{"id":"https://openalex.org/W4393086987","doi":"https://doi.org/10.1158/1538-7445.am2024-5432","title":"Abstract 5432: The role of nuclear factor\u03baB-inducing kinase in ovarian cancer stem cells, chemoresistance, and relapse","display_name":"Abstract 5432: The role of nuclear factor\u03baB-inducing kinase in ovarian cancer stem cells, chemoresistance, and relapse","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393086987","doi":"https://doi.org/10.1158/1538-7445.am2024-5432"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5432","doi":"https://doi.org/10.1158/1538-7445.am2024-5432","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5432","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094222367","display_name":"Cassidy Lucht","orcid":"https://orcid.org/0000-0002-7995-5429","observed_orcids":["https://orcid.org/0000-0002-7995-5429"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassidy C. Lucht","raw_affiliation_strings":["1San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021979414","display_name":"Mikella Robinson","orcid":"https://orcid.org/0000-0001-6198-7185","observed_orcids":["https://orcid.org/0000-0001-6198-7185"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikella Robinson","raw_affiliation_strings":["1San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031985000","display_name":"Samuel F. Gilbert","orcid":"https://orcid.org/0000-0002-0440-1173","observed_orcids":["https://orcid.org/0000-0002-0440-1173","https://orcid.org/0000-0002-6833-6788"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel F. Gilbert","raw_affiliation_strings":["1San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094099547","display_name":"Omar Lujano Olazaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Lujano Olazaba","raw_affiliation_strings":["1San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059436422","display_name":"Carrie Danielle House","orcid":"https://orcid.org/0000-0002-1870-5872","observed_orcids":["https://orcid.org/0000-0002-1870-5872"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie D. House","raw_affiliation_strings":["1San Diego State University, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1San Diego State University, San Diego, CA","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5432","last_page":"5432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9269999861717224},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.8130000233650208},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7302047610282898},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6961943507194519},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6787103414535522},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6062207221984863},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5704011917114258},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.4855758547782898},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4777590334415436},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47266778349876404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45560282468795776},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4540092349052429},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.425981342792511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40250909328460693},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.29153287410736084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.261801540851593},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1887798011302948},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09415054321289062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06587696075439453},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5432","doi":"https://doi.org/10.1158/1538-7445.am2024-5432","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5432","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2401488816","https://openalex.org/W1739249602","https://openalex.org/W4303985909","https://openalex.org/W7149103452","https://openalex.org/W2741790100","https://openalex.org/W3083267966","https://openalex.org/W4409690330","https://openalex.org/W1553667993","https://openalex.org/W2750580784","https://openalex.org/W2079