{"id":"https://openalex.org/W4393089889","doi":"https://doi.org/10.1158/1538-7445.am2024-6521","title":"Abstract 6521: Macrophage-targeting immunotherapy enhances chemotherapy response in primary and metastatic triple-negative breast cancer models","display_name":"Abstract 6521: Macrophage-targeting immunotherapy enhances chemotherapy response in primary and metastatic triple-negative breast cancer models","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393089889","doi":"https://doi.org/10.1158/1538-7445.am2024-6521"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-6521","doi":"https://doi.org/10.1158/1538-7445.am2024-6521","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6521","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008412963","display_name":"Matthew Emilio Fernandez","orcid":"https://orcid.org/0009-0009-0411-341X","observed_orcids":["https://orcid.org/0009-0009-0411-341X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Emilio Fernandez","raw_affiliation_strings":["1Virginia Commonwealth University - VCU, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virginia Commonwealth University - VCU, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010987016","display_name":"Yasir Alshehry","orcid":"https://orcid.org/0000-0003-3820-1986","observed_orcids":["https://orcid.org/0000-0003-3820-1986"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasir Alshehry","raw_affiliation_strings":["1Virginia Commonwealth University - VCU, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virginia Commonwealth University - VCU, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056460512","display_name":"Laura Graham","orcid":"https://orcid.org/0000-0002-7093-9748","observed_orcids":["https://orcid.org/0000-0002-7093-9748"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Graham","raw_affiliation_strings":["1Virginia Commonwealth University - VCU, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virginia Commonwealth University - VCU, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071844087","display_name":"Jennifer E. Koblinski","orcid":"https://orcid.org/0000-0002-7156-2030","observed_orcids":["https://orcid.org/0000-0002-7156-2030"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E. Koblinski","raw_affiliation_strings":["1Virginia Commonwealth University - VCU, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virginia Commonwealth University - VCU, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064069772","display_name":"Harry D. Bear","orcid":"https://orcid.org/0000-0002-7632-9019","observed_orcids":["https://orcid.org/0000-0002-7632-9019"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry D. Bear","raw_affiliation_strings":["1Virginia Commonwealth University - VCU, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virginia Commonwealth University - VCU, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113150007","display_name":"Doug H. Sweet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doug H. Sweet","raw_affiliation_strings":["1Virginia Commonwealth University - VCU, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virginia Commonwealth University - VCU, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048804815","display_name":"Sandro R. da Rocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandro R. da Rocha","raw_affiliation_strings":["1Virginia Commonwealth University - VCU, Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Virginia Commonwealth University - VCU, Richmond, VA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"6521","last_page":"6521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9440000057220459},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8679999709129333},{"id":"https://openalex.org/keywords/csf1r-inhibitor","display_name":"CSF1R inhibitor","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pexidartinib","display_name":"pexidartinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.48399999737739563},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8330000042915344},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.7570000290870667},{"id":"https://openalex.org/keywords/4t1-mammary-carcinoma","display_name":"4T1 mammary carcinoma","score":0.7089999914169312},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6899999976158142},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.39800000190734863},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7893787622451782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7573631405830383},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6057072281837463},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5941063165664673},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5706771612167358},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5541577935218811},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.522365391254425},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5052095055580139},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4278073310852051},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35982227325439453}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-6521","doi":"https://doi.org/10.1158/1538-7445.am2024-6521","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6521","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362592273","https://openalex.org/W4409630238","https://openalex.org/W7015601819","https://openalex.org/W4322774564","https://openalex.org/W6908534028","https://openalex.org/W4224227874","https://openalex.org/W7141651103","https://openalex.org/W3034775828","https://openalex.org/W3129839950","https://openalex.org/W7161239340"],"abstract_inverted_index