Germany. nils.gassen@ukbonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5003863265","https://openalex.org/A5030860744","https://openalex.org/A5073581575"],"corresponding_institution_ids":["https://openalex.org/I135140700","https://openalex.org/I136199984","https://openalex.org/I2801148111","https://openalex.org/I4210145969"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":6790,"currency":"USD","value_usd":6790},"fwci":4.9636,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.9614128,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"2635","last_page":"2635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.2257000058889389,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-autophagy","display_name":"secretory autophagy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ska2","display_name":"SKA2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fkbp5","display_name":"FKBP5","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-1beta-secretion","display_name":"IL-1\u03b2 secretion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hippocampal-atrophy","display_name":"hippocampal atrophy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.9198882579803467},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8937264680862427},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5839171409606934},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5397570729255676},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.527661919593811},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5153221487998962},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.48310232162475586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48215267062187195},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.4807188808917999},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3658566474914551},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.339133083820343},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2851036489009857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25853800773620605},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14771035313606262},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09409430623054504},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":16,"locations":[{"id":"doi:10.1038/s41467-024-46953-x","doi":"https://doi.org/10.1038/s41467-024-46953-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46953-x","pdf_url":"https://www.nature.com/articles/s41467-024-46953-x.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.03.534570","doi":"https://doi.org/10.1101/2023.04.03.534570","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2023.04.03.534570","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10963788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10963788","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10963788/pdf/41467_2024_Article_46953.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37066393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37066393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:38528004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38528004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/1054fcf4-9c43-42fe-9b48-53c01dac58bc","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/1054fcf4-9c43-42fe-9b48-53c01dac58bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:156111","doi":null,"is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/view/person/Hartmann=3AJakob=3A=3A.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Artikel"},{"id":"pmh:oai:tuprints.ulb.tu-darmstadt.de:29224","doi":null,"is_oa":true,"landing_page_url":"https://tuprints.ulb.tu-darmstadt.de/29224/5/41467_2024_46953_MOESM4_ESM.xlsx","pdf_url":null,"source":{"id":"https://openalex.org/S4306401590","display_name":"Technischen Universit\u00e4t Darmstadt","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:e-space.mmu.ac.uk:634271","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-1960-8177","pdf_url":"https://e-space.mmu.ac.uk/634271/1/SKA2%20regulated%20hyperactive%20secretory%20autophagy%20drives%20neuroinflammation-induced%20neurodegeneration.pdf","source":{"id":"https://openalex.org/S4306401617","display_name":"e-space (Manchester Metropolitan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11983389","host_organization_name":"Manchester Metropolitan University","host_organization_lineage":["https://openalex.org/I11983389"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_3589851","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/21.11116/0000-000F-4CAC-B","pdf_url":"https://hdl.handle.net/21.11116/0000-0013-0CA2-7","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10103985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10103985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46953-x","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-46953-x","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:83209dbad20940cdab3e3f6f4104353f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/83209dbad20940cdab3e3f6f4104353f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)","raw_type":"article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/142529","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/142529","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:tuprints.ulb.tu-darmstadt.de:tuda/13152","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.26083/tuprints-00029224","pdf_url":null,"source":{"id":"https://openalex.org/S4306401590","display_name":"Technischen Universit\u00e4t Darmstadt","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"doi:10.26083/tuprints-00029224","doi":"https://doi.org/10.26083/tuprints-00029224","is_oa":true,"landing_page_url":"https://doi.org/10.26083/tuprints-00029224","pdf_url":null,"source":{"id":"https://openalex.org/S4306401590","display_name":"Technischen Universit\u00e4t Darmstadt","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-46953-x","doi":"https://doi.org/10.1038/s41467-024-46953-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-46953-x","pdf_url":"https://www.nature.com/articles/s41467-024-46953-x.