{"id":"https://openalex.org/W4393090430","doi":"https://doi.org/10.1158/1538-7445.am2024-6280","title":"Abstract 6280: Vitamin D enhances luminal differentiation of prostate organoids more than androgens","display_name":"Abstract 6280: Vitamin D enhances luminal differentiation of prostate organoids more than androgens","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393090430","doi":"https://doi.org/10.1158/1538-7445.am2024-6280"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-6280","doi":"https://doi.org/10.1158/1538-7445.am2024-6280","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6280","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113150030","display_name":"Oscar Fernando Cerna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar Fernando Cerna","raw_affiliation_strings":["1University of Illinois at Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois at Chicago, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019107791","display_name":"Larisa Nonn","orcid":"https://orcid.org/0000-0002-0852-7726","observed_orcids":["https://orcid.org/0000-0002-0852-7726"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larisa Nonn","raw_affiliation_strings":["1University of Illinois at Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois at Chicago, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113150031","display_name":"Mike Schlicht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Schlicht","raw_affiliation_strings":["1University of Illinois at Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois at Chicago, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108910959","display_name":"Kirty Krieger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirty Krieger","raw_affiliation_strings":["1University of Illinois at Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Illinois at Chicago, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"6280","last_page":"6280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.953000009059906},{"id":"https://openalex.org/keywords/prostate-organoids","display_name":"prostate organoids","score":0.9020000100135803},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.906000018119812},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.8389999866485596},{"id":"https://openalex.org/keywords/african-american-men","display_name":"African American men","score":0.7789999842643738},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d3","display_name":"25-hydroxyvitamin D3","score":0.7979999780654907},{"id":"https://openalex.org/keywords/melanin","display_name":"melanin","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8991959095001221},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6183072328567505},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.43748152256011963},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4137202501296997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4086664319038391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3801760673522949},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.36064648628234863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3353903889656067},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2033405303955078},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1327354907989502}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-6280","doi":"https://doi.org/10.1158/1538-7445.am2024-6280","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6280","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2886786431","https://openalex.org/W3116500759","https://openalex.org/W7130389466","https://openalex.org/W1736845235","https://openalex.org/W6945314027","https://openalex.org/W134556950","https://openalex.org/W1998160990","https://openalex.org/W4319594010","https://openalex.org/W3082595321","https://openalex.org/W1985337420"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Prostate":[2],"Cancer":[3,390,408],"(PCa)":[4],"is":[5,17,22,42,122],"a":[6,18,104,290],"prevalent":[7,251],"disease":[8],"affecting":[9],"over":[10],"two":[11,202],"million":[12],"men":[13,348],"worldwide.":[14],"Vitamin":[15,40,72,371],"D":[16,41,73,101,321,353,372],"fat-soluble":[19],"hormone":[20,95],"that":[21