{"id":"https://openalex.org/W4393100723","doi":"https://doi.org/10.1158/1538-7445.am2024-2620","title":"Abstract 2620: BCG016, a first-in-class bispecific antibody-drug conjugate targeting 5T4 and MUC1, demonstrates potent preclinical anti-tumor activity","display_name":"Abstract 2620: BCG016, a first-in-class bispecific antibody-drug conjugate targeting 5T4 and MUC1, demonstrates potent preclinical anti-tumor activity","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393100723","doi":"https://doi.org/10.1158/1538-7445.am2024-2620"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-2620","doi":"https://doi.org/10.1158/1538-7445.am2024-2620","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-2620","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039073563","display_name":"Zhenyan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099020","display_name":"Beijing Biocytogen (China)","ror":"https://ror.org/01spyyb53","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210099020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyan Han","raw_affiliation_strings":["1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China","institution_ids":["https://openalex.org/I4210099020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050289958","display_name":"Chengzhang Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099020","display_name":"Beijing Biocytogen (China)","ror":"https://ror.org/01spyyb53","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210099020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengzhang Shang","raw_affiliation_strings":["1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China","institution_ids":["https://openalex.org/I4210099020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100703810","display_name":"Yifu Zhang","orcid":"https://orcid.org/0000-0002-4603-9539","observed_orcids":["https://orcid.org/0000-0002-4603-9539"]},"institutions":[{"id":"https://openalex.org/I4210099020","display_name":"Beijing Biocytogen (China)","ror":"https://ror.org/01spyyb53","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210099020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifu Zhang","raw_affiliation_strings":["1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China","institution_ids":["https://openalex.org/I4210099020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030383063","display_name":"Gao An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099020","display_name":"Beijing Biocytogen (China)","ror":"https://ror.org/01spyyb53","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210099020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gao An","raw_affiliation_strings":["1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China","institution_ids":["https://openalex.org/I4210099020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101260857","display_name":"Chaoshe Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099020","display_name":"Beijing Biocytogen (China)","ror":"https://ror.org/01spyyb53","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210099020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoshe Guo","raw_affiliation_strings":["1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China","institution_ids":["https://openalex.org/I4210099020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113551845","display_name":"W. Frank An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099020","display_name":"Beijing Biocytogen (China)","ror":"https://ror.org/01spyyb53","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210099020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. Frank An","raw_affiliation_strings":["1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China","institution_ids":["https://openalex.org/I4210099020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101461348","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0002-3707-5052","observed_orcids":["https://orcid.org/0000-0002-3707-5052"]},"institutions":[{"id":"https://openalex.org/I4210099020","display_name":"Beijing Biocytogen (China)","ror":"https://ror.org/01spyyb53","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210099020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yang","raw_affiliation_strings":["1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing, China","institution_ids":["https://openalex.org/I4210099020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210099020"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"2620","last_page":"2620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-antibody-drug-conjugate","display_name":"bispecific antibody-drug conjugate","score":0.984000027179718},{"id":"https://openalex.org/keywords/5t4","display_name":"5T4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/muc1-c","display_name":"MUC1-C","score":0.6290000081062317},{"id":"https://openalex.org/keywords/monomethyl-auristatin-e","display_name":"monomethyl auristatin E","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7570000290870667},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antibody-internalization","display_name":"antibody