{"id":"https://openalex.org/W4393085408","doi":"https://doi.org/10.1158/1538-7445.am2024-5539","title":"Abstract 5539: PRDM16 is an intrinsic regulator of dormancy in bone disseminated prostate cancer cells","display_name":"Abstract 5539: PRDM16 is an intrinsic regulator of dormancy in bone disseminated prostate cancer cells","publication_year":2024,"publication_date":"2024-03-22","ids":{"openalex":"https://openalex.org/W4393085408","doi":"https://doi.org/10.1158/1538-7445.am2024-5539"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2024-5539","doi":"https://doi.org/10.1158/1538-7445.am2024-5539","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5539","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089191214","display_name":"Mostafa Nasr","orcid":"https://orcid.org/0000-0001-7834-6384","observed_orcids":["https://orcid.org/0000-0001-7834-6384"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mostafa M. Nasr","raw_affiliation_strings":["1H.Lee Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1H.Lee Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124732006","display_name":"Tao Li","orcid":"https://orcid.org/0000-0002-2681-0429","observed_orcids":["https://orcid.org/0000-0002-2681-0429"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Li","raw_affiliation_strings":["1H.Lee Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1H.Lee Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074163739","display_name":"Ryan T. Bishop","orcid":"https://orcid.org/0000-0002-1332-4798","observed_orcids":["https://orcid.org/0000-0002-1332-4798"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan T. Bishop","raw_affiliation_strings":["1H.Lee Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1H.Lee Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057667884","display_name":"Jeremy Steven Frieling","orcid":"https://orcid.org/0000-0002-2181-1836","observed_orcids":["https://orcid.org/0000-0002-2181-1836"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy S. Frieling","raw_affiliation_strings":["1H.Lee Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1H.Lee Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005942374","display_name":"Conor C. Lynch","orcid":"https://orcid.org/0000-0002-4506-6244","observed_orcids":["https://orcid.org/0000-0002-4506-6244"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conor C. Lynch","raw_affiliation_strings":["1H.Lee Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1H.Lee Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"6_Supplement","first_page":"5539","last_page":"5539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prdm16","display_name":"PRDM16","score":0.9700000286102295},{"id":"https://openalex.org/keywords/prostate-cancer-bone-metastasis","display_name":"prostate cancer bone metastasis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cancer-cell-dormancy","display_name":"cancer cell dormancy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rorc","display_name":"RORC","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bmp-7","display_name":"BMP-7","score":0.9160000085830688},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.515999972820282},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.6299999952316284},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.3140000104904175},{"id":"https://openalex.org/keywords/transcription-factor-overexpression","display_name":"transcription factor overexpression","score":0.36899998784065247},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-quiescence","display_name":"hematopoietic stem cell quiescence","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.6922353506088257},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6450430154800415},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5867316722869873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.548304557800293},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.46852487325668335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45633453130722046},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43705445528030396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3715856969356537},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36886537075042725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3644229769706726},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.07937359809875488},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.07524144649505615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.050409525632858276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2024-5539","doi":"https://doi.org/10.1158/1538-7445.am2024-5539","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2024-5539","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362541550","https://openalex.org/W4415293371","https://openalex.org/W7124403425","https://openalex.org/W4387535872","https://openalex.org/W4282960065","https://openalex.org/W4379143215","https://openalex.org/W2790091979","https://openalex.org/W4220737377","https://openalex.org/W4404451123","https://openalex.org/W2119180957"],"abstract_inverted_index":{"Abstract":[0],"Metastatic":[1],"prostate":[2,417],"cancer":[3,254,418],"(PCa)":[4],"frequently":[5],"occurs":[6],"