{"id":"https://openalex.org/W4393093166","doi":"https://doi.org/10.1158/1538-7445.am2024-3006","title":"Abstract 3006: Morphogen-driven regulation of nuclear shape and its implication for colorectal cancer","display_name":"Abstract 3006: Morphogen-driven regulation of nuclear shape and its implication for colorectal cancer","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393093166","doi":"https://doi.org/10.1158/1538-7445.am2024-3006"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-3006","doi":"https://doi.org/10.1158/1538-7445.am2024-3006","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3006","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094224091","display_name":"Mona A. El Gendi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona A. El Gendi","raw_affiliation_strings":["1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066773533","display_name":"Sol\u00e8ne Herv\u00e9","orcid":"https://orcid.org/0000-0002-5015-8493","observed_orcids":["https://orcid.org/0000-0002-5015-8493"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sol\u00e8ne Herv\u00e9","raw_affiliation_strings":["1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059628530","display_name":"Sudeep Gautam","orcid":"https://orcid.org/0009-0008-6441-8621","observed_orcids":["https://orcid.org/0009-0008-6441-8621","https://orcid.org/0000-0002-0039-384X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudeep Gautam","raw_affiliation_strings":["1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087171342","display_name":"Yekaterina A. Miroshnikova","orcid":"https://orcid.org/0000-0001-9771-4963","observed_orcids":["https://orcid.org/0000-0001-9771-4963"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yekaterina A. Miroshnikova","raw_affiliation_strings":["1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"3006","last_page":"3006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.133200004696846,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-shape","display_name":"nuclear shape","score":0.8429999947547913},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/morphogen-gradients","display_name":"morphogen gradients","score":0.5899999737739563},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/adenomatous-polyposis-coli","display_name":"adenomatous polyposis coli","score":0.9449999928474426},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nucleoskeleton","display_name":"nucleoskeleton","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.7689999938011169},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2778386714","wikidata":"https://www.wikidata.org/wiki/Q417084","display_name":"Morphogen","level":3,"score":0.8017584085464478},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7520387172698975},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6036578416824341},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4118545353412628},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41137802600860596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3906461000442505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38939574360847473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29979562759399414},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1256178319454193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-3006","doi":"https://doi.org/10.1158/1538-7445.am2024-3006","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3006","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W12813343","https://openalex.org/W1986672866","https://openalex.org/W3087730663","https://openalex.org/W2911664057","https://openalex.org/W2079956148","https://openalex.org/W2135795211","https://openalex.org/W1078150404","https://openalex.org/W2150695642","https://openalex.org/W4403432319","https://openalex.org/W4400231961"],"abstract_inverted_index":{"Abstract":[0],"Colorectal":[1],"cancer":[2,37,225],"(CRC)":[3],"is":[4,75,101,128,134,181],"the":[5,29,88,96,102,107,135,148,194,230],"second":[6],"leading":[7],"cause":[8],"of":[9,16,21,25,31,90,93,104,123,137,178,196,217,229],"cancer-related":[10],"deaths":[11],"worldwide":[12],"despite":[13],"improved":[14],"rates":[15],"early":[17],"detection":[18],"and":[19,28,39,45,51,56,70,72,80,141,153,159,170,193,200,220],"development":[20],"targeted":[22],"treatments.":[23],"Dysregulation":[24],"nuclear":[26,60,66,139,154,198,218],"shape":[27,67,140,155,199,219],"emergence":[30,195],"aberrant":[32,121,197],"chromatin":[33,54],"architecture":[34],"correlate":[35],"with":[36],"onset":[38],"progression,":[40],"including":[41],"CRC.":[42],"Both":[43],"extrinsic":[44],"intrinsic":[46],"factors,":[47],"most":[48],"critically":[49],"cytoskeletal":[50],"nucleoskeletal":[52],"organization,":[53],"architecture,":[55],"metabolic":[57],"signaling,":[58],"impact":[59],"shape.":[61],"Yet,":[62],"what":[63],"precisely":[64],"determines":[65],"in":[68,106,157,163,168],"health":[69],"disease":[71],"how":[73],"it":[74],"linked":[76],"to":[77,120,146,182],"cell":[78],"fate":[79],"function":[81,105],"remains":[82],"a":[83,185],"fundamental":[84],"open":[85],"question.":[86],"In":[87],"case":[89],"over":[91],"75%":[92],"CRC":[94],"cases,":[95],"first":[97],"transformative":[98],"genetic":[99],"event":[100],"loss":[103],"tumor":[108],"suppressor":[109],"gene,":[110],"adenomatous":[111],"polyposis":[112],"coli":[113],"(APC).":[114],"Mechanistically,":[115],"perturbed":[116],"APC":[117],"signaling":[118],"leads":[119],"activation":[122],"Wnt/beta-catenin":[124],"signaling.":[125],"This":[126],"pathway":[127],"essential":[129],"for":[130,223,233],"intestinal":[131],"homeostasis,":[132],"as":[133,165,167],"regulation":[136,156,216],"proper":[138],"function.":[142,201],"Here,":[143],"we":[144],"aim":[145],"decipher":[147],"crosstalk":[149],"between":[150,189],"Wnt":[151],"gradients":[152],"non-transformed":[158],"APC-mutated":[160],"epithelial":[161],"cells":[162],"vitro,":[164],"well":[166],"WT":[169],"APC-mutant":[171],"mouse":[172],"colon":[173],"tissues.":[174],"The":[175],"long-term":[176],"goal":[177],"this":[179],"work":[180],"test":[183],"whether":[184],"mechanistic":[186],"link":[187],"exists":[188],"Wnt-driven":[190],"cellular":[191],"transformation":[192],"Citation":[202],"Format:":[203],"Mona":[204],"A.":[205,213],"El":[206],"Gendi,":[207],"Sol\u00e8ne":[208],"Herv\u00e9,":[209],"Sudeep":[210],"Gautam,":[211],"Yekaterina":[212],"Miroshnikova.":[214],"Morphogen-driven":[215],"its":[221],"implication":[222],"colorectal":[224],"[abstract].":[226],"In:":[227],"Proceedings":[228],"American":[231],"Association":[232],"Cancer":[234,252],"Research":[235],"Annual":[236],"Meeting":[237],"2024;":[238],"Part":[239],"1":[240],"(Regular":[241],"Abstracts);":[242],"2024":[243],"Apr":[244],"5-10;":[245],"San":[246],"Diego,":[247],"CA.":[248],"Philadelphia":[249],"(PA):":[250],"AACR;":[251],"Res":[253],"2024;84(6_Suppl):Abstract":[254],"nr":[255],"3006.":[256]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-03-23T00:00:00"}
