{"id":"https://openalex.org/W4393095328","doi":"https://doi.org/10.1158/1538-7445.am2024-2998","title":"Abstract 2998: Regulation of epidermal growth factor receptor signaling by BRCA1-microRNA 146a network","display_name":"Abstract 2998: Regulation of epidermal growth factor receptor signaling by BRCA1-microRNA 146a network","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393095328","doi":"https://doi.org/10.1158/1538-7445.am2024-2998"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-2998","doi":"https://doi.org/10.1158/1538-7445.am2024-2998","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-2998","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053069445","display_name":"Easwari Kumaraswamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Easwari Kumaraswamy","raw_affiliation_strings":["1The University of Kansas Cancer Center, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Kansas Cancer Center, Kansas City, KS;","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086329183","display_name":"Raeann M. Koren Shimak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raeann M. Koren Shimak","raw_affiliation_strings":["1The University of Kansas Cancer Center, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Kansas Cancer Center, Kansas City, KS;","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029700070","display_name":"Sumedha Gunewardena","orcid":"https://orcid.org/0000-0003-2097-135X","observed_orcids":["https://orcid.org/0000-0003-2097-135X"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumedha Gunewardena","raw_affiliation_strings":["2University of Kansas Medical Center, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Kansas Medical Center, Kansas City, KS;","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karen L. Wendt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen L. Wendt","raw_affiliation_strings":["3The University of Oklahoma, Norman, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The University of Oklahoma, Norman, OK","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dani Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dani Alexander","raw_affiliation_strings":["2University of Kansas Medical Center, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Kansas Medical Center, Kansas City, KS;","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088317387","display_name":"Stacey L. Hembruff","orcid":"https://orcid.org/0009-0006-3224-4773","observed_orcids":["https://orcid.org/0009-0006-3224-4773"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey L. Hembruff","raw_affiliation_strings":["1The University of Kansas Cancer Center, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Kansas Cancer Center, Kansas City, KS;","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024030506","display_name":"Roy A. Jensen","orcid":"https://orcid.org/0000-0003-4430-2281","observed_orcids":["https://orcid.org/0000-0003-4430-2281"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy A. Jensen","raw_affiliation_strings":["1The University of Kansas Cancer Center, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Kansas Cancer Center, Kansas City, KS;","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210097601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"2998","last_page":"2998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mir-146a","display_name":"miR-146a","score":0.9419999718666077},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8849999904632568},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8830000162124634},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7789999842643738},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.777999997138977},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8569999933242798},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5979999899864197},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6619429588317871},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6523926258087158},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5425660014152527},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49235212802886963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46463799476623535},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42393890023231506},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40299975872039795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.380839467048645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33936309814453125},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32220184803009033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3108925521373749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2554372549057007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15858393907546997}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-2998","doi":"https://doi.org/10.1158/1538-7445.am2024-2998","