{"id":"https://openalex.org/W4393088515","doi":"https://doi.org/10.1158/1538-7445.am2024-6817","title":"Abstract 6817: Control of breast cancer via pro-resolving mediators","display_name":"Abstract 6817: Control of breast cancer via pro-resolving mediators","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393088515","doi":"https://doi.org/10.1158/1538-7445.am2024-6817"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-6817","doi":"https://doi.org/10.1158/1538-7445.am2024-6817","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6817","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104263098","display_name":"Sarina A. Virani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarina A. Virani","raw_affiliation_strings":["1Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Gillespie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Gillespie","raw_affiliation_strings":["1Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023085226","display_name":"Haixia Yang","orcid":"https://orcid.org/0000-0002-4410-9257","observed_orcids":["https://orcid.org/0000-0002-4410-9257"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haixia Yang","raw_affiliation_strings":["2College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China;","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059413396","display_name":"Diane Renee Bielenberg","orcid":"https://orcid.org/0000-0003-3905-0059","observed_orcids":["https://orcid.org/0000-0003-3905-0059"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane R. Bielenberg","raw_affiliation_strings":["3Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060208068","display_name":"Mark W. Kieran","orcid":"https://orcid.org/0000-0003-2184-7692","observed_orcids":["https://orcid.org/0000-0003-2184-7692"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark W. Kieran","raw_affiliation_strings":["4Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School; Department of Pediatric Hematology/Oncology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA;","Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School; Department of Pediatric Hematology/Oncology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019206785","display_name":"Sui Huang","orcid":"https://orcid.org/0000-0002-3545-4665","observed_orcids":["https://orcid.org/0000-0002-3545-4665"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sui Huang","raw_affiliation_strings":["5Institute of Systems Biology, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Institute of Systems Biology, Seattle, WA;","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles N. Serhan","raw_affiliation_strings":["6Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075631226","display_name":"Dipak Panigrahy","orcid":"https://orcid.org/0009-0007-2302-0919","observed_orcids":["https://orcid.org/0009-0007-2302-0919"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipak Panigrahy","raw_affiliation_strings":["1Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"6817","last_page":"6817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.3991999924182892,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.3991999924182892,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.2287999987602234,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.14579999446868896,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/specialized-pro-resolving-mediators","display_name":"specialized pro-resolving mediators","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.6859999895095825},{"id":"https://openalex.org/keywords/maresin-1","display_name":"maresin 1","score":0.7879999876022339},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7919999957084656},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.7639999985694885},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6474288702011108},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6357194781303406},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5896812677383423},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46397218108177185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4234773516654968},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.32021087408065796}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-6817","doi":"https://doi.org/10.1158/1538-7445.am2024-6817","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-6817","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282964800","https://openalex.org/W2346072700","https://openalex.org/W4225405765","https://openalex.org/W1026909922","https://openalex.org/W4280540109","https://openalex.org/W2771932310","https://openalex.org/W2887886132","https://openalex.org/W2040500351","https://openalex.org/W3182175212","https://openalex.org/W4388673783"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"recurrence":[2],"is":[3,120],"the":[4,13,71,134,244,264,331,345,385],"principal":[5],"cause":[6],"of