{"id":"https://openalex.org/W4393092499","doi":"https://doi.org/10.1158/1538-7445.am2024-6217","title":"Abstract 6217: Differential genome-wide gene regulatory networks for lung cancer","display_name":"Abstract 6217: Differential genome-wide gene regulatory networks for lung cancer","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393092499","doi":"https://doi.org/10.1158/1538-7445.am2024-6217"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-6217","doi":"https://doi.org/10.1158/1538-7445.am2024-6217","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6217","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100574425","display_name":"Min Zhang","orcid":"https://orcid.org/0009-0004-4883-8379","observed_orcids":["https://orcid.org/0009-0004-4883-8379"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Zhang","raw_affiliation_strings":["1University of California, Irvine, Irvine, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Irvine, Irvine, CA;","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759077","display_name":"Zhongli Jiang","orcid":"https://orcid.org/0000-0002-7989-6502","observed_orcids":["https://orcid.org/0000-0002-7989-6502"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongli Jiang","raw_affiliation_strings":["2Purdue University, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021108739","display_name":"Dabao Zhang","orcid":"https://orcid.org/0000-0003-0629-8672","observed_orcids":["https://orcid.org/0000-0003-0629-8672"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dabao Zhang","raw_affiliation_strings":["1University of California, Irvine, Irvine, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, Irvine, Irvine, CA;","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"6217","last_page":"6217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.2117999941110611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.875},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.8700000047683716},{"id":"https://openalex.org/keywords/differential-gene-regulation","display_name":"differential gene regulation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5389999747276306},{"id":"https://openalex.org/keywords/extracellular-matrix-organization","display_name":"extracellular matrix organization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hematopoietic-lineage","display_name":"hematopoietic lineage","score":0.8849999904632568},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6919999718666077},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9520000219345093},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.781000018119812},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.9129999876022339},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5798704624176025},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5412366986274719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5292054414749146},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5271707773208618},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4835774302482605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47148701548576355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4177870750427246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38433948159217834},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2242996096611023}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-6217","doi":"https://doi.org/10.1158/1538-7445.am2024-6217","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6217","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388082213","https://openalex.org/W2553829819","https://openalex.org/W4394334257","https://openalex.org/W2805214175","https://openalex.org/W2333572441","https://openalex.org/W2549341378","https://openalex.org/W2904088440","https://openalex.org/W4206059905","https://openalex.org/W4410759584","https://openalex.org/W6902481586"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Lung":[2],"cancer":[3,9,64,79,101,357,397,421],"remains":[4],"the":[5,14,30,54,72,81,116,161,191,221,233,286,295,301,325,379,386,392,400,426],"leading":[6],"cause":[7],"of":[8,76,85,97,140,143,182,184,196,229,364,395,402,425],"death":[10],"worldwide":[11],"due":[12],"to":[13,39],"fact":[15],"that":[16],"most":[17,82,344],"cases":[18],"are":[19],"diagnosed":[20],"at":[21,215],"distant":[22],"stages,":[23],"and":[24,43,62,103,110,122,137,160,180,245,249,267,282,299,305,311,313,315,329,337,355,359,362,398],"treatment":[25,