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-2998","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7117774005","https://openalex.org/W2057680108","https://openalex.org/W2071576944","https://openalex.org/W2144977086","https://openalex.org/W2156010403","https://openalex.org/W2139030718","https://openalex.org/W2092294599","https://openalex.org/W2800307545","https://openalex.org/W4307909819","https://openalex.org/W2187448632"],"abstract_inverted_index":{"Abstract":[0],"Inherited":[1],"defects":[2],"in":[3,57,150,182,204],"the":[4,91,111,120,223,234,290,339],"breast":[5,26,151,252],"cancer":[6,253],"susceptibility":[7],"gene,":[8],"BRCA1":[9,106,133,187,300],"are":[10,29,80],"associated":[11,63,165,301],"with":[12,64,166],"an":[13],"increased":[14],"risk":[15],"for":[16,119,237,251,299,342],"hereditary":[17],"breast,":[18],"ovarian,":[19],"and":[20,67,72,74,115,188,201,271,289],"other":[21,224,247,291],"cancers.":[22],"BRCA1-associated":[23],"basal":[24],"like":[25],"cancers":[27],"(BLBCs)":[28],"high-grade":[30],"ductal":[31],"carcinomas":[32],"that":[33,132,143,158,186,210,282],"do":[34],"not":[35],"express":[36],"ER,":[37],"PR":[38],"or":[39,177],"HER2,":[40],"but":[41],"frequently":[42],"overexpress":[43],"epidermal":[44,326],"growth":[45,327],"factor":[46,78,328],"receptor":[47,329],"(EGFR/ErbB1/HER1).":[48],"The":[49],"EGFR-driven":[50],"signaling":[51,274,288,330],"network":[52,334],"plays":[53],"a":[54,101,117,147,295],"pivotal":[55],"role":[56,149],"BLBC":[58,221],"pathogenesis.":[59],"EGFR":[60,108,191,240],"overexpression":[61,212],"is":[62,164],"tumor":[65,214],"progression":[66],"metastasis,":[68],"resistance":[69],"to":[70,145,217,245,260,280],"radiation":[71],"chemotherapy,":[73],"poor":[75,168,261],"prognosis.":[76],"Growth":[77],"receptors":[79],"regulated":[81],"by":[82,104,331],"multiple":[83,269,273],"miRNAs,":[84],"each":[85],"having":[86],"many":[87],"targets,":[88],"coordinately":[89],"controlling":[90],"complex":[92],"pathways":[93],"of":[94,113,122,140,161,171,179,325,338],"downstream":[95],"signaling.":[96],"We":[97],"have":[98,130,242,254],"previously":[99],"reported":[100],"post-transcriptional":[102],"mechanism":[103],"which":[105],"regulates":[107],"expression":[109,160],"through":[110],"induction":[112],"miR-146a":[114,123,175,189,211,284],"provided":[116],"rationale":[118],"development":[121],"based":[124],"therapeutic":[125,297],"strategies.":[126],"In":[127],"addition,":[128],"we":[129,156,184,208],"shown":[131],"also":[134],"exerts":[135],"regulatory":[136],"control":[137],"over":[138],"dozens":[139],"important":[141],"miRNAs":[142,163],"appear":[144],"play":[146],"critical":[148],"neoplasia.":[152],"From":[153],"TCGA":[154],"analysis,":[155],"show":[157,185],"low":[159],"these":[162],"distinctively":[167],"overall":[169,219],"survival":[170],"TNBC":[172],"patients.":[173],"Using":[174,203],"loss":[176],"gain":[178],"function":[180],"experiments":[181],"vitro,":[183],"regulate":[190,272],"signaling,":[192],"stemness,":[193],"epithelial-to-mesenchymal":[194],"transition":[195],"(EMT),":[196],"extracellular":[197],"matrix":[198],"(ECM)":[199],"remodeling":[200],"chemoresistance.":[202],"vivo":[205],"mouse":[206],"models,":[207],"demonstrate":[209],"delays":[213],"formation":[215],"leading":[216],"better":[218],"survival.":[220],"unlike":[222],"subtypes,":[225],"lacks":[226],"targeted":[227,296],"therapy":[228],"approaches":[229],"making":[230],"cytotoxic":[231],"chemotherapy":[232],"essentially":[233],"only":[235],"option":[236,298],"treatment.":[238],"Though":[239],"inhibitors":[241],"been":[243,257],"used":[244],"treat":[246],"cancers,":[248],"clinical":[249],"trials":[250],"so":[255],"far":[256],"unsuccessful":[258],"due":[259],"response":[262],"rates.":[263],"Since":[264],"one":[265],"miRNA":[266],"can":[267],"target":[268],"genes":[270],"pathways,":[275,293],"our":[276],"study":[277],"provides":[278],"evidence":[279],"suggest":[281],"restoring":[283],"could":[285],"suppress":[286],"EGFR-RAS-MEK":[287],"compensatory":[292],"providing":[294],"BLBC.":[302],"Citation":[303],"Format:":[304],"Easwari":[305],"Kumaraswamy,":[306],"Raeann":[307],"M.":[308],"Koren":[309],"Shimak,":[310],"Sumedha":[311],"Gunewardena,":[312],"Karen":[313],"L.":[314,319],"Wendt,":[315],"Dani":[316],"Alexander,":[317],"Stacey":[318],"Hembruff,":[320],"Roy":[321],"A.":[322],"Jensen.":[323],"Regulation":[324],"BRCA1-microRNA":[332],"146a":[333],"[abstract].":[335],"In:":[336],"Proceedings":[337],"American":[340],"Association":[341],"Cancer":[343,361],"Research":[344],"Annual":[345],"Meeting":[346],"2024;":[347],"Part":[348],"1":[349],"(Regular":[350],"Abstracts);":[351],"2024":[352],"Apr":[353],"5-10;":[354],"San":[355],"Diego,":[356],"CA.":[357],"Philadelphia":[358],"(PA):":[359],"AACR;":[360],"Res":[362],"2024;84(6_Suppl):Abstract":[363],"nr":[364],"2998.":[365]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-03-23T00:00:00"}