":[7,32,73,104,136,176,239,255,273,297,347,375,384],"mortality":[8],"in":[9,143,152,160,190,228,243,325,349],"breast":[10,58,80,127,140,182,196,275,326,350,376],"cancer,":[11,59],"yet":[12],"underlying":[14],"mechanisms":[15],"are":[16,165],"not":[17],"well":[18],"understood.":[19],"Anti-estrogen":[20],"therapy,":[21],"including":[22,288],"tamoxifen,":[23],"reduces":[24],"tumor":[25,41,81,95,105,117,188,247,276,280],"burden":[26],"by":[27,43,84,107],"inducing":[28],"apoptosis":[29],"and":[30,47,50,63,112,157,179,192,211,236,259,282,294,316,333],"necrosis":[31],"cancerous":[33],"tissue.":[34,328],"The":[35],"resulting":[36],"cellular":[37],"debris":[38,119,137],"may":[39,337],"stimulate":[40,93,344],"growth":[42,96,189,210],"disrupting":[44],"inflammation":[45,348],"resolution":[46,346],"creating":[48],"pro-inflammatory":[49,111],"pro-tumorigenic":[51],"microenvironments.":[52],"Compared":[53],"to":[54,70,214,343],"estrogen":[55],"receptor":[56,304,309,314,320],"(ER)-positive":[57],"ER-negative":[60,245],"behaves":[61],"aggressively,":[62],"patients":[64],"have":[65],"a":[66,100,109,121,252,284,339],"poor":[67],"prognosis":[68],"due":[69],"lack":[72],"treatment":[74,262],"options.":[75],"Here,":[76],"we":[77,145],"demonstrate":[78],"that":[79],"cells":[82,106],"killed":[83],"cytotoxic":[85],"anti-estrogen":[86],"therapy":[87],"or":[88,217,227],"chemotherapy":[89,215,231,257],"(\u201ctumor":[90],"cell":[91,118,277],"debris\u201d)":[92],"primary":[94],"when":[97],"co-injected":[98],"with":[99,230],"subthreshold":[101],"(nontumorigenic)":[102],"inoculum":[103],"triggering":[108],"macrophage-derived":[110],"pro-angiogenic":[113,240],"\u201ccytokine":[114],"storm.\u201d":[115],"Thus,":[116],"critical":[122],"risk":[123],"factor":[124,241],"for":[125,388],"aggressive":[126],"cancer":[128,141,197,327,377],"growth.":[129],"To":[130],"assess":[131],"whether":[132],"stimulating":[133],"clearance":[135],"would":[138],"impact":[139],"progression":[142],"vivo,":[144],"utilized":[146],"maresin":[147,150,185,311,332],"1":[148,312,395],"(MaR1),":[149],"conjugates":[151,159],"tissue":[153,161],"regeneration":[154,162],"(MCTR1,":[155],"MCTR2)":[156],"protectin":[158,334],"(PCTRs),":[163],"which":[164],"specialized":[166],"pro-resolving":[167,379],"lipid":[168],"autacoid":[169],"mediators":[170,336,380],"(SPMs).":[171],"We":[172],"treated":[173],"established":[174],"models":[175,198],"ER-positive":[177,250],"(EO771)":[178],"negative":[180],"(4T1)":[181,209,246],"cancer.":[183,351],"Each":[184],"sharply":[186],"reduced":[187,233],"debris-stimulated":[191],"spontaneous":[193],"(e.g.":[194,300],"MMTV-PyMT)":[195],"at":[199],"nanogram":[200],"concentrations":[201],"without":[202],"toxicity.":[203],"Notably,":[204],"PCTR1":[205,225],"inhibited":[206,279],"orthotopic":[207],"triple-negative":[208],"proliferation":[212],"compared":[213],"(paclitaxel)":[216,232],"immunotherapy":[218,260],"(anti-cytotoxic":[219],"T-lymphocyte-associated":[220],"protein":[221,237],"4,":[222],"CTLA4).":[223],"Similarly,":[224],"alone":[226],"combination":[229,254],"gene":[234],"expression":[235],"levels":[238],"CXCL12/SDF1":[242],"microenvironment.":[248],"In":[249],"(EO771),":[251],"triple":[253],"PCTR1,":[256],"(paclitaxel),":[258],"(anti-CTLA4)":[261],"potentiated":[263],"immune":[265],"checkpoint":[266],"blockade.":[267],"Maresins":[268],"also":[269],"stimulated":[270],"macrophage":[271],"phagocytosis":[272],"therapy-generated":[274],"debris,":[278],"angiogenesis,":[281],"dampened":[283],"therapy-induced":[285],"cytokine":[286],"storm,":[287],"TNF-\u03b1,":[289],"MIP-2/CXCL2,":[290],"CCL2/MCP-1,":[291],"IL-":[292],"1ra/IL-1F3,":[293],"G-CSF.":[295],"Expression":[296],"SPM":[298],"receptors":[299],"resolvin":[301,306,317],"D1":[302],"(RvD1)":[303],"ALX/FPR2,":[305],"D2":[307],"(RvD2)":[308],"GPR18,":[310],"(MaR1)":[313],"LGR6,":[315],"E1":[318],"(RvE1)":[319],"ChemR23)":[321],"were":[322],"specifically":[323],"identified":[324],"Taken":[329],"together,":[330],"pathway":[335],"represent":[338],"new":[340],"therapeutic":[341],"approach":[342],"Citation":[352],"Format:":[353],"Sarina":[354],"A.":[355],"Virani,":[356],"Michael":[357],"Gillespie,":[358],"Haixia":[359],"Yang,":[360],"Diane":[361],"R.":[362],"Bielenberg,":[363],"Mark":[364],"W.":[365],"Kieran,":[366],"Sui":[367],"Huang,":[368],"Charles":[369],"N.":[370],"Serhan,":[371],"Dipak":[372],"Panigrahy.":[373],"Control":[374],"via":[378],"[abstract].":[381],"In:":[382],"Proceedings":[383],"American":[386],"Association":[387],"Cancer":[389,407],"Research":[390],"Annual":[391],"Meeting":[392],"2024;":[393],"Part":[394],"(Regular":[396],"Abstracts);":[397],"2024":[398],"Apr":[399],"5-10;":[400],"San":[401],"Diego,":[402],"CA.":[403],"Philadelphia":[404],"(PA):":[405],"AACR;":[406],"Res":[408],"2024;84(6_Suppl):Abstract":[409],"nr":[410],"6817.":[411]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-03-23T00:00:00"}