,305,318],"well-known":[23],"for":[24,233,299,338,389],"its":[25],"role":[26,172],"in":[27,37,44,47,69,115,125,165,178,252,271,311,345],"the":[28,45,87,93,99,110,123,140,146,151,162,171,179,297,339,386],"maintenance":[29],"of":[30,84,153,173,183,210,266,284,296,326,341,376,385],"strong":[31],"bones":[32],"and":[33,52,79,118,149,167,181,197,212,226,231,236,264,294],"has":[34,336],"anti-cancer":[35],"effects":[36],"prostate":[38,116,158,189,285,313,328,377],"cancer.":[39],"synthesized":[43],"skin":[46],"response":[48],"to":[49,160,168,256,276,331,356],"sun":[50],"exposure":[51],"may":[53,323],"be":[54],"supplemented":[55],"with":[56,208,289],"diet.":[57],"However,":[58],"since":[59],"melanin":[60],"hinders":[61],"this":[62],"synthesis":[63],"many":[64],"African":[65,346],"Americans":[66],"are":[67,109,145,150],"deficient":[68],"vitamin":[70,100,291,320,352],"D.":[71],"circulates":[74],"as":[75,135,199,241],"25-hydroxyvitamin":[76],"D3":[77,81],"(25D)":[78],"25-dihydroxyvitamin":[80],"(1,25D).":[82],"Hydroxylation":[83],"25D":[85],"by":[86],"kidney":[88],"or":[89,128,137,244,258],"within":[90],"tissues":[91],"forms":[92],"active":[94],"1,25D.":[96],"1,25D":[97,174,211,222,253,272,306],"binds":[98],"receptor":[102],"(VDR),":[103],"steroid":[105],"transcription":[106],"factor.":[107],"Androgens":[108],"main":[111],"regulatory":[112],"hormones":[113],"involved":[114],"growth":[117],"differentiation.":[119,334],"Epithelial":[120],"differentiation":[121,163,177,300,310,375],"process":[124,164],"which":[126],"progenitor":[127],"stem":[129],"cells":[130,144,190],"become":[131],"specialized":[132],"cells,":[133],"such":[134],"basal":[136],"luminal.":[138],"In":[139],"prostate,":[141],"luminal":[142,267,308,374],"epithelial":[143,176,309,333],"most":[147],"differentiated":[148],"origin":[152],"PCa.":[154],"We":[155,303],"used":[156],"mouse":[157,188,312],"organoids":[159,207,268,286,298,378],"replicate":[161],"vitro":[166],"help":[169],"identify":[170],"on":[175],"presence":[180],"absence":[182],"other":[184,278],"androgens.":[185],"Methods:":[186],"Primary":[187],"were":[191,220,229,239,249],"isolated":[192],"from":[193,287],"dorsal":[194],"lateral":[195],"lobes":[196],"grown":[198],"organoids.":[200,314],"Over":[201],"weeks,":[203],"we":[204],"treated":[205],"these":[206],"concentrations":[209],"androgen":[213],"(dihydrotestosterone,":[214],"DHT).":[215],"The":[216,261],"four":[217],"treatment":[218],"groups":[219],"control,":[221],"only,":[223],"DHT":[224,259,274],"only":[225],"1,25D+DHT.":[227],"Organoids":[228],"imaged":[230],"analyzed":[232],"number,":[234,262],"size":[235,263],"phenotype.":[237],"Phenotypes":[238],"identified":[240],"luminal,":[242],"acinar,":[243],"solid.":[245],"Results:":[246],"Luminal":[247],"phenotypes":[248],"more":[250,379],"conditions":[254],"compared":[255,275,355],"control":[257],"alone.":[260],"percent":[265],"was":[269],"highest":[270],"+":[273],"all":[277],"groups.":[279],"Ongoing":[280],"studies":[281],"include":[282],"examination":[283],"mice":[288],"D-deficient":[292],"diet":[293],"staining":[295],"markers.":[301],"Conclusions/Significance:":[302],"observed":[304,344],"enhanced":[307],"These":[315],"findings":[316],"suggest":[317],"chronic":[319],"deficiency":[322],"increase":[324],"risk":[325],"aggressive":[327,342],"cancer,":[329],"due":[330],"decreased":[332],"This":[335],"implications":[337],"disparity":[340],"PCa":[343],"American":[347,387],"who":[349],"have":[350],"lower":[351],"levels":[354],"their":[357],"white":[358],"counterparts.":[359],"Citation":[360],"Format:":[361],"Oscar":[362],"Fernando":[363],"Cerna,":[364],"Larisa":[365],"Nonn,":[366],"Mike":[367],"Schlicht,":[368],"Kirty":[369],"Krieger.":[370],"enhances":[373],"than":[380],"androgens":[381],"[abstract].":[382],"In:":[383],"Proceedings":[384],"Association":[388],"Research":[391],"Annual":[392],"Meeting":[393],"2024;":[394],"Part":[395],"1":[396],"(Regular":[397],"Abstracts);":[398],"2024":[399],"Apr":[400],"5-10;":[401],"San":[402],"Diego,":[403],"CA.":[404],"Philadelphia":[405],"(PA):":[406],"AACR;":[407],"Res":[409],"2024;84(6_Suppl):Abstract":[410],"nr":[411],"6280.":[412]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-03-23T00:00:00"}
