{"id":"https://openalex.org/W4393095055","doi":"https://doi.org/10.1158/1538-7445.am2024-3219","title":"Abstract 3219: STAT3 inhibition synergizes with epigenetic therapy to suppress glutamine metabolism and clonogenic potential in non-small cell lung cancer","display_name":"Abstract 3219: STAT3 inhibition synergizes with epigenetic therapy to suppress glutamine metabolism and clonogenic potential in non-small cell lung cancer","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393095055","doi":"https://doi.org/10.1158/1538-7445.am2024-3219"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-3219","doi":"https://doi.org/10.1158/1538-7445.am2024-3219","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3219","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Julia An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia An","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692972","display_name":"Yingyu Chen","orcid":"https://orcid.org/0000-0002-1415-337X","observed_orcids":["https://orcid.org/0000-0002-1415-337X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Yu Chen","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752297","display_name":"Jina Park","orcid":"https://orcid.org/0000-0001-5951-4928","observed_orcids":["https://orcid.org/0000-0001-5951-4928"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jina Park","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Baylin","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059640571","display_name":"Michael J. Topper","orcid":"https://orcid.org/0000-0002-2778-4920","observed_orcids":["https://orcid.org/0000-0002-2778-4920"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Topper","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"3219","last_page":"3219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.10740000009536743,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3-inhibition","display_name":"STAT3 inhibition","score":0.8949999809265137},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8999999761581421},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dna-methyltransferase-inhibition","display_name":"DNA methyltransferase inhibition","score":0.9319999814033508},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":1.0},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9580000042915344},{"id":"https://openalex.org/keywords/clonogenicity","display_name":"clonogenicity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.703000009059906},{"id":"https://openalex.org/keywords/anoikis-resistance","display_name":"anoikis resistance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8790000081062317},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5320000052452087},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.7319999933242798},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/three-dimensional-tumor-models","display_name":"3D tumor models","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.7338731288909912},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6534461975097656},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.5976142883300781},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5846626162528992},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5499399304389954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47829800844192505},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.452282190322876},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4172346293926239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39289653301239014},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2751536965370178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2548147439956665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14650830626487732},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06519648432731628},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-3219","doi":"https://doi.org/10.1158/1538-7445.am2024-3219","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3219","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409821115","https://openalex.org/W4313890762","https://openalex.org/W2342737942","https://openalex.org/W2554694872","https://openalex.org/W4411331900","https://openalex.org/W7117355138","https://openalex.org/W1980696888","https://openalex.org/W2504573995","https://openalex.org/W2094725281","https://openalex.org/W1611641438"],"abstract_inverted_index":{"Abstract":[0],"Non-small":[1],"cell":[2,144,152,159,214,292,409],"lung":[3,410],"cancer":[4,276,291,411],"(NSCLC)":[5],"remains":[6],"one":[7],"of":[8,19,52,133,140,158,178,201,250,253,262,275,302,307,337,366,415],"the":[9,16,41,49,131,197,285,335,364,416],"deadliest":[10],"cancers":[11],"with":[12,69,93,111,146,242,354,397],"metastatic":[13,298,303,371],"disease":[14,31,38],"being":[15],"primary":[17],"driver