in":[7,53,60,174,189,227,232,247,261,345,350,386,414],"the":[8,22,32,126,183,283,320,340,380,424],"bone":[9,152,262,415],"and":[10,70,99,119,168,177,198,208,222,238,278,304],"can":[11],"remain":[12],"inactive":[13],"for":[14,360,379,427],"extended":[15,243],"periods":[16],"after":[17,79],"primary":[18,175],"tumor":[19],"treatment.":[20],"Understanding":[21],"intricate":[23],"molecular":[24],"mechanisms":[25],"that":[26,64,224,312,373],"govern":[27],"this":[28],"phenomenon":[29],"could":[30,71,376],"open":[31],"door":[33],"to":[34,49,76,151,194,250,329],"novel":[35,47],"therapies,":[36],"potentially":[37],"reducing":[38],"mortality":[39],"rates.":[40],"To":[41],"address":[42],"this,":[43],"we":[44,181,213,291],"developed":[45],"a":[46,138,156],"protocol":[48],"induce":[50],"cellular":[51],"dormancy":[52,85,109,161,188,196,289,413],"PCa":[54,121,176,324,347,384],"cell":[55,93,122,144,199,348],"lines":[56],"(RM1,":[57],"22Rv1,":[58],"LAPC4)":[59],"vitro.":[61,190],"We":[62,130,367],"noted":[63],"dormant":[65,323,383],"cells":[66,230,255,325,385,419],"exhibited":[67],"distinctive":[68],"clustering":[69],"be":[72,377],"reactivated":[73],"when":[74,245,327],"exposed":[75],"serum":[77],"even":[78],"21":[80],"days":[81],"of":[82,124,141,160,165,185,235,315,322,343,382,412,423],"stasis.":[83],"The":[84],"program":[86],"was":[87],"validated":[88,182],"by":[89],"multiple":[90,117],"assays":[91],"including":[92],"cycle":[94],"analysis,":[95],"membrane":[96],"dye":[97],"retention,":[98],"Edu+":[100],"incorporation.":[101],"RNASeq":[102],"analysis":[103,303],"showed":[104],"significant":[105,233],"transcriptional":[106],"changes":[107],"during":[108,187],"induction,":[110],"with":[111,242,256,388],"8":[112],"genes":[113],"commonly":[114],"upregulated":[115],"across":[116],"human":[118],"mouse":[120],"lines,":[123],"which":[125,286],"transcription":[127],"factor,":[128],"PRDM16.":[129],"focused":[131,292],"on":[132,293,301,370],"PRDM16":[133,166,171,186,192,226,257,276,287,307,344,407],"since,":[134],"1)":[135],"it":[136],"is":[137,172,408],"known":[139],"regulator":[140,411],"hematopoietic":[142],"stem":[143],"quiescence,":[145],"2)":[146],"our":[147,336,371],"emerging":[148],"data":[149,310],"points":[150],"morphogenetic":[153],"protein-7":[154],"(BMP7),":[155],"well-known":[157],"exogenous":[158],"mediator":[159],"as":[162,264],"an":[163,215,272,409],"inducer":[164],"expression":[167,240,277],"3)":[169],"clinically,":[170],"suppressed":[173],"active":[178,228],"metastases.":[179],"First,":[180],"upregulation":[184],"Silencing":[191],"led":[193],"impaired":[195],"phenotype":[197],"death,":[200],"while":[201],"its":[202],"overexpression":[203],"significantly":[204],"mitigated":[205],"proliferation":[206],"rates":[207],"promoted":[209,319],"survival.":[210],"In":[211,281,334],"vivo,":[212],"employed":[214],"intra-iliac":[216],"immunocompetent":[217],"model":[218],"(RM1":[219],"&":[220],"C57BL6J)":[221],"demonstrated":[223],"overexpressing":[225],"RM1":[229],"resulted":[231],"reduction":[234],"metastasis":[236],"formation":[237],"Ki67":[239],"concurrent":[241],"survival":[244],"injected":[246],"vivo":[248],"compared":[249,328],"control":[251],"cells.":[252],"Prostate":[253],"over-expression":[258],"were":[259],"detected":[260],"sections":[263],"solitary":[265],"or":[266],"small":[267],"clusters":[268],"(<20":[269],"cells)":[270],"demonstrating":[271],"inverse":[273],"relationship":[274],"between":[275],"metastatic":[279],"outbreak.":[280],"defining":[282],"targets":[284],"via":[285,352],"controls":[288],"entry,":[290],"RAR":[294],"related":[295],"orphan":[296],"receptor":[297],"C":[298],"(RORC)":[299],"based":[300,369],"bioinformatic":[302],"publicly":[305],"available":[306],"ChIP-Seq.":[308],"Our":[309],"demonstrate":[311],"pharmacological":[313],"inhibition":[314],"RORC":[316,358],"using":[317],"GSK805":[318],"apoptosis":[321],"specifically":[326],"their":[330],"actively":[331],"growing":[332],"counterparts.":[333],"conclusion,":[335],"studies":[337],"have":[338,364],"revealed":[339],"critical":[341],"role":[342],"promoting":[346],"dormancy,":[349],"part":[351],"upregulating":[353],"RORC.":[354],"Translationally,":[355],"clinically":[356],"approved":[357],"inhibitors":[359,375],"non-cancerous":[361],"conditions":[362],"(psoriasis)":[363],"been":[365],"developed.":[366],"expect,":[368],"results,":[372],"these":[374],"repurposed":[378],"eradication":[381],"patients":[387],"advanced":[389],"disease.":[390],"Citation":[391],"Format:":[392],"Mostafa":[393],"M.":[394],"Nasr,":[395],"Tao":[396],"Li,":[397],"Ryan":[398],"T.":[399],"Bishop,":[400],"Jeremy":[401],"S.":[402],"Frieling,":[403],"Conor":[404],"C.":[405],"Lynch.":[406],"intrinsic":[410],"disseminated":[416],"[abstract].":[420],"In:":[421],"Proceedings":[422],"American":[425],"Association":[426],"Cancer":[428,446],"Research":[429],"Annual":[430],"Meeting":[431],"2024;":[432],"Part":[433],"1":[434],"(Regular":[435],"Abstracts);":[436],"2024":[437],"Apr":[438],"5-10;":[439],"San":[440],"Diego,":[441],"CA.":[442],"Philadelphia":[443],"(PA):":[444],"AACR;":[445],"Res":[447],"2024;84(6_Suppl):Abstract":[448],"nr":[449],"5539.":[450]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-03-23T00:00:00"}