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1171821952","display_name":null,"funder_award_id":"9A889","funder_id":"https://openalex.org/F4320320882","funder_display_name":"Volkswagen Foundation"},{"id":"https://openalex.org/G1431534341","display_name":"Effects of Stress and Obesity on Longitudinal Epigenetic Programming","funder_award_id":"R21HD097524","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G1712118094","display_name":null,"funder_award_id":"01EW2003","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3455584400","display_name":"Longitudinal DNA methylation in a non-human primate model of early-life stress","funder_award_id":"R21HD088931","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4110325148","display_name":"A role for circular RNAs in schizophrenia","funder_award_id":"R21MH117609","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6175350809","display_name":null,"funder_award_id":"MH115874","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7132297665","display_name":"Understanding the transgenerational epigenetic effect of maternal psychosocial trauma exposure on infants via lncRNA-sequencing","funder_award_id":"R01HD102974","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7196841991","display_name":null,"funder_award_id":"25348","funder_id":"https://openalex.org/F4320311440","funder_display_name":"National Alliance for Research on Schizophrenia and Depression"},{"id":"https://openalex.org/G7623571525","display_name":"Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital","funder_award_id":"P50MH115874","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000888064","display_name":"Site 3/3, Understanding PTSD through Postmortem Targeted Brain Multiomics","funder_award_id":"R01MH117292","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320317015","display_name":"Alzheimer's Society","ror":"https://ror.org/0472gwq90"},{"id":"https://openalex.org/F4320320882","display_name":"Volkswagen Foundation","ror":"https://ror.org/03bsmfz84"},{"id":"https://openalex.org/F4320328160","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393139864.pdf","grobid_xml":"https://content.openalex.org/works/W4393139864.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1211983638","https://openalex.org/W1820249097","https://openalex.org/W1820796661","https://openalex.org/W1970017566","https://openalex.org/W1974793156","https://openalex.org/W1977321427","https://openalex.org/W1985747467","https://openalex.org/W1986875278","https://openalex.org/W1988971030","https://openalex.org/W1995742542","https://openalex.org/W2003179114","https://openalex.org/W2010314148","https://openalex.org/W2031754652","https://openalex.org/W2034888251","https://openalex.org/W2035618305","https://openalex.org/W2036194871","https://openalex.org/W2039808529","https://openalex.org/W2056613924","https://openalex.org/W2067274883","https://openalex.org/W2074871646","https://openalex.org/W2079054696","https://openalex.org/W2080689345","https://openalex.org/W2084399551","https://openalex.org/W2096086497","https://openalex.org/W2097086441","https://openalex.org/W2100323383","https://openalex.org/W2109070574","https://openalex.org/W2119848745","https://openalex.org/W2127810309","https://openalex.org/W2135914135","https://openalex.org/W2137944397","https://openalex.org/W2151471104","https://openalex.org/W2154516787","https://openalex.org/W2167369519","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2197124664","https://openalex.org/W2201607793","https://openalex.org/W2232723922","https://openalex.org/W2254807163","https://openalex.org/W2288507071","https://openalex.org/W2329569272","https://openalex.org/W2416643466","https://openalex.org/W2432815617","https://openalex.org/W2443768325","https://openalex.org/W2462773201","https://openalex.org/W2474892006","https://openalex.org/W2518751885","https://openalex.org/W2546898428","https://openalex.org/W2560020248","https://openalex.org/W2592811885","https://openalex.org/W2594608863","https://openalex.org/W2753593979","https://openalex.org/W2758892165","https://openalex.org/W2790756470","https://openalex.org/W2791785701","https://openalex.org/W2795682982","https://openalex.org/W2804845995","https://openalex.org/W2806326812","https://openalex.org/W2885927965","https://openalex.org/W2890670389","https://openalex.org/W2897081989","https://openalex.org/W2901417671","https://openalex.org/W2903199137","https://openalex.org/W2923204865","https://openalex.org/W2952240309","https://openalex.org/W2969996045","https://openalex.org/W2978969137","https://openalex.org/W2991414673","https://openalex.org/W3000018611","https://openalex.org/W3005318734","https://openalex.org/W3009835371","https://openalex.org/W3022464411","https://openalex.org/W3040075005","https://openalex.org/W3108936441","https://openalex.org/W3120392574","https://openalex.org/W3134372233","https://openalex.org/W3185482044","https://openalex.org/W4243182520","https://openalex.org/W6906534812","https://openalex.org/W6931025989"],"related_works":["https://openalex.org/W4400090958","https://openalex.org/W7204446112","https://openalex.org/W2964106507","https://openalex.org/W2593268935","https://openalex.org/W2052859130","https://openalex.org/W4212914340","https://openalex.org/W7159806825","https://openalex.org/W2035207977","https://openalex.org/W4291148925","https://openalex.org/W3177872122"],"abstract_inverted_index":{"High":[0],"levels":[1],"of":[2,30,34,76,106,143],"proinflammatory":[3],"cytokines":[4],"induce":[5],"neurotoxicity":[6],"and":[7,42,67,91,103,108,131],"catalyze":[8],"inflammation-driven":[9],"neurodegeneration,":[10],"but":[11],"the":[12,141],"specific":[13],"release":[14,49],"mechanisms":[15],"from":[16,100],"microglia":[17],"remain":[18],"elusive.":[19],"Here":[20],"we":[21],"show":[22],"that":[23,114,125],"secretory":[24],"autophagy":[25,31],"(SA),":[26],"a":[27],"non-lytic":[28],"modality":[29],"for":[32],"secretion":[33],"vesicular":[35],"cargo,":[36],"regulates":[37],"neuroinflammation-mediated":[38],"neurodegeneration":[39,66],"via":[40],"SKA2":[41,45],"FKBP5":[43,52],"signaling.":[44],"inhibits":[46],"SA-dependent":[47],"IL-1\u03b2":[48,79],"by":[50],"counteracting":[51],"function.":[53],"Hippocampal":[54],"Ska2":[55],"knockdown":[56],"in":[57,63,118],"male":[58,107],"mice":[59],"hyperactivates":[60],"SA":[61,77,115,128],"resulting":[62],"neuroinflammation,":[64],"subsequent":[65],"complete":[68],"hippocampal":[69],"atrophy":[70],"within":[71],"six":[72],"weeks.":[73],"The":[74],"hyperactivation":[75],"increases":[78],"release,":[80],"contributing":[81],"to":[82,134],"an":[83],"inflammatory":[84],"feed-forward":[85],"vicious":[86],"cycle":[87],"including":[88],"NLRP3-inflammasome":[89],"activation":[90],"Gasdermin":[92],"D-mediated":[93],"neurotoxicity,":[94],"which":[95],"ultimately":[96],"drives":[97],"neurodegeneration.":[98],"Results":[99],"protein":[101],"expression":[102],"co-immunoprecipitation":[104],"analyses":[105],"female":[109],"postmortem":[110],"human":[111],"brains":[112],"demonstrate":[113],"is":[116,132],"hyperactivated":[117],"Alzheimer's":[119,135],"disease.":[120],"Overall,":[121],"our":[122],"findings":[123],"suggest":[124],"SKA2-regulated,":[126],"hyperactive":[127],"facilitates":[129],"neuroinflammation":[130],"linked":[133],"disease,":[136],"providing":[137],"mechanistic":[138],"insight":[139],"into":[140],"biology":[142],"neuroinflammation.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-26T00:00:00"}
