{"id":"https://openalex.org/W4393096006","doi":"https://doi.org/10.1158/1538-7445.am2024-630","title":"Abstract 630: The role of AKT pathway in \u03b2-catenin mutated hepatocellular carcinoma","display_name":"Abstract 630: The role of AKT pathway in \u03b2-catenin mutated hepatocellular carcinoma","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393096006","doi":"https://doi.org/10.1158/1538-7445.am2024-630"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-630","doi":"https://doi.org/10.1158/1538-7445.am2024-630","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-630","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087037756","display_name":"Xue Wang","orcid":"https://orcid.org/0000-0001-5973-6686","observed_orcids":["https://orcid.org/0000-0001-5973-6686"]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Wang","raw_affiliation_strings":["1University of Hawai'i Cancer Center, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Hawai'i Cancer Center, Honolulu, HI","institution_ids":["https://openalex.org/I4390039246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["1University of Hawai'i Cancer Center, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Hawai'i Cancer Center, Honolulu, HI","institution_ids":["https://openalex.org/I4390039246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4390039246"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"630","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.08760000020265579,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ctnnb1-mutation","display_name":"CTNNB1 mutation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mtorc2","display_name":"mTORC2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rictor","display_name":"Rictor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.953000009059906},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.550000011920929},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9419999718666077},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.5569999814033508},{"id":"https://openalex.org/keywords/hydrodynamic-transfection","display_name":"hydrodynamic transfection","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8289352655410767},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5961422920227051},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5817314982414246},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5429558157920837},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4579658806324005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45350268483161926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4472289979457855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3233747184276581},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.26857540011405945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21595308184623718},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20752635598182678}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-630","doi":"https://doi.org/10.1158/1538-7445.am2024-630","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-630","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2338681688","https://openalex.org/W4362541450","https://openalex.org/W2944267355","https://openalex.org/W4389018566","https://openalex.org/W2020914717","https://openalex.org/W4416929256","https://openalex.org/W2294090452","https://openalex.org/W4389021799","https://openalex.org/W4414161605","https://openalex.org/W3016749320"],"abstract_inverted_index":{"Abstract":[0],"The":[1,18,349],"Wnt/\u03b2-catenin":[2,20,106],"and":[3,59,67,78,107,144,184,200,214,327],"PI3K/AKT":[4],"pathways":[5,109],"are":[6,98,186,203],"pivotal":[7,175],"contributors":[8],"to":[9,27,117,136,151,275],"the":[10,13,41,57,103,119,122,147,153,159,166,174,187,193,219,232,246,252,257,262,313,317,320,329,335,363],"development":[11],"of":[12,44,54,61,89,121,141,149,161,165,177,212,216,236,245,259,265,281,291,301,319,333,351,362],"malignant":[14],"phenotype":[15],"in":[16,110