{"id":"https://openalex.org/W4393090847","doi":"https://doi.org/10.1158/1538-7445.am2024-137","title":"Abstract 137: Increased activity of protein kinase A is sufficient to cause fibrolamellar carcinoma","display_name":"Abstract 137: Increased activity of protein kinase A is sufficient to cause fibrolamellar carcinoma","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393090847","doi":"https://doi.org/10.1158/1538-7445.am2024-137"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-137","doi":"https://doi.org/10.1158/1538-7445.am2024-137","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-137","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078928895","display_name":"Mahsa Shirani","orcid":"https://orcid.org/0009-0008-5171-3808","observed_orcids":["https://orcid.org/0009-0008-5171-3808"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahsa Shirani","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103236180","display_name":"Michael D. Tomasini","orcid":"https://orcid.org/0000-0002-9634-2560","observed_orcids":["https://orcid.org/0000-0002-9634-2560"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Tomasini","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008500010","display_name":"Solomon Levin","orcid":"https://orcid.org/0000-0003-1548-8881","observed_orcids":["https://orcid.org/0000-0003-1548-8881"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Solomon Levin","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059602565","display_name":"Soeren Heissel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"soeren heissel","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026244741","display_name":"Henrik Molina","orcid":"https://orcid.org/0000-0001-8950-4990","observed_orcids":["https://orcid.org/0000-0001-8950-4990"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henrik Molina","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034685257","display_name":"Ype P. de Jong","orcid":"https://orcid.org/0000-0001-6357-2370","observed_orcids":["https://orcid.org/0000-0001-6357-2370"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ype De Jong","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019683467","display_name":"Charles M. Rice","orcid":"https://orcid.org/0000-0003-3087-8079","observed_orcids":["https://orcid.org/0000-0003-3087-8079"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"charles Rice","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015312742","display_name":"Philip Coffino","orcid":"https://orcid.org/0000-0003-0344-5083","observed_orcids":["https://orcid.org/0000-0003-0344-5083"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Coffino","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091794044","display_name":"Barbara A. Lyons","orcid":"https://orcid.org/0000-0003-3242-2104","observed_orcids":["https://orcid.org/0000-0003-3242-2104"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Lyons","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036195107","display_name":"Sanford M. Simon","orcid":"https://orcid.org/0000-0002-8615-4224","observed_orcids":["https://orcid.org/0000-0002-8615-4224"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanford Simon","raw_affiliation_strings":["1The Rockefeller University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Rockefeller University, New York, NY","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"137","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.41260001063346863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.41260001063346863,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.11479999870061874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrolamellar-carcinoma","display_name":"fibrolamellar hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7689999938011169},{"id":"https://openalex.org/keywords/protein-kinase-substrate-specificity","display_name":"kinase substrate specificity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/liver-cancer-pathogenesis","display_name":"liver cancer