{"id":"https://openalex.org/W4393093777","doi":"https://doi.org/10.1158/1538-7445.am2024-3404","title":"Abstract 3404: Body weight trajectory among patients with non-small-cell lung cancer receiving immune checkpoint inhibitors","display_name":"Abstract 3404: Body weight trajectory among patients with non-small-cell lung cancer receiving immune checkpoint inhibitors","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393093777","doi":"https://doi.org/10.1158/1538-7445.am2024-3404"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-3404","doi":"https://doi.org/10.1158/1538-7445.am2024-3404","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3404","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088345646","display_name":"Ting\u2010Yuan David Cheng","orcid":"https://orcid.org/0000-0002-4105-828X","observed_orcids":["https://orcid.org/0000-0002-4105-828X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting-Yuan David Cheng","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108237996","display_name":"Ben Kinder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Kinder","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010874983","display_name":"Rand T. Akasheh","orcid":"https://orcid.org/0000-0002-0018-0342","observed_orcids":["https://orcid.org/0000-0002-0018-0342"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rand T. Akasheh","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094218872","display_name":"Cuthbert Mario Mahenge","orcid":"https://orcid.org/0009-0000-4328-788X","observed_orcids":["https://orcid.org/0009-0000-4328-788X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cuthbert Mario Mahenge","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006468163","display_name":"Carolyn Jean Presley","orcid":"https://orcid.org/0000-0002-2607-5639","observed_orcids":["https://orcid.org/0000-0002-2607-5639"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn J. Presley","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079716545","display_name":"Peter G. Shields","orcid":"https://orcid.org/0000-0002-7404-217X","observed_orcids":["https://orcid.org/0000-0002-7404-217X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G. Shields","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027544134","display_name":"Xuan V. Nguyen","orcid":"https://orcid.org/0000-0002-2617-1938","observed_orcids":["https://orcid.org/0000-0002-2617-1938"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuan Nguyen","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044452976","display_name":"Aditi Shendre","orcid":"https://orcid.org/0000-0003-4123-7613","observed_orcids":["https://orcid.org/0000-0003-4123-7613"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditi Shendre","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002360335","display_name":"Zihai Li","orcid":"https://orcid.org/0000-0003-4603-927X","observed_orcids":["https://orcid.org/0000-0003-4603-927X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zihai Li","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100383618","display_name":"Lang Li","orcid":"https://orcid.org/0000-0002-0746-1809","observed_orcids":["https://orcid.org/0000-0002-0746-1809","https://orcid.org/0000-0002-5334-8719","https://orcid.org/0000-0002-4528-3927"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lang Li","raw_affiliation_strings":["1The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"3404","last_page":"3404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/weight-change","display_name":"weight change","score":0.7139999866485596},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.8059999942779541},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.828000009059906},{"id":"https://openalex.org/keywords/pd-1-pd-l1-inhibitors","display_name":"PD-1/PD-L1 inhibitors","score":0.9160000085830688},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.765999972820282},{"id":"https://openalex.org/keywords/immunotherapy-toxicity","display_name":"immunotherapy toxicity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.3720000088214874},{"id":"https://openalex.org/keywords/combination-targeted-therapy","display_name":"combination targeted therapy","score":0.7839999794960022},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/body-weight-trajectories","display_name":"body weight trajectories","score":0.4440000057220459},{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.5979999899864197},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.34299999475479126},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.3370000123977661},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.46799999475479126},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6913274526596069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.616688072681427},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5929387211799622},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5622574687004089},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4671252369880676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4455983340740204},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.41828081011772156},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.325707346200943}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-3404","doi":"https://doi.org/10.1158/1538-7445.am2024-3404","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3404","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7055151809","https://openalex.org/W4405120663","https://openalex.org/W2981164635","https://openalex.org/W4223572259","https://openalex.org/W4311146124","https://openalex.org/W3167312477","https://openalex.org/W4416821723