{"id":"https://openalex.org/W4393096501","doi":"https://doi.org/10.1158/1538-7445.am2024-4047","title":"Abstract 4047: Unraveling synergistic therapeutic strategies involving FAK inhibition and immunotherapy using anti-PD1 antibody in KRAS and LKB1-driven lung cancer","display_name":"Abstract 4047: Unraveling synergistic therapeutic strategies involving FAK inhibition and immunotherapy using anti-PD1 antibody in KRAS and LKB1-driven lung cancer","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393096501","doi":"https://doi.org/10.1158/1538-7445.am2024-4047"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-4047","doi":"https://doi.org/10.1158/1538-7445.am2024-4047","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-4047","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009155962","display_name":"Junghui Koo","orcid":"https://orcid.org/0009-0008-9696-2760","observed_orcids":["https://orcid.org/0009-0008-9696-2760"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junghui Koo","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039933611","display_name":"Carol Tucker\u2010Burden","orcid":"https://orcid.org/0009-0002-9715-5676","observed_orcids":["https://orcid.org/0009-0002-9715-5676"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Tucker-Burden","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Melissa Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Roy","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050788933","display_name":"Chunzi Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunzi Huang","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069603616","display_name":"Wei Zhou","orcid":"https://orcid.org/0000-0002-6783-9957","observed_orcids":["https://orcid.org/0000-0002-6783-9957"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052926415","display_name":"Melissa Gilbert\u2010Ross","orcid":"https://orcid.org/0000-0002-1960-8302","observed_orcids":["https://orcid.org/0000-0002-1960-8302"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Gilbert-Ross","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072454821","display_name":"Haian Fu","orcid":"https://orcid.org/0000-0002-2362-7979","observed_orcids":["https://orcid.org/0000-0002-2362-7979"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haian Fu","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088178599","display_name":"Suresh S. Ramalingam","orcid":"https://orcid.org/0000-0002-0757-3106","observed_orcids":["https://orcid.org/0000-0002-0757-3106"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh S. Ramalingam","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064924657","display_name":"Adam I. Marcus","orcid":"https://orcid.org/0000-0003-0484-3569","observed_orcids":["https://orcid.org/0000-0003-0484-3569"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam I. Marcus","raw_affiliation_strings":["1Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"4047","last_page":"4047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fak-inhibition","display_name":"FAK inhibition","score":0.7440000176429749},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/lkb1-mutation","display_name":"LKB1 mutation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6510000228881836},{"id":"https://openalex.org/keywords/genetically-engineered-mouse-models","display_name":"genetically engineered mouse models","score":0.8529999852180481},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-resistance","display_name":"immune checkpoint inhibitor resistance","score":0.5839999914169312},{"id":"https://openalex.org/keywords/sex-differences-in-cancer","display_name":"sex differences in cancer","score":0.703000009059906},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5419999957084656},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.5199999809265137},{"id":"https://openalex.org/keywords/preclinical-mouse-models","display_name":"preclinical mouse