{"id":"https://openalex.org/W4393096604","doi":"https://doi.org/10.1158/1538-7445.am2024-5757","title":"Abstract 5757: Graphene quantum dots-covered AuAg alloy nanoparticles as drug delivery platforms for anticancer applications","display_name":"Abstract 5757: Graphene quantum dots-covered AuAg alloy nanoparticles as drug delivery platforms for anticancer applications","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393096604","doi":"https://doi.org/10.1158/1538-7445.am2024-5757"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5757","doi":"https://doi.org/10.1158/1538-7445.am2024-5757","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2024-5757","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084079262","display_name":"Alondra Veloz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Alondra Del Mar Veloz Bonilla","raw_affiliation_strings":["1University of Puerto Rico, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029412939","display_name":"Brad R. Weiner","orcid":"https://orcid.org/0000-0002-5255-1918","observed_orcids":["https://orcid.org/0000-0002-5255-1918"]},"institutions":[{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Brad Weiner","raw_affiliation_strings":["1University of Puerto Rico, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066612752","display_name":"Gerardo Morell","orcid":"https://orcid.org/0000-0003-4787-2239","observed_orcids":["https://orcid.org/0000-0003-4787-2239"]},"institutions":[{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Gerardo Morell","raw_affiliation_strings":["1University of Puerto Rico, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092243817","display_name":"Nataniel Medina-Berr\u00edos","orcid":"https://orcid.org/0000-0002-4507-2687","observed_orcids":["https://orcid.org/0000-0002-4507-2687"]},"institutions":[{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]}],"countries":["PR"],"is_corresponding":false,"raw_author_name":"Nataniel Medina-Berr\u00edos","raw_affiliation_strings":["1University of Puerto Rico, San Juan, Puerto Rico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I200399037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200399037"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5757","last_page":"5757"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphene-quantum-dots","display_name":"graphene quantum dots","score":0.9340000152587891},{"id":"https://openalex.org/keywords/andrographolide","display_name":"andrographolide","score":0.9229999780654907},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.9549999833106995},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/drug-solubility-enhancement","display_name":"drug solubility enhancement","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/red-blood-cell-morphology","display_name":"erythrocyte morphology","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.7409999966621399},{"id":"https://openalex.org/keywords/nanoparticle-stability","display_name":"nanoparticle stability","score":0.6370000243186951},{"id":"https://openalex.org/keywords/anticancer-drug-delivery-systems","display_name":"anticancer drug delivery systems","score":0.5809999704360962},{"id":"https://openalex.org/keywords/gold-silver-nanoparticles","display_name":"gold-silver nanoparticles","score":0.6259999871253967},{"id":"https://openalex.org/keywords/drug-hydrophobicity","display_name":"drug hydrophobicity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C124657808","wikidata":"https://www.wikidata.org/wiki/Q1133068","display_name":"Quantum dot","level":2,"score":0.7824838161468506},{"id":"https://openalex.org/C30080830","wikidata":"https://www.wikidata.org/wiki/Q169917","display_name":"Graphene","level":2,"score":0.7779115438461304},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6753515601158142},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6516075134277344},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.6498158574104309},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6175855994224548},{"id":"https://openalex.org/C2780026712","wikidata":"https://www.wikidata.org/wiki/Q37756","display_name":"Alloy","level":2,"score":0.5521244406700134},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5110005140304565},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46044501662254333},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.4481465220451355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15851357579231262},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.128119558095932},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.12576454877853394}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5757","doi":"https://doi.org/10.1158/1538-7445.am2024-5757","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2024-5757","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393072067","https://openalex.org/W4393096827","https://openalex.org/W4393166825","https://openalex.org/W4393096562","https://openalex.org/W4417031168","https://openalex.org/W1974044349","https://openalex.org/W3198387937","https://openalex.org/W4392501746","https://openalex.org/W4391064755","https://openalex.org/W4411079322"],"abstract_inverted_index":{"Abstract":[0],"Cancer":[1,430,448],"continues":[2],"to":[3,106,162,165,199,215,238,253,302,329,361],"be":[4],"a":[5,22,71,78,123,208,337,354],"global":[6],"health":[7,24],"challenge,":[8,171],"with":[9],"millions":[10],"suffering":[11],"from":[12,372],"its":[13,146,153,156,248,304],"various":[14],"forms.":[15],"Prostate":[16],"cancer,":[17,86],"in":[18,29,36,53,81,132,190,270,332,339,390],"particular,":[19],"emerges":[20],"as":[21,322,415],"significant":[23],"risk":[25],"for":[26,67,98,145,247,292,419,429],"men.":[27],"Originating":[28],"the":[30,37,43,54,61,82,94,110,136,175,193,217,240,245,264,272,276,280,289,293,307,318,363,386,391,426],"prostate":[31,68,85,285],"gland\u2014a":[32],"small":[33],"organ":[34],"nestled":[35],"male":[38],"pelvis\u2014this":[39],"type":[40],"of":[41,48,96,152,177,195,211,226,233,242,259,282,284,309,365,381,388,393,425],"cancer":[42,69,286],"second":[44],"most":[45],"common":[46],"cause":[47],"cancer-related":[49],"deaths":[50],"among":[51],"men":[52],"U.S.":[55],"Despite":[56],"numerous":[57,196],"medical":[58],"breakthroughs":[59],"over":[60],"years,":[62],"finding":[63],"an":[64,89],"effective":[65,127],"treatment":[66,128,356],"remains":[70],"challenge.":[72],"Our":[73],"research":[74,261],"is":[75,135,155,237,268,295,336],"venturing":[76],"into":[77],"new":[79],"frontier":[80],"fight":[83],"against":[84],"focusing":[87],"on":[88,119,203,306],"innovative":[90],"method,":[91,357],"it":[92,160,341],"explores":[93],"potential":[95,224,383],"nanoparticles":[97,389,414],"targeted":[99,103,249],"drug":[100,137,277,344,366,416],"delivery.":[101],"This":[102],"approach":[104,236],"promises":[105],"not":[107,351],"only":[108],"intensify":[109],"therapeutic":[111,382],"effect,":[112],"but":[113,358],"also":[114,359],"minimize":[115],"adverse":[116],"side":[117],"effects":[118,305],"healthy":[120],"cells,":[121],"ensuring":[122],"more":[124],"balanced":[125],"and":[126,180,250,324,384],"regimen.":[129],"A":[130],"key":[131],"this":[133,170,234,347,373],"study":[134,374],"Andrographolide":[138],"(ADG),":[139],"which":[140,158,267,275],"has":[141],"been":[142,192],"previously":[143],"recognized":[144],"robust":[147],"anti-cancer":[148],"properties.":[149],"However,":[150],"one":[151],"limitations":[154],"hydrophobicity,":[157],"makes":[159],"challenging":[161],"administer":[163],"due":[164,198],"solubility":[166,241],"concerns.":[167],"To":[168],"navigate":[169],"we":[172,213,327,349],"are":[173,350],"pioneering":[174],"synthesis":[176],"AuAg":[178,188,412],"(gold":[179],"silver)":[181],"graphene":[182],"quantum":[183,410],"dots":[184],"(GQDs)":[185],"alloy":[186,413],"nanoparticles.":[187],"particles,":[189],"have":[191],"subject":[194],"studies":[197],"their":[200,325],"profound":[201],"impact":[202],"cellular":[204],"processes.":[205],"By":[206,314],"integrating":[207],"protective":[209],"layer":[210],"GQDs,":[212],"aim":[214,328],"boost":[216],"nanoparticles'":[218],"stability,":[219],"all":[220],"while":[221],"preventing":[222],"any":[223],"release":[225],"harmful":[227],"metallic":[228],"ions.":[229],"The":[230,369],"primary":[231],"objective":[232],"advanced":[235],"augment":[239],"andrographolide,":[243],"paving":[244],"way":[246],"efficient":[251],"delivery":[252,367,417],"PC-3":[254],"cells.":[255,287],"An":[256],"integral":[257],"part":[258],"our":[260,298,379],"involves":[262],"determining":[263],"IC50":[265,290],"value,":[266],"pivotal":[269],"indicating":[271],"concentration":[273],"at":[274],"can":[278],"inhibit":[279],"growth":[281],"50%":[283],"Once":[288],"value":[291],"AuAgGQDs":[294,323],"firmly":[296],"established,":[297],"focus":[299],"will":[300],"shift":[301],"evaluating":[303],"morphology":[308],"Red":[310],"Blood":[311],"Cells":[312],"(RBCs).":[313],"encapsulating":[315],"andrographolide":[316],"within":[317],"designed":[319],"nanoparticles,":[320],"such":[321],"derivatives,":[326],"observe":[330],"changes":[331],"morphology.":[333],"If":[334],"there":[335],"change":[338],"morphology,":[340],"indicates":[342],"successful":[343],"encapsulation.":[345],"Through":[346],"research,":[348],"just":[352],"seeking":[353],"viable":[355],"aiming":[360],"expand":[362],"horizons":[364],"systems.":[368],"insights":[370],"gained":[371],"could":[375],"very":[376],"well":[377],"revolutionize":[378],"understanding":[380],"underscore":[385],"importance":[387],"realm":[392],"biomedical":[394],"applications.":[395],"Citation":[396],"Format:":[397],"Alondra":[398],"Del":[399],"Mar":[400],"Veloz":[401],"Bonilla,":[402],"Brad":[403],"Weiner,":[404],"Gerardo":[405],"Morell,":[406],"Nataniel":[407],"Medina-Berr\u00edos.":[408],"Graphene":[409],"dots-covered":[411],"platforms":[418],"anticancer":[420],"applications":[421],"[abstract].":[422],"In:":[423],"Proceedings":[424],"American":[427],"Association":[428],"Research":[431],"Annual":[432],"Meeting":[433],"2024;":[434],"Part":[435],"1":[436],"(Regular":[437],"Abstracts);":[438],"2024":[439],"Apr":[440],"5-10;":[441],"San":[442],"Diego,":[443],"CA.":[444],"Philadelphia":[445],"(PA):":[446],"AACR;":[447],"Res":[449],"2024;84(6_Suppl):Abstract":[450],"nr":[451],"5757.":[452]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-03-23T00:00:00"}