","https://openalex.org/W4408979011","https://openalex.org/W2888045392","https://openalex.org/W2981677950"],"abstract_inverted_index":{"Abstract":[0],"Objectives:":[1],"Body":[2,390,483],"weight":[3,19,38,136,154,172,236,297,303,333,353,365,391,410,425,484],"is":[4,32],"an":[5],"important":[6],"prognostic":[7],"factor":[8],"in":[9,87,101,146,152,210,332,362,439],"patients":[10,54,67,132,196,219,226,269,281,292,338,356,372,386,405,487],"with":[11,55,83,103,197,220,270,282,285,301,339,373,387,406,488],"lung":[12,490],"cancer.":[13],"As":[14],"immunotherapy":[15],"involves":[16],"toxicities,":[17],"body":[18,113,135,153,182,235,296],"may":[20,396],"be":[21],"affected":[22],"during":[23,393],"the":[24,35,46,71,201,228,363,385,409,500],"treatment":[25,93,126,178,345,377,399],"course.":[26],"The":[27,241,256,436],"objective":[28],"of":[29,37,48,130,141,150,203,217,231,244,351,431,499],"this":[30,88],"study":[31,89,437],"to":[33,156,321,414,421],"examine":[34],"trajectory":[36,485],"changes":[39,354,411],"at":[40,70,161,454],"180":[41,120,162],"and":[42,61,80,107,119,175,180,252,273,341,376,401,416,429,448],"365":[43,140],"days":[44,121,165,263,275],"after":[45,122,383],"initiation":[47,118,143],"immune":[49,493],"checkpoint":[50,494],"inhibitors":[51,495],"(ICIs)":[52],"among":[53,66,268,280,299,313,355,371,404,486],"NSCLC.":[56,407],"Methods:":[57],"Retrospective":[58],"chart":[59],"review":[60],"data":[62,137,237],"extraction":[63],"were":[64,85,144,158,250,254,334],"performed":[65,192],"receiving":[68,293,342,357,492],"ICIs":[69],"Ohio":[72],"State":[73],"University":[74],"Comprehensive":[75],"Cancer":[76,504,522],"Center":[77],"between":[78],"2015":[79],"2021.":[81],"Patients":[82],"NSCLC":[84,221],"included":[86,145],"if":[90,108],"their":[91,112,211],"initial":[92],"entailed":[94],"a":[95,343],"PD-1/PD-L1":[96],"ICI),":[97],"either":[98],"alone":[99],"or":[100,163,206,287,325],"combination":[102],"chemotherapy/targeted":[104],"cancer":[105,289,491],"drugs,":[106],"they":[109],"also":[110,335],"had":[111,134,234],"weights":[114],"recorded":[115],"on":[116,138,238,259,424],"ICI":[117,142,260,271,283,294,358,394,427],"(\u00b1":[123],"30":[124],"days)":[125,267,279],"initiation.":[127],"A":[128,188,215],"subset":[129],"these":[131],"who":[133],"day":[139,239],"additional":[147],"analysis.":[148],"Percentages":[149],"change":[151,307,392],"relative":[155],"pre-ICI":[157,167,171,181,402],"calculated":[159],"([weight":[160],"360":[164],"minus":[166],"weight]":[168],"divided":[169],"by":[170,177,193,200,398,442],"x":[173],"100%)":[174],"examined":[176],"regimen":[179,400],"mass":[183],"index":[184],"(BMI)":[185],"using":[186],"t-tests.":[187],"sensitivity":[189],"analysis":[190],"was":[191,246,261,438],"excluding":[194,384],"11":[195],"cachexia":[198],"defined":[199],"presence":[202],"ICD-9":[204],"(799.4)":[205],"10":[207],"(R64)":[208],"codes":[209],"medical":[212],"records.":[213],"Results:":[214],"total":[216],"554":[218],"received":[222],"any":[223],"ICI;":[224],"139":[225],"met":[227],"inclusion":[229],"criteria,":[230],"which":[232],"96":[233],"365.":[240],"mean":[242,306],"age":[243],"diagnosis":[245],"63.8":[247],"(SD=10.1);":[248],"80%":[249],"White":[251],"18.7%":[253],"Black.":[255],"median":[257],"time":[258],"195":[262],"(inter-quartile":[264,276],"range,":[265,277],"55-392":[266],"only":[272,359],"255":[274],"126-479":[278],"combined":[284,344],"chemotherapy":[286],"targeted":[288],"drugs.":[290],"Among":[291],"only,":[295],"increased":[298],"those":[300,314],"normal":[302,364],"(BMI":[304,318,327],"<25.0;":[305],"=":[308,319],"+7.57%,":[309],"P=0.013)":[310],"but":[311,369],"decreased":[312],"classified":[315],"as":[316],"overweight":[317],"25.0":[320],"29.9;":[322],"\u22125.2%,":[323],"P=0.037)":[324],"obese":[326],"\u226530;":[328],"\u22126.5%,":[329],"P=0.025).":[330],"Decreases":[331],"observed":[336],"for":[337,451,503],"obesity":[340],"(\u22129.65%,":[346],"P=0.043).":[347],"After":[348],"one":[349],"year":[350],"treatment,":[352],"remained":[360,381],"significant":[361],"group":[366],"(+15.6%,":[367],"P=0.007),":[368],"not":[370],"other":[374],"BMIs":[375],"regimens.":[378],"These":[379],"associations":[380],"similar":[382],"cachexia.":[388],"Conclusions:":[389],"therapy":[395],"vary":[397],"BMI":[403],"Whether":[408],"are":[412],"related":[413],"toxicities":[415],"survival":[417],"warrants":[418],"further":[419],"research":[420],"shed":[422],"light":[423],"management,":[426],"efficacy,":[428],"prevention":[430],"treatment-related":[432],"adverse":[433],"events.":[434],"Funding:":[435],"part":[440],"funded":[441],"NIH/NCI":[443],"R37CA248371,":[444],"OSUCCC":[445],"CCSG":[446],"P30CA016058,":[447],"Pelotonia":[449],"Institute":[450],"Immuno-Oncology":[452],"(PIIO)":[453],"OSUCCC.":[455],"Citation":[456],"Format:":[457],"Ting-Yuan":[458],"David":[459],"Cheng,":[460],"Ben":[461],"Kinder,":[462],"Rand":[463],"T.":[464],"Akasheh,":[465],"Cuthbert":[466],"Mario":[467],"Mahenge,":[468],"Carolyn":[469],"J.":[470],"Presley,":[471],"Peter":[472],"G.":[473],"Shields,":[474],"Xuan":[475],"Nguyen,":[476],"Aditi":[477],"Shendre,":[478],"Zihai":[479],"Li,":[480],"Lang":[481],"Li.":[482],"non-small-cell":[489],"[abstract].":[496],"In:":[497],"Proceedings":[498],"American":[501],"Association":[502],"Research":[505],"Annual":[506],"Meeting":[507],"2024;":[508],"Part":[509],"1":[510],"(Regular":[511],"Abstracts);":[512],"2024":[513],"Apr":[514],"5-10;":[515],"San":[516],"Diego,":[517],"CA.":[518],"Philadelphia":[519],"(PA):":[520],"AACR;":[521],"Res":[523],"2024;84(6_Suppl):Abstract":[524],"nr":[525],"3404.":[526]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-03-23T00:00:00"}