":[18],"mortality.":[20],"Therefore,":[21],"there":[22],"is":[23,54,124,271,295,352],"a":[24,138,155,182,232,251,273,345,361],"critical":[25],"need":[26],"for":[27,297,363,419],"therapies":[28],"that":[29,46,109,121,210,309],"prevent":[30],"dissemination":[32],"in":[33,58,91,106,162,168,181,237,256,284,319,407],"both":[34,257],"early":[35],"and":[36,61,116,149,216,225,234,260,264,289,313,322,342,348,404],"late-stage":[37],"presentations.":[39],"Among":[40],"recent":[42],"novel":[43,203,367],"therapeutic":[44,204],"combinations":[45],"have":[47,118],"transformed":[48],"treatment":[50,241],"landscape":[51],"NSCLC":[53,143,338],"an":[55,103,169],"approach":[56],"developed":[57],"our":[59,202,320,328],"lab":[60],"others":[62,117],"utilizing":[63],"DNA":[64],"methyltransferase":[65],"inhibition":[66,72,395],"(DNMTi)":[67],"paired":[68],"histone":[70],"deacetylase":[71],"(HDACi)":[73],"to":[74,77,188,195,340,344,369,400],"sensitize":[75],"patients":[76,81],"immunotherapy.":[78],"However,":[79],"most":[80],"do":[82],"not":[83],"benefit":[84],"durably":[85],"from":[86,378],"epigenetic":[87,112,127,398],"therapy":[88,113,148,212,333,399],"alone":[89],"or":[90],"combination":[92],"other":[94],"therapies.":[95],"In":[96,186],"this":[97,134],"study,":[98],"we":[99,136,191,246],"identified":[100,150],"STAT3":[101,122,394],"as":[102],"actionable":[104],"target":[105],"tumor":[107,376],"cells":[108,304,339,377],"synergizes":[110,396],"(DNMTi+HDACi).":[114],"We":[115,229],"previously":[119],"shown":[120],"signaling":[123],"augmented":[125],"after":[126,240],"therapy.":[128,244],"To":[129],"interrogate":[130],"importance":[132],"finding,":[135],"treated":[137],"panel":[139],"12":[141],"human":[142],"lines":[145,153],"STAT3i+epigenetic":[147,211,243,332],"five":[151],"demonstrating":[154],"synergistic":[156],"reduction":[157,236],"viability.":[160],"These":[161,206],"vitro":[163],"monolayer":[164],"observations":[165],"were":[166,221],"recapitulated":[167],"intermediate":[170],"complexity":[171],"3D":[172],"model,":[173],"thus":[174],"providing":[175],"orthogonal":[176],"validation":[177],"response":[179],"applicability":[180],"more":[183],"treatment-resistant":[184],"setting.":[185],"addition":[187],"phenotypic":[189,321],"characterization,":[190],"deployed":[192],"RNA":[193],"sequencing":[194],"define":[196],"whole":[198],"transcriptome":[199],"consequences":[200],"paradigm.":[205],"transcriptional":[207,323],"data":[208],"showed":[209],"suppressed":[213,318],"cycle":[215],"activated":[217],"apoptotic":[218],"pathways,":[219],"which":[220,294,316],"validated":[222],"by":[223,373],"immunoblotting":[224],"flow":[226],"cytometry-based":[227],"approaches.":[228],"further":[230],"demonstrated":[231],"significant":[233,248],"durable":[235],"colony":[238],"formation":[239],"Additionally,":[245,300],"observed":[247],"perturbation":[249],"subset":[252],"genes":[254],"involved":[255],"epithelial-to-mesenchymal":[258],"transition":[259],"suppression":[261],"glutamine":[263,270,279,402],"fatty":[265],"acid":[266],"metabolism.":[267,277],"Reliance":[268],"on":[269],"considered":[272],"hallmark":[274],"Furthermore,":[278],"metabolism":[280,403],"has":[281],"been":[282],"implicated":[283],"plasticity":[286],"between":[287],"epithelial":[288],"mesenchymal":[290],"states,":[293],"required":[296],"success.":[299],"survival":[301],"requires":[305],"upregulation":[306],"pathways":[308],"promote":[310],"anchorage-independent":[311],"growth":[312],"anoikis":[314],"resistance,":[315],"are":[317],"data,":[324],"respectively.":[325],"Taken":[326],"together,":[327],"results":[329],"suggest":[330],"1.":[331],"diminishes":[334],"ability":[336],"survive":[341],"return":[343],"colony-forming":[346],"state":[347],"2.":[349],"This":[350],"phenotype":[351],"associated":[353],"metabolic":[355],"dysfunction.":[356],"Our":[357],"studies":[358],"therefore":[359],"provide":[360],"basis":[362],"development":[365],"strategies":[368],"intercept":[370],"recolonization":[372],"impairing":[374],"circulating":[375],"seeding":[379],"distant":[380],"sites.":[381],"Citation":[382],"Format:":[383],"Julia":[384],"An,":[385],"Ying-Yu":[386],"Chen,":[387],"Jina":[388],"Park,":[389],"Stephen":[390],"Baylin,":[391],"Michael":[392],"Topper.":[393],"suppress":[401],"clonogenic":[405],"potential":[406],"non-small":[408],"[abstract].":[412],"In:":[413],"Proceedings":[414],"American":[417],"Association":[418],"Cancer":[420,438],"Research":[421],"Annual":[422],"Meeting":[423],"2024;":[424],"Part":[425],"1":[426],"(Regular":[427],"Abstracts);":[428],"2024":[429],"Apr":[430],"5-10;":[431],"San":[432],"Diego,":[433],"CA.":[434],"Philadelphia":[435],"(PA):":[436],"AACR;":[437],"Res":[439],"2024;84(6_Suppl):Abstract":[440],"nr":[441],"3219.":[442]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-03-23T00:00:00"}
