{"id":"https://openalex.org/W4393096470","doi":"https://doi.org/10.1158/1538-7445.am2024-2476","title":"Abstract 2476: Electroporation-mediated novel albumin-fused Flt3L DNA delivery promotes cDC1-associated anticancer immunity","display_name":"Abstract 2476: Electroporation-mediated novel albumin-fused Flt3L DNA delivery promotes cDC1-associated anticancer immunity","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393096470","doi":"https://doi.org/10.1158/1538-7445.am2024-2476"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-2476","doi":"https://doi.org/10.1158/1538-7445.am2024-2476","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-2476","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048093569","display_name":"Ming\u2010Hung Hu","orcid":"https://orcid.org/0000-0002-9923-0281","observed_orcids":["https://orcid.org/0000-0002-9923-0281"]},"institutions":[{"id":"https://openalex.org/I4210142271","display_name":"Wan Fang Hospital","ror":"https://ror.org/058y0nn10","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210142271"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Hung Hu","raw_affiliation_strings":["1Wan Fang Hospital, Taipei, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Wan Fang Hospital, Taipei, Taiwan;","institution_ids":["https://openalex.org/I4210142271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111589874","display_name":"Tzyy-Choou Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tzyy-Choou Wu","raw_affiliation_strings":["2Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003534152","display_name":"Chien\u2010Fu Hung","orcid":"https://orcid.org/0000-0001-9170-7797","observed_orcids":["https://orcid.org/0000-0001-9170-7797"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chien-Fu Hung","raw_affiliation_strings":["2Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"2476","last_page":"2476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flt3l","display_name":"Flt3L","score":0.8399999737739563},{"id":"https://openalex.org/keywords/albumin-fusion-protein","display_name":"albumin fusion protein","score":0.921999990940094},{"id":"https://openalex.org/keywords/dendritic-cell-expansion","display_name":"dendritic cell expansion","score":0.5580000281333923},{"id":"https://openalex.org/keywords/cdc1","display_name":"cDC1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/electroporation","display_name":"electroporation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.44600000977516174},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6970000267028809},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/tc-1-tumor","display_name":"TC-1 tumor","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.5820000171661377},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.5059999823570251},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.44200000166893005},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.6897382140159607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5460207462310791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49715426564216614},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.493389755487442},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4857109487056732},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4760299026966095},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3954802453517914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3339235186576843},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2653356194496155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19435808062553406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16841545701026917},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1367945373058319},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-2476","doi":"https://doi.org/10.1158/1538-7445.am2024-2476","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-2476","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403909006","https://openalex.org/W4313382594","https://openalex.org/W4313374753","https://openalex.org/W2064327372","https://openalex.org/W4388219953","https://openalex.org/W2094215026","https://openalex.org/W2063960069","https://openalex.org/W2092899585","https://openalex.org/W3137573777","https://openalex.org/W4313366200"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Dendritic":[2],"cells":[3,214,218,324],"(DCs)":[4],"constitute":[5],"a":[6,16,67,103,128,142,177,203,337,353,382],"distinct":[7],"type":[8],"of":[9,77,85,113,162,174,179,205,239,317,378,385,411],"immune":[10,217,228,249,323],"cell":[11,53,229,388],"found":[12,326],"within":[13,37],"tumors,":[14,303],"serving":[15],"central":[17],"role":[18],"in":[19,79,82,208,259,306,327,364,375],"mediating":[20],"tumor":[21,39,270,355],"antigen-specific":[22],"immunity":[23,301,407],"