models","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7420222759246826},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6657900810241699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6517735719680786},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6454613208770752},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6245315074920654},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5399579405784607},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5343320369720459},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5305495858192444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2927003502845764},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2520689368247986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1932281255722046},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10341149568557739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-4047","doi":"https://doi.org/10.1158/1538-7445.am2024-4047","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-4047","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391350439","https://openalex.org/W2493445040","https://openalex.org/W2740391398","https://openalex.org/W4289935959","https://openalex.org/W4404052939","https://openalex.org/W2504030260","https://openalex.org/W6920637774","https://openalex.org/W2594591478","https://openalex.org/W6958566791","https://openalex.org/W4409631162"],"abstract_inverted_index":{"Abstract":[0],"Lung":[1],"cancer":[2,92,169,267],"presents":[3],"a":[4,68,135,199],"global":[5],"health":[6],"challenge":[7],"demanding":[8],"innovative":[9,183],"preclinical":[10],"models":[11,19,36],"forresearch":[12],"and":[13,26,37,53,78,106,118,126,157,213,257,264],"therapeutic":[14,252],"advancement.":[15],"Genetically":[16],"engineered":[17],"mouse":[18,71,76],"(GEMMs)":[20],"have":[21,110],"seenremarkable":[22],"growth":[23],"in":[24,48,164,221,262],"complexity":[25],"application":[27],"over":[28],"the":[29,43,49,99,103,113,165,179,203,208,214,272],"past":[30],"two":[31],"decades.":[32],"Our":[33,64],"work":[34],"leveragesthese":[35],"is":[38],"specifically":[39],"designed":[40],"to":[41,61,88,123,130],"address":[42],"pressing":[44],"need":[45],"for":[46,97,181,186,275],"effectiveimmunochemotherapies":[47],"context":[50],"of":[51,134,146,202,210,216,225,271],"KRAS":[52,263],"LKB1":[54,114],"(KL)":[55],"mutant":[56,115,205],"lung":[57,77,91,168,189,226,266],"adenocarcinoma,which":[58],"shows":[59],"resistance":[60],"most":[62],"immunotherapies.":[63],"study":[65],"centers":[66],"around":[67],"preclinicalsyngeneic":[69],"orthotopic":[70,167],"model":[72],"we":[73,109,128,177],"developed":[74],"using":[75,172,196,259],"metastatic":[79],"tumor":[80],"cell":[81,116,175],"linesderived":[82],"from":[83],"KL-GEMM.":[84],"This":[85],"model,":[86],"optimized":[87],"mimic":[89],"human":[90],"closely,":[93],"providesan":[94],"ideal":[95],"platform":[96],"exploring":[98],"intricate":[100],"interplay":[101],"between":[102],"immune":[104],"system":[105],"tumorprogression.":[107],"Furthermore,":[108,195],"previously":[111],"shown":[112],"lines":[117],"tumormodels":[119],"are":[120],"uniquely":[121],"sensitive":[122],"FAK":[124,136,147,255],"inhibitors,":[125],"therefore":[127],"wanted":[129],"test":[131],"whether":[132],"thecombination":[133],"inhibitor":[137,148],"with":[138,150,161,191],"anti-PD1":[139,151,260],"therapy":[140,163],"can":[141],"improve":[142],"sensitivity.":[143],"The":[144],"combinatoryadministration":[145],"(VS-6063)":[149],"mAb":[152],"synergistically":[153],"increased":[154],"anti-tumor":[155],"response":[156],"survival":[158],"outcome":[159],"compared":[160],"single-agent":[162],"KL-mediatedsyngeneic":[166],"model.":[170],"By":[171],"GEMM-derived":[173],"syngeneic":[174],"lines,":[176],"haveevaluated":[178],"potential":[180],"creating":[182],"immunochemotherapies,":[184],"customized":[185],"KL":[187,204],"co-mutant":[188],"adenocarcinomas":[190],"promising":[192],"clinical":[193],"potential.":[194],"this":[197],"modelenables":[198],"deeper":[200],"understanding":[201],"disease's":[206],"pathogenesis,":[207],"impact":[209],"sex-biasedcancer":[211],"development,":[212],"assessment":[215],"novel":[217],"immunochemotherapy":[218],"treatment":[219],"strategies":[220,253],"theKL":[222],"genetic":[223],"sub-type":[224],"adenocarcinoma.":[227],"Citation":[228],"Format:":[229],"Junghui":[230],"Koo,":[231],"Carol":[232],"Tucker-Burden,":[233],"Melissa":[234,240],"Roy,":[235],"Chunzi":[236],"Huang,":[237],"Wei":[238],"Zhou,":[239],"Gilbert-Ross,":[241],"Haian":[242],"Fu,":[243],"Suresh":[244],"S.":[245],"Ramalingam,":[246],"Adam":[247],"I.":[248],"Marcus.":[249],"Unraveling":[250],"synergistic":[251],"involving":[254],"inhibition":[256],"immunotherapy":[258],"antibody":[261],"LKB1-driven":[265],"[abstract].":[268],"In:":[269],"Proceedings":[270],"American":[273],"Association":[274],"Cancer":[276,294],"Research":[277],"Annual":[278],"Meeting":[279],"2024;":[280],"Part":[281],"1":[282],"(Regular":[283],"Abstracts);":[284],"2024":[285],"Apr":[286],"5-10;":[287],"San":[288],"Diego,":[289],"CA.":[290],"Philadelphia":[291],"(PA):":[292],"AACR;":[293],"Res":[295],"2024;84(6_Suppl):Abstract":[296],"nr":[297],"4047.":[298]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-03-23T00:00:00"}