725404"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1],"cancer":[2,8,29,75,99,321],"is":[3,60,128],"the":[4,10,86,105,188,224,249,271,331],"most":[5],"lethal":[6],"gynecological":[7],"in":[9,79,125,187,194,204,228,236,243,277,294,319],"United":[11],"States,":[12],"largely":[13],"due":[14,27],"to":[15,28,41,51,56,63,73,93,152,202,212,217,258],"its":[16,123],"high":[17,23],"relapse":[18,24,245,260,326],"rates.":[19],"Research":[20,336],"suggests":[21],"these":[22,126],"rates":[25],"are":[26,39,91,222],"stem-like":[30],"cells":[31,37,127,139,157],"(CSCs),":[32],"a":[33,192,253,287],"subpopulation":[34],"of":[35,68,88,104,197,226,238,251,273,283,315,330],"tumor":[36],"that":[38,59,66,137],"resistant":[40,62],"chemotherapy":[42,257],"and":[43,77,149,173,181,209,214,234,261,281,285,325],"have":[44,145,162],"enhanced":[45],"tumor-initiation":[46,229],"capacity.":[47],"Post-treatment,":[48],"CSCs":[49,279,293],"self-renew":[50],"re-establish":[52],"new":[53,288],"tumors,":[54,81],"leading":[55],"recurrent":[57],"disease":[58],"now":[61],"chemotherapy.":[64],"Given":[65],"over-expression":[67],"NF-\u03baB":[69,107],"has":[70],"been":[71],"linked":[72],"CSCs,":[74,121],"progression,":[76],"chemoresistance":[78],"various":[80],"including":[82],"ovarian,":[83],"studies":[84,221],"uncovering":[85],"mechanisms":[87],"this":[89,266],"pathway":[90,275],"needed":[92],"develop":[94],"novel":[95],"therapeutics":[96],"for":[97,119,291,334],"ovarian":[98,295,320],"treatment.":[100],"The":[101,313],"upstream":[102],"activator":[103],"alternative":[106,205],"pathway,":[108],"Nuclear":[109],"Factor":[110],"\u03baB-inducing":[111],"Kinase":[112],"(NIK),":[113],"could":[114],"be":[115],"an":[116,169,242],"enticing":[117],"target":[118,290],"eliminating":[120,292],"however":[122],"function":[124],"not":[129],"established.":[130],"In":[131],"our":[132],"current":[133],"studies,":[134],"we":[135],"show":[136],"HGSOC":[138],"grown":[140],"as":[141],"CSC-enriching":[142],"3D":[143],"spheroids":[144],"increased":[146,163,186],"NIK":[147,164,172,183,198,227,254],"expression":[148,185,237],"activity":[150,208],"relative":[151,216],"monolayer":[153],"cultured":[154],"cells.":[155],"Moreover,":[156],"expressing":[158],"CSC":[159,174],"markers":[160],"(CD117+/CD133+),":[161],"gene":[165,184],"expression,":[166],"further":[167,269],"supporting":[168],"association":[170],"between":[171],"maintenance.":[175],"Upon":[176],"treatment":[177],"with":[178],"chemotherapies":[179],"carboplatin":[180,213],"paclitaxel,":[182],"surviving":[189],"population,":[190],"indicating":[191],"role":[193,225,272,314],"chemoresistance.":[195],"Knockdown":[196],"using":[199,252],"siRNA":[200],"led":[201],"changes":[203,235],"NF-kB":[206,274],"transcriptional":[207],"higher":[210],"sensitivity":[211],"paclitaxel":[215],"vehicle":[218],"controls.":[219],"Current":[220],"evaluating":[223],"capacity,":[230],"asymmetric":[231],"division,":[232],"proliferation,":[233],"stemness":[239],"genes.":[240],"Lastly,":[241],"vivo":[244],"model":[246],"will":[247,268],"test":[248],"feasibility":[250],"inhibitor":[255],"following":[256],"prevent":[259],"prolong":[262],"survival.":[263],"Findings":[264],"from":[265],"work":[267],"define":[270],"components":[276],"facilitating":[278],"survival":[280],"re-establishment":[282],"tumors":[284],"identify":[286],"potential":[289],"cancer.":[296],"Citation":[297],"Format:":[298],"Cassidy":[299],"C.":[300],"Lucht,":[301],"Mikella":[302],"Robinson,":[303],"Samuel":[304],"F.":[305],"Gilbert,":[306],"Omar":[307],"Lujano":[308],"Olazaba,":[309],"Carrie":[310],"D.":[311],"House.":[312],"nuclear":[316],"factor\u03baB-inducing":[317],"kinase":[318],"stem":[322],"cells,":[323],"chemoresistance,":[324],"[abstract].":[327],"In:":[328],"Proceedings":[329],"American":[332],"Association":[333],"Cancer":[335,353],"Annual":[337],"Meeting":[338],"2024;":[339],"Part":[340],"1":[341],"(Regular":[342],"Abstracts);":[343],"2024":[344],"Apr":[345],"5-10;":[346],"San":[347],"Diego,":[348],"CA.":[349],"Philadelphia":[350],"(PA):":[351],"AACR;":[352],"Res":[354],"2024;84(6_Suppl):Abstract":[355],"nr":[356],"5432.":[357]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-03-23T00:00:00"}
