{"id":"https://openalex.org/W4393090385","doi":"https://doi.org/10.1158/1538-7445.am2024-3231","title":"Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer","display_name":"Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393090385","doi":"https://doi.org/10.1158/1538-7445.am2024-3231"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-3231","doi":"https://doi.org/10.1158/1538-7445.am2024-3231","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3231","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079460736","display_name":"Richard C. Centore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard C. Centore","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062835956","display_name":"Mark D. Charles","orcid":"https://orcid.org/0000-0002-6278-8249","observed_orcids":["https://orcid.org/0000-0002-6278-8249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Charles","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061882560","display_name":"Mansi Arora","orcid":"https://orcid.org/0009-0009-8832-4926","observed_orcids":["https://orcid.org/0009-0009-8832-4926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mansi Arora","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439331","display_name":"Yiwen Chen","orcid":"https://orcid.org/0000-0002-7706-7540","observed_orcids":["https://orcid.org/0000-0002-7706-7540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiwen Chen","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew Watson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Watson","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055353022","display_name":"Charlotte Kelley","orcid":"https://orcid.org/0000-0001-5778-1432","observed_orcids":["https://orcid.org/0000-0001-5778-1432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotte Kelley","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031836910","display_name":"Magdalena A. Czekalska","orcid":"https://orcid.org/0000-0002-4494-4463","observed_orcids":["https://orcid.org/0000-0002-4494-4463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Czekalska","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054279597","display_name":"Marius Rebmann","orcid":"https://orcid.org/0000-0003-1462-0975","observed_orcids":["https://orcid.org/0000-0003-1462-0975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marius Rebmann","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000230644","display_name":"Mahmoud Ghandi","orcid":"https://orcid.org/0000-0003-1897-2265","observed_orcids":["https://orcid.org/0000-0003-1897-2265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahmoud Ghandi","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094223182","display_name":"Jerome Cattin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerome Cattin","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006084918","display_name":"Nagakumar Bharatham","orcid":"https://orcid.org/0000-0003-4904-7726","observed_orcids":["https://orcid.org/0000-0003-4904-7726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagakumar Bharatham","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Prathima Radhakrishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prathima Radhakrishnan","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113150029","display_name":"Alex Howarth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Howarth","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094223183","display_name":"Gale Rudlaff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gale Rudlaff","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048226666","display_name":"William E. Arter","orcid":"https://orcid.org/0000-0002-3615-1885","observed_orcids":["https://orcid.org/0000-0002-3615-1885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. Arter","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058191684","display_name":"Seema Qamar","orcid":"https://orcid.org/0000-0003-1189-206X","observed_orcids":["https://orcid.org/0000-0003-1189-206X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seema Qamar","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045077852","display_name":"Kadi Liis Saar","orcid":"https://orcid.org/0000-0002-5926-3628","observed_orcids":["https://orcid.org/0000-0002-5926-3628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kadi Saar","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061947985","display_name":"Douglas