against":[24,55,302],"cancer":[25,56],"cells.":[26],"Frequently,":[27],"DC":[28,43,285,360],"functions":[29],"are":[30],"dysregulated":[31],"by":[32,90,169,200,352,358],"the":[33,38,50,73,111,121,145,160,236,243,307,366,376,412],"immunosuppressive":[34],"signals":[35],"present":[36],"microenvironment":[40],"(TME).":[41],"Consequently,":[42],"manipulation":[44],"holds":[45],"great":[46],"potential":[47],"to":[48,115,132,245,329,343],"enhance":[49],"cytotoxic":[51],"T":[52,387],"response":[54],"diseases.":[57],"The":[58,81,347],"Fms-like":[59],"tyrosine":[60],"kinase":[61],"receptor":[62],"3":[63],"ligand":[64,166],"(Flt3L)":[65],"is":[66,88,110,119,127,293,350],"pluripotent":[68],"growth":[69],"factor":[70],"that":[71,120,278],"regulates":[72],"maturation":[74],"and":[75,176,183,215,272,299,311,321,362,369,381],"differentiation":[76],"DCs":[78],"hematopoiesis.":[80],"vivo":[83],"administration":[84,281],"Flt3L":[86,190,401],"itself":[87],"limited":[89],"its":[91,151],"short":[92],"serum":[93],"half-life.":[94],"To":[95],"overcome":[96,133],"this":[97,233],"major":[98],"drawback,":[99],"our":[100],"group":[101],"developed":[102,304],"novel":[104,139,338,399],"fusion":[105,253],"protein":[106],"albumin-Flt3L":[107],"(alb-Flt3L),":[108],"which":[109,123,292],"conjugation":[112],"albumin":[114,252],"Flt3L.":[116],"Our":[117,334],"hypothesis":[118],"Flt3L,":[122],"has":[124],"extended":[125],"bioavailability,":[126],"feasible":[129],"therapeutic":[130],"strategy":[131],"these":[134],"treatment":[135,267,348],"limitations.":[136],"Method:":[137],"A":[138],"alb-Flt3L":[140,146,187,240,265,279,345],"DNA,":[141],"plasmid":[143],"encoding":[144],"protein,":[147],"was":[148,167,196,225],"administrated":[149],"for":[150,202,227,415],"anti-tumor":[152,248],"effect":[153,349],"on":[154],"TC-1":[155],"tumor-bearing":[156],"C57BL/6":[157],"mice.":[158],"For":[159],"generation":[161],"pcDNA3-albFlt3L,":[163],"mouse":[164],"Flt3":[165],"amplified":[168],"PCR":[170],"using":[171,341],"cDNA":[172],"template":[173],"pcDNA3-Flt3L1":[175],"set":[178],"primers,":[180],"5\u2032-":[181,184],"TTTGAATTCGGGACACCTGACTGTTACTTC-3\u2032":[182],"AAACTTAAGCTACTGCCTGGGCCGAGGCTCTGG":[185],"-3\u2032.":[186],"DNA":[188,191,241,266,280,402],"(10ug),":[189],"(10ug)":[192],"or":[193],"vehicle":[194],"control":[195,271],"injected":[197],"intratumorally":[198],"followed":[199],"electroporation":[201,342],"total":[204],"three":[206],"times":[207],"5-day":[209],"intervals.":[210],"Peripheral":[211],"blood":[212],"mononuclear":[213],"tumor-infiltrated":[216,322],"were":[219,325],"isolated":[220],"after":[221],"treatment.":[222],"Flow":[223],"cytometry":[224],"performed":[226],"analysis.":[230],"Results:":[231],"In":[232,287,313],"current":[234],"study,":[235],"electroporation-mediated":[237],"delivery":[238,403],"demonstrated":[242],"ability":[244],"induce":[246],"an":[247,373],"response.":[250],"This":[251],"construct":[254],"possesses":[255],"more":[256],"persistent":[257],"bioactivity":[258],"targeted":[260],"organs.":[261],"Furthermore,":[262],"mice":[263],"receiving":[264],"presented":[268],"better":[269],"superior":[273,296],"survival.":[274],"Cellular":[275],"analysis":[276],"revealed":[277,351],"displayed":[282],"greater":[283,330],"systemic":[284],"population.":[286,332],"addition,":[288,314],"robust":[289],"cDC1":[290,331,379],"expansion,":[291],"associated":[294],"with":[295,372],"antigen":[297],"cross-presentation":[298],"cellular":[300],"extensively":[305],"tumor,":[308],"lymph":[309,367],"node,":[310],"blood.":[312],"increased":[315],"levels":[316],"IFN-\u03b3-secreting":[318],"CD8+":[319,386],"lymphocytes":[320],"correlation":[328],"Conclusion:":[333],"data":[335],"showcases":[336],"DC-based":[339],"immunotherapy":[340],"administer":[344],"DNA.":[346],"controlled":[354],"response,":[356],"characterized":[357],"enhanced":[359],"mobilization":[361],"accumulation":[363],"both":[365],"nodes":[368],"TME,":[370],"coupled":[371],"increase":[374],"expansion":[377],"subsets":[380],"heightened":[383],"level":[384],"activation.":[389],"Citation":[390],"Format:":[391],"Ming-Hung":[392],"Hu,":[393],"Tzyy-Choou":[394],"Wu,":[395],"Chien-Fu":[396],"Hung.":[397],"Electroporation-mediated":[398],"albumin-fused":[400],"promotes":[404],"cDC1-associated":[405],"anticancer":[406],"[abstract].":[408],"In:":[409],"Proceedings":[410],"American":[413],"Association":[414],"Cancer":[416,434],"Research":[417],"Annual":[418],"Meeting":[419],"2024;":[420],"Part":[421],"1":[422],"(Regular":[423],"Abstracts);":[424],"2024":[425],"Apr":[426],"5-10;":[427],"San":[428],"Diego,":[429],"CA.":[430],"Philadelphia":[431],"(PA):":[432],"AACR;":[433],"Res":[435],"2024;84(6_Suppl):Abstract":[436],"nr":[437],"2476.":[438]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-03-23T00:00:00"}