internalization","score":0.7120000123977661},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.753000020980835},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.5609999895095825},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5870000123977661},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6517919898033142},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.6051648259162903},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.5821684002876282},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.5652045011520386},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5060681700706482},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4931575655937195},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41810423135757446},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.29925715923309326},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2840132713317871},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.20386335253715515},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-2620","doi":"https://doi.org/10.1158/1538-7445.am2024-2620","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-2620","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7148714863","https://openalex.org/W4365512032","https://openalex.org/W7148823933","https://openalex.org/W2016711318","https://openalex.org/W2016453663","https://openalex.org/W4388042586","https://openalex.org/W4393075975","https://openalex.org/W3081624137","https://openalex.org/W4379984055","https://openalex.org/W4365512036"],"abstract_inverted_index":{"Abstract":[0],"5T4":[1,35,76,116,135,159,214,268,300,329],"is":[2,17,54],"a":[3,99,104,263,296,323],"highly":[4],"expressed":[5],"tumor-associated":[6],"antigen":[7,36,74],"associated":[8],"with":[9,59,98,207],"adverse":[10],"clinical":[11,43,57,63],"outcomes":[12],"in":[13,41,62,82,147,178,228,235,245,287],"solid":[14,84],"tumors,":[15,85],"and":[16,77,90,111,117,189,234,253,269,290,301,330],"an":[18],"attractive":[19],"therapeutic":[20,32,106,298],"target":[21,73],"due":[22,68],"to":[23,69,164,185,212,231,250,294],"low":[24],"expression":[25],"on":[26,277],"normal":[27],"adult":[28],"tissues.":[29],"While":[30],"several":[31],"agents":[33],"targeting":[34,95,114,267,328],"are":[37,79],"currently":[38,55],"being":[39],"evaluated":[40,112],"human":[42,115,124,149],"trials,":[44],"none":[45],"have":[46,261],"yet":[47],"entered":[48],"the":[49,72,157,173,186,201,270,292,341],"market.":[50],"Another":[51],"target,":[52],"MUC1,":[53,331],"under":[56],"investigation,":[58],"most":[60],"drugs":[61],"trials":[64],"showing":[65],"limited":[66],"efficacy":[67,237,242,286],"shedding":[70],"of":[71,175,243,340],"MUC1-N.":[75],"MUC1":[78,137,216,302],"commonly":[80],"co-expressed":[81],"various":[83],"including":[86],"lung,":[87],"breast,":[88],"colorectal":[89],"pancreatic":[91],"cancers,":[92],"suggesting":[93],"that":[94,172,222],"both":[96],"antigens":[97],"single":[100],"drug":[101],"could":[102],"be":[103,295],"promising":[105],"strategy.":[107],"We":[108],"previously":[109],"identified":[110],"antibodies":[113,131,139],"MUC1-C":[118,272],"(cleaved":[119],"MUC1)":[120],"using":[121],"RenLite\u00ae":[122],"fully":[123],"common":[125],"light":[126],"chain":[127],"mice.":[128],"Here,":[129],"selected":[130],"were":[132],"constructed":[133],"into":[134],"\u00d7":[136],"bispecific":[138,265,325],"(bsAb).":[140],"The":[141,280],"5T4-MUC1":[142,176,202,281],"bsAb":[143,177,203],"demonstrated":[144],"high":[145],"avidity":[146],"multiple":[148],"tumor":[150,166,225,278],"cell":[151,167,198,226],"lines":[152],"by":[153,195],"flow":[154],"cytometry.":[155],"Notably,":[156],"parental":[158,187,254],"antibody":[160],"also":[161],"binds":[162],"strongly":[163],"many":[165],"lines.":[168],"Internalization":[169],"assays":[170,220],"demonstrate":[171],"internalization":[174],"breast":[179],"cancer":[180],"cells":[181],"was":[182,204],"enhanced":[183],"compared":[184,230,249],"anti-5T4":[188],"anti-MUC1":[190],"monoclonal":[191],"antibodies,":[192],"as":[193],"measured":[194],"Incucyte\u00ae":[196],"live":[197],"imaging.":[199],"Subsequently,":[200],"then":[205],"conjugated":[206],"monomethyl":[208],"auristatin":[209],"E":[210],"(MMAE)":[211],"generate":[213],"x":[215],"bsADC":[217,282],"(BCG016).":[218],"Cytotoxicity":[219],"indicate":[221],"BCG016":[223,244],"improved":[224],"killing":[227],"vitro":[229],"benchmark":[232,251],"ADCs,":[233],"vivo":[236],"studies":[238],"showed":[239,283],"superior":[240,284],"anti-tumor":[241,285,335],"patient-derived":[246],"NSCLC":[247],"xenografts":[248],"ADCs":[252],"ADC":[255,266],"combination":[256],"therapy.":[257],"In":[258],"summary,":[259],"we":[260],"generated":[262],"novel":[264,297],"cleaved":[271],"protein,":[273],"which":[274],"remains":[275],"membrane-bound":[276],"cells.":[279],"PDX":[288],"models":[289],"has":[291],"potential":[293],"for":[299,344],"co-expressing":[303],"tumors.":[304],"Citation":[305],"Format:":[306],"Zhenyan":[307],"Han,":[308],"Chengzhang":[309],"Shang,":[310],"Yifu":[311],"Zhang,":[312],"Gao":[313],"An,":[314,319],"Chaoshe":[315],"Guo,":[316],"W.":[317],"Frank":[318],"Yi":[320],"Yang.":[321],"BCG016,":[322],"first-in-class":[324],"antibody-drug":[326],"conjugate":[327],"demonstrates":[332],"potent":[333],"preclinical":[334],"activity":[336],"[abstract].":[337],"In:":[338],"Proceedings":[339],"American":[342],"Association":[343],"Cancer":[345,363],"Research":[346],"Annual":[347],"Meeting":[348],"2024;":[349],"Part":[350],"1":[351],"(Regular":[352],"Abstracts);":[353],"2024":[354],"Apr":[355],"5-10;":[356],"San":[357],"Diego,":[358],"CA.":[359],"Philadelphia":[360],"(PA):":[361],"AACR;":[362],"Res":[364],"2024;84(6_Suppl):Abstract":[365],"nr":[366],"2620.":[367]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-03-23T00:00:00"}