404],"is":[26],"less":[27],"effective.":[28],"During":[29],"past":[31],"two":[32,73],"decades,":[33],"much":[34],"effort":[35],"has":[36],"been":[37],"devoted":[38],"understanding":[40],"tumor":[41],"biology":[42],"developing":[44],"targeted":[45],"therapeutics,":[46],"which":[47],"have":[48],"significantly":[49],"improved":[50],"patient":[51],"survival.":[52],"With":[53],"increasingly":[55],"available":[56,129],"multi-omics":[57,367],"data":[58,98,112,142,368],"from":[59,99,105,115,149,232,370,385],"healthy":[60,106,283,306,316,352],"controls":[61],"lung":[63,78,86,100,119,123,145,205,353,356,371,396,420],"patients,":[65],"we":[66,198,323,346],"constructed":[67,93,165],"gene":[68,349,416],"regulatory":[69,417],"networks":[70,91,156,163,186,278,418],"for":[71,157,419,429],"main":[74],"subtypes":[75],"non-small-cell":[77],"(NSCLC),":[80],"common":[83],"type":[84],"cancer.":[87],"In":[88,321],"addition,":[89,322],"differential":[90,162,277,348],"were":[92,113,147,164],"by":[94,166],"integrative":[95],"analysis":[96,181,255,387],"tissue":[102,128,146,354,358],"tissues":[104],"lungs.":[107],"Methods:":[108],"Transcriptomics":[109],"genomic":[111],"obtained":[114],"patients":[117],"with":[118,204,225,374],"adenocarcinoma":[120],"(LUAD)":[121],"squamous":[124],"cell":[125,274],"carcinoma":[126],"(LUSC)":[127],"in":[130],"The":[131,150,155,276],"Cancer":[132,430,448],"Genome":[133],"Atlas":[134],"(TCGA)":[135],"project,":[136],"both":[138],"types":[139],"omics":[141],"normal":[144],"downloaded":[148],"Genotype-Tissue":[151],"Expression":[152],"(GTEx)":[153],"consortium.":[154],"each":[158],"subtype":[159],"utilizing":[167],"our":[168],"newly":[169],"developed":[170],"machine":[171,376],"learning":[172,377],"tools,":[173],"two-stage":[174],"penalized":[175],"least":[176],"square":[177],"(2SPLS)":[178],"approach,":[179],"variance":[183],"directed":[185],"(NetANOVA),":[187],"respectively.":[188,320],"Results:":[189],"For":[190],"top":[192,222],"three":[193,223,291],"identified":[194,199,324,347],"subnetworks":[195,224],"LUAD,":[197,280],"some":[200],"well-known":[201],"genes":[202,384],"associated":[203],"cancer,":[206],"such":[207,271,293,331],"as":[208,272,294,332],"EGFR,":[209],"IRF1,":[210],"KRAS,":[211],"ERBB2,":[212],"PIK3CA,":[213],"MYC,":[214],"bootstrap":[216,227],"frequency":[217,228],">90%.":[218],"Based":[219],"on":[220],"a":[226],"100%,":[230],"results":[231],"Ingenuity":[234],"Pathway":[235],"Analysis":[236],"(IPA)":[237],"indicated":[238],"several":[239],"significant":[240,258,268],"pathways,":[241],"primary":[242],"immunodeficiency":[243],"signaling":[244],"communication":[246],"between":[247,279,297,303,309,327,335,351,360,382],"innate":[248],"adaptive":[250],"immune":[251,262],"cells.":[252],"GO":[253],"enrichment":[254],"showed":[256,285],"statistically":[257],"biological":[259],"processes,":[260],"including":[261],"response,":[263],"extracellular":[264],"matrix":[265],"organization,":[266],"KEGG":[269],"pathways":[270],"Hematopoietic":[273],"lineage.":[275],"LUSC,":[281,330],"lungs":[284],"same":[287],"regulations":[288,308,334,350],"across":[289],"all":[290,341],"groups,":[292],"regulation":[296],"EEF2":[298],"RACK1,":[300],"perturbations":[302],"LUAD":[304,328,361],"(two-way":[307],"HIGD2A":[310],"ARL10),":[312],"LUSC":[314,363],"(GRB14":[317],"regulates":[318],"EIF3E)":[319],"differences":[326],"bi-directional":[333],"CLTB":[336],"ARL10.":[338],"Conclusion:":[339],"Although":[340],"groups":[342],"share":[343],"regulations,":[345],"NSCLC.":[365],"Using":[366],"generated":[369],"tissues,":[372],"coupled":[373],"advanced":[375],"methods,":[378],"causal":[380],"relationships":[381],"genome-wide":[383,415],"will":[388],"help":[389],"us":[390],"understand":[391],"molecular":[393],"mechanism":[394],"facilitate":[399],"development":[401],"personalized":[403],"strategies.":[405],"Citation":[406],"Format:":[407],"Min":[408],"Zhang,":[409],"Zhongli":[410],"Jiang,":[411],"Dabao":[412],"Zhang.":[413],"Differential":[414],"[abstract].":[422],"In:":[423],"Proceedings":[424],"American":[427],"Association":[428],"Research":[431],"Annual":[432],"Meeting":[433],"2024;":[434],"Part":[435],"1":[436],"(Regular":[437],"Abstracts);":[438],"2024":[439],"Apr":[440],"5-10;":[441],"San":[442],"Diego,":[443],"CA.":[444],"Philadelphia":[445],"(PA):":[446],"AACR;":[447],"Res":[449],"2024;84(6_Suppl):Abstract":[450],"nr":[451],"6217.":[452]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-03-23T00:00:00"}