":{"Abstract":[0],"Triple-negative":[1],"breast":[2,9,470],"cancer":[3,10,471],"(TNBC)":[4],"is":[5],"a":[6,54,336,372,387],"highly":[7],"aggressive":[8],"subtype":[11],"that":[12,412],"lacks":[13],"targeted":[14],"treatment":[15,27],"options.":[16],"While":[17],"immune":[18,100],"checkpoint":[19],"blockade":[20],"leads":[21],"to":[22,49,61,127,160,215,270,279,313,340,379,399],"significant":[23,337,373],"benefits":[24],"in":[25,31,70,81,102,134,183,196,261,318,407,417,427,436,465],"the":[26,51,63,66,76,97,103,135,142,197,206,251,262,281,319,326,400,408,418,430,477],"of":[28,45,53,65,73,79,84,144,208,218,225,329,363,403,476],"TNBC":[29,104,171,428],"when":[30],"combination":[32,303,365,396,413,433],"with":[33,109,179,193,240,257,291,335,434],"chemotherapy,":[34,156],"recurrence,":[35],"metastasis,":[36],"and":[37,75,106,114,131,152,166,202,222,246,287,295,346,358,392,405,420,467],"chemoresistance":[38],"still":[39],"remain":[40],"major":[41],"challenges.":[42],"The":[43,236],"purpose":[44],"this":[46],"study":[47],"was":[48,238,354],"assess":[50],"ability":[52,159],"colony-stimulating":[55],"factor":[56],"1":[57,487],"receptor":[58],"inhibitor":[59],"(CSF-1Ri)":[60],"shift":[62],"phenotype":[64,391],"tumor":[67,129,283,376,390,431],"microenvironment":[68],"(TME)":[69],"murine":[71],"models":[72,472],"TNBC,":[74],"potential":[77,149],"benefit":[78],"such":[80],"enhancing":[82],"standard":[83],"care":[85],"chemotherapy.":[86],"We":[87,137],"focused":[88],"on":[89,284,375],"targeting":[90,425],"tumor-associated":[91],"macrophages":[92],"(TAMs)":[93],"as":[94,141,155,186,272],"they":[95],"are":[96,107],"most":[98],"abundant":[99],"infiltrate":[101],"TME":[105,237,352],"associated":[108],"worsening":[110],"overall":[111],"survival":[112,117,277],"(OS)":[113],"metastasis":[115],"free":[116],"(MFS).":[118],"Targeting":[119],"TAMs,":[120,123],"specifically":[121],"M2-like":[122,167,330],"has":[124,415],"been":[125],"shown":[126],"inhibit":[128],"progression":[130],"improve":[132],"OS":[133,296,406],"clinic.":[136],"selected":[138],"pexidartinib":[139],"(PLX)":[140],"CSF-1Ri":[143],"choice,":[145],"given":[146,157],"its":[147,158],"translational":[148],"(FDA":[150],"approved)":[151],"gemcitabine":[153],"(GEM)":[154],"target":[161],"myeloid":[162],"derived":[163],"suppressor":[164],"cells":[165,177,195,260],"TAMs.":[168],"For":[169,250],"primary":[170,282,320,466],"we":[172],"employed":[173],"4T1":[174],"mammary":[175,199],"carcinoma":[176],"transfected":[178],"luciferase":[180],"reporter":[181],"gene":[182],"BALB/c":[184],"mice":[185,254,267],"an":[187],"immunocompetent":[188],"model.":[189],"Mice":[190,211,275],"were":[191,212,231,255,268,288,297],"injected":[192],"100,000":[194,258],"4th":[198],"fat":[200],"pad,":[201],"tumors":[203],"established":[204],"over":[205],"course":[207],"fifteen":[209],"days.":[210],"then":[213,289],"exposed":[214,269],"daily":[216],"administrations":[217,224],"PLX":[219],"(8":[220],"mg/kg),":[221],"weekly":[223],"GEM":[226,347,380],"(60":[227],"mg/kg).":[228],"Tumor":[229],"volumes":[230],"recorded":[232],"every":[233],"other":[234],"day.":[235],"analyzed":[239],"flow":[241],"cytometry":[242],"(FC),":[243],"immunohistochemistry":[244],"(IHC),":[245],"multiplex":[247],"immunofluorescence":[248],"(mIF).":[249],"metastatic":[252,468],"model,":[253,410],"inoculated":[256],"4T1-luc":[259],"flank.":[263],"On":[264],"day":[265,285],"six,":[266],"treatments":[271],"outlined":[273],"above.":[274],"underwent":[276],"surgery":[278],"remove":[280],"thirteen":[286],"treated":[290],"adjuvant":[292,421],"therapy.":[293],"Metastasis":[294],"tracked.":[298],"FC":[299],"analysis":[300],"indicated":[301],"only":[302],"therapy":[304,323,366,397,414],"(11.8%":[305],"\u00b1":[306,316,333,344,349,369,384],"2.1)":[307],"significantly":[308],"decreased":[309],"total":[310],"TAMs":[311,331,426],"compared":[312,339,378],"vehicle":[314,342],"(22%":[315],"2)":[317],"tumor.":[321],"Combination":[322],"also":[324],"showed":[325],"greatest":[327,401],"depletion":[328],"(2.2%":[332],"0.6),":[334],"decrease":[338],"both":[341],"(15.6%":[343],"0.4)":[345],"(6.6%":[348],"0.9).":[350],"This":[351],"modulation":[353],"confirmed":[355],"using":[356],"IHC":[357],"mIF.":[359],"After":[360],"four":[361],"cycles":[362],"treatment,":[364],"(232.9":[367],"mm3":[368,383],"130.8)":[370],"had":[371],"effect":[374],"burden":[377],"alone":[381],"(369.7":[382],"165.8),":[385],"indicating":[386,411],"correlation":[388],"between":[389],"therapeutic":[393],"benefit.":[394],"Furthermore,":[395],"led":[398],"prolongation":[402],"MFS":[404],"resection":[409],"efficacy":[416],"neoadjuvant":[419],"setting.":[422],"In":[423],"conclusion,":[424],"primes":[429],"for":[432,480],"chemotherapy":[435,463],"TNBC.":[437],"Citation":[438],"Format:":[439],"Matthew":[440],"Emilio":[441],"Fernandez,":[442],"Yasir":[443],"Alshehry,":[444],"Laura":[445],"Graham,":[446],"Jennifer":[447],"E.":[448],"Koblinski,":[449],"Harry":[450],"D.":[451],"Bear,":[452],"Doug":[453],"H.":[454],"Sweet,":[455],"Sandro":[456],"R.":[457],"da":[458],"Rocha.":[459],"Macrophage-targeting":[460],"immunotherapy":[461],"enhances":[462],"response":[464],"triple-negative":[469],"[abstract].":[473],"In:":[474],"Proceedings":[475],"American":[478],"Association":[479],"Cancer":[481,499],"Research":[482],"Annual":[483],"Meeting":[484],"2024;":[485],"Part":[486],"(Regular":[488],"Abstracts);":[489],"2024":[490],"Apr":[491],"5-10;":[492],"San":[493],"Diego,":[494],"CA.":[495],"Philadelphia":[496],"(PA):":[497],"AACR;":[498],"Res":[500],"2024;84(6_Suppl):Abstract":[501],"nr":[502],"6521.":[503]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2024-03-23T00:00:00"}