pathogenesis","score":0.640999972820282},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.547618567943573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44910192489624023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3667184114456177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-137","doi":"https://doi.org/10.1158/1538-7445.am2024-137","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-137","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414502456","https://openalex.org/W4399758425","https://openalex.org/W4282960950","https://openalex.org/W2767490888","https://openalex.org/W4402886836","https://openalex.org/W7080457509","https://openalex.org/W2772912444","https://openalex.org/W2953258979","https://openalex.org/W2325926003","https://openalex.org/W4307502948"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"cells":[2,212,250,283],"of":[3,22,31,38,61,75,101,114,124,142,156,172,219,251,259,281,303,313,339,356,365,395,408],"almost":[4],"all":[5],"patients":[6],"with":[7,337],"fibrolamellar":[8,403],"carcinoma":[9,404],"(FLC)":[10],"have":[11,229],"a":[12,15,28,181,214,353],"somatic":[13],"mutation,":[14],"~400":[16],"kB":[17],"deletion":[18],"on":[19,322,327],"one":[20],"copy":[21],"chromosome":[23],"19":[24],"that":[25,86,148,231,280,289,315],"results":[26],"in":[27,97,111,152,165,184,189,204,209,216,223,234,245,248,257,271],"fusion":[29,44],"transcript":[30],"DNAJB1":[32,291,345,349],"to":[33,65,194,240,401],"PRKACA,":[34,340],"the":[35,59,73,79,91,98,112,133,153,157,166,169,173,190,195,210,217,220,224,243,246,272,275,290,344,348,359,366,409],"catalytic":[36,126,170,187,207,221,236,368],"subunit":[37,171,188,222],"protein":[39,396],"kinase":[40,48,103,116,127,174,262,266,397],"A.":[41],"The":[42],"resulting":[43],"oncoprotein,":[45],"DNAJB1::PRKACA,":[46],"has":[47],"activity,":[49],"and":[50,53,64,144,175,213,274,295,310,325,358],"is":[51,201,238,293,351,362,399],"required":[52],"sufficient":[54,239,400],"for":[55,242,298,412],"transformation.":[56,299],"To":[57],"understand":[58],"oncogenesis":[60],"this":[62,232],"tumor":[63,143,211,225,249,282],"help":[66],"identify":[67],"potential":[68],"therapeutic":[69],"targets,":[70],"we":[71,228,306],"explored":[72,83],"pathways":[74],"pathogenesis":[76],"mediated":[77],"by":[78,90],"aberrant":[80],"kinase.":[81,107,120,159],"We":[82,137,178],"three":[84],"mechanisms":[85],"might":[87],"explain":[88],"transformation":[89],"oncogenic":[92],"kinase:":[93],"-":[94,108,121],"A":[95,109,398],"difference":[96,110],"substrate":[99,154],"specificity":[100,155],"DNAJB1::PRKACA":[102,115,158,261],"versus":[104,117,132],"native":[105,118,134,264],"PRKACA":[106,119,135,186,265],"interactome":[113],"An":[122],"increase":[123,183,203,233,364],"total":[125,185],"activity":[128,208,237,394],"(DNAJB1::PRKACA":[129],"+":[130],"PRKACA)":[131],"condition.":[136],"found,":[138],"comparing":[139],"cytosolic":[140,176],"extracts":[141],"normal":[145],"liver":[146],"cells,":[147],"there":[149,200],"are":[150,316,335],"differences":[151,164],"Additionally,":[160,227],"such":[161],"comparisons":[162],"revealed":[163],"interactions":[167],"between":[168],"components.":[177],"also":[179],"demonstrated":[180],"consistent":[182],"FLC":[191,252,285,314],"tumor,":[192],"relative":[193],"adjacent":[196],"nontransformed":[197],"tissue.":[198],"Further,":[199],"an":[202,363],"free,":[205],"unregulated":[206],"change":[215],"localization":[218],"cells.":[226],"found":[230,307],"free":[235],"account":[241],"changes":[244,270,338],"transcriptome":[247,324],"patients.":[253,286],"Importantly,":[254,332],"enhanced":[255],"expression":[256],"hepatocytes":[258],"either":[260],"or":[263],"caused":[267],"very":[268],"similar":[269],"transcriptome,":[273],"resultant":[276],"transcriptomes":[277],"closely":[278],"resembled":[279],"from":[284,318],"This":[287],"suggests":[288],"domain":[292,350],"dispensable":[294],"not":[296,352],"critical":[297,354],"In":[300],"our":[301],"investigation":[302],"patient":[304],"tumors":[305],"two":[308],"rare":[309],"different":[311],"subclasses":[312,334],"indistinguishable":[317],"\u201cclassic\u201d":[319],"FLC,":[320],"based":[321,326],"their":[323,328],"drug":[329],"response":[330],"profiles.":[331],"both":[333],"associated":[336],"but":[341],"neither":[342],"involves":[343],"domain.":[346],"Thus,":[347],"component":[355],"transformation,":[357],"significant":[360],"driver":[361],"cellular":[367],"activity.":[369],"Citation":[370],"Format:":[371],"Mahsa":[372],"Shirani,":[373],"Michael":[374],"Tomasini,":[375],"Solomon":[376],"Levin,":[377],"soeren":[378],"heissel,":[379],"Henrik":[380],"Molina,":[381],"Ype":[382],"De":[383],"Jong,":[384],"charles":[385],"Rice,":[386],"Philip":[387],"Coffino,":[388],"Barbara":[389],"Lyons,":[390],"Sanford":[391],"Simon.":[392],"Increased":[393],"cause":[402],"[abstract].":[405],"In:":[406],"Proceedings":[407],"American":[410],"Association":[411],"Cancer":[413,431],"Research":[414],"Annual":[415],"Meeting":[416],"2024;":[417],"Part":[418],"1":[419],"(Regular":[420],"Abstracts);":[421],"2024":[422],"Apr":[423],"5-10;":[424],"San":[425],"Diego,":[426],"CA.":[427],"Philadelphia":[428],"(PA):":[429],"AACR;":[430],"Res":[432],"2024;84(6_Suppl):Abstract":[433],"nr":[434],"137.":[435]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-03-23T00:00:00"}