,125,146,179,192,218,223,267,287,323,338,354],"cancer.":[17],"activated":[19,127,247],"pathway":[21,124,322,337,353],"synergizes":[22],"with":[23,340],"various":[24],"signaling":[25,238],"cascades":[26],"propel":[28],"HCC":[29,128,154,277,294,325],"formation,":[30],"operating":[31],"through":[32],"its":[33],"downstream":[34,70,234],"effectors.":[35],"It":[36],"has":[37],"been":[38],"well-established":[39],"that":[40,86,197,228],"mammalian":[42],"target":[43],"rapamycin":[45],"complex":[46,81],"2":[47,82],"(mTORC2)":[48],"serves":[49],"as":[50],"an":[51],"upstream":[52],"regulator":[53],"AKT,":[55],"orchestrating":[56],"phosphorylation":[58,88],"activation":[60,215],"AKT.":[62],"Once":[63],"activated,":[64],"AKT":[65,108,123,178,237,321,336,352],"phosphorylates":[66],"inhibits":[68],"canonical":[69],"targets":[71],"like":[72],"forkhead":[73],"box":[74],"O":[75],"protein":[76],"(FOXO)":[77],"tuberous":[79],"sclerosis":[80],"(TSC2).":[83],"Studies":[84],"indicated":[85],"AKT-mediated":[87],"TSC2":[90],"activates":[91],"mTORC1,":[92],"subsequently":[93],"suppressing":[94],"autophagy.":[95],"However,":[96],"there":[97],"limited":[99,263],"data":[100],"exist":[101],"on":[102,273],"interplay":[104],"between":[105],"HCC.":[111,342],"In":[112],"this":[113],"study,":[114,311],"we":[115,269],"sought":[116],"explore":[118],"role":[120,176,318,350],"\u03b2-catenin":[126,142,355],"tumors.":[129],"Sleeping":[130],"beauty-mediated":[131],"hydrodynamic":[132],"transfection":[133],"was":[134],"used":[135],"overexpress":[137],"constitutively":[138],"active":[139],"forms":[140],"(N90-\u03b2-catenin)":[143],"c-MET":[145],"livers":[148],"mice":[150],"establish":[152],"model":[155,221],"(c-Met/\u03b2-catenin":[156],"model).":[157],"Notably,":[158],"knockout":[160,211],"Rictor,":[162],"a":[163,298],"component":[164],"mTORC2":[167],"complex,":[168],"significantly":[169,250],"impeded":[170],"tumor":[171,181,207,225,241,253,285],"growth,":[172,226,254],"underscoring":[173],"c-Met/\u03b2-catenin":[180,206,220],"development.":[182,242],"AKT1":[183,199],"AKT2":[185,201],"two":[188],"main":[189],"isoforms":[190,202],"expressed":[191],"liver.":[194],"We":[195],"determined":[196],"both":[198],"critical":[204],"for":[205,312,366],"growth.":[208],"Intriguingly,":[209],"simultaneous":[210],"Rictor":[213],"mTORC1":[217,229],"resulted":[222],"delayed":[224,251,284],"indicating":[227],"is":[230],"not":[231],"sole":[233],"determinant":[235],"during":[239],"c-Met/\u03b2-Catenin":[240],"Furthermore,":[243],"overexpression":[244],"FOXO1":[248,266,274,308],"(FOXO1AAA)":[249],"which":[255],"highlighted":[256],"importance":[258],"FOXO1.":[260],"Given":[261],"understanding":[264],"HCC,":[268],"extended":[270],"our":[271],"investigation":[272],"human":[276,293],"cell":[278,295],"lines.":[279],"Overexpression":[280],"FOXO1AAA":[282],"notably":[283],"growth":[286,326],"vitro.":[288],"RNAseq":[289],"analysis":[290],"FOXO1AAA-overexpressed":[292],"lines":[296],"revealed":[297],"significant":[299],"upregulation":[300],"\"metabolic":[302],"pathways\",":[303],"suggesting":[304],"metabolic":[305],"reprogramming":[306],"post":[307],"activation.":[309],"This":[310],"first":[314],"time,":[315],"unveils":[316],"\u03b2-catenin-mutated":[324,341],"highlights":[328],"potential":[330],"therapeutic":[331],"value":[332],"targeting":[334],"patients":[339],"Citation":[343],"Format:":[344],"Xue":[345],"Wang,":[346],"Xin":[347],"Chen.":[348],"mutated":[356],"hepatocellular":[357],"carcinoma":[358],"[abstract].":[359],"In:":[360],"Proceedings":[361],"American":[364],"Association":[365],"Cancer":[367,385],"Research":[368],"Annual":[369],"Meeting":[370],"2024;":[371],"Part":[372],"1":[373],"(Regular":[374],"Abstracts);":[375],"2024":[376],"Apr":[377],"5-10;":[378],"San":[379],"Diego,":[380],"CA.":[381],"Philadelphia":[382],"(PA):":[383],"AACR;":[384],"Res":[386],"2024;84(6_Suppl):Abstract":[387],"nr":[388],"630.":[389]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2024-03-23T00:00:00"}