S. Williamson","orcid":"https://orcid.org/0000-0002-5094-5200","observed_orcids":["https://orcid.org/0000-0002-5094-5200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Williamson","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054110838","display_name":"Andrew Seeber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Seeber","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041530719","display_name":"Tuomas P. J. Knowles","orcid":"https://orcid.org/0000-0002-7879-0140","observed_orcids":["https://orcid.org/0000-0002-7879-0140","https://orcid.org/0000-0002-0016-3008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tuomas Knowles","raw_affiliation_strings":["2Transition Bio, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Transition Bio, Cambridge, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087252132","display_name":"Shilpi Arora","orcid":"https://orcid.org/0000-0002-8918-6061","observed_orcids":["https://orcid.org/0000-0002-8918-6061","https://orcid.org/0000-0001-5133-3612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shilpi Arora","raw_affiliation_strings":["1Transition Bio, Watertown, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Transition Bio, Watertown, MA;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"3231","last_page":"3231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ythdc1","display_name":"YTHDC1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/biomolecular-condensates","display_name":"biomolecular condensates","score":0.8790000081062317},{"id":"https://openalex.org/keywords/phase-separation","display_name":"phase separation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rna-methylation","display_name":"RNA methylation","score":0.722000002861023},{"id":"https://openalex.org/keywords/mettl3","display_name":"METTL3","score":0.6809999942779541},{"id":"https://openalex.org/keywords/rna-binding-pocket","display_name":"RNA binding pocket","score":0.8149999976158142},{"id":"https://openalex.org/keywords/myc-expression","display_name":"MYC expression","score":0.6629999876022339},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.6759999990463257},{"id":"https://openalex.org/keywords/adme-properties","display_name":"ADME properties","score":0.6060000061988831},{"id":"https://openalex.org/keywords/differentiation-therapy","display_name":"differentiation therapy","score":0.5059999823570251},{"id":"https://openalex.org/keywords/epigenetic-dysregulation","display_name":"epigenetic dysregulation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6435369253158569},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4528639018535614},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4451954960823059},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36244478821754456},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36112114787101746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3338509798049927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3008735775947571},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.21267324686050415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14246517419815063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13196507096290588},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.061958491802215576}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-3231","doi":"https://doi.org/10.1158/1538-7445.am2024-3231","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-3231","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405040363","https://openalex.org/W7148789670","https://openalex.org/W4409690784","https://openalex.org/W4368351354","https://openalex.org/W7148633143","https://openalex.org/W4206107028","https://openalex.org/W7127593395","https://openalex.org/W7160549584","https://openalex.org/W4393095258","https://openalex.org/W3164493493"],"abstract_inverted_index":{"Abstract":[0],"Epigenetic":[1],"dysregulation":[2],"is":[3,40,51,62,190],"a":[4,75,114,191,302,365],"hallmark":[5],"of":[6,32,42,77,122,148,169,174,182,195,202,224,308,358,377],"cancer,":[7],"and":[8,58,61,69,89,92,103,120,187,207,226,246,251,268,279],"tumors":[9],"have":[10,156,212],"evolved":[11],"complex":[12],"mechanisms":[13],"to":[14,117,144,166,291,305,368],"fine-tune":[15],"oncogenic":[16,149,243],"gene":[17,244],"expression.":[18],"In":[19],"acute":[20],"myeloid":[21],"leukemia":[22],"(AML),":[23],"one":[24],"such":[25,66,151],"regulatory":[26],"mechanism":[27,194],"involves":[28],"post":[29,37],"transcriptional":[30,38],"modification":[31,39,50],"RNAs.":[33],"The":[34],"most":[35],"abundant":[36],"methylation":[41],"adenosine":[43],"at":[44,233],"the":[45,54,118,126,146,183,220,306,359,378],"N6":[46],"position":[47],"(m6A).":[48],"This":[49],"catalyzed":[52],"by":[53,64],"m6A":[55,71,107,129,134,188,231,360],"\u201cwriter\u201d,":[56],"METTL3":[57,93],"METTL14":[59],"complex,":[60],"removed":[63],"\u201cerasers\u201d":[65],"as":[67,113,152,364],"FTO":[68],"ALKBH5.":[70],"RNAs":[72,136],"can":[73,81],"regulate":[74],"variety":[76],"cellular":[78,239],"processes":[79],"which":[80],"impact":[82],"tumor":[83],"phenotypes,":[84],"including":[85],"RNA":[86,189,221,232,361],"stability,":[87],"splicing,":[88],"nuclear":[90,128,278],"export;":[91],"catalytic":[94],"inhibitors":[95,217],"are":[96,259,269],"currently":[97],"in":[98,137,200,248,254,272,293,372],"clinical":[99],"development":[100],"for":[101,261,381],"AML":[102,123,255],"other":[104,214,264,277],"cancers":[105],"(NCT05584111).The":[106],"\u201creader\u201d,":[108],"YTHDC1,":[109,363],"has":[110,287],"been":[111],"recognized":[112],"critical":[115],"contributor":[116],"proliferation":[119],"survival":[121],"cells.":[124],"As":[125],"primary":[127],"reader,":[130,362],"YTHDC1":[131,170,186,203,225,240,262,274,298],"localizes":[132],"with":[133,230],"marked":[135],"phase-separated":[138],"assemblies,":[139],"termed":[140],"biomolecular":[141,171,299,370],"condensates,":[142,241],"helping":[143],"maintain":[145],"stability":[147],"transcripts":[150],"MYC.":[153],"Here,":[154],"we":[155,211],"employed":[157],"our":[158],"proprietary":[159],"microfluidics":[160],"based":[161,209],"screening":[162,176],"platform":[163],"(termed":[164],"PhaseScanTM)":[165],"identify":[167,179],"modulators":[168],"condensates.":[172,204],"Evaluation":[173],"early":[175],"hits":[177],"helped":[178],"that":[180,198,218],"disruption":[181],"interaction":[184,229],"between":[185],"functionally":[192],"relevant":[193],"action":[196],"(MoA)":[197],"results":[199],"dissolution":[201],"Using":[205],"computational":[206],"knowledge":[208],"approaches,":[210],"identified":[213],"structurally":[215],"distinct":[216],"occupy":[219],"binding":[222],"pocket":[223],"disrupt":[227,238],"its":[228],"nanomolar":[234],"potencies.":[235],"These":[236],"compounds":[237],"suppress":[242],"expression,":[245],"result":[247],"anti":[249],"proliferative":[250],"pro-differentiation":[252],"phenotypes":[253],"cell":[256],"lines.":[257],"Compounds":[258],"selective":[260,271],"over":[263,276],"YTH":[265],"family":[266],"members":[267],"also":[270],"dissolving":[273],"condensates":[275,300,371],"cytosolic":[280],"condensate":[281],"systems.":[282],"Our":[283],"optimized":[284],"chemical":[285],"matter":[286],"suitable":[288],"ADME":[289],"properties":[290],"support":[292],"vivo":[294],"studies.":[295],"Thus,":[296],"targeting":[297,369],"represents":[301],"novel":[303,366],"approach":[304,367],"treatment":[307],"AML.":[309],"Citation":[310],"Format:":[311],"Richard":[312],"C.":[313],"Centore,":[314],"Mark":[315],"Charles,":[316],"Mansi":[317],"Arora,":[318],"Yiwen":[319],"Chen,":[320],"Matthew":[321],"Watson,":[322],"Charlotte":[323],"Kelley,":[324],"Magdalena":[325],"Czekalska,":[326],"Marius":[327],"Rebmann,":[328],"Mahmoud":[329],"Ghandi,":[330],"Jerome":[331],"Cattin,":[332],"Nagakumar":[333],"Bharatham,":[334],"Prathima":[335],"Radhakrishnan,":[336],"Alex":[337],"Howarth,":[338],"Gale":[339],"Rudlaff,":[340],"William":[341],"E.":[342],"Arter,":[343],"Seema":[344],"Qamar,":[345],"Kadi":[346],"Saar,":[347],"Douglas":[348],"Williamson,":[349],"Andrew":[350],"Seeber,":[351],"Tuomas":[352],"Knowles,":[353],"Shilpi":[354],"Arora.":[355],"Pharmacological":[356],"inhibition":[357],"cancer":[373],"[abstract].":[374],"In:":[375],"Proceedings":[376],"American":[379],"Association":[380],"Cancer":[382,400],"Research":[383],"Annual":[384],"Meeting":[385],"2024;":[386],"Part":[387],"1":[388],"(Regular":[389],"Abstracts);":[390],"2024":[391],"Apr":[392],"5-10;":[393],"San":[394],"Diego,":[395],"CA.":[396],"Philadelphia":[397],"(PA):":[398],"AACR;":[399],"Res":[401],"2024;84(6_Suppl):Abstract":[402],"nr":[403],"3231.":[404]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-03-